[Hub]/) : Traits : Blood Eosinophil Count : ← →

chr3:11,350,553-13,608,348

Best TWAS P=1.35e-22 · Best GWAS P=1.34e-38 conditioned to 7.09e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TIMP4	0.11	0.05	bslmm	508	0.06	6.8e-08	2.95	7.5	9.0e-14	-0.31	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	RAF1	0.08	0.02	lasso	6	0.04	5.2e-04	4.88	-5.6	2.2e-08	0.00	0.77	0.01	FALSE
3	GTEx	Adipose Subcutaneous	SYN2	0.10	0.04	lasso	5	0.05	9.3e-05	5.81	6.0	1.8e-09	-0.30	0.86	0.04	FALSE
4	GTEx	Artery Aorta	TSEN2	0.11	0.01	enet	22	0.02	1.7e-02	4.78	7.5	5.9e-14	-0.23	0.37	0.11	FALSE
5	GTEx	Artery Aorta	SYN2	0.14	0.08	enet	15	0.09	1.0e-05	3.07	5.5	4.0e-08	-0.27	0.95	0.02	FALSE
6	GTEx	Brain Cerebellar Hemisphere	PPARG	0.57	0.57	lasso	5	0.54	3.6e-16	9.78	9.8	1.4e-22	-0.26	1.00	0.00	TRUE
7	GTEx	Brain Cerebellum	PPARG	0.64	0.57	lasso	7	0.57	4.1e-20	9.78	9.7	4.5e-22	-0.26	1.00	0.00	FALSE
8	GTEx	Brain Hypothalamus	TIMP4	0.24	0.10	lasso	4	0.11	1.7e-03	6.33	6.2	6.2e-10	-0.34	0.33	0.06	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	PPARG	0.23	0.09	lasso	12	0.07	2.1e-03	11.33	9.4	3.4e-21	-0.30	0.45	0.03	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	TSEN2	0.48	0.27	lasso	12	0.26	6.3e-09	4.70	5.9	4.4e-09	-0.14	0.94	0.01	FALSE
11	GTEx	Cells Transformed fibroblasts	CAND2	0.34	0.08	lasso	14	0.13	8.1e-10	-1.60	-5.5	3.2e-08	0.48	0.18	0.81	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	SYN2	0.23	0.09	lasso	4	0.12	3.3e-05	5.70	6.8	1.2e-11	-0.34	0.84	0.03	FALSE
13	GTEx	Esophagus Mucosa	SYN2	0.25	0.17	lasso	6	0.17	1.1e-11	5.89	6.0	2.3e-09	-0.29	1.00	0.00	FALSE
14	GTEx	Esophagus Muscularis	TSEN2	0.12	0.03	enet	36	0.05	5.6e-04	0.65	7.5	4.4e-14	-0.39	0.09	0.26	TRUE
15	GTEx	Esophagus Muscularis	SYN2	0.20	0.18	lasso	6	0.18	5.1e-11	5.85	6.7	1.8e-11	-0.34	1.00	0.00	FALSE
16	GTEx	Heart Left Ventricle	SYN2	0.15	0.14	lasso	7	0.11	3.0e-06	5.09	6.7	1.8e-11	-0.38	0.87	0.08	FALSE
17	GTEx	Lung	SYN2	0.19	0.12	lasso	6	0.12	2.1e-09	5.85	6.0	2.0e-09	-0.33	1.00	0.00	FALSE
18	GTEx	Muscle Skeletal	SYN2	0.18	0.10	enet	28	0.14	5.3e-14	4.90	6.1	1.0e-09	-0.31	1.00	0.00	FALSE
19	GTEx	Nerve Tibial	MKRN2	0.12	0.00	enet	41	0.00	3.0e-01	-4.29	7.2	5.3e-13	-0.08	0.19	0.12	TRUE
20	GTEx	Skin Not Sun Exposed Suprapubic	SYN2	0.12	0.08	lasso	4	0.03	1.4e-02	5.85	5.4	5.2e-08	-0.31	0.76	0.01	FALSE
21	METSIM	Adipose	TIMP4	0.06	0.03	blup	512	0.03	4.6e-05	5.70	-7.5	6.5e-14	0.20	0.91	0.00	FALSE
22	METSIM	Adipose	TSEN2	0.06	0.02	enet	30	0.06	9.3e-10	-8.60	6.9	4.5e-12	-0.66	0.03	0.97	FALSE
23	NTR	Blood	MKRN2	0.05	0.04	enet	14	0.04	5.9e-14	7.04	-5.9	3.9e-09	-0.03	1.00	0.00	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	TIMP4	0.07	0.05	lasso	7	0.06	5.5e-08	7.51	6.3	3.0e-10	-0.37	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SYN2	0.04	0.04	lasso	2	0.04	4.9e-05	5.89	6.4	2.1e-10	-0.33	0.38	0.02	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	SYN2	0.03	0.02	enet	6	0.02	4.0e-03	6.33	6.3	3.4e-10	-0.29	0.28	0.03	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYN2	0.11	0.12	lasso	6	0.11	1.0e-11	5.77	5.4	5.8e-08	-0.30	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	TIMP4	0.03	0.03	blup	32	0.02	1.4e-03	6.04	7.0	2.1e-12	-0.32	0.04	0.07	TRUE
29	The Cancer Genome Atlas	Thyroid Carcinoma	TSEN2	0.09	0.04	blup	78	0.05	9.2e-06	4.78	-5.5	4.8e-08	-0.04	0.28	0.12	FALSE