Hub : Genes

ERBB4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0968	0.0313	0.0012	0.010	0.032	0.031	0.033	0.032	0.019	4.7e-05	6.9e-05	4e-05	4.8e-05
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0875	0.0326	0.0015	-0.001	0.029	0.019	NA	0.000	0.500	3.1e-04	2.7e-03	NA	3.4e-01
3	TCGA	Testicular Germ Cell Tumors	0.3810	0.1270	0.0038	0.010	0.020	0.002	NA	0.011	0.140	6.2e-02	2.7e-01	NA	1.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.2	0.4	-0.2	0.3
Bipolar Disorder or Schizophrenia	1.0	2.5	3.7	1.2	1.4	1.9
Depressed Affect (Nagel 2018)	0.8	1.6	3.4	-1.1	0.4	-1.9
Depression (Nagel 2018)	0.7	1.0	2.4	-1.5	0.9	0.1
Intelligence (Savage-Jansen 2018)	1.0	3.0	8.4	2.9	0.1	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	0.9	-0.9	0.6	-1.0
Schizophrenia (2018)	1.7	3.6	5.0	1.2	2.0	2.2
Schizophrenia vs Biploar Disorder	1.6	2.1	3.9	0.1	2.0	1.6
Worry (Nagel 2018)	0.1	0.2	0.2	-0.4	0.4	0.4
Alzheimer’s Disease (in mother)	1.0	1.1	1.5	0.9	1.2	-1.0
Alzheimer’s Disease (in father)	0.4	0.5	1.3	0.3	-1.1	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.2	0.6	-0.2
Crohns Disease (2017)	1.3	2.8	3.5	-1.1	1.9	1.9
Irritable Bowel Disease (IBD)	1.3	3.0	5.1	-1.7	1.1	2.2
Ulcerative Colitis (UC)	0.9	1.6	3.6	-1.9	0.1	1.1
Major Depression (MDD)	1.4	1.7	3.1	-1.1	-0.9	1.8
Reaction Time	0.2	0.3	0.9	0.9	-0.3	-0.0
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.1	2.0	0.2	-1.6
Breast Cancer	1.0	2.5	4.3	-2.1	-0.7	-1.6
Ovarian Cancer	2.1	2.8	7.4	0.9	2.7	-0.4
Prostate Cancer	0.3	0.4	1.2	0.1	1.1	-0.1
Age at First Birth	0.6	0.8	1.7	0.8	1.3	-0.0
Bipolar Disorder (2011)	0.7	0.6	1.1	1.1	-0.8	0.4
Body Mass Index (BMI) (2010)	0.5	0.7	2.0	0.1	-0.2	-1.4
Coronary Artery Disease (CAD)	2.0	2.4	6.3	0.3	2.5	1.0
Crohns Disease (2012)	0.5	0.9	1.4	-0.9	0.6	1.2
Mean Putamen Volume	1.6	1.8	3.9	1.3	-0.2	2.0
Fasting Glucose	0.7	0.8	1.9	-0.7	0.2	-1.4
HbA1C	1.0	1.1	2.0	1.4	1.1	-0.6
HDL Cholesterol	0.2	0.4	0.7	-0.1	-0.6	0.8
LDL Cholesterol	0.6	1.0	2.7	1.6	-0.0	-0.5
Lupus	0.8	1.2	3.3	-1.8	0.1	-0.5
Neuroticism (2016)	0.2	0.2	0.5	-0.4	0.7	-0.2
Primary Biliary Cirrhosis	0.4	0.6	1.1	1.0	-0.6	0.4
Rheumatoid Arthritis	0.7	1.0	2.4	-0.6	0.5	1.5
Schizophrenia (2014)	1.8	4.1	5.7	1.6	2.4	2.0
Triglycerides	0.3	0.4	1.2	-1.1	-0.0	-0.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.0	-1.0	-1.4	-0.2
Ulcerative Colitis	0.4	0.6	1.6	-1.3	-0.0	0.2
Blood Eosinophil Count	1.4	11.0	31.1	-5.6	-1.4	0.0
Blood Platelet Count	0.0	0.1	0.3	0.6	0.3	-0.1
Blood Red Count	0.1	1.2	3.6	0.0	-0.3	1.9
Blood White Count	0.3	2.0	4.0	-0.1	-2.0	1.4
Heel T-Score	0.1	1.1	3.0	1.7	-0.4	0.2
BMI	0.7	4.2	10.8	0.2	-3.3	1.3
Height	0.1	2.3	4.5	-1.3	2.1	0.9
Waist Hip Ratio (WHR)	1.0	4.5	6.1	-2.5	-1.7	-2.1
Systolic Blood Pressure	0.5	2.5	4.3	1.3	-1.3	-2.1
