TWAS hub - IKZF2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.179	0.055	6.2e-05	0.076	NA	0.096	NA	0.094	1.8e-06	NA	8.9e-08	NA	1.2e-07
2	TCGA	Pheochromocytoma and Paraganglioma	0.114	0.060	8.2e-03	0.002	0.031	0.020	NA	0.045	2.7e-01	0.022	5.5e-02	NA	7.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	25.0	192.5	216.1	13.0	14.7
Supplements: Calcium	7.9	8.7	10.1	3.2	2.7
Pulse wave Arterial Stiffness index	6.1	7.1	11.2	1.7	3.3
Pulse wave peak to peak time	5.0	5.9	9.5	-1.5	-3.1
Supplements: Glucosamine	4.8	6.2	7.7	2.2	2.8
Average weekly red wine intake	4.8	7.1	11.1	1.7	3.3
Mineral and other dietary supplements	4.7	6.3	10.1	-1.6	-3.2
Alcohol drinker status: Previous	4.6	5.2	9.2	1.1	3.0
Prostate Cancer	4.4	6.2	7.8	2.8	2.1
Mouth/teeth dental problems: Dentures	4.3	7.3	11.8	3.4	1.7
Average weekly beer plus cider intake	3.9	5.6	9.9	-1.1	-3.1
Blood White Count	3.6	26.8	32.7	5.7	4.6
Glaucoma (self-reported)	3.5	4.1	6.8	2.6	1.2
Intelligence (Savage-Jansen 2018)	3.4	10.5	12.9	-2.8	-3.6
Ulcerative Colitis (UC)	3.4	6.3	7.6	2.8	2.2
Osteoporosis (self-reported)	3.4	4.2	6.4	2.5	1.4
Lung cancer (father)	3.3	3.8	3.9	1.9	2.0
Tinnitus: Yes, now most or all of the time	3.1	3.7	5.4	-1.4	-2.3
Coronary Artery Disease (CAD)	3.0	3.6	4.3	-1.7	-2.1
Medication: Omeprazole (e.g. Zanprol)	2.9	3.6	5.8	-1.1	-2.4
Alzheimer’s Disease (in father)	2.8	3.1	3.2	1.7	1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	10.1	-1.6	-3.2
Supplements: Vitamin C	2.8	3.3	4.9	-2.2	-1.3
Back pain experienced in last month	2.7	4.0	4.5	-1.9	-2.1
Medication: Blood pressure	2.6	4.9	6.6	1.8	2.6
Medication: Lisinopril	2.6	3.4	4.1	2.0	1.6
Medication: Levothyroxine sodium	2.5	4.2	4.9	-2.2	-1.9
Had other major operations	2.5	3.1	4.2	1.4	2.0
Average weekly champagne plus white wine intake	2.5	3.4	3.8	-1.8	-1.9
Financial difficulties in last 2 years	2.4	3.2	6.2	2.5	-0.3
Hypothyroidism (self reported)	2.3	5.2	5.7	-2.1	-2.4
Pain all over the body in last month	2.3	2.5	4.4	-2.1	-0.7
Chronic bronchitis/emphysema (mother)	2.3	2.6	4.0	2.0	1.1
Exposure to tobacco smoke outside home	2.3	3.1	6.1	-0.2	-2.5
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	3.2	1.8	1.3
Heel bone mineral density (BMD) T-score, automated (right)	2.2	4.9	9.1	-0.9	-3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	6.3	-2.5	-1.7
Mother’s age at death	2.2	2.7	3.0	-1.7	-1.6
Medication for hormone replacement therapy	2.1	2.4	4.5	2.1	0.5
Relative age voice broke	2.1	3.2	4.4	-1.4	-2.1
Comparative height size at age 10	2.1	11.5	13.6	3.1	3.7
Breast Cancer	2.0	4.9	8.6	-2.9	-1.1
Relative age of first facial hair	2.0	4.1	7.5	-2.7	-0.9
Comparative body size at age 10	2.0	5.6	9.8	1.2	3.1
Verbal and Numeric Reasoning (VNR)	1.9	4.5	5.1	-2.0	-2.3
Diabetes (father)	1.9	2.4	4.7	0.2	-2.2
Leg pain on walking	1.9	2.3	4.2	-2.1	-0.7
Pain experienced in last month	1.9	3.2	5.2	1.1	2.3
Irritable Bowel Disease (IBD)	1.8	4.4	5.2	1.9	2.3
