Hub : Genes

ERBB4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0968 0.0313 0.0012 0.010 0.032 0.031 0.033 0.032 0.019 4.7e-05 6.9e-05 4e-05 4.8e-05
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0875 0.0326 0.0015 -0.001 0.029 0.019 NA 0.000 0.500 3.1e-04 2.7e-03 NA 3.4e-01
3 TCGA Testicular Germ Cell Tumors 0.3810 0.1270 0.0038 0.010 0.020 0.002 NA 0.011 0.140 6.2e-02 2.7e-01 NA 1.3e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.2 0.4 -0.2 0.3
Bipolar Disorder or Schizophrenia 1.0 2.5 3.7 1.2 1.4 1.9
Depressed Affect (Nagel 2018) 0.8 1.6 3.4 -1.1 0.4 -1.9
Depression (Nagel 2018) 0.7 1.0 2.4 -1.5 0.9 0.1
Intelligence (Savage-Jansen 2018) 1.0 3.0 8.4 2.9 0.1 -0.7
Neuroticism (Nagel 2018) 0.3 0.7 0.9 -0.9 0.6 -1.0
Schizophrenia (2018) 1.7 3.6 5.0 1.2 2.0 2.2
Schizophrenia vs Biploar Disorder 1.6 2.1 3.9 0.1 2.0 1.6
Worry (Nagel 2018) 0.1 0.2 0.2 -0.4 0.4 0.4
Alzheimer’s Disease (in mother) 1.0 1.1 1.5 0.9 1.2 -1.0
Alzheimer’s Disease (in father) 0.4 0.5 1.3 0.3 -1.1 -0.1
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.2 0.6 -0.2
Crohns Disease (2017) 1.3 2.8 3.5 -1.1 1.9 1.9
Irritable Bowel Disease (IBD) 1.3 3.0 5.1 -1.7 1.1 2.2
Ulcerative Colitis (UC) 0.9 1.6 3.6 -1.9 0.1 1.1
Major Depression (MDD) 1.4 1.7 3.1 -1.1 -0.9 1.8
Reaction Time 0.2 0.3 0.9 0.9 -0.3 -0.0
Verbal and Numeric Reasoning (VNR) 0.9 2.2 4.1 2.0 0.2 -1.6
Breast Cancer 1.0 2.5 4.3 -2.1 -0.7 -1.6
Ovarian Cancer 2.1 2.8 7.4 0.9 2.7 -0.4
Prostate Cancer 0.3 0.4 1.2 0.1 1.1 -0.1
Age at First Birth 0.6 0.8 1.7 0.8 1.3 -0.0
Bipolar Disorder (2011) 0.7 0.6 1.1 1.1 -0.8 0.4
Body Mass Index (BMI) (2010) 0.5 0.7 2.0 0.1 -0.2 -1.4
Coronary Artery Disease (CAD) 2.0 2.4 6.3 0.3 2.5 1.0
Crohns Disease (2012) 0.5 0.9 1.4 -0.9 0.6 1.2
Mean Putamen Volume 1.6 1.8 3.9 1.3 -0.2 2.0
Fasting Glucose 0.7 0.8 1.9 -0.7 0.2 -1.4
HbA1C 1.0 1.1 2.0 1.4 1.1 -0.6
HDL Cholesterol 0.2 0.4 0.7 -0.1 -0.6 0.8
LDL Cholesterol 0.6 1.0 2.7 1.6 -0.0 -0.5
Lupus 0.8 1.2 3.3 -1.8 0.1 -0.5
Neuroticism (2016) 0.2 0.2 0.5 -0.4 0.7 -0.2
Primary Biliary Cirrhosis 0.4 0.6 1.1 1.0 -0.6 0.4
Rheumatoid Arthritis 0.7 1.0 2.4 -0.6 0.5 1.5
Schizophrenia (2014) 1.8 4.1 5.7 1.6 2.4 2.0
Triglycerides 0.3 0.4 1.2 -1.1 -0.0 -0.4
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.0 -1.0 -1.4 -0.2
Ulcerative Colitis 0.4 0.6 1.6 -1.3 -0.0 0.2
Blood Eosinophil Count 1.4 11.0 31.1 -5.6 -1.4 0.0
Blood Platelet Count 0.0 0.1 0.3 0.6 0.3 -0.1
Blood Red Count 0.1 1.2 3.6 0.0 -0.3 1.9
Blood White Count 0.3 2.0 4.0 -0.1 -2.0 1.4
Heel T-Score 0.1 1.1 3.0 1.7 -0.4 0.2
BMI 0.7 4.2 10.8 0.2 -3.3 1.3
Height 0.1 2.3 4.5 -1.3 2.1 0.9
Waist Hip Ratio (WHR) 1.0 4.5 6.1 -2.5 -1.7 -2.1
Systolic Blood Pressure 0.5 2.5 4.3 1.3 -1.3 -2.1
Smoking Status 0.4 1.0 1.8 0.1 -1.3 1.1
