TWAS hub - GRPEL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1131	0.0420	4.5e-03	0.088	NA	0.055	NA	0.071	2.0e-07	NA	4.1e-05	NA	3.1e-06
2	GTEx	Brain Cerebellum	0.3710	0.1100	3.0e-03	0.170	NA	0.009	NA	0.133	9.7e-06	NA	1.7e-01	NA	9.7e-05
3	GTEx	Cells EBV-transformed lymphocytes	0.2540	0.0970	9.9e-03	0.121	NA	0.064	NA	0.062	9.2e-05	NA	3.9e-03	NA	4.6e-03
4	GTEx	Cells Transformed fibroblasts	0.2680	0.0510	1.2e-09	0.131	NA	0.176	NA	0.178	4.7e-10	NA	3.6e-13	NA	2.3e-13
5	GTEx	Esophagus Muscularis	0.1240	0.0470	7.5e-03	0.000	NA	0.006	NA	-0.001	3.4e-01	NA	1.3e-01	NA	3.6e-01
6	GTEx	Muscle Skeletal	0.1033	0.0353	1.0e-03	0.050	NA	0.052	NA	0.054	1.2e-05	NA	7.9e-06	NA	5.0e-06
7	GTEx	Nerve Tibial	0.1635	0.0582	1.5e-03	0.070	NA	0.031	NA	0.063	1.1e-05	NA	2.8e-03	NA	2.9e-05
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0921	0.0303	1.0e-13	0.102	0.116	0.105	NA	0.107	1.6e-11	5.4e-13	8.3e-12	NA	4.7e-12
9	TCGA	Brain Lower Grade Glioma	0.0580	0.0209	1.1e-09	0.089	0.094	0.098	NA	0.097	2.4e-10	7.4e-11	3.1e-11	NA	4.0e-11
10	TCGA	Lung Adenocarcinoma	0.0286	0.0169	3.8e-03	0.017	0.022	0.015	NA	0.021	3.5e-03	1.1e-03	5.7e-03	NA	1.4e-03
11	TCGA	Lung Squamous Cell Carcinoma	0.0317	0.0152	2.4e-04	0.038	0.026	0.036	NA	0.043	3.6e-05	5.2e-04	5.0e-05	NA	1.0e-05
12	TCGA	Prostate Adenocarcinoma	0.0547	0.0278	8.5e-06	0.045	0.048	0.041	NA	0.043	1.6e-05	9.0e-06	3.9e-05	NA	2.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	6	7	8	9	10	11	12
Alcohol usually taken with meals	8.1	13.1	20.0	4.5	4.0	4.2	3.7	2.9	4.0	3.3	3.9	3.3	4.2	3.1
Number of treatments/medications taken	7.6	13.6	25.0	3.2	2.9	3.4	4.2	5.0	3.0	4.0	4.1	4.2	3.6	4.2
Number of operations (self-reported)	7.1	10.5	12.8	3.3	3.4	3.3	3.5	3.4	3.3	3.5	3.4	3.6	3.3	3.2
Taking other prescription medications	6.6	10.1	18.3	3.1	2.5	2.6	3.6	4.3	2.6	3.3	3.7	3.3	3.4	3.7
Pain experienced in last month	5.7	9.5	13.3	-2.7	-3.1	-3.1	-3.6	-3.6	-2.8	-3.5	-3.1	-3.5	-3.0	-3.2
Medication: Allopurinol	5.5	7.3	11.4	2.3	2.6	2.6	3.1	3.1	2.5	3.4	2.7	3.1	2.6	2.8
Neck or shoulder pain in last month	4.8	6.8	12.0	2.9	2.7	2.9	3.5	2.8	2.4	3.0	2.4	2.0	2.6	2.5
Heel bone mineral density (BMD) T-score, automated (left)	4.4	10.0	14.5	2.7	3.4	3.7	3.4	3.4	3.3	3.8	3.2	3.0	3.0	3.4
