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chr3:100,350,244-102,243,332

Best TWAS P=8.58e-24 · Best GWAS P=2.38e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SENP7	0.22	0.10	enet	45	0.16	1.2e-19	6.99	-8.0	1.2e-15	-0.70	0.78	0.22	FALSE
2	GTEx	Adipose Subcutaneous	SENP7	0.10	0.11	enet	30	0.10	1.9e-08	6.99	-7.9	3.9e-15	-0.59	0.99	0.01	FALSE
3	GTEx	Adipose Visceral Omentum	ZBTB11-AS1	0.13	0.02	lasso	3	0.03	1.5e-02	-8.49	6.3	3.6e-10	0.79	0.18	0.48	FALSE
4	GTEx	Adrenal Gland	SENP7	0.11	0.06	lasso	5	0.03	4.0e-02	6.82	-6.3	2.3e-10	-0.37	0.10	0.46	FALSE
5	GTEx	Artery Aorta	SENP7	0.11	0.03	lasso	5	0.04	4.7e-03	4.79	-5.9	3.6e-09	-0.59	0.35	0.25	FALSE
6	GTEx	Artery Aorta	ZBTB11-AS1	0.19	0.13	lasso	6	0.12	5.3e-07	-7.90	7.4	1.2e-13	0.74	0.72	0.25	FALSE
7	GTEx	Artery Coronary	SENP7	0.11	0.02	enet	40	0.01	1.8e-01	6.01	-5.2	1.8e-07	-0.45	0.36	0.15	FALSE
8	GTEx	Artery Tibial	SENP7	0.17	0.15	enet	43	0.20	9.6e-16	7.52	-7.8	4.4e-15	-0.66	0.99	0.01	FALSE
9	GTEx	Artery Tibial	RP11-49I4.3	0.07	0.03	lasso	5	0.05	4.6e-05	7.01	-6.8	8.6e-12	-0.53	0.74	0.14	FALSE
10	GTEx	Artery Tibial	ZBTB11-AS1	0.19	0.13	enet	14	0.14	7.7e-11	-7.91	8.0	8.6e-16	0.70	0.98	0.02	TRUE
11	GTEx	Brain Cerebellar Hemisphere	PDCL3P4	0.30	0.37	enet	21	0.38	1.3e-10	4.54	5.3	1.3e-07	0.48	0.99	0.00	FALSE
12	GTEx	Brain Cortex	TRMT10C	0.18	0.01	enet	23	0.02	6.9e-02	1.13	5.4	6.2e-08	0.20	0.06	0.17	FALSE
13	GTEx	Brain Hypothalamus	PDCL3P4	0.45	0.24	lasso	4	0.21	1.1e-05	6.00	5.2	2.0e-07	0.51	0.29	0.09	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	SENP7	0.30	0.08	enet	40	0.22	9.2e-08	7.03	-9.7	3.9e-22	-0.77	0.07	0.93	FALSE
15	GTEx	Cells Transformed fibroblasts	NXPE3	0.21	0.13	lasso	4	0.17	4.5e-13	4.71	-5.7	1.5e-08	-0.48	1.00	0.00	FALSE
16	GTEx	Colon Sigmoid	SENP7	0.10	0.09	lasso	3	0.13	2.2e-05	7.52	-8.2	1.8e-16	-0.65	0.17	0.58	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	NXPE3	0.10	0.03	lasso	6	0.01	1.1e-01	-7.87	-6.1	1.1e-09	-0.74	0.07	0.40	TRUE
18	GTEx	Esophagus Gastroesophageal Junction	RP11-49I4.3	0.16	0.01	enet	8	0.03	2.5e-02	4.56	-5.5	4.9e-08	-0.51	0.12	0.19	FALSE
19	GTEx	Esophagus Mucosa	SENP7	0.11	0.04	lasso	2	0.06	7.4e-05	6.82	-6.8	9.5e-12	-0.42	0.52	0.40	TRUE
20	GTEx	Esophagus Muscularis	NXPE3	0.13	0.12	lasso	4	0.11	2.7e-07	4.56	-5.2	2.3e-07	-0.56	0.93	0.06	FALSE
21	GTEx	Esophagus Muscularis	ZBTB11-AS1	0.16	0.10	lasso	5	0.10	7.2e-07	-8.42	7.0	3.0e-12	0.66	0.68	0.30	FALSE
22	GTEx	Heart Atrial Appendage	SENP7	0.18	0.19	lasso	7	0.23	1.6e-10	7.43	-7.7	1.9e-14	-0.60	0.97	0.03	FALSE
23	GTEx	Heart Left Ventricle	PDCL3P4	0.11	0.03	enet	14	0.02	2.2e-02	4.54	5.4	5.2e-08	0.43	0.42	0.08	FALSE
24	GTEx	Liver	RP11-234A1.1	0.25	0.00	enet	4	0.00	2.4e-01	-8.42	8.6	8.5e-18	0.87	0.05	0.13	FALSE
