Best TWAS P=4.66e-49 · Best GWAS P=5.29e-160 conditioned to 3.14e-95
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Thyroid | IKZF2 | 0.18 | 0.08 | enet | 21 | 0.10 | 8.9e-08 | 4.7 | 13.0 | 1.0e-38 | -0.34 | 0.95 | 0.03 | TRUE |
| 2 | GTEx | Thyroid | RP11-105N14.1 | 0.14 | 0.02 | lasso | 3 | 0.03 | 1.4e-03 | -11.6 | 10.3 | 7.5e-25 | -0.22 | 0.70 | 0.01 | TRUE |
| 3 | GTEx | Vagina | RP11-105N14.1 | 0.27 | 0.07 | enet | 21 | 0.07 | 1.0e-02 | -4.1 | 10.1 | 8.1e-24 | -0.20 | 0.09 | 0.05 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | ERBB4 | 0.10 | 0.01 | bslmm | 1050 | 0.03 | 4.0e-05 | -2.1 | -5.6 | 2.4e-08 | 0.12 | 0.24 | 0.05 | TRUE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | IKZF2 | 0.11 | 0.00 | lasso | 6 | 0.04 | 7.2e-03 | -11.6 | 14.7 | 4.7e-49 | -0.38 | 0.04 | 0.22 | TRUE |