Had other major operations	4.4	5.4	8.2	2.9	2.4	2.3	2.6	2.2	2.7	2.5	2.3	2.1	2.8	1.6
Mean Putamen Volume	4.1	4.7	7.5	1.8	2.6	2.3	2.1	2.3	1.8	2.5	2.1	2.7	2.0	2.4
Average weekly spirits intake	4.1	5.1	7.3	1.9	2.3	2.7	2.6	2.6	2.3	2.5	2.1	2.1	2.4	2.2
Medication for hormone replacement therapy	3.9	4.4	6.8	2.0	1.6	1.6	2.1	2.4	2.2	2.2	2.6	2.6	2.2	2.3
Vitamin and mineral supplements	3.8	5.2	7.4	-2.6	-2.2	-2.3	-2.7	-2.5	-2.1	-2.1	-2.6	-1.8	-2.4	-2.6
Had major operations	3.8	4.4	6.5	2.2	1.8	1.8	2.4	2.4	1.9	2.1	2.5	2.3	2.1	2.5
Illnesses of father: None of the above (group 1)	3.6	4.5	8.7	-2.0	-2.0	-2.1	-1.9	-2.2	-2.1	-2.5	-2.4	-3.0	-2.0	-2.0
Crohns Disease (2012)	3.5	5.7	8.8	-2.3	-2.2	-2.5	-2.3	-2.4	-2.3	-2.5	-3.0	-2.7	-2.1	-3.0
High blood pressure (mother)	3.5	4.9	8.1	1.5	2.4	2.4	2.3	2.6	2.1	2.8	2.2	2.4	2.0	2.4
Birth weight of first child	3.5	6.3	8.3	-2.6	-2.5	-2.6	-2.8	-2.7	-2.6	-2.8	-2.6	-2.2	-2.5	-2.9
Worry too long after embarrassment	3.5	6.0	8.3	-2.3	-2.1	-2.6	-2.4	-2.9	-2.6	-2.7	-2.9	-2.5	-2.7	-2.3
Qualifications: CSEs or equivalent	3.4	4.5	7.2	-2.7	-2.6	-2.2	-2.4	-1.5	-2.3	-2.0	-2.4	-2.0	-2.4	-1.7
Number of live births	3.4	4.8	6.1	2.3	2.4	2.4	2.4	1.9	2.5	2.2	2.3	2.0	2.3	2.4
Medication: Bendroflumethiazide	3.3	4.9	7.3	2.2	2.5	2.4	2.2	2.2	2.3	2.3	2.3	2.7	2.4	2.1
Ulcerative Colitis	3.2	4.6	7.6	-2.8	-2.3	-2.1	-2.6	-1.7	-2.6	-2.5	-2.3	-1.9	-2.4	-1.3
Blood Platelet Count	3.2	37.5	58.8	-5.0	-6.0	-6.0	-6.2	-7.1	-6.0	-6.7	-6.7	-6.7	-5.7	-7.7
Irritable Bowel Disease (IBD)	3.1	7.5	10.1	-2.9	-2.8	-3.0	-2.9	-2.5	-3.0	-3.0	-3.2	-2.9	-2.7	-2.5
Commuting to job workplace: Walk	3.1	3.3	7.2	2.7	1.9	1.8	1.8	0.9	2.5	1.6	2.0	2.0	2.1	0.8
Wears glasses or contact lenses	3.1	3.6	5.7	2.4	2.3	2.0	2.2	1.8	2.1	1.8	1.9	1.1	2.2	1.7
Leg fat percentage (left)	3.1	11.2	14.5	3.5	3.2	3.5	3.7	3.3	3.8	3.5	3.5	3.7	3.6	3.1
Leg fat percentage (right)	3.0	10.7	13.7	3.4	3.0	3.3	3.6	3.3	3.7	3.4	3.5	3.7	3.6	3.1
Smoking status: Previous	3.0	4.6	6.2	2.2	2.1	2.0	2.2	2.3	2.3	2.1	2.2	2.5	2.3	2.2
Breast cancer (self-reported)	3.0	3.6	6.6	1.6	1.9	1.8	1.9	2.0	1.6	2.1	1.9	2.6	2.0	2.1
Blood Eosinophil Count	2.9	22.6	38.4	6.2	4.7	4.9	5.3	4.2	5.4	4.5	5.2	4.0	5.8	3.7
