Best TWAS P=5.6e-10 · Best GWAS P=2.88e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | GRPEL1 | 0.11 | 0.09 | lasso | 3 | 0.07 | 3.1e-06 | 5.8 | 6.2 | 5.6e-10 | 0.95 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | GRPEL1 | 0.27 | 0.13 | lasso | 9 | 0.18 | 2.3e-13 | 5.8 | 5.3 | 1.2e-07 | 0.96 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Nerve Tibial | GRPEL1 | 0.16 | 0.07 | lasso | 4 | 0.06 | 2.9e-05 | 4.4 | 5.4 | 5.3e-08 | 0.96 | 0.01 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GRPEL1 | 0.06 | 0.09 | enet | 9 | 0.10 | 3.1e-11 | 5.8 | 5.2 | 2.2e-07 | 0.95 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRPEL1 | 0.03 | 0.04 | lasso | 2 | 0.04 | 1.0e-05 | 5.8 | 5.8 | 5.4e-09 | 0.98 | 0.00 | 1.00 | FALSE |