Smoking Status	0.4	1.0	1.8	0.1	-1.3	1.1
Allergy or Eczema	0.4	1.1	2.4	0.9	0.5	-1.5
Cardiovascular Disease	0.3	1.0	2.4	1.6	0.8	-0.3
Hypothyroidism (self reported)	0.1	0.3	0.8	0.2	0.9	-0.1
Respiratory disease	0.0	0.0	0.1	-0.2	-0.2	0.2
Type 2 Diabetes (T2D) (2018)	1.5	2.9	7.8	2.8	-0.8	-0.3
Lung FEV1/FVC ratio	0.0	0.1	0.2	0.4	0.2	-0.4
Lung FVC	0.1	0.6	0.7	-0.8	0.8	0.6
Neuroticism	0.0	0.1	0.1	-0.3	0.3	0.2
Chronotype (morning person)	0.9	2.0	5.7	-0.3	2.4	0.5
Hair Pigment	0.1	1.6	4.0	-0.6	0.6	-2.0
Tanning	0.2	3.0	4.8	-2.2	-0.4	2.0
Hand grip strength (left)	0.6	1.6	3.7	-0.6	-0.9	-1.9
Number of treatments/medications taken	0.7	1.2	1.3	1.1	-1.0	-1.2
Average weekly spirits intake	0.6	0.8	1.3	-0.9	-0.5	1.1
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.4	-0.4	0.0
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.5	-1.6	0.0	-0.5
Hearing difficulty/problems: Yes	1.2	1.8	2.9	-1.3	-1.7	-0.9
Relative age of first facial hair	0.8	1.7	2.4	1.6	1.2	-1.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.4	-1.4	-0.2	-1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.9	-0.4	-0.9	-0.8
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	0.1	-0.5	-1.2
Systolic blood pressure, automated reading	0.1	0.2	0.6	0.2	-0.8	-0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.1	0.2	-0.4	-0.0	0.0
Angina	2.3	3.0	5.0	-2.2	0.5	-1.9
Medication for hormone replacement therapy	1.4	1.5	2.3	1.5	-1.5	-0.1
Vitamin and mineral supplements	1.1	1.5	3.3	-1.8	-0.2	1.1
Supplements: Zinc	0.7	0.8	2.3	1.5	0.2	-0.1
Medication: Co-codamol	0.5	0.6	0.7	-0.8	-0.7	0.8
Medication: Metformin	1.4	2.0	4.9	1.0	-0.2	2.2
Diabetes (father)	0.4	0.6	1.2	0.7	-1.1	-0.0
Diabetes (mother)	1.2	1.6	3.0	1.7	1.0	0.9
Severe depression (siblings)	0.6	0.7	1.3	-0.6	0.6	1.1
Pack years adult smoking proportion	0.5	0.7	1.5	-0.7	-0.5	1.2
Impedance of leg (right)	0.5	2.4	4.0	0.4	2.0	1.8
Leg fat-free mass (left)	0.2	1.3	3.1	-0.7	-1.8	0.4
Trunk fat percentage	0.8	3.3	9.2	0.3	-0.8	3.0
Hand grip strength (right)	0.8	2.1	4.1	-0.9	-2.0	-1.1
Townsend deprivation index at recruitment	1.8	2.6	6.0	1.3	-2.4	-0.5
Current tobacco smoking	0.9	1.4	2.8	-1.0	-1.7	-0.8
Average weekly fortified wine intake	1.3	1.5	3.0	0.2	1.7	-1.2
Maternal smoking around birth	0.5	0.7	1.9	-0.2	-1.4	-0.1
Fed-up feelings	1.1	2.1	5.9	0.1	-0.5	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.6	0.0	-0.5	-1.3
Relative age voice broke	1.5	2.3	3.8	1.8	2.0	0.0
Taking other prescription medications	0.2	0.3	0.5	0.7	-0.3	-0.4
Age when periods started (menarche)	2.6	6.3	14.9	2.0	3.9	-0.0
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	7.4	0.0	-1.3	-2.7
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	3.0	1.7	1.7	-1.1