Diabetes (father)	2.9	3.5	7.0	2.7	2.3	2.4	2.0	1.5	2.0	1.5	1.8	1.2	2.0	1.5
Long-standing illness, disability or infirmity	2.9	4.5	8.8	1.7	1.8	1.8	2.3	3.0	1.6	2.2	2.6	2.2	1.9	2.9
Tinnitus: Yes, now most or all of the time	2.9	3.4	6.2	1.9	2.5	2.1	1.8	1.2	2.1	1.8	1.9	2.1	2.0	1.6
Osteoarthritis (self-reported)	2.8	3.6	5.3	1.9	1.7	2.1	1.9	2.1	1.8	2.0	2.2	2.3	1.9	1.9
Bipolar Disorder or Schizophrenia	2.7	6.7	9.1	-2.8	-2.7	-2.7	-2.6	-2.3	-3.0	-2.7	-2.5	-2.9	-2.8	-2.6
Body mass index (BMI)	2.7	11.7	15.2	3.3	3.2	3.4	3.7	3.6	3.6	3.6	3.6	3.9	3.5	3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.2	5.7	-1.4	-1.6	-2.0	-2.1	-2.4	-1.5	-2.3	-1.7	-2.4	-1.6	-1.1
Medication for cholesterol	2.7	4.1	5.8	-1.9	-1.9	-2.0	-2.1	-2.1	-2.2	-2.2	-2.3	-2.4	-2.0	-2.1
Bipolar Disorder (2018)	2.6	4.1	5.4	-2.2	-2.2	-2.0	-2.0	-2.0	-2.3	-2.2	-2.0	-2.3	-2.1	-2.0
Sensitivity / hurt feelings	2.6	4.5	7.7	-2.8	-2.0	-2.4	-2.4	-2.0	-2.1	-2.1	-2.3	-1.5	-2.7	-1.6
Supplements: Glucosamine	2.6	3.4	5.9	2.4	2.3	2.1	1.8	1.2	2.2	1.4	2.0	1.6	2.3	1.2
Arm fat percentage (left)	2.6	10.6	14.1	3.4	3.2	3.4	3.4	3.2	3.7	3.4	3.5	3.8	3.4	3.1
Number of self-reported non-cancer illnesses	2.6	4.5	8.8	1.9	1.7	1.7	2.3	3.0	1.8	2.2	2.5	2.5	2.0	2.4
Illnesses of father: High blood pressure	2.6	3.2	4.8	2.0	2.2	2.2	1.6	1.3	2.0	1.9	1.9	2.0	1.8	1.7
Alcohol drinker status: Never	2.6	3.2	4.7	-2.1	-1.5	-2.0	-2.2	-1.7	-1.9	-1.7	-2.1	-1.3	-2.0	-1.5
Crohns Disease (2017)	2.5	5.5	8.5	-2.0	-2.2	-2.6	-2.2	-2.4	-2.2	-2.6	-2.8	-2.8	-1.9	-2.9
Average weekly fortified wine intake	2.5	3.0	5.8	1.4	1.6	1.8	1.5	2.0	1.7	2.0	1.7	2.4	1.7	1.7
Diabetes diagnosed by doctor	2.5	4.2	6.8	1.9	2.1	2.2	2.2	2.6	1.9	2.0	2.1	1.7	2.2	2.3
Ulcerative Colitis (UC)	2.4	4.5	6.8	-2.5	-2.3	-2.3	-2.3	-1.7	-2.6	-2.3	-2.3	-2.1	-2.3	-1.2
Cardiovascular Disease	2.3	7.6	10.4	2.9	3.2	3.0	3.1	2.6	2.9	2.9	2.8	2.5	2.9	2.9
Multivitamins +/- minerals	2.3	2.9	5.1	1.7	1.6	1.8	2.3	2.0	1.6	1.7	1.8	1.0	1.6	2.2
Risk taking	2.3	3.4	5.2	1.9	1.4	1.9	2.3	2.0	1.9	2.1	2.2	1.6	1.8	2.0
Number of full brothers	2.2	2.8	4.6	1.0	1.8	1.9	1.7	1.9	1.6	2.1	1.4	2.2	1.5	1.9
Medication: Blood pressure	2.2	3.8	6.6	1.8	1.4	1.7	2.2	2.6	1.8	1.9	2.2	2.1	2.1	2.3