Past tobacco smoking	1.8	3.3	4.2	-2.1	-1.5
Alcohol usually taken with meals	1.8	2.9	5.3	-0.6	2.3
Medication: Omeprazole	1.8	2.1	3.9	-0.6	-2.0
Fractured/broken bones in last 5 years	1.8	2.3	2.5	-1.5	-1.6
Medication: Metformin	1.7	2.5	4.3	2.1	0.8
Medication: Atenolol	1.7	2.2	4.1	-0.4	-2.0
Mouth/teeth dental problems	1.7	2.6	5.2	-2.3	-0.3
Fluid intelligence score	1.7	3.4	4.4	-1.6	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	7.0	-2.6	-1.9
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	3.3	-1.8	-1.8
Primary Biliary Cirrhosis	1.6	2.3	3.7	-0.9	-1.9
Average weekly fortified wine intake	1.6	1.9	2.7	-1.6	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.3	1.8	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	3.9	2.0	0.3
Wears glasses or contact lenses	1.6	1.8	3.5	-0.4	1.9
Unable to work because of sickness or disability	1.6	2.1	3.6	1.9	0.7
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	2.2	-1.5	-1.4
Pack years of smoking	1.6	2.4	4.0	2.0	0.9
HbA1C	1.5	1.7	2.8	-0.7	-1.7
HDL Cholesterol	1.5	2.5	2.5	1.6	1.6
Triglycerides	1.5	2.4	2.4	-1.6	-1.6
Lung FEV1/FVC ratio	1.5	7.4	7.4	-2.7	-2.7
Ever used hormone-replacement therapy (HRT)	1.5	1.9	2.0	1.4	1.4
Blood clot in the leg (DVT)	1.5	2.0	2.0	-1.4	-1.4
Shortness of breath walking on level ground	1.5	1.8	2.9	0.9	1.7
Diabetes diagnosed by doctor	1.5	2.5	5.0	2.2	0.2
Medication for cholesterol	1.5	2.3	3.7	-1.9	-1.0
Ever smoked	1.5	2.7	3.8	1.9	1.3
Age started oral contraceptive pill	1.5	1.9	3.8	0.1	1.9
Cholesterol lowering medication	1.5	2.2	3.6	0.9	1.9
Chronotype (morning person)	1.4	3.2	5.1	-2.3	-1.1
Systolic blood pressure, automated reading	1.4	3.9	6.6	1.2	2.6
Nervous feelings	1.4	2.7	4.0	-2.0	-1.2
Diabetes (self-reported)	1.4	2.1	4.1	2.0	0.4
Wheeze or whistling in the chest in last year	1.4	2.6	4.4	2.1	0.9
Family relationship satisfaction	1.4	1.7	2.5	-0.9	-1.6
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.5	0.4	1.9
Illnesses of father: High blood pressure	1.4	1.7	2.8	-1.7	-0.7
Rheumatoid Arthritis	1.3	1.7	2.1	1.2	1.4
Sensitivity / hurt feelings	1.3	2.2	4.2	0.5	2.0
Stomach or abdominal pain in last month	1.3	1.6	1.9	-1.4	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.2	1.5	1.0
Eye problems/disorders: Glaucoma	1.3	1.5	2.2	1.5	0.9
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.0	-1.2	-1.4
Neuroticism (2016)	1.2	1.7	3.0	-0.7	1.7
Heel T-Score	1.2	9.8	17.4	-1.5	-4.2
Type 2 Diabetes (T2D) (2018)	1.2	2.2	2.4	1.4	-1.6
Vitamin and mineral supplements	1.2	1.6	2.0	1.4	1.1
Impedance of leg (right)	1.2	5.9	9.7	-1.4	-3.1
Current tobacco smoking	1.2	2.0	3.2	1.8	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	1.8	-1.3	-1.0
Breastfed as a baby	1.2	1.5	1.9	1.1	1.4
Emphysema/chronic bronchitis	1.2	1.3	2.7	1.6	0.1
Illnesses of father: None of the above (group 1)	1.2	1.5	1.7	1.1	1.3
Smoking Status	1.1	2.7	4.2	2.0	1.1