Allergy or Eczema 0.4 1.1 2.4 0.9 0.5 -1.5
Cardiovascular Disease 0.3 1.0 2.4 1.6 0.8 -0.3
Hypothyroidism (self reported) 0.1 0.3 0.8 0.2 0.9 -0.1
Respiratory disease 0.0 0.0 0.1 -0.2 -0.2 0.2
Type 2 Diabetes (T2D) (2018) 1.5 2.9 7.8 2.8 -0.8 -0.3
Lung FEV1/FVC ratio 0.0 0.1 0.2 0.4 0.2 -0.4
Lung FVC 0.1 0.6 0.7 -0.8 0.8 0.6
Neuroticism 0.0 0.1 0.1 -0.3 0.3 0.2
Chronotype (morning person) 0.9 2.0 5.7 -0.3 2.4 0.5
Hair Pigment 0.1 1.6 4.0 -0.6 0.6 -2.0
Tanning 0.2 3.0 4.8 -2.2 -0.4 2.0
Hand grip strength (left) 0.6 1.6 3.7 -0.6 -0.9 -1.9
Number of treatments/medications taken 0.7 1.2 1.3 1.1 -1.0 -1.2
Average weekly spirits intake 0.6 0.8 1.3 -0.9 -0.5 1.1
Sensitivity / hurt feelings 0.1 0.1 0.2 -0.4 -0.4 0.0
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.5 -1.6 0.0 -0.5
Hearing difficulty/problems: Yes 1.2 1.8 2.9 -1.3 -1.7 -0.9
Relative age of first facial hair 0.8 1.7 2.4 1.6 1.2 -1.1
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.4 -1.4 -0.2 -1.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 0.9 -0.4 -0.9 -0.8
Ever had hysterectomy (womb removed) 0.5 0.6 1.5 0.1 -0.5 -1.2
Systolic blood pressure, automated reading 0.1 0.2 0.6 0.2 -0.8 -0.1
Eye problems/disorders: Diabetes related eye disease 0.0 0.1 0.2 -0.4 -0.0 0.0
Angina 2.3 3.0 5.0 -2.2 0.5 -1.9
Medication for hormone replacement therapy 1.4 1.5 2.3 1.5 -1.5 -0.1
Vitamin and mineral supplements 1.1 1.5 3.3 -1.8 -0.2 1.1
Supplements: Zinc 0.7 0.8 2.3 1.5 0.2 -0.1
Medication: Co-codamol 0.5 0.6 0.7 -0.8 -0.7 0.8
Medication: Metformin 1.4 2.0 4.9 1.0 -0.2 2.2
Diabetes (father) 0.4 0.6 1.2 0.7 -1.1 -0.0
Diabetes (mother) 1.2 1.6 3.0 1.7 1.0 0.9
Severe depression (siblings) 0.6 0.7 1.3 -0.6 0.6 1.1
Pack years adult smoking proportion 0.5 0.7 1.5 -0.7 -0.5 1.2
Impedance of leg (right) 0.5 2.4 4.0 0.4 2.0 1.8
Leg fat-free mass (left) 0.2 1.3 3.1 -0.7 -1.8 0.4
Trunk fat percentage 0.8 3.3 9.2 0.3 -0.8 3.0
Hand grip strength (right) 0.8 2.1 4.1 -0.9 -2.0 -1.1
Townsend deprivation index at recruitment 1.8 2.6 6.0 1.3 -2.4 -0.5
Current tobacco smoking 0.9 1.4 2.8 -1.0 -1.7 -0.8
Average weekly fortified wine intake 1.3 1.5 3.0 0.2 1.7 -1.2
Maternal smoking around birth 0.5 0.7 1.9 -0.2 -1.4 -0.1
Fed-up feelings 1.1 2.1 5.9 0.1 -0.5 -2.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.6 0.0 -0.5 -1.3
Relative age voice broke 1.5 2.3 3.8 1.8 2.0 0.0
Taking other prescription medications 0.2 0.3 0.5 0.7 -0.3 -0.4
Age when periods started (menarche) 2.6 6.3 14.9 2.0 3.9 -0.0
Bilateral oophorectomy (both ovaries removed) 2.7 3.1 7.4 0.0 -1.3 -2.7
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.4 3.0 1.7 1.7 -1.1
Tinnitus: Yes, but not now, but have in the past 1.8 2.0 5.3 -2.3 -0.8 0.0
