Best TWAS P=1e-28 · Best GWAS P=2.31e-32 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AP000350.4 | 0.49 | 0.25 | enet | 35 | 0.16 | 8.7e-05 | 2.1 | 5.4 | 5.7e-08 | -0.27 | 0.32 | 0.12 | TRUE |
| 2 | GTEx | Lung | KB-226F1.2 | 0.16 | 0.06 | enet | 14 | 0.07 | 2.5e-06 | -4.1 | -5.2 | 2.2e-07 | 0.18 | 0.96 | 0.02 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | AP000351.10 | 0.33 | 0.20 | enet | 35 | 0.14 | 5.0e-08 | -4.0 | 5.3 | 1.4e-07 | -0.06 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | ADORA2A-AS1 | 0.12 | 0.16 | lasso | 4 | 0.15 | 3.0e-12 | 6.5 | -6.7 | 2.0e-11 | 0.38 | 1.00 | 0.00 | FALSE |
| 5 | METSIM | Adipose | SPECC1L | 0.07 | 0.08 | bslmm | 454 | 0.08 | 2.8e-12 | 4.1 | 5.4 | 5.4e-08 | -0.17 | 1.00 | 0.00 | FALSE |
| 6 | METSIM | Adipose | UPB1 | 0.08 | 0.11 | lasso | 9 | 0.10 | 3.3e-15 | 8.0 | 8.3 | 9.7e-17 | -0.44 | 1.00 | 0.00 | FALSE |
| 7 | NTR | Blood | MIF | 0.02 | 0.00 | lasso | 4 | 0.01 | 6.5e-05 | 4.4 | -5.6 | 2.7e-08 | 0.22 | 0.70 | 0.01 | TRUE |
| 8 | NTR | Blood | SNRPD3 | 0.02 | 0.02 | lasso | 4 | 0.01 | 1.3e-05 | 1.7 | 5.2 | 1.6e-07 | -0.29 | 0.89 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | POM121L9P | 0.07 | 0.06 | lasso | 1 | 0.05 | 8.6e-05 | 7.3 | 7.3 | 2.5e-13 | -0.50 | 0.20 | 0.03 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POM121L9P | 0.09 | 0.09 | enet | 9 | 0.09 | 1.6e-18 | 7.3 | 11.1 | 1.0e-28 | -0.83 | 0.16 | 0.84 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UPB1 | 0.01 | 0.02 | lasso | 3 | 0.01 | 6.5e-04 | 6.5 | 6.6 | 5.0e-11 | -0.36 | 0.09 | 0.24 | TRUE |
| 12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GGT5 | 0.09 | 0.03 | blup | 36 | 0.05 | 1.7e-03 | 1.6 | 6.7 | 1.5e-11 | -0.63 | 0.01 | 0.54 | FALSE |
| 13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | POM121L9P | 0.08 | 0.05 | lasso | 4 | 0.05 | 1.8e-03 | 7.3 | 7.9 | 2.1e-15 | -0.54 | 0.12 | 0.35 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | POM121L9P | 0.12 | 0.03 | enet | 5 | 0.08 | 1.7e-05 | 7.3 | 9.1 | 6.0e-20 | -0.70 | 0.06 | 0.82 | TRUE |
| 15 | The Cancer Genome Atlas | Esophageal Carcinoma | POM121L9P | 0.37 | 0.18 | blup | 27 | 0.21 | 3.2e-07 | -9.5 | 5.7 | 1.6e-08 | -0.32 | 0.28 | 0.10 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GGT5 | 0.02 | 0.02 | blup | 36 | 0.02 | 1.1e-03 | 2.4 | 5.2 | 2.2e-07 | -0.47 | 0.03 | 0.27 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POM121L9P | 0.08 | 0.11 | lasso | 2 | 0.12 | 4.0e-13 | 7.5 | 9.3 | 1.2e-20 | -0.68 | 0.84 | 0.16 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C22orf45 | 0.10 | 0.03 | lasso | 2 | 0.06 | 3.4e-07 | 1.2 | -5.4 | 6.0e-08 | 0.39 | 0.01 | 0.98 | TRUE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | POM121L9P | 0.14 | 0.10 | lasso | 5 | 0.14 | 4.5e-16 | -9.5 | 10.2 | 1.6e-24 | -0.70 | 0.99 | 0.01 | TRUE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GGT5 | 0.09 | 0.06 | blup | 35 | 0.08 | 1.6e-09 | 1.5 | 6.4 | 1.7e-10 | -0.59 | 0.92 | 0.08 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | POM121L9P | 0.10 | 0.05 | lasso | 4 | 0.09 | 3.1e-10 | -9.5 | 10.3 | 9.0e-25 | -0.72 | 0.77 | 0.23 | FALSE |
| 22 | The Cancer Genome Atlas | Lung Adenocarcinoma | POM121L9P | 0.11 | 0.11 | enet | 8 | 0.14 | 4.7e-16 | 7.5 | 9.7 | 2.0e-22 | -0.72 | 1.00 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | POM121L9P | 0.15 | 0.16 | lasso | 4 | 0.16 | 9.9e-18 | 7.3 | 8.6 | 5.5e-18 | -0.57 | 1.00 | 0.00 | TRUE |
| 24 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | POM121L9P | 0.08 | 0.06 | blup | 28 | 0.05 | 4.7e-04 | 7.3 | 6.9 | 3.9e-12 | -0.48 | 0.13 | 0.54 | TRUE |
| 25 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | POM121L9P | 0.19 | 0.08 | enet | 5 | 0.07 | 8.5e-04 | 7.5 | 8.3 | 7.3e-17 | -0.58 | 0.23 | 0.27 | FALSE |
| 26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POM121L9P | 0.12 | 0.07 | lasso | 7 | 0.11 | 6.8e-12 | 7.5 | 9.8 | 1.3e-22 | -0.80 | 0.04 | 0.96 | FALSE |
| 27 | The Cancer Genome Atlas | Stomach Adenocarcinoma | POM121L9P | 0.18 | 0.11 | lasso | 4 | 0.12 | 9.0e-09 | 7.3 | 8.6 | 6.3e-18 | -0.58 | 0.99 | 0.01 | FALSE |
| 28 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | POM121L9P | 0.15 | 0.08 | lasso | 1 | 0.00 | 2.8e-01 | 7.5 | 7.5 | 5.1e-14 | -0.55 | 0.02 | 0.57 | FALSE |
| 29 | The Cancer Genome Atlas | Thyroid Carcinoma | C22orf45 | 0.08 | 0.02 | enet | 5 | 0.01 | 3.1e-02 | 8.5 | -8.5 | 1.4e-17 | 0.52 | 0.00 | 0.70 | FALSE |
| 30 | The Cancer Genome Atlas | Thyroid Carcinoma | GGT5 | 0.06 | 0.01 | enet | 5 | 0.02 | 2.1e-03 | -9.5 | 7.7 | 1.8e-14 | -0.74 | 0.02 | 0.48 | FALSE |
| 31 | The Cancer Genome Atlas | Thyroid Carcinoma | POM121L9P | 0.29 | 0.16 | enet | 14 | 0.24 | 2.5e-23 | 7.3 | 9.6 | 8.9e-22 | -0.78 | 0.09 | 0.91 | FALSE |
| 32 | The Cancer Genome Atlas | Thyroid Carcinoma | UPB1 | 0.06 | 0.07 | lasso | 4 | 0.06 | 6.3e-07 | 7.7 | 7.8 | 8.8e-15 | -0.37 | 0.20 | 0.80 | FALSE |