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	5.3	-2.3	-0.8	0.0
Qualifications: CSEs or equivalent	0.4	0.5	0.8	0.7	-0.9	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	1.1	0.0	-0.0	1.1
High blood pressure	0.3	0.7	1.7	0.7	1.3	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.1	1.0	0.4	-1.4
Multivitamins +/- minerals	0.7	0.8	1.6	1.0	0.1	-1.3
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.5	-0.3	-0.6
Supplements: Glucosamine	1.2	1.6	2.8	-0.8	1.2	-1.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.8	0.0	-0.3
Medication: Atenolol	1.3	1.6	2.6	-1.5	-0.4	1.6
Medication: Levothyroxine sodium	0.3	0.5	1.5	-0.2	1.2	0.1
Sitting height	0.2	1.5	2.9	0.2	1.7	1.3
Chronic bronchitis/emphysema (father)	0.7	0.8	1.5	-1.2	-0.2	0.9
High blood pressure (mother)	0.4	0.5	1.2	1.1	-0.1	-0.5
Body mass index (BMI)	0.8	3.3	9.2	-0.5	-3.0	0.8
Impedance of leg (left)	0.4	1.9	3.6	0.8	1.9	1.1
Leg predicted mass (left)	0.3	1.4	3.1	-0.8	-1.8	0.6
Trunk fat mass	0.6	2.7	6.8	-0.1	-1.1	2.6
Waist circumference	0.9	3.4	7.9	-1.3	-2.8	0.7
Number of incorrect matches in round	0.1	0.1	0.3	0.5	0.1	0.3
Past tobacco smoking	0.6	1.1	2.6	-0.6	0.5	-1.6
Alcohol usually taken with meals	0.6	0.9	2.3	-0.3	1.5	-0.6
Nervous feelings	0.7	1.3	2.8	-0.5	0.9	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.8	-0.9	-0.4	0.5
Hearing difficulty/problems with background noise	1.0	1.6	2.4	0.6	-1.4	-1.5
Hair/balding pattern: Pattern 2	0.7	0.8	1.3	-1.1	-0.3	-1.1
Had menopause	2.4	3.0	5.5	-1.7	2.4	0.9
Had other major operations	0.8	0.9	1.8	0.9	1.3	-0.5
Forced vital capacity (FVC)	0.6	2.5	3.6	-1.9	1.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	1.7	1.0	0.1
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	7.8	-1.9	0.6	2.8
Qualifications: None of the above	0.7	1.5	3.3	-1.8	-1.1	-0.2
Financial difficulties in last 2 years	0.9	1.2	1.7	0.7	-1.2	1.3
Mouth/teeth dental problems	0.5	0.8	2.0	1.4	-0.0	-0.6
Heart attack	1.4	1.7	3.8	-1.9	0.1	-1.2
Allergy	0.1	0.3	0.4	-0.7	-0.6	-0.3
Pain all over the body in last month	1.2	1.3	3.8	0.2	-2.0	0.0
Diabetes (self-reported)	0.1	0.1	0.2	0.4	0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.1	0.4	-2.0	-0.6
Medication: Ramipril	0.9	1.2	3.0	-1.7	0.1	0.7
Medication: Simvastatin	0.7	1.0	2.8	0.4	-1.7	-0.2
Fluid intelligence score	1.1	2.3	4.8	1.1	-1.0	-2.2
Illnesses of siblings	0.6	0.8	1.8	0.5	1.4	0.6
Neuroticism score	0.1	0.2	0.4	-0.6	0.6	0.2
Weight	0.4	1.9	3.5	-0.8	-1.9	1.1
Impedance of arm (right)	0.8	3.9	6.0	1.3	2.4	2.0
Arm fat percentage (right)	0.7	2.9	4.5	-0.1	-2.1	2.1
Trunk fat-free mass	0.4	2.0	3.7	-1.9	-1.4	-0.7
Hip circumference	0.6	2.4	4.0	-0.5	-2.0	1.7
Time employed in main current job	1.4	1.7	4.0	-0.5	2.0	0.8
Alcohol intake versus 10 years previously	1.1	1.7	4.1	0.9	-2.0	0.4
