Best TWAS P=2.53e-10 · Best GWAS P=2.87e-09 conditioned to 0.273
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | UBE2L3 | 0.10 | 0.12 | enet | 16 | 0.11 | 9.7e-14 | 5.9 | 5.4 | 6.4e-08 | 0.97 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CCDC116 | 0.15 | 0.12 | lasso | 7 | 0.13 | 1.7e-10 | 5.9 | -5.7 | 1.2e-08 | -0.98 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | CCDC116 | 0.09 | 0.05 | lasso | 3 | 0.03 | 1.4e-02 | 5.8 | -5.9 | 4.4e-09 | -1.00 | 0.03 | 0.95 | FALSE |
| 4 | GTEx | Artery Aorta | CCDC116 | 0.18 | 0.18 | lasso | 10 | 0.18 | 5.5e-10 | 5.8 | -5.8 | 5.6e-09 | -1.00 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Artery Coronary | CCDC116 | 0.16 | 0.06 | lasso | 4 | 0.09 | 5.6e-04 | 5.9 | -5.9 | 4.4e-09 | -0.97 | 0.03 | 0.95 | FALSE |
| 6 | GTEx | Artery Tibial | CCDC116 | 0.14 | 0.15 | lasso | 5 | 0.14 | 2.7e-11 | 5.9 | -5.9 | 3.8e-09 | -1.00 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Brain Cerebellum | CCDC116 | 0.25 | 0.16 | lasso | 4 | 0.10 | 6.5e-04 | 5.8 | -5.6 | 1.9e-08 | -0.99 | 0.03 | 0.95 | FALSE |
| 8 | GTEx | Brain Cortex | CCDC116 | 0.17 | 0.17 | lasso | 2 | 0.15 | 7.3e-05 | 5.9 | -5.9 | 3.9e-09 | -0.99 | 0.02 | 0.94 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | CCDC116 | 0.15 | 0.12 | enet | 20 | 0.13 | 5.1e-07 | 5.9 | -6.3 | 2.5e-10 | -0.85 | 0.02 | 0.97 | TRUE |
| 10 | GTEx | Breast Mammary Tissue (Female) | CCDC116 | 0.11 | -0.01 | enet | 15 | -0.01 | 5.7e-01 | 5.8 | -5.7 | 1.3e-08 | -0.84 | 0.02 | 0.70 | FALSE |
| 11 | GTEx | Colon Sigmoid | CCDC116 | 0.30 | 0.14 | lasso | 5 | 0.24 | 6.0e-09 | 2.8 | -5.2 | 1.9e-07 | -0.85 | 0.03 | 0.97 | FALSE |
| 12 | GTEx | Esophagus Gastroesophageal Junction | CCDC116 | 0.20 | 0.08 | lasso | 8 | 0.12 | 6.0e-05 | 5.8 | -5.6 | 2.2e-08 | -1.00 | 0.03 | 0.96 | FALSE |
| 13 | GTEx | Esophagus Mucosa | CCDC116 | 0.10 | 0.06 | lasso | 4 | 0.06 | 8.7e-05 | 5.9 | -5.9 | 4.1e-09 | -1.00 | 0.03 | 0.97 | FALSE |
| 14 | GTEx | Esophagus Muscularis | CCDC116 | 0.15 | 0.20 | lasso | 1 | 0.19 | 6.5e-12 | 5.8 | -5.8 | 5.3e-09 | -1.00 | 0.02 | 0.98 | FALSE |
| 15 | GTEx | Heart Atrial Appendage | CCDC116 | 0.11 | 0.03 | lasso | 3 | 0.05 | 1.8e-03 | 5.6 | -5.7 | 1.5e-08 | -0.96 | 0.03 | 0.94 | FALSE |
| 16 | GTEx | Lung | CCDC116 | 0.12 | 0.15 | lasso | 2 | 0.14 | 5.3e-11 | 5.7 | -5.8 | 8.7e-09 | -0.99 | 0.02 | 0.98 | FALSE |
| 17 | GTEx | Nerve Tibial | CCDC116 | 0.22 | 0.25 | enet | 9 | 0.29 | 1.8e-20 | 5.9 | -5.8 | 6.7e-09 | -1.00 | 0.02 | 0.98 | FALSE |
| 18 | GTEx | Skin Sun Exposed Lower leg | CCDC116 | 0.07 | 0.08 | enet | 8 | 0.08 | 6.6e-07 | 5.9 | -5.5 | 3.0e-08 | -0.91 | 0.02 | 0.98 | FALSE |