25	GTEx	Lung	SENP7	0.11	0.09	lasso	6	0.09	2.8e-07	7.52	-8.2	1.9e-16	-0.70	0.17	0.83	FALSE
26	GTEx	Muscle Skeletal	PDCL3P4	0.07	0.08	enet	21	0.07	2.5e-07	4.68	5.7	9.9e-09	0.54	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	SENP7	0.20	0.17	lasso	5	0.18	2.0e-12	6.00	-8.5	1.9e-17	-0.68	0.70	0.30	FALSE
28	GTEx	Nerve Tibial	ZBTB11-AS1	0.21	0.18	lasso	3	0.18	7.9e-13	-7.90	7.9	2.7e-15	0.67	0.99	0.01	FALSE
29	GTEx	Pituitary	SENP7	0.14	0.15	lasso	2	0.15	1.3e-04	4.68	-6.1	8.7e-10	-0.58	0.32	0.26	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	SENP7	0.14	0.08	lasso	6	0.11	8.0e-07	4.56	-6.3	2.7e-10	-0.51	0.83	0.06	FALSE
31	GTEx	Skin Sun Exposed Lower leg	SENP7	0.07	0.03	lasso	3	0.05	5.6e-05	7.52	-7.0	3.1e-12	-0.68	0.30	0.68	FALSE
32	GTEx	Skin Sun Exposed Lower leg	NXPE3	0.12	0.05	lasso	7	0.06	2.1e-05	5.02	-5.6	2.3e-08	-0.39	0.26	0.60	FALSE
33	GTEx	Spleen	SENP7	0.25	0.09	enet	43	0.09	3.3e-03	-6.56	-8.4	4.1e-17	-0.53	0.12	0.70	FALSE
34	GTEx	Spleen	ZBTB11-AS1	0.27	0.17	lasso	3	0.11	8.2e-04	-7.84	7.4	1.3e-13	0.73	0.08	0.07	FALSE
35	GTEx	Stomach	SENP7	0.10	0.09	lasso	4	0.04	6.3e-03	6.99	-6.4	1.7e-10	-0.38	0.56	0.04	TRUE
36	GTEx	Testis	CEP97	0.20	0.15	lasso	6	0.17	4.3e-08	4.54	7.6	3.4e-14	0.67	0.98	0.01	FALSE
37	GTEx	Testis	ZBTB11-AS1	0.26	0.27	enet	27	0.25	1.8e-11	4.53	6.6	5.6e-11	0.64	0.99	0.01	FALSE
38	GTEx	Thyroid	SENP7	0.07	0.02	lasso	4	0.02	1.3e-02	6.99	-5.7	9.7e-09	-0.47	0.74	0.04	FALSE
39	GTEx	Whole Blood	SENP7	0.10	0.06	enet	42	0.06	7.3e-06	-8.85	-8.5	1.8e-17	-0.51	0.04	0.96	FALSE
40	GTEx	Whole Blood	NXPE3	0.14	0.08	lasso	4	0.11	1.4e-10	5.02	-5.4	8.2e-08	-0.43	0.99	0.00	FALSE
41	METSIM	Adipose	SENP7	0.05	0.05	blup	478	0.07	2.5e-10	6.82	-9.0	2.1e-19	-0.56	0.28	0.72	FALSE
42	NTR	Blood	FAM55C	0.05	0.04	bslmm	345	0.04	4.6e-13	5.02	-5.9	4.8e-09	-0.33	1.00	0.00	FALSE
43	NTR	Blood	SENP7	0.02	0.00	bslmm	476	0.01	9.1e-04	-8.83	-8.9	4.7e-19	-0.47	0.08	0.65	FALSE
44	YFS	Blood	PCNP	0.02	0.01	lasso	4	0.01	3.4e-05	-8.49	7.5	4.4e-14	0.82	0.10	0.88	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SENP7	0.07	0.04	enet	17	0.07	9.3e-07	9.24	-10.1	8.6e-24	-0.81	0.01	0.98	TRUE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100009676	0.03	0.02	blup	26	0.02	6.0e-05	-7.90	7.8	7.9e-15	0.62	0.00	0.98	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	SENP7	0.04	0.05	enet	10	0.06	1.0e-11	6.99	-9.2	4.9e-20	-0.71	0.74	0.26	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LOC100009676	0.18	0.05	blup	26	0.07	3.2e-04	-7.84	5.8	8.0e-09	0.56	0.00	0.69	FALSE
49	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SENP7	0.07	0.04	enet	20	0.08	5.6e-05	7.00	-5.2	2.0e-07	-0.44	0.22	0.12	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	SENP7	0.18	0.15	enet	24	0.18	1.0e-10	6.77	-7.9	3.2e-15	-0.71	0.72	0.28	FALSE