Qualifications: CSEs or equivalent 0.4 0.5 0.8 0.7 -0.9 -0.5
Serious illness, injury or assault to yourself 0.3 0.4 1.1 0.0 -0.0 1.1
High blood pressure 0.3 0.7 1.7 0.7 1.3 0.3
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.1 1.0 0.4 -1.4
Multivitamins +/- minerals 0.7 0.8 1.6 1.0 0.1 -1.3
Stomach or abdominal pain in last month 0.2 0.2 0.3 -0.5 -0.3 -0.6
Supplements: Glucosamine 1.2 1.6 2.8 -0.8 1.2 -1.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 -0.8 0.0 -0.3
Medication: Atenolol 1.3 1.6 2.6 -1.5 -0.4 1.6
Medication: Levothyroxine sodium 0.3 0.5 1.5 -0.2 1.2 0.1
Sitting height 0.2 1.5 2.9 0.2 1.7 1.3
Chronic bronchitis/emphysema (father) 0.7 0.8 1.5 -1.2 -0.2 0.9
High blood pressure (mother) 0.4 0.5 1.2 1.1 -0.1 -0.5
Body mass index (BMI) 0.8 3.3 9.2 -0.5 -3.0 0.8
Impedance of leg (left) 0.4 1.9 3.6 0.8 1.9 1.1
Leg predicted mass (left) 0.3 1.4 3.1 -0.8 -1.8 0.6
Trunk fat mass 0.6 2.7 6.8 -0.1 -1.1 2.6
Waist circumference 0.9 3.4 7.9 -1.3 -2.8 0.7
Number of incorrect matches in round 0.1 0.1 0.3 0.5 0.1 0.3
Past tobacco smoking 0.6 1.1 2.6 -0.6 0.5 -1.6
Alcohol usually taken with meals 0.6 0.9 2.3 -0.3 1.5 -0.6
Nervous feelings 0.7 1.3 2.8 -0.5 0.9 1.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.8 -0.9 -0.4 0.5
Hearing difficulty/problems with background noise 1.0 1.6 2.4 0.6 -1.4 -1.5
Hair/balding pattern: Pattern 2 0.7 0.8 1.3 -1.1 -0.3 -1.1
Had menopause 2.4 3.0 5.5 -1.7 2.4 0.9
Had other major operations 0.8 0.9 1.8 0.9 1.3 -0.5
Forced vital capacity (FVC) 0.6 2.5 3.6 -1.9 1.8 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.0 1.7 1.0 0.1
Ever unenthusiastic/disinterested for a whole week 3.3 4.0 7.8 -1.9 0.6 2.8
Qualifications: None of the above 0.7 1.5 3.3 -1.8 -1.1 -0.2
Financial difficulties in last 2 years 0.9 1.2 1.7 0.7 -1.2 1.3
Mouth/teeth dental problems 0.5 0.8 2.0 1.4 -0.0 -0.6
Heart attack 1.4 1.7 3.8 -1.9 0.1 -1.2
Allergy 0.1 0.3 0.4 -0.7 -0.6 -0.3
Pain all over the body in last month 1.2 1.3 3.8 0.2 -2.0 0.0
Diabetes (self-reported) 0.1 0.1 0.2 0.4 0.1 -0.2
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 4.1 0.4 -2.0 -0.6
Medication: Ramipril 0.9 1.2 3.0 -1.7 0.1 0.7
Medication: Simvastatin 0.7 1.0 2.8 0.4 -1.7 -0.2
Fluid intelligence score 1.1 2.3 4.8 1.1 -1.0 -2.2
Illnesses of siblings 0.6 0.8 1.8 0.5 1.4 0.6
Neuroticism score 0.1 0.2 0.4 -0.6 0.6 0.2
Weight 0.4 1.9 3.5 -0.8 -1.9 1.1
Impedance of arm (right) 0.8 3.9 6.0 1.3 2.4 2.0
Arm fat percentage (right) 0.7 2.9 4.5 -0.1 -2.1 2.1
Trunk fat-free mass 0.4 2.0 3.7 -1.9 -1.4 -0.7
Hip circumference 0.6 2.4 4.0 -0.5 -2.0 1.7
Time employed in main current job 1.4 1.7 4.0 -0.5 2.0 0.8
Alcohol intake versus 10 years previously 1.1 1.7 4.1 0.9 -2.0 0.4
Father’s age at death 1.5 2.0 4.7 0.1 1.1 2.2