Pack years adult smoking proportion	1.1	1.7	3.0	1.7	0.5
Hair/balding pattern: Pattern 2	1.1	1.4	2.3	-0.6	-1.5
Heart attack	1.1	1.4	1.4	-1.2	-1.2
Illnesses of siblings	1.1	1.5	2.3	-0.8	-1.5
Hair/balding pattern: Pattern 3	1.1	1.6	2.4	-1.6	-0.9
Pulse rate	1.1	1.9	3.0	0.8	1.7
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	2.1	-1.4	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.1	-0.7	-1.4
Number of operations (self-reported)	1.1	1.6	2.7	0.7	1.6
Lung FVC	1.0	5.0	6.9	-2.6	-1.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.7	0.0	1.6
Ever had hysterectomy (womb removed)	1.0	1.2	1.8	1.4	0.7
Impedance of leg (left)	1.0	5.0	8.4	-1.2	-2.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.4	-1.6	-0.4
Length of working week for main job	1.0	1.1	1.3	1.0	1.2
Exposure to tobacco smoke at home	1.0	1.1	2.1	-0.4	-1.4
Eye problems/disorders: None of the above	1.0	1.1	2.0	-1.4	-0.5
Suffer from ‘nerves’	1.0	1.6	2.5	-1.6	-0.8
Illnesses of father: Heart disease	1.0	1.4	1.9	-1.4	-0.9
Long-standing illness, disability or infirmity	1.0	1.6	3.0	1.7	0.3
Smoking status: Current	1.0	1.6	2.4	1.6	0.8
Crohns Disease (2012)	0.9	1.4	2.8	0.0	1.7
Ulcerative Colitis	0.9	1.3	1.9	1.4	0.9
Diabetes (mother)	0.9	1.2	2.2	1.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.3	0.6	-1.5
Smoking status: Previous	0.9	1.4	1.4	1.2	1.2
Impedance of whole body	0.9	4.7	8.6	-0.9	-2.9
Depression (Nagel 2018)	0.8	1.2	1.7	1.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	1.5	-1.2	-1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	2.7	-1.6	-1.6
Happiness	0.8	0.9	1.0	0.9	1.0
Trunk predicted mass	0.8	4.5	7.6	1.2	2.8
Health satisfaction	0.8	1.1	1.1	1.0	-1.1
Medication for pain relief, constipation, heartburn	0.8	1.4	2.6	-1.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.6	-1.3	0.6
Loneliness, isolation	0.8	1.0	1.8	1.3	0.5
Depressed Affect (Nagel 2018)	0.7	1.5	1.6	1.2	1.2
Major Depression (MDD)	0.7	0.8	1.5	0.3	1.2
Waist circumference	0.7	2.4	2.9	1.4	1.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.8	1.3	0.2
Trunk fat-free mass	0.7	4.3	7.2	1.1	2.7
Overall health rating	0.7	1.4	2.7	1.6	-0.4
Leg fat-free mass (right)	0.7	3.5	4.4	1.6	2.1
Whole body water mass	0.7	4.1	6.7	1.3	2.6
Guilty feelings	0.7	1.0	1.1	-1.0	-1.0
Financial situation satisfaction	0.7	0.8	1.6	1.3	-0.3
Heart disease (siblings)	0.7	0.9	1.7	1.3	-0.1
Body Mass Index (BMI) (2010)	0.6	0.9	1.7	-1.3	0.3
Hand grip strength (left)	0.6	1.6	2.8	1.7	0.6
Hearing difficulty/problems: Yes	0.6	0.9	1.3	-1.1	-0.7
Hand grip strength (right)	0.6	1.7	3.4	1.8	-0.3
Leg predicted mass (left)	0.6	3.0	3.7	1.6	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.9	0.2	-1.4
Age at first live birth	0.6	1.0	1.5	-0.7	1.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	0.9	0.6	0.9
Medication: Ibuprofen	0.6	0.7	1.4	1.2	0.3
Pulse rate, automated reading	0.6	1.8	2.8	0.9	1.7
Alcohol intake frequency.	0.6	1.4	2.7	0.2	1.6