Father’s age at death	1.5	2.0	4.7	0.1	1.1	2.2
Worrier / anxious feelings	0.7	1.3	3.0	-1.7	0.7	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.4	0.3	0.4	-2.1
Falls in the last year	0.9	1.2	3.5	-1.9	-0.1	-0.2
Hair/balding pattern: Pattern 3	1.6	2.4	3.7	-0.3	1.9	1.9
Number of live births	2.6	3.6	8.2	-2.9	-0.8	1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	2.5	-1.6	1.3	0.6
Pulse rate	0.4	0.7	1.6	0.2	-0.7	1.3
Happiness	0.5	0.7	0.9	0.6	0.9	-0.9
Noisy workplace	0.3	0.4	0.7	0.1	-0.6	-0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.9	3.1	1.3	1.8	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	1.9	1.0	1.4	1.0
Mouth/teeth dental problems: Dentures	2.1	3.5	6.4	-1.4	1.4	2.5
Asthma	0.1	0.1	0.2	0.5	-0.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.3	0.2	-1.8	-0.7
Medication: Cholesterol lowering	0.3	0.5	1.4	0.1	-0.4	-1.2
Depression (self-reported)	0.3	0.3	0.7	0.4	0.8	0.3
Medication: Lansoprazole	0.6	0.7	1.1	-0.1	-1.1	-1.0
Prospective memory result	0.5	0.6	0.7	-0.8	-0.8	0.6
Lung cancer (father)	1.6	1.9	3.1	-1.8	-1.6	0.1
Illnesses of mother	2.0	2.4	4.8	-1.5	-2.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	-0.5	1.0	0.4
Pulse wave Arterial Stiffness index	4.0	4.6	11.8	-3.4	1.1	0.9
Impedance of arm (left)	1.1	5.1	7.1	2.3	2.7	1.7
Arm fat mass (right)	0.6	2.4	4.9	-0.6	-2.2	1.4
Trunk predicted mass	0.4	2.1	4.1	-2.0	-1.4	-0.7
Standing height	0.2	2.2	4.7	-0.9	2.2	1.0
Length of working week for main job	0.4	0.5	0.8	0.9	-0.7	-0.4
Exposure to tobacco smoke at home	1.4	1.6	3.2	-1.1	-1.8	-0.5
Breastfed as a baby	1.4	1.7	5.2	0.1	2.3	-0.1
Tense / ‘highly strung’	0.2	0.4	0.9	0.4	1.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.8	-0.1	0.5	2.4
Hair/balding pattern: Pattern 4	0.9	2.2	3.9	-1.3	-2.0	-1.1
Birth weight of first child	0.6	1.2	1.6	-0.7	1.3	-1.2
Peak expiratory flow (PEF)	0.3	0.6	1.1	-1.0	0.8	0.3
Pulse wave reflection index	0.5	0.6	1.0	-0.8	1.0	-0.3
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.1	-1.1	0.7	1.8
Loud music exposure frequency	0.8	0.9	1.2	1.1	-0.8	0.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.8	1.7	-0.6	-1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.8	-0.4	0.6
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.0	0.5	0.6
Medication: Paracetamol	2.0	3.3	5.2	-2.1	-0.4	-2.3
Headache pain in last month	1.1	1.9	4.0	-1.3	0.5	-2.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.6	-0.4	0.2
Glaucoma (self-reported)	1.6	1.9	5.0	0.2	2.2	-0.9
Gout (self-reported)	0.4	0.6	1.0	-1.0	-0.3	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.9	-0.8	1.7	0.1
Medication: Amlodipine	0.7	1.0	2.0	0.8	0.5	-1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.0	0.6	1.4	1.0