Worrier / anxious feelings 0.7 1.3 3.0 -1.7 0.7 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 4.4 0.3 0.4 -2.1
Falls in the last year 0.9 1.2 3.5 -1.9 -0.1 -0.2
Hair/balding pattern: Pattern 3 1.6 2.4 3.7 -0.3 1.9 1.9
Number of live births 2.6 3.6 8.2 -2.9 -0.8 1.4
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 2.5 -1.6 1.3 0.6
Pulse rate 0.4 0.7 1.6 0.2 -0.7 1.3
Happiness 0.5 0.7 0.9 0.6 0.9 -0.9
Noisy workplace 0.3 0.4 0.7 0.1 -0.6 -0.9
Qualifications: A levels/AS levels or equivalent 0.8 1.9 3.1 1.3 1.8 0.9
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 1.9 1.0 1.4 1.0
Mouth/teeth dental problems: Dentures 2.1 3.5 6.4 -1.4 1.4 2.5
Asthma 0.1 0.1 0.2 0.5 -0.2 0.4
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.3 0.2 -1.8 -0.7
Medication: Cholesterol lowering 0.3 0.5 1.4 0.1 -0.4 -1.2
Depression (self-reported) 0.3 0.3 0.7 0.4 0.8 0.3
Medication: Lansoprazole 0.6 0.7 1.1 -0.1 -1.1 -1.0
Prospective memory result 0.5 0.6 0.7 -0.8 -0.8 0.6
Lung cancer (father) 1.6 1.9 3.1 -1.8 -1.6 0.1
Illnesses of mother 2.0 2.4 4.8 -1.5 -2.2 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.9 -0.5 1.0 0.4
Pulse wave Arterial Stiffness index 4.0 4.6 11.8 -3.4 1.1 0.9
Impedance of arm (left) 1.1 5.1 7.1 2.3 2.7 1.7
Arm fat mass (right) 0.6 2.4 4.9 -0.6 -2.2 1.4
Trunk predicted mass 0.4 2.1 4.1 -2.0 -1.4 -0.7
Standing height 0.2 2.2 4.7 -0.9 2.2 1.0
Length of working week for main job 0.4 0.5 0.8 0.9 -0.7 -0.4
Exposure to tobacco smoke at home 1.4 1.6 3.2 -1.1 -1.8 -0.5
Breastfed as a baby 1.4 1.7 5.2 0.1 2.3 -0.1
Tense / ‘highly strung’ 0.2 0.4 0.9 0.4 1.0 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 5.8 -0.1 0.5 2.4
Hair/balding pattern: Pattern 4 0.9 2.2 3.9 -1.3 -2.0 -1.1
Birth weight of first child 0.6 1.2 1.6 -0.7 1.3 -1.2
Peak expiratory flow (PEF) 0.3 0.6 1.1 -1.0 0.8 0.3
Pulse wave reflection index 0.5 0.6 1.0 -0.8 1.0 -0.3
Ever highly irritable/argumentative for 2 days 1.3 1.6 3.1 -1.1 0.7 1.8
Loud music exposure frequency 0.8 0.9 1.2 1.1 -0.8 0.9
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.8 1.7 -0.6 -1.3
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.6 0.8 -0.4 0.6
Blood clot in the leg (DVT) 0.2 0.2 0.4 -0.0 0.5 0.6
Medication: Paracetamol 2.0 3.3 5.2 -2.1 -0.4 -2.3
Headache pain in last month 1.1 1.9 4.0 -1.3 0.5 -2.0
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 -0.6 -0.4 0.2
Glaucoma (self-reported) 1.6 1.9 5.0 0.2 2.2 -0.9
Gout (self-reported) 0.4 0.6 1.0 -1.0 -0.3 0.9
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.9 -0.8 1.7 0.1
Medication: Amlodipine 0.7 1.0 2.0 0.8 0.5 -1.4
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.0 0.6 1.4 1.0
Birth weight 0.4 0.8 2.0 -1.4 -0.5 -0.4