| 19 | GTEx | Spleen | CCDC116 | 0.20 | 0.07 | enet | 15 | 0.14 | 1.8e-04 | 5.9 | -5.3 | 9.7e-08 | -0.89 | 0.03 | 0.87 | FALSE |
| 20 | GTEx | Thyroid | CCDC116 | 0.10 | 0.07 | lasso | 4 | 0.07 | 3.7e-06 | 5.9 | -5.9 | 4.2e-09 | -1.00 | 0.02 | 0.98 | FALSE |
| 21 | GTEx | Thyroid | HIC2 | 0.07 | 0.00 | lasso | 4 | 0.00 | 5.9e-01 | 5.9 | 5.9 | 4.5e-09 | 1.00 | 0.03 | 0.64 | FALSE |
| 22 | GTEx | Whole Blood | UBE2L3 | 0.06 | 0.00 | enet | 22 | 0.01 | 4.0e-02 | 5.9 | 5.2 | 2.0e-07 | 0.76 | 0.02 | 0.90 | FALSE |
| 23 | METSIM | Adipose | CCDC116 | 0.06 | 0.07 | enet | 22 | 0.08 | 4.6e-12 | 5.7 | -5.3 | 1.1e-07 | -0.93 | 0.03 | 0.97 | FALSE |
| 24 | YFS | Blood | UBE2L3 | 0.13 | 0.25 | bslmm | 330 | 0.25 | 1.3e-82 | 5.8 | 5.8 | 5.3e-09 | 1.00 | 0.02 | 0.98 | FALSE |
| 25 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CCDC116 | 0.03 | 0.02 | enet | 12 | 0.02 | 5.1e-03 | 5.6 | -5.4 | 6.3e-08 | -0.84 | 0.01 | 0.74 | FALSE |
| 26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC116 | 0.04 | 0.04 | blup | 40 | 0.05 | 1.1e-09 | 5.9 | -5.5 | 5.0e-08 | -0.88 | 0.02 | 0.98 | FALSE |
| 27 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CCDC116 | 0.05 | 0.06 | lasso | 1 | 0.05 | 1.3e-03 | 5.6 | -5.6 | 2.3e-08 | -0.96 | 0.01 | 0.85 | FALSE |
| 28 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC116 | 0.10 | 0.06 | blup | 39 | 0.07 | 4.4e-03 | 5.6 | -6.0 | 2.3e-09 | -0.97 | 0.01 | 0.83 | FALSE |
| 29 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC116 | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.4e-03 | 5.6 | -5.6 | 1.8e-08 | -0.96 | 0.02 | 0.85 | FALSE |
| 30 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | YDJC | 0.04 | 0.00 | blup | 34 | 0.02 | 4.0e-02 | 5.7 | 5.6 | 2.6e-08 | 0.94 | 0.01 | 0.65 | FALSE |
| 31 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCDC116 | 0.07 | 0.12 | blup | 40 | 0.11 | 1.2e-12 | 5.7 | -5.9 | 3.1e-09 | -0.96 | 0.02 | 0.98 | FALSE |
| 32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | YDJC | 0.08 | 0.14 | blup | 34 | 0.15 | 2.9e-16 | 5.7 | 5.5 | 4.4e-08 | 0.98 | 0.02 | 0.98 | FALSE |
| 33 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CCDC116 | 0.07 | 0.02 | blup | 40 | 0.03 | 1.5e-02 | 5.9 | -5.3 | 9.9e-08 | -0.96 | 0.01 | 0.79 | FALSE |
| 34 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC116 | 0.11 | 0.14 | enet | 14 | 0.12 | 2.3e-05 | 5.9 | -5.9 | 4.7e-09 | -1.00 | 0.02 | 0.98 | FALSE |
| 35 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC116 | 0.06 | 0.05 | blup | 40 | 0.06 | 4.3e-07 | 5.9 | -5.1 | 2.7e-07 | -0.91 | 0.01 | 0.99 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | CCDC116 | 0.05 | 0.07 | blup | 40 | 0.07 | 4.6e-07 | 5.9 | -5.7 | 1.3e-08 | -0.97 | 0.01 | 0.99 | FALSE |