Birth weight	0.4	0.8	2.0	-1.4	-0.5	-0.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.3	1.5	0.6	0.1
High blood pressure (siblings)	1.2	1.8	2.9	0.2	-1.6	-1.7
Forced vital capacity (FVC), Best measure	0.4	1.3	1.8	-1.1	1.3	0.9
Body fat percentage	0.8	3.2	7.5	-0.1	-1.5	2.7
Leg fat percentage (right)	0.8	3.0	4.7	-1.0	-2.2	1.9
Arm fat-free mass (right)	0.2	1.1	1.8	-1.3	-1.2	-0.2
Exposure to tobacco smoke outside home	0.8	1.1	2.0	0.4	-1.4	-1.0
Comparative body size at age 10	0.7	2.0	4.6	0.2	-2.1	-1.1
Number of full brothers	0.5	0.6	1.8	1.3	0.1	-0.3
Worry too long after embarrassment	0.8	1.3	1.8	-0.8	1.2	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.3	6.8	1.1	1.4	2.6
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	1.6	0.1	-0.6
Number of children fathered	1.9	2.1	4.6	-2.1	-1.0	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.2	0.8	1.4	1.5
Age at first live birth	1.6	2.8	5.6	1.1	1.3	2.4
Pulse wave peak to peak time	3.2	3.8	9.3	3.0	-1.1	-0.9
Health satisfaction	0.5	0.7	1.7	-1.3	-0.0	-0.6
Shortness of breath walking on level ground	0.2	0.3	0.5	0.6	0.1	-0.7
Qualifications: College or University degree	1.4	4.3	9.3	3.1	1.9	-0.0
Eye problems/disorders: None of the above	1.8	2.1	4.9	-0.2	-2.2	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.3	0.1	-0.0	-1.1
Emphysema/chronic bronchitis	0.1	0.2	0.5	0.7	-0.0	0.1
Medication for pain relief, constipation, heartburn	0.3	0.6	1.3	0.1	0.7	1.1
Neck or shoulder pain in last month	0.1	0.2	0.3	0.6	-0.4	0.0
Medication: Blood pressure	0.2	0.3	0.4	0.4	0.6	0.7
Angina (self-reported)	2.4	3.2	5.1	-2.3	0.4	-2.0
Migraine (self-reported)	0.9	1.1	2.6	-0.8	0.3	-1.6
Medication: Ibuprofen	1.1	1.3	3.5	-0.2	-1.9	-0.7
Medication: Allopurinol	0.1	0.1	0.3	-0.2	-0.0	0.5
Medication: Omeprazole	0.2	0.3	0.8	0.9	-0.0	0.1
Medication: Seretide 50 evohaler	1.5	1.7	2.0	1.3	-1.1	1.4
Mean time to correctly identify matches	0.2	0.3	0.6	0.8	-0.5	-0.2
Heart disease (mother)	1.6	2.0	2.8	0.8	1.6	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.7	-0.1	0.6	1.3
Whole body fat mass	0.6	2.6	4.5	-0.5	-1.7	2.1
Leg fat mass (right)	0.7	2.9	5.0	-0.7	-2.2	1.8
Arm predicted mass (right)	0.2	1.3	2.1	-1.4	-1.3	-0.2
Pulse rate, automated reading	0.6	2.1	4.0	0.2	-1.5	2.0
Alcohol intake frequency.	0.2	0.6	1.5	-0.2	0.5	-1.2
Comparative height size at age 10	0.4	2.2	5.2	-2.3	-0.2	1.1
Number of full sisters	0.7	0.8	1.7	-0.9	-1.3	0.1
Suffer from ‘nerves’	0.3	0.4	0.8	-0.4	0.9	0.6
Overall health rating	0.8	1.8	3.4	-0.9	-1.9	-1.0
Chest pain or discomfort	0.5	0.8	2.4	-0.1	0.0	-1.5
Had major operations	2.3	2.6	4.7	-2.2	-1.7	0.5
Age at last live birth	1.1	1.6	3.2	0.8	-1.8	1.0
Family relationship satisfaction	0.7	0.8	1.7	1.3	0.2	0.8
Leg pain on walking	0.6	0.8	1.2	-0.9	-0.7	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	-1.1	-0.4	0.3