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.3 1.5 0.6 0.1
High blood pressure (siblings) 1.2 1.8 2.9 0.2 -1.6 -1.7
Forced vital capacity (FVC), Best measure 0.4 1.3 1.8 -1.1 1.3 0.9
Body fat percentage 0.8 3.2 7.5 -0.1 -1.5 2.7
Leg fat percentage (right) 0.8 3.0 4.7 -1.0 -2.2 1.9
Arm fat-free mass (right) 0.2 1.1 1.8 -1.3 -1.2 -0.2
Exposure to tobacco smoke outside home 0.8 1.1 2.0 0.4 -1.4 -1.0
Comparative body size at age 10 0.7 2.0 4.6 0.2 -2.1 -1.1
Number of full brothers 0.5 0.6 1.8 1.3 0.1 -0.3
Worry too long after embarrassment 0.8 1.3 1.8 -0.8 1.2 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.3 6.8 1.1 1.4 2.6
Wheeze or whistling in the chest in last year 0.5 0.9 2.5 1.6 0.1 -0.6
Number of children fathered 1.9 2.1 4.6 -2.1 -1.0 0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 2.2 0.8 1.4 1.5
Age at first live birth 1.6 2.8 5.6 1.1 1.3 2.4
Pulse wave peak to peak time 3.2 3.8 9.3 3.0 -1.1 -0.9
Health satisfaction 0.5 0.7 1.7 -1.3 -0.0 -0.6
Shortness of breath walking on level ground 0.2 0.3 0.5 0.6 0.1 -0.7
Qualifications: College or University degree 1.4 4.3 9.3 3.1 1.9 -0.0
Eye problems/disorders: None of the above 1.8 2.1 4.9 -0.2 -2.2 1.2
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.3 0.1 -0.0 -1.1
Emphysema/chronic bronchitis 0.1 0.2 0.5 0.7 -0.0 0.1
Medication for pain relief, constipation, heartburn 0.3 0.6 1.3 0.1 0.7 1.1
Neck or shoulder pain in last month 0.1 0.2 0.3 0.6 -0.4 0.0
Medication: Blood pressure 0.2 0.3 0.4 0.4 0.6 0.7
Angina (self-reported) 2.4 3.2 5.1 -2.3 0.4 -2.0
Migraine (self-reported) 0.9 1.1 2.6 -0.8 0.3 -1.6
Medication: Ibuprofen 1.1 1.3 3.5 -0.2 -1.9 -0.7
Medication: Allopurinol 0.1 0.1 0.3 -0.2 -0.0 0.5
Medication: Omeprazole 0.2 0.3 0.8 0.9 -0.0 0.1
Medication: Seretide 50 evohaler 1.5 1.7 2.0 1.3 -1.1 1.4
Mean time to correctly identify matches 0.2 0.3 0.6 0.8 -0.5 -0.2
Heart disease (mother) 1.6 2.0 2.8 0.8 1.6 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 1.7 -0.1 0.6 1.3
Whole body fat mass 0.6 2.6 4.5 -0.5 -1.7 2.1
Leg fat mass (right) 0.7 2.9 5.0 -0.7 -2.2 1.8
Arm predicted mass (right) 0.2 1.3 2.1 -1.4 -1.3 -0.2
Pulse rate, automated reading 0.6 2.1 4.0 0.2 -1.5 2.0
Alcohol intake frequency. 0.2 0.6 1.5 -0.2 0.5 -1.2
Comparative height size at age 10 0.4 2.2 5.2 -2.3 -0.2 1.1
Number of full sisters 0.7 0.8 1.7 -0.9 -1.3 0.1
Suffer from ‘nerves’ 0.3 0.4 0.8 -0.4 0.9 0.6
Overall health rating 0.8 1.8 3.4 -0.9 -1.9 -1.0
Chest pain or discomfort 0.5 0.8 2.4 -0.1 0.0 -1.5
Had major operations 2.3 2.6 4.7 -2.2 -1.7 0.5
Age at last live birth 1.1 1.6 3.2 0.8 -1.8 1.0
Family relationship satisfaction 0.7 0.8 1.7 1.3 0.2 0.8
Leg pain on walking 0.6 0.8 1.2 -0.9 -0.7 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.2 -1.1 -0.4 0.3