Alcohol drinker status: Previous	2.2	2.5	3.8	1.6	1.1	1.4	1.9	1.5	1.9	1.8	2.0	1.5	1.8	1.3
HbA1C	2.1	2.3	3.6	-1.7	-1.7	-1.9	-1.5	-1.3	-1.4	-1.4	-1.9	-1.8	-1.3	-1.5
BMI	2.1	12.0	15.8	3.5	3.2	3.4	3.8	3.7	3.8	3.6	4.0	3.6	3.5	3.6
Noisy workplace	2.1	2.6	3.6	-1.8	-1.6	-1.6	-1.7	-1.8	-1.9	-1.7	-1.6	-1.7	-1.9	-1.2
Back pain experienced in last month	2.1	3.0	4.2	1.4	1.9	1.6	2.1	2.1	1.8	2.0	1.8	1.8	1.9	1.7
Eye problems/disorders: Glaucoma	2.1	2.4	4.0	1.4	1.3	1.4	1.7	1.9	1.2	1.6	2.0	2.0	1.4	1.9
Lupus	2.0	3.1	6.4	-1.1	-1.7	-1.5	-1.6	-2.2	-1.5	-2.3	-1.5	-2.0	-1.7	-2.5
Arm fat percentage (right)	2.0	7.9	10.4	2.9	2.7	2.9	2.9	2.8	3.2	2.9	3.0	3.2	2.9	2.6
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	6.9	-1.5	-1.4	-1.6	-2.0	-2.6	-1.4	-1.8	-1.9	-2.0	-1.9	-2.4
Gout (self-reported)	2.0	2.7	5.1	1.0	1.7	1.6	1.9	2.0	1.6	2.3	1.3	1.9	1.6	1.7
Medication: Aspirin	2.0	2.6	4.2	1.6	1.7	1.4	2.1	1.6	1.7	1.7	1.5	2.0	1.9	1.4
Medication: Paracetamol	2.0	3.1	6.8	1.4	1.0	1.5	2.4	2.3	1.3	1.9	2.0	1.5	1.6	2.6
Leg fat mass (left)	2.0	7.9	10.4	2.9	2.5	2.9	3.1	2.8	3.2	2.9	2.9	3.2	3.0	2.5
Past tobacco smoking	1.9	3.4	4.4	-1.8	-1.7	-1.7	-2.0	-2.1	-2.1	-1.9	-1.9	-2.1	-2.1	-1.8
Hearing difficulty/problems with background noise	1.9	3.0	4.5	2.0	1.5	1.5	2.0	2.0	1.5	1.9	2.0	2.1	1.8	1.5
Illnesses of mother	1.9	2.4	3.8	-1.2	-1.7	-1.7	-1.7	-1.7	-1.6	-1.9	-1.6	-1.2	-1.4	-2.0
Standing height	1.9	18.4	28.9	-4.1	-4.7	-4.7	-4.7	-4.4	-4.3	-4.5	-4.3	-3.8	-4.2	-5.4
Breastfed as a baby	1.9	2.4	5.0	1.0	1.6	2.2	1.7	1.9	1.2	2.0	1.3	1.5	1.2	1.6
Glaucoma (self-reported)	1.9	2.3	3.9	1.4	1.3	1.5	1.5	1.9	1.2	1.6	1.8	2.0	1.4	1.7
Body fat percentage	1.9	7.6	10.3	3.1	2.7	2.9	3.0	2.7	3.2	2.8	2.9	3.1	3.0	2.4
Leg fat mass (right)	1.9	7.5	10.4	2.8	2.4	2.7	3.0	2.9	3.1	2.9	2.9	3.2	3.0	2.5
Illnesses of siblings: Diabetes	1.9	2.3	3.3	1.4	1.7	1.5	1.5	1.7	1.7	1.6	1.5	1.4	1.8	1.6
Medication: Co-codamol	1.8	2.1	3.2	1.6	1.3	1.1	1.8	1.7	1.6	1.4	1.7	1.2	1.7	1.4
Hand grip strength (right)	1.8	4.9	7.8	-2.0	-2.8	-2.2	-2.4	-2.1	-2.4	-2.5	-1.9	-2.3	-2.4	-2.1
Forced vital capacity (FVC)	1.8	7.1	10.8	-2.3	-2.5	-2.5	-3.0	-3.0	-2.5	-3.0	-2.6	-3.3	-2.7	-3.0
Friendships satisfaction	1.8	2.3	4.4	-1.4	-1.4	-1.2	-1.6	-2.1	-1.1	-1.8	-1.5	-1.4	-1.7	-1.8