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.6	-1.9	0.8	1.2
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	5.7	-0.6	-0.3	-2.4
Medication: Aspirin	0.7	0.9	2.1	-0.1	1.5	-0.8
Supplements: Vitamin C	1.7	2.0	5.9	2.4	-0.3	-0.3
Knee pain experienced in last month	0.9	1.4	3.8	-0.4	0.4	-1.9
Hypertension (Self-reported)	0.2	0.5	1.4	0.3	1.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	0.6	-0.1	0.4
Illnesses of father: Heart disease	0.8	1.1	3.2	-1.8	-0.2	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.7	0.0	-1.3	-0.3
Smoking status: Previous	1.5	2.2	5.3	0.9	0.7	2.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	0.1	-1.1	0.7
Whole body fat-free mass	0.3	1.4	2.1	-1.4	-1.5	-0.2
Leg fat-free mass (right)	0.2	1.0	2.9	-0.5	-1.7	-0.1
Arm fat percentage (left)	0.6	2.5	4.2	0.3	-2.0	1.8
Average weekly red wine intake	0.7	1.0	2.4	-0.5	1.6	0.6
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.3	-0.8	1.2	-0.8
Mood swings	0.5	0.9	2.3	-0.7	0.2	-1.5
Loneliness, isolation	0.0	0.0	0.1	-0.0	0.1	-0.4
Long-standing illness, disability or infirmity	0.2	0.4	0.6	-0.8	-0.7	-0.1
Ever had bowel cancer screening	0.9	1.0	1.5	0.5	1.2	1.2
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.2	-0.6	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.6	10.2	-0.3	-3.2	0.6
Friendships satisfaction	0.4	0.5	1.4	-0.1	1.2	-0.2
Qualifications: nursing, teaching	3.5	5.4	10.4	1.6	3.2	1.8
Commuting to job workplace: Walk	1.8	1.9	5.6	0.4	-0.0	-2.4
Eye problems/disorders: Cataract	0.7	0.8	2.1	0.3	1.4	0.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	3.4	-1.8	-0.9	-1.5
Medication for cholesterol	0.2	0.4	0.7	-0.7	0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.6	0.5	-1.3	-0.4
Back pain experienced in last month	1.7	2.5	7.0	-2.6	-0.4	0.6
Mineral and other dietary supplements	1.6	2.2	5.2	-0.4	-1.1	2.3
Breast cancer (self-reported)	0.5	0.6	1.1	0.4	1.0	0.7
Asthma (self-reported)	0.0	0.1	0.1	0.3	0.1	0.3
Osteoporosis (self-reported)	0.6	0.7	1.5	-0.1	-1.2	-0.7
Osteoarthritis (self-reported)	0.8	1.1	3.2	-1.8	-0.1	-0.1
Medication: Aspirin	0.4	0.6	1.3	0.1	1.2	-0.6
Medication: Gliclazide	1.0	1.1	1.9	1.1	0.4	1.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.6	-0.2	-1.1
Smoking status: Current	1.0	1.6	3.4	-0.5	-1.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.3	-0.7	1.5	-0.2
Whole body water mass	0.3	1.4	2.3	-1.4	-1.5	-0.1
Leg predicted mass (right)	0.2	1.0	2.8	-0.5	-1.7	-0.1
Arm fat mass (left)	0.6	2.3	5.0	-0.3	-2.2	1.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.0	-0.6	-0.1
Average weekly champagne plus white wine intake	0.9	1.3	2.3	1.5	0.0	1.2
Miserableness	1.2	2.1	5.6	-0.7	-0.3	-2.4
Guilty feelings	0.1	0.1	0.3	-0.4	-0.0	-0.5