Whole body fat-free mass	0.6	3.7	5.8	1.2	2.4
Leg predicted mass (right)	0.6	3.4	4.5	1.5	2.1
Miserableness	0.6	1.0	1.1	1.1	1.0
Hearing aid user	0.6	0.7	1.2	1.1	-0.4
Alcohol drinker status: Never	0.6	0.7	1.2	0.3	1.1
Basal metabolic rate	0.6	3.1	4.9	1.2	2.2
Arm fat-free mass (left)	0.6	3.2	5.8	0.8	2.4
Arm predicted mass (left)	0.6	2.9	5.2	0.7	2.3
Fasting Glucose	0.5	0.6	1.0	-1.0	0.3
Schizophrenia (2014)	0.5	1.0	1.6	0.6	-1.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.6	0.8	-0.8
Leg fat-free mass (left)	0.5	2.7	3.5	1.4	1.9
Townsend deprivation index at recruitment	0.5	0.7	1.3	0.3	-1.1
Age when periods started (menarche)	0.5	1.3	1.3	-1.1	-1.1
High blood pressure	0.5	1.5	2.3	0.8	1.5
Multivitamins +/- minerals	0.5	0.7	0.8	-0.9	-0.7
Had menopause	0.5	0.6	1.1	0.3	1.1
Falls in the last year	0.5	0.6	1.1	0.4	1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.2	-1.1	-1.1
Medication: Cholesterol lowering	0.5	0.8	1.4	-0.4	-1.2
Prospective memory result	0.5	0.6	1.1	0.3	1.0
Headache pain in last month	0.5	0.8	1.5	1.2	-0.2
Worry too long after embarrassment	0.5	0.9	1.7	0.1	-1.3
Number of full sisters	0.5	0.6	1.0	-0.5	-1.0
Medication: Aspirin	0.5	0.6	0.9	0.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.0	-0.2	-1.4
Mood swings	0.5	0.8	1.1	1.1	0.8
Diastolic blood pressure, automated reading	0.5	1.5	1.7	-1.2	1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	1.1	0.2
Number of treatments/medications taken	0.4	0.7	1.3	1.1	-0.2
Weight	0.4	2.1	2.6	1.2	1.6
Hip circumference	0.4	1.9	2.5	1.1	1.6
Time employed in main current job	0.4	0.5	0.7	0.4	0.9
Father’s age at death	0.4	0.5	0.5	-0.6	0.7
Impedance of arm (left)	0.4	1.9	3.8	0.3	-1.9
Peak expiratory flow (PEF)	0.4	0.9	1.4	-0.7	-1.2
Pulse wave reflection index	0.4	0.5	0.7	0.6	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	0.4	1.1
Medication: Amlodipine	0.4	0.5	0.7	0.8	0.6
High blood pressure (siblings)	0.4	0.6	1.1	-1.1	0.3
Number of full brothers	0.4	0.5	0.9	0.9	0.5
Age at last live birth	0.4	0.7	1.3	-0.1	1.1
Commuting to job workplace: Walk	0.4	0.5	0.9	-0.9	-0.2
Osteoarthritis (self-reported)	0.4	0.5	0.5	0.6	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.6	-0.6	-1.3
Neuroticism (Nagel 2018)	0.3	0.7	0.7	0.8	0.9
Crohns Disease (2017)	0.3	0.8	1.3	0.4	1.2
Lupus	0.3	0.4	0.7	-0.4	0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	-0.8	-0.3
Neuroticism	0.3	0.6	1.1	0.4	1.1
Medication: Co-codamol	0.3	0.3	0.6	0.8	-0.3
Severe depression (siblings)	0.3	0.3	0.5	-0.7	-0.3
Maternal smoking around birth	0.3	0.5	0.9	0.9	0.2
Qualifications: CSEs or equivalent	0.3	0.5	0.9	0.1	-0.9
Serious illness, injury or assault to yourself	0.3	0.4	0.5	0.7	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	-1.1	-0.2
High blood pressure (mother)	0.3	0.4	0.7	-0.8	0.3
Impedance of arm (right)	0.3	1.2	1.9	0.7	-1.4
Number of live births	0.3	0.4	0.7	-0.9	0.0