Qualifications: nursing, teaching	1.8	2.8	4.5	2.0	2.1	1.9	1.7	1.2	1.9	1.6	1.7	1.4	1.8	1.4
Medication: Gliclazide	1.8	2.0	3.1	1.2	1.4	1.7	1.4	1.7	1.2	1.4	1.3	1.6	1.5	1.8
Arm fat mass (left)	1.8	7.6	11.4	2.8	2.6	2.8	2.8	2.8	3.1	2.9	2.9	3.4	2.9	2.5
Type 2 Diabetes (T2D) (2018)	1.7	3.3	5.5	1.7	2.2	2.0	1.9	2.3	1.6	1.7	1.7	1.4	2.0	2.1
Father’s age at death	1.7	2.2	4.5	1.9	2.1	2.0	1.7	0.7	1.7	1.6	1.1	1.3	1.5	0.8
Arm fat mass (right)	1.7	7.1	10.2	2.7	2.4	2.7	2.8	2.7	3.1	2.8	2.9	3.2	2.8	2.5
Illnesses of father: Heart disease	1.7	2.3	4.8	1.3	1.3	1.4	1.2	1.9	1.2	1.7	1.6	2.2	1.6	1.7
Medication: Atenolol	1.6	2.0	3.3	1.1	1.8	1.7	1.4	1.4	1.4	1.5	1.5	1.8	1.4	1.2
Waist circumference	1.6	5.9	7.6	2.4	2.2	2.4	2.7	2.6	2.7	2.5	2.5	2.8	2.8	2.5
Hair/balding pattern: Pattern 2	1.6	2.0	3.6	-1.3	-1.7	-1.9	-1.2	-1.1	-1.4	-1.6	-1.4	-1.9	-1.6	-0.8
Supplements: Vitamin C	1.6	1.9	3.7	1.1	1.3	1.4	1.4	1.8	1.0	1.4	1.2	1.4	1.3	1.9
Heart disease (siblings)	1.6	1.9	3.0	1.4	1.4	1.3	1.4	1.4	1.4	1.5	1.6	1.7	1.4	1.4
Frequency of depressed mood in last 2 weeks	1.5	2.2	4.3	-2.0	-1.6	-1.7	-1.3	-0.7	-2.1	-1.2	-1.9	-1.2	-1.8	-0.7
Illnesses of siblings	1.5	2.0	5.5	-1.0	-1.3	-1.1	-1.4	-1.5	-1.5	-1.7	-1.3	-2.3	-1.5	-1.3
Ever highly irritable/argumentative for 2 days	1.5	1.7	3.9	-1.1	-1.3	-1.3	-1.1	-1.5	-1.1	-1.6	-1.3	-2.0	-1.3	-1.4
Loud music exposure frequency	1.5	1.6	2.6	1.6	1.1	1.3	1.4	1.1	1.6	1.3	1.4	1.1	1.5	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.7	1.4	0.8	1.4	1.6	1.9	1.1	1.1	1.8	0.5	1.4	1.5
Overall health rating	1.5	3.1	5.1	1.7	1.6	1.7	2.3	2.1	1.8	1.9	1.8	1.4	1.8	2.1
Medication: Aspirin	1.5	1.9	3.5	1.3	1.3	1.1	1.9	1.6	1.3	1.5	1.4	1.5	1.5	1.5
Guilty feelings	1.5	2.2	3.3	-1.3	-1.5	-1.7	-1.5	-1.8	-1.6	-1.8	-1.5	-1.5	-1.7	-1.4
Schizophrenia (2018)	1.4	2.9	4.0	-1.8	-1.7	-1.9	-1.8	-1.4	-2.0	-1.8	-1.6	-1.8	-1.9	-1.7
Reaction Time	1.4	2.7	5.9	-1.5	-1.5	-1.6	-1.4	-1.6	-2.0	-1.8	-1.8	-2.4	-2.0	-0.9
Age at First Birth	1.4	2.0	4.4	1.3	1.9	2.1	1.6	1.1	1.3	2.1	0.8	1.4	1.2	1.2
Height	1.4	26.3	37.3	-4.7	-5.8	-5.7	-5.6	-5.2	-5.1	-5.6	-5.3	-4.8	-4.8	-6.1
Angina (self-reported)	1.4	1.8	3.2	1.1	1.4	1.2	1.4	1.8	1.4	1.5	1.5	1.6	1.3	1.2
Mineral and other dietary supplements	1.4	1.9	2.8	-1.5	-1.4	-1.7	-1.6	-1.4	-1.5	-1.0	-1.6	-0.8	-1.7	-1.5
