Best TWAS P=1.62e-16 · Best GWAS P=8.46e-35 conditioned to 2.71e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CD200 | 0.05 | 0.02 | bslmm | 530 | 0.02 | 4.4e-03 | 11.12 | 7.7 | 1.5e-14 | -0.58 | 0.06 | 0.81 | TRUE |
| 2 | GTEx | Heart Left Ventricle | SLC35A5 | 0.18 | 0.13 | enet | 10 | 0.12 | 3.5e-07 | 4.31 | -6.4 | 1.9e-10 | 0.21 | 0.86 | 0.01 | TRUE |
| 3 | METSIM | Adipose | GTPBP8 | 0.06 | 0.03 | lasso | 4 | 0.03 | 2.4e-05 | -6.24 | -6.1 | 1.1e-09 | 0.04 | 0.98 | 0.01 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C3orf17 | 0.06 | 0.04 | blup | 25 | 0.04 | 1.4e-04 | 3.15 | 7.4 | 1.1e-13 | 0.00 | 0.09 | 0.65 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GTPBP8 | 0.02 | 0.02 | blup | 31 | 0.02 | 2.5e-05 | 3.66 | -5.2 | 1.8e-07 | 0.05 | 0.08 | 0.07 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | GTPBP8 | 0.04 | 0.02 | blup | 31 | 0.01 | 9.8e-02 | 3.25 | -6.9 | 4.4e-12 | 0.02 | 0.02 | 0.17 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | CD200R1 | 0.04 | 0.01 | blup | 50 | 0.03 | 1.8e-04 | 6.94 | 6.7 | 2.5e-11 | 0.09 | 0.01 | 0.96 | TRUE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C3orf17 | 0.22 | -0.01 | blup | 25 | 0.02 | 7.5e-02 | -0.43 | -5.1 | 2.9e-07 | -0.07 | 0.00 | 0.09 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | GTPBP8 | 0.13 | 0.05 | enet | 19 | 0.07 | 6.3e-04 | 2.60 | -6.6 | 3.7e-11 | 0.03 | 0.05 | 0.34 | FALSE |
| 10 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SLC9A10 | 0.09 | 0.00 | blup | 123 | 0.02 | 3.4e-02 | -6.29 | 8.2 | 1.6e-16 | -0.42 | 0.03 | 0.09 | TRUE |