Standing height	0.3	3.3	3.6	1.9	1.7
Forced vital capacity (FVC), Best measure	0.3	1.2	2.1	-1.4	-0.5
Arm fat-free mass (right)	0.3	1.4	2.8	0.2	1.7
Medication: Blood pressure	0.3	0.5	0.9	-0.9	-0.2
Migraine (self-reported)	0.3	0.3	0.6	-0.2	0.8
Arm predicted mass (right)	0.3	1.4	2.8	0.2	1.7
Chest pain or discomfort	0.3	0.5	0.6	0.8	-0.6
Hypertension (Self-reported)	0.3	0.9	1.5	0.5	1.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.1	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	-0.4
Friendships satisfaction	0.3	0.4	0.5	0.7	-0.6
Medication: Gliclazide	0.3	0.3	0.5	0.7	0.4
Risk taking	0.3	0.4	0.4	0.6	0.6
Myopia	0.3	0.4	0.8	0.9	-0.1
Schizophrenia (2018)	0.2	0.5	0.9	-0.1	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	0.5	-0.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	0.4	-0.6
Ovarian Cancer	0.2	0.3	0.5	0.2	-0.7
Age at First Birth	0.2	0.3	0.5	-0.2	0.7
Bipolar Disorder (2011)	0.2	0.2	0.3	0.4	0.6
BMI	0.2	1.4	1.9	0.9	1.4
Waist Hip Ratio (WHR)	0.2	0.8	0.8	0.9	0.9
Angina	0.2	0.3	0.5	-0.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	-0.7	-0.3
Sitting height	0.2	1.1	1.1	-1.1	-1.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.2	0.4	0.5
Trunk fat mass	0.2	0.9	1.4	1.2	0.7
Number of incorrect matches in round	0.2	0.3	0.6	-0.2	0.8
Hearing difficulty/problems with background noise	0.2	0.4	0.7	0.2	0.8
Medication: Simvastatin	0.2	0.2	0.4	0.6	0.3
Noisy workplace	0.2	0.2	0.4	-0.6	0.3
Arm fat mass (right)	0.2	1.0	1.2	0.9	1.1
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	-0.6	-0.8
Loud music exposure frequency	0.2	0.2	0.3	-0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.0	0.6
Birth weight	0.2	0.5	0.5	-0.6	-0.7
Neck or shoulder pain in last month	0.2	0.2	0.3	0.6	-0.3
Medication: Allopurinol	0.2	0.2	0.3	0.6	-0.3
Medication: Seretide 50 evohaler	0.2	0.3	0.4	0.7	-0.4
Mean time to correctly identify matches	0.2	0.4	0.4	0.6	0.6
Had major operations	0.2	0.2	0.4	0.6	-0.2
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.7	-0.1
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.5	0.7	-0.6
Medication: Aspirin	0.2	0.2	0.3	0.6	-0.4
Arm fat mass (left)	0.2	0.8	1.2	0.6	1.1
High cholesterol (Self-reported)	0.2	0.4	0.7	0.2	-0.8
Medication: Atorvastatin	0.2	0.2	0.3	-0.4	-0.5
Ever depressed for a whole week	0.2	0.2	0.5	0.7	0.2
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.6	-0.3
Bipolar Disorder (2018)	0.1	0.2	0.2	0.3	0.4
Worry (Nagel 2018)	0.1	0.3	0.3	-0.5	-0.5
Reaction Time	0.1	0.1	0.2	0.4	-0.4
LDL Cholesterol	0.1	0.2	0.5	0.0	-0.7
Blood Platelet Count	0.1	1.0	1.5	1.2	0.6
Blood Red Count	0.1	0.8	1.7	-1.3	0.0
Height	0.1	2.5	3.8	1.1	2.0
Allergy or Eczema	0.1	0.3	0.5	-0.7	-0.3
Cardiovascular Disease	0.1	0.3	0.5	0.7	-0.3
Respiratory disease	0.1	0.1	0.3	-0.0	-0.5
Tanning	0.1	0.8	1.1	-0.6	1.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.4	-0.1
Supplements: Zinc	0.1	0.2	0.3	0.0	0.6
