Best TWAS P=1.22e-22 · Best GWAS P=9.44e-26 conditioned to 0.000126
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | PLCL2 | 0.10 | 0.06 | lasso | 5 | 0.09 | 4.5e-07 | -10.2 | -9.2 | 2.7e-20 | 0.94 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | PLCL2-AS1 | 0.06 | 0.01 | lasso | 5 | 0.02 | 9.9e-03 | 4.5 | -6.7 | 2.6e-11 | 0.61 | 0.08 | 0.80 | FALSE |
| 3 | GTEx | Esophagus Muscularis | PLCL2-AS1 | 0.09 | 0.00 | lasso | 3 | 0.01 | 1.1e-01 | -6.0 | -6.5 | 8.8e-11 | 0.63 | 0.13 | 0.19 | FALSE |
| 4 | GTEx | Whole Blood | PLCL2 | 0.06 | 0.03 | enet | 7 | 0.02 | 2.8e-03 | -5.0 | -7.4 | 1.8e-13 | 0.80 | 0.08 | 0.88 | FALSE |
| 5 | METSIM | Adipose | PLCL2 | 0.08 | 0.03 | lasso | 6 | 0.04 | 2.3e-06 | -4.6 | -6.9 | 6.7e-12 | 0.63 | 0.39 | 0.61 | FALSE |
| 6 | NTR | Blood | PLCL2 | 0.05 | 0.02 | lasso | 5 | 0.03 | 1.1e-09 | -10.2 | -9.8 | 1.2e-22 | 0.90 | 0.00 | 1.00 | TRUE |
| 7 | YFS | Blood | PLCL2 | 0.10 | 0.10 | lasso | 7 | 0.11 | 3.7e-34 | -10.5 | -9.7 | 2.0e-22 | 0.94 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLCL2 | 0.06 | 0.07 | lasso | 4 | 0.07 | 1.3e-14 | -6.0 | -6.6 | 4.8e-11 | 0.69 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLCL2 | 0.09 | 0.05 | enet | 13 | 0.04 | 1.1e-05 | -6.7 | -5.3 | 1.5e-07 | 0.45 | 0.84 | 0.01 | FALSE |