Commuting to job workplace: Car/motor vehicle 1.6 1.9 3.6 -1.9 0.8 1.2
Illness, injury, bereavement, stress in last 2 years 1.7 2.0 5.7 -0.6 -0.3 -2.4
Medication: Aspirin 0.7 0.9 2.1 -0.1 1.5 -0.8
Supplements: Vitamin C 1.7 2.0 5.9 2.4 -0.3 -0.3
Knee pain experienced in last month 0.9 1.4 3.8 -0.4 0.4 -1.9
Hypertension (Self-reported) 0.2 0.5 1.4 0.3 1.2 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.3 0.6 -0.1 0.4
Illnesses of father: Heart disease 0.8 1.1 3.2 -1.8 -0.2 -0.2
Illnesses of siblings: Diabetes 0.5 0.6 1.7 0.0 -1.3 -0.3
Smoking status: Previous 1.5 2.2 5.3 0.9 0.7 2.3
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.3 0.1 -1.1 0.7
Whole body fat-free mass 0.3 1.4 2.1 -1.4 -1.5 -0.2
Leg fat-free mass (right) 0.2 1.0 2.9 -0.5 -1.7 -0.1
Arm fat percentage (left) 0.6 2.5 4.2 0.3 -2.0 1.8
Average weekly red wine intake 0.7 1.0 2.4 -0.5 1.6 0.6
Handedness (chirality/laterality): Left-handed 0.7 0.9 1.3 -0.8 1.2 -0.8
Mood swings 0.5 0.9 2.3 -0.7 0.2 -1.5
Loneliness, isolation 0.0 0.0 0.1 -0.0 0.1 -0.4
Long-standing illness, disability or infirmity 0.2 0.4 0.6 -0.8 -0.7 -0.1
Ever had bowel cancer screening 0.9 1.0 1.5 0.5 1.2 1.2
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.2 -0.6 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 3.4 3.6 10.2 -0.3 -3.2 0.6
Friendships satisfaction 0.4 0.5 1.4 -0.1 1.2 -0.2
Qualifications: nursing, teaching 3.5 5.4 10.4 1.6 3.2 1.8
Commuting to job workplace: Walk 1.8 1.9 5.6 0.4 -0.0 -2.4
Eye problems/disorders: Cataract 0.7 0.8 2.1 0.3 1.4 0.4
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 3.4 -1.8 -0.9 -1.5
Medication for cholesterol 0.2 0.4 0.7 -0.7 0.8 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.6 0.5 -1.3 -0.4
Back pain experienced in last month 1.7 2.5 7.0 -2.6 -0.4 0.6
Mineral and other dietary supplements 1.6 2.2 5.2 -0.4 -1.1 2.3
Breast cancer (self-reported) 0.5 0.6 1.1 0.4 1.0 0.7
Asthma (self-reported) 0.0 0.1 0.1 0.3 0.1 0.3
Osteoporosis (self-reported) 0.6 0.7 1.5 -0.1 -1.2 -0.7
Osteoarthritis (self-reported) 0.8 1.1 3.2 -1.8 -0.1 -0.1
Medication: Aspirin 0.4 0.6 1.3 0.1 1.2 -0.6
Medication: Gliclazide 1.0 1.1 1.9 1.1 0.4 1.4
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 -0.6 -0.2 -1.1
Smoking status: Current 1.0 1.6 3.4 -0.5 -1.8 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.3 -0.7 1.5 -0.2
Whole body water mass 0.3 1.4 2.3 -1.4 -1.5 -0.1
Leg predicted mass (right) 0.2 1.0 2.8 -0.5 -1.7 -0.1
Arm fat mass (left) 0.6 2.3 5.0 -0.3 -2.2 1.4
Number of self-reported non-cancer illnesses 0.1 0.1 0.3 0.0 -0.6 -0.1
Average weekly champagne plus white wine intake 0.9 1.3 2.3 1.5 0.0 1.2
Miserableness 1.2 2.1 5.6 -0.7 -0.3 -2.4
Guilty feelings 0.1 0.1 0.3 -0.4 -0.0 -0.5