Trunk fat percentage	0.1	0.3	0.7	0.8	-0.1
Fed-up feelings	0.1	0.2	0.4	0.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	-0.3	-0.3
Taking other prescription medications	0.1	0.1	0.2	0.2	-0.5
Body mass index (BMI)	0.1	0.6	0.9	0.5	1.0
Medication: Ramipril	0.1	0.2	0.3	0.1	0.5
Arm fat percentage (right)	0.1	0.3	0.4	0.6	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.2	-0.6
Worrier / anxious feelings	0.1	0.2	0.3	0.5	-0.2
Asthma	0.1	0.2	0.3	-0.6	0.0
Medication: Lansoprazole	0.1	0.1	0.1	0.2	0.3
Illnesses of mother	0.1	0.1	0.3	-0.0	-0.5
Birth weight of first child	0.1	0.2	0.3	-0.5	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.0	0.5
Medication: Paracetamol	0.1	0.2	0.3	0.6	0.2
Gout (self-reported)	0.1	0.1	0.2	-0.3	-0.4
Number of children fathered	0.1	0.1	0.2	0.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	0.3	0.5
Qualifications: College or University degree	0.1	0.4	0.6	-0.5	-0.8
Angina (self-reported)	0.1	0.2	0.4	-0.6	-0.1
Whole body fat mass	0.1	0.4	0.6	0.8	0.4
Leg fat mass (right)	0.1	0.4	0.4	0.6	0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.3	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	-0.3	-0.3
Knee pain experienced in last month	0.1	0.2	0.2	0.4	-0.5
Ever had bowel cancer screening	0.1	0.1	0.1	0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.2	-0.3
Asthma (self-reported)	0.1	0.1	0.1	-0.4	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	0.1	-0.5
Medication: Bendroflumethiazide	0.1	0.2	0.3	0.3	0.5
Medication: Paracetamol	0.1	0.1	0.2	0.4	0.1
Irritability	0.1	0.2	0.4	0.6	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.5	0.0
Leg fat mass (left)	0.1	0.4	0.4	0.6	0.7
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.1	-0.5
Mean Putamen Volume	0.0	0.0	0.1	0.2	0.0
Systolic Blood Pressure	0.0	0.2	0.4	-0.1	0.6
Hair Pigment	0.0	0.2	0.3	-0.4	-0.5
Average weekly spirits intake	0.0	0.0	0.0	0.2	-0.0
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.1	0.2
Forced vital capacity (FVC)	0.0	0.2	0.2	-0.4	-0.4
Qualifications: None of the above	0.0	0.0	0.0	0.2	0.1
Allergy	0.0	0.1	0.1	0.4	0.3
Neuroticism score	0.0	0.0	0.1	-0.1	0.3
Depression (self-reported)	0.0	0.1	0.1	-0.3	0.2
Tense / ‘highly strung’	0.0	0.0	0.0	-0.1	0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	0.0	-0.1
Body fat percentage	0.0	0.2	0.2	0.5	-0.3
Leg fat percentage (right)	0.0	0.1	0.1	0.2	0.3
Heart disease (mother)	0.0	0.0	0.1	-0.3	-0.1
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.1	-0.1
Arm fat percentage (left)	0.0	0.0	0.1	0.3	0.0
Breast cancer (self-reported)	0.0	0.0	0.1	0.0	-0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	0.0	-0.1
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.2	0.2
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.2	-0.2
Leg fat percentage (left)	0.0	0.2	0.2	0.4	0.4
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	-0.2	0.2

Hub : Genes

IKZF2

Models

Trait associations