Mother’s age at death	1.4	1.8	4.0	2.0	1.4	1.3	1.7	0.9	1.7	1.0	1.4	0.8	1.6	1.0
Medication: Blood pressure	1.4	2.6	4.0	1.4	1.8	2.0	1.7	1.5	1.8	1.9	1.6	1.9	1.4	1.4
Angina	1.3	1.7	3.1	1.1	1.3	1.1	1.4	1.8	1.3	1.4	1.4	1.5	1.3	1.2
Medication: Simvastatin	1.3	1.9	3.3	1.0	1.5	1.4	1.5	1.8	1.0	1.5	1.2	1.5	1.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	5.3	-2.1	-1.9	-1.5	-2.0	-0.7	-2.3	-1.3	-1.5	-1.2	-2.0	-1.5
Diastolic blood pressure, automated reading	1.3	4.1	5.9	2.2	1.9	2.1	2.2	1.9	2.2	1.8	2.4	2.3	2.3	2.0
Neuroticism (Nagel 2018)	1.2	2.9	4.8	-2.2	-1.5	-1.8	-2.0	-1.6	-1.9	-1.6	-1.7	-1.2	-2.2	-1.7
Breast Cancer	1.2	2.8	5.7	1.4	1.6	1.6	1.4	2.1	1.5	1.9	1.8	2.4	1.7	1.4
Current tobacco smoking	1.2	1.9	4.0	-1.5	-2.0	-1.8	-1.1	-1.0	-1.4	-1.3	-1.3	-1.7	-1.4	-1.0
Sitting height	1.2	8.2	11.6	-3.2	-3.1	-3.2	-3.3	-2.5	-3.3	-2.8	-2.7	-2.1	-3.1	-3.4
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.1	1.1	1.7	2.1	1.7	1.9	1.8	2.3	1.6	1.6	1.4	1.9
Qualifications: None of the above	1.2	2.5	4.5	-2.1	-1.8	-2.1	-1.5	-1.0	-1.7	-1.5	-1.6	-1.8	-1.7	-1.3
Medication: Cholesterol lowering	1.2	1.8	4.8	0.8	1.0	1.1	1.4	2.2	0.8	1.6	1.1	1.7	1.3	1.9
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.3	1.2	1.5	1.4	1.2	1.2	1.2	1.1	1.2	1.2	1.5	1.3
Medication: Paracetamol	1.2	2.0	4.3	1.1	0.8	1.2	1.8	1.8	1.3	1.6	1.7	1.2	1.3	2.1
Mean time to correctly identify matches	1.2	2.2	4.4	-1.4	-1.3	-1.3	-1.4	-1.5	-1.8	-1.8	-1.4	-2.1	-1.8	-0.8
Age at last live birth	1.2	1.7	3.4	1.9	1.6	1.2	1.7	1.1	1.4	1.1	1.2	0.6	1.7	1.0
Average weekly red wine intake	1.2	1.7	3.7	1.9	1.9	1.7	1.2	0.2	1.9	0.9	1.0	0.9	1.5	0.8
Mood swings	1.2	2.2	4.1	-2.0	-1.5	-1.9	-1.5	-0.8	-2.0	-1.2	-1.6	-0.7	-2.0	-1.1
Blood White Count	1.1	8.2	14.7	-1.3	-3.4	-3.1	-2.4	-3.4	-3.0	-3.3	-2.6	-3.5	-2.5	-3.8
Financial difficulties in last 2 years	1.1	1.5	2.7	-1.6	-1.5	-1.1	-1.2	-1.0	-1.3	-1.1	-1.0	-1.5	-1.4	-0.8
Fluid intelligence score	1.1	2.4	5.3	2.3	2.1	1.7	1.3	0.7	1.9	1.2	1.5	1.3	1.9	0.9
Impedance of arm (right)	1.1	5.4	10.2	-1.7	-1.9	-2.2	-2.6	-2.9	-1.8	-2.7	-2.3	-2.6	-2.1	-3.2
Medication: Lansoprazole	1.1	1.3	1.9	1.2	1.1	1.0	1.2	1.1	1.1	1.2	1.3	1.1	1.3	1.4