Wears glasses or contact lenses	0.6	0.7	1.0	1.0	-0.1	-1.0
Ever taken oral contraceptive pill	1.4	1.6	3.2	0.9	-1.8	0.8
Hearing aid user	0.4	0.5	1.0	-1.0	0.4	-0.6
Mother’s age at death	2.4	3.0	8.4	0.6	2.9	-0.5
Financial situation satisfaction	0.5	0.7	1.3	-0.6	-1.2	-0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	0.1	0.4	-1.1
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.5	0.6	0.1
Eye problems/disorders: Glaucoma	1.3	1.5	4.4	-0.5	2.1	-0.3
Medication: Blood pressure	0.6	1.1	2.5	-0.7	0.5	-1.6
Pain type(s) experienced in last month: Hip pain	2.9	3.6	10.2	-3.2	-0.7	-0.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	1.9	1.4	0.8	-1.3
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.3	0.5	-0.6
Medication: Bendroflumethiazide	0.2	0.4	0.7	-0.1	-0.8	-0.6
Medication: Paracetamol	2.7	4.2	6.4	-2.5	-0.6	-2.5
Medication: Lisinopril	0.4	0.6	1.1	-1.0	-0.7	0.5
Medication: Atorvastatin	3.0	3.7	6.3	-2.0	-1.0	-2.5
Illnesses of father: High blood pressure	1.4	1.7	3.4	1.9	-0.0	-1.3
Alcohol drinker status: Never	1.2	1.4	3.8	-0.6	2.0	-0.1
Ever smoked	0.3	0.5	1.2	0.4	-0.5	1.1
Basal metabolic rate	0.3	1.5	2.9	-1.3	-1.7	0.1
Leg fat percentage (left)	0.7	2.4	4.8	-0.6	-2.2	1.4
Arm fat-free mass (left)	0.3	1.6	2.7	-1.7	-1.4	0.0
Number of operations (self-reported)	0.5	0.7	2.1	-1.4	-0.3	0.2
Average weekly beer plus cider intake	0.4	0.6	1.1	0.3	-1.0	0.8
Irritability	0.4	0.7	2.0	1.4	0.0	-0.2
Risk taking	0.3	0.4	1.1	0.4	1.0	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	0.5	0.5	0.2
Fractured/broken bones in last 5 years	1.5	1.9	4.8	0.1	-2.2	-0.9
Age started oral contraceptive pill	2.5	3.1	5.6	-0.3	2.4	1.9
Diastolic blood pressure, automated reading	0.2	0.7	1.7	0.6	-1.3	0.4
Ever depressed for a whole week	0.9	1.1	3.1	0.1	0.6	1.8
Unable to work because of sickness or disability	0.7	0.8	2.3	-0.5	-1.5	0.0
Commuting to job workplace: Cycle	0.3	0.4	0.6	-0.8	-0.4	-0.7
Myopia	2.5	3.6	7.3	2.7	0.1	1.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.2	0.2	-1.5	0.2
Cholesterol lowering medication	0.9	1.4	2.7	-1.0	-1.6	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.2	1.8	-0.4	-0.8
Pain experienced in last month	0.7	1.1	3.3	1.8	-0.2	0.2
Supplements: Calcium	0.3	0.4	0.6	-0.1	-0.8	-0.7
Basal cell carcinoma (self-reported)	1.3	1.5	4.5	2.1	-0.0	-0.1
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.9	-2.0	0.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	0.4	0.5	0.6
Heart disease (siblings)	0.9	1.1	2.5	0.7	1.6	0.5
Alcohol drinker status: Previous	0.8	0.9	2.8	-0.1	1.7	-0.2
Pack years of smoking	0.6	0.9	1.8	-0.8	-0.3	1.3
Impedance of whole body	0.9	4.5	8.2	1.5	2.9	1.7
Leg fat mass (left)	0.7	2.7	5.4	-0.5	-2.3	1.5
Arm predicted mass (left)	0.3	1.7	2.7	-1.6	-1.6	0.1