51	The Cancer Genome Atlas	Glioblastoma Multiforme	LOC285359	0.17	0.12	blup	24	0.07	3.0e-03	4.56	5.1	2.8e-07	0.50	0.20	0.23	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LOC100009676	0.02	0.01	blup	26	0.00	9.5e-02	-7.91	7.0	2.7e-12	0.65	0.00	0.84	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SENP7	0.04	0.03	lasso	2	0.03	1.3e-04	6.77	-7.2	5.6e-13	-0.54	0.66	0.20	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC100009676	0.06	0.04	enet	18	0.03	1.1e-04	-7.90	6.4	1.9e-10	0.60	0.00	0.99	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SENP7	0.04	0.04	lasso	5	0.04	2.1e-05	7.01	-6.8	1.0e-11	-0.43	0.86	0.01	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SENP7	0.04	0.02	blup	84	0.03	4.6e-03	7.43	-8.6	6.2e-18	-0.57	0.08	0.44	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100009676	0.17	0.08	enet	17	0.16	4.0e-18	-7.91	5.8	6.1e-09	0.52	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	SENP7	0.02	0.03	blup	84	0.02	3.4e-03	6.80	-7.8	5.3e-15	-0.52	0.43	0.21	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC285359	0.02	0.01	lasso	8	0.01	2.6e-02	4.56	6.3	2.5e-10	0.60	0.02	0.64	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	SENP7	0.04	0.05	enet	15	0.05	1.1e-06	6.99	-8.7	3.8e-18	-0.56	0.88	0.12	TRUE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SENP7	0.04	0.02	blup	84	0.02	8.1e-04	7.00	-7.2	5.4e-13	-0.47	0.48	0.20	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SENP7	0.07	0.09	lasso	5	0.08	2.6e-06	6.99	-7.0	2.7e-12	-0.42	0.98	0.01	FALSE
63	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FAM55C	0.40	0.03	enet	9	0.10	6.2e-05	-7.69	-6.2	5.1e-10	-0.53	0.00	0.90	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SENP7	0.15	0.03	blup	84	0.09	1.4e-04	-0.72	-5.6	1.7e-08	-0.51	0.21	0.23	FALSE
65	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC100009676	0.11	0.09	lasso	2	0.06	1.8e-03	-7.84	7.8	4.4e-15	0.72	0.00	0.91	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	SENP7	0.10	0.10	lasso	14	0.10	7.6e-11	6.99	-7.8	5.8e-15	-0.62	0.97	0.03	FALSE
67	The Cancer Genome Atlas	Rectum Adenocarcinoma	SENP7	0.15	0.07	blup	84	0.09	4.5e-03	7.43	-9.0	1.7e-19	-0.69	0.03	0.55	FALSE
68	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SENP7	0.07	0.01	blup	84	0.04	2.1e-02	6.99	-8.0	1.1e-15	-0.43	0.07	0.36	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	LOC100009676	0.13	0.07	blup	26	0.09	6.5e-09	-7.91	6.3	3.4e-10	0.48	0.00	1.00	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	SENP7	0.14	0.12	blup	84	0.15	1.6e-14	7.04	-7.7	1.6e-14	-0.60	1.00	0.00	FALSE