Best TWAS P=1.5e-11 · Best GWAS P=8.42e-10 conditioned to 0.273
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ARVCF | 0.30 | 0.22 | lasso | 3 | 0.23 | 6.0e-13 | 6.1 | -5.9 | 3.1e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Tibial | ARVCF | 0.17 | 0.10 | lasso | 5 | 0.11 | 7.8e-09 | 6.1 | -5.8 | 5.4e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | AC006547.14 | 0.09 | 0.00 | lasso | 4 | 0.00 | 6.9e-01 | 6.0 | -6.8 | 1.5e-11 | -0.81 | 0.02 | 0.56 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | AC006547.13 | 0.49 | 0.00 | lasso | 13 | 0.08 | 5.7e-03 | 2.9 | 5.5 | 2.8e-08 | 0.40 | 0.05 | 0.52 | FALSE |
| 5 | GTEx | Brain Cerebellum | AC006547.13 | 0.24 | -0.01 | enet | 15 | 0.00 | 3.4e-01 | 5.2 | 5.9 | 3.3e-09 | 0.77 | 0.04 | 0.36 | FALSE |
| 6 | GTEx | Nerve Tibial | ARVCF | 0.19 | 0.09 | lasso | 6 | 0.13 | 2.3e-09 | 6.0 | 5.7 | 1.3e-08 | 0.94 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARVCF | 0.03 | 0.01 | blup | 116 | 0.01 | 1.1e-02 | -1.6 | -5.4 | 7.5e-08 | -0.62 | 0.02 | 0.26 | FALSE |