Best TWAS P=1.98e-15 · Best GWAS P=5.93e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BID | 0.11 | 0.06 | enet | 12 | 0.12 | 3.0e-14 | -3.1 | 6.2 | 5.0e-10 | 0.81 | 0.17 | 0.83 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | BID | 0.32 | 0.17 | enet | 10 | 0.20 | 5.7e-06 | -3.1 | 5.8 | 6.5e-09 | 0.76 | 0.05 | 0.92 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | BCL2L13 | 0.21 | 0.01 | lasso | 5 | 0.01 | 3.4e-02 | -6.0 | 6.2 | 4.1e-10 | 0.71 | 0.13 | 0.13 | FALSE |
| 4 | GTEx | Nerve Tibial | BID | 0.17 | 0.11 | enet | 16 | 0.11 | 4.0e-08 | -3.3 | 5.4 | 8.4e-08 | 0.69 | 0.43 | 0.56 | FALSE |
| 5 | GTEx | Testis | BID | 0.33 | 0.12 | enet | 35 | 0.23 | 1.6e-10 | -3.3 | 5.2 | 1.6e-07 | 0.62 | 0.03 | 0.97 | FALSE |
| 6 | METSIM | Adipose | BID | 0.08 | 0.04 | lasso | 4 | 0.03 | 1.1e-05 | 7.6 | 7.6 | 3.1e-14 | 0.91 | 0.01 | 0.99 | FALSE |
| 7 | NTR | Blood | IL17RA | 0.07 | 0.07 | lasso | 3 | 0.08 | 2.3e-23 | 5.5 | -5.4 | 7.5e-08 | 0.00 | 0.05 | 0.95 | FALSE |
| 8 | YFS | Blood | BID | 0.17 | 0.21 | bslmm | 489 | 0.21 | 5.2e-68 | 8.1 | 7.9 | 2.0e-15 | 0.99 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL17RA | 0.14 | 0.07 | enet | 11 | 0.13 | 3.8e-11 | 5.1 | 5.3 | 1.2e-07 | -0.01 | 0.39 | 0.60 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IL17RA | 0.26 | 0.13 | blup | 77 | 0.18 | 1.5e-19 | -2.2 | 6.5 | 5.9e-11 | 0.02 | 0.99 | 0.00 | TRUE |
| 11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BCL2L13 | 0.22 | 0.07 | enet | 12 | 0.10 | 1.1e-04 | 2.9 | -6.0 | 1.8e-09 | -0.71 | 0.04 | 0.66 | FALSE |