Wears glasses or contact lenses 0.6 0.7 1.0 1.0 -0.1 -1.0
Ever taken oral contraceptive pill 1.4 1.6 3.2 0.9 -1.8 0.8
Hearing aid user 0.4 0.5 1.0 -1.0 0.4 -0.6
Mother’s age at death 2.4 3.0 8.4 0.6 2.9 -0.5
Financial situation satisfaction 0.5 0.7 1.3 -0.6 -1.2 -0.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.3 0.1 0.4 -1.1
Commuting to job workplace: Public transport 0.2 0.2 0.3 0.5 0.6 0.1
Eye problems/disorders: Glaucoma 1.3 1.5 4.4 -0.5 2.1 -0.3
Medication: Blood pressure 0.6 1.1 2.5 -0.7 0.5 -1.6
Pain type(s) experienced in last month: Hip pain 2.9 3.6 10.2 -3.2 -0.7 -0.3
Supplements: Fish oil (including cod liver oil) 1.1 1.4 1.9 1.4 0.8 -1.3
High cholesterol (Self-reported) 0.1 0.2 0.4 -0.3 0.5 -0.6
Medication: Bendroflumethiazide 0.2 0.4 0.7 -0.1 -0.8 -0.6
Medication: Paracetamol 2.7 4.2 6.4 -2.5 -0.6 -2.5
Medication: Lisinopril 0.4 0.6 1.1 -1.0 -0.7 0.5
Medication: Atorvastatin 3.0 3.7 6.3 -2.0 -1.0 -2.5
Illnesses of father: High blood pressure 1.4 1.7 3.4 1.9 -0.0 -1.3
Alcohol drinker status: Never 1.2 1.4 3.8 -0.6 2.0 -0.1
Ever smoked 0.3 0.5 1.2 0.4 -0.5 1.1
Basal metabolic rate 0.3 1.5 2.9 -1.3 -1.7 0.1
Leg fat percentage (left) 0.7 2.4 4.8 -0.6 -2.2 1.4
Arm fat-free mass (left) 0.3 1.6 2.7 -1.7 -1.4 0.0
Number of operations (self-reported) 0.5 0.7 2.1 -1.4 -0.3 0.2
Average weekly beer plus cider intake 0.4 0.6 1.1 0.3 -1.0 0.8
Irritability 0.4 0.7 2.0 1.4 0.0 -0.2
Risk taking 0.3 0.4 1.1 0.4 1.0 0.0
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.3 0.5 0.5 0.2
Fractured/broken bones in last 5 years 1.5 1.9 4.8 0.1 -2.2 -0.9
Age started oral contraceptive pill 2.5 3.1 5.6 -0.3 2.4 1.9
Diastolic blood pressure, automated reading 0.2 0.7 1.7 0.6 -1.3 0.4
Ever depressed for a whole week 0.9 1.1 3.1 0.1 0.6 1.8
Unable to work because of sickness or disability 0.7 0.8 2.3 -0.5 -1.5 0.0
Commuting to job workplace: Cycle 0.3 0.4 0.6 -0.8 -0.4 -0.7
Myopia 2.5 3.6 7.3 2.7 0.1 1.9
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.2 0.2 -1.5 0.2
Cholesterol lowering medication 0.9 1.4 2.7 -1.0 -1.6 -0.7
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.2 1.8 -0.4 -0.8
Pain experienced in last month 0.7 1.1 3.3 1.8 -0.2 0.2
Supplements: Calcium 0.3 0.4 0.6 -0.1 -0.8 -0.7
Basal cell carcinoma (self-reported) 1.3 1.5 4.5 2.1 -0.0 -0.1
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.9 -2.0 0.4 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.4 0.4 0.5 0.6
Heart disease (siblings) 0.9 1.1 2.5 0.7 1.6 0.5
Alcohol drinker status: Previous 0.8 0.9 2.8 -0.1 1.7 -0.2
Pack years of smoking 0.6 0.9 1.8 -0.8 -0.3 1.3
Impedance of whole body 0.9 4.5 8.2 1.5 2.9 1.7
Leg fat mass (left) 0.7 2.7 5.4 -0.5 -2.3 1.5
Arm predicted mass (left) 0.3 1.7 2.7 -1.6 -1.6 0.1