Birth weight	1.1	2.4	6.2	-1.0	-1.6	-1.4	-1.2	-1.6	-1.4	-1.6	-1.7	-1.9	-1.4	-2.5
Whole body fat mass	1.1	4.8	7.0	2.3	1.9	2.1	2.3	2.3	2.5	2.3	2.3	2.6	2.4	1.9
Comparative height size at age 10	1.1	5.8	8.5	-2.4	-2.9	-2.7	-2.7	-2.1	-2.6	-2.5	-2.5	-1.9	-2.4	-2.9
Ever had bowel cancer screening	1.1	1.2	2.6	0.8	1.0	1.3	0.9	1.5	1.1	0.9	1.6	1.1	1.1	1.1
Smoking status: Current	1.1	1.8	3.6	-1.3	-1.9	-1.7	-1.1	-1.0	-1.3	-1.3	-1.2	-1.9	-1.3	-1.0
Myopia	1.1	1.5	3.1	1.6	1.4	1.4	1.4	1.1	1.0	1.3	1.8	1.1	1.1	0.6
Schizophrenia (2014)	1.0	2.1	2.8	-1.6	-1.3	-1.5	-1.6	-1.3	-1.6	-1.5	-1.5	-1.7	-1.7	-1.6
Systolic Blood Pressure	1.0	4.8	6.7	2.4	2.4	2.3	2.3	1.8	2.5	2.1	2.4	2.1	2.6	2.2
Neuroticism score	1.0	2.2	4.3	-2.1	-1.4	-1.8	-1.5	-1.1	-1.7	-1.4	-1.7	-0.9	-1.9	-1.1
Hypertension (Self-reported)	1.0	2.9	3.8	1.7	1.9	1.8	1.9	1.5	1.8	1.6	1.9	1.8	1.7	1.7
Pack years of smoking	1.0	1.4	4.6	-1.5	-2.1	-1.4	-0.9	-0.2	-1.2	-1.1	-0.7	-1.5	-1.2	-0.8
Alzheimer’s Disease (in mother)	0.9	1.0	2.5	-0.9	-0.9	-0.9	-1.0	-1.1	-1.1	-1.4	-0.7	-1.6	-1.1	-0.6
Rheumatoid Arthritis	0.9	1.2	2.3	1.2	1.2	1.3	1.1	1.2	1.4	1.0	1.5	0.7	1.0	0.9
Systolic blood pressure, automated reading	0.9	2.8	4.5	1.9	1.5	1.6	1.7	1.6	1.8	1.5	2.1	1.9	1.8	1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.1	1.0	0.9	1.2	1.5	1.1	1.1	1.0	0.9	0.6	1.4	0.7
Trunk fat percentage	0.9	3.6	5.5	2.3	1.8	2.0	2.0	1.8	2.3	1.8	2.0	2.1	2.1	1.5
Medication: Levothyroxine sodium	0.9	1.6	3.4	0.2	1.0	0.9	1.3	1.8	1.1	1.8	1.0	1.5	0.9	1.9
Lung cancer (father)	0.9	1.1	1.6	-1.1	-1.1	-1.2	-1.2	-0.7	-1.2	-1.1	-1.2	-1.2	-1.3	-0.6
Headache pain in last month	0.9	1.5	2.8	0.9	1.3	1.2	1.3	1.6	1.0	1.7	1.0	1.4	1.1	1.3
Forced vital capacity (FVC), Best measure	0.9	3.3	6.6	-1.5	-1.8	-1.6	-2.0	-1.9	-1.8	-2.1	-1.5	-2.6	-1.9	-2.1
Eye problems/disorders: None of the above	0.9	1.0	2.4	0.8	1.5	1.0	0.9	0.9	1.1	1.2	0.6	1.1	0.9	1.3
Medication: Lisinopril	0.9	1.1	2.3	-1.5	-1.5	-1.2	-1.0	-0.6	-1.3	-1.1	-0.9	-1.1	-1.2	-0.5
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.4	1.5	0.8	0.9	1.4	1.0	1.2	0.9	1.1	0.8	1.3	0.3
Vascular/heart problems diagnosed by doctor	0.9	2.6	3.5	-1.6	-1.7	-1.6	-1.9	-1.7	-1.8	-1.6	-1.9	-1.7	-1.6	-1.5
Cholesterol lowering medication	0.9	1.3	2.7	0.7	1.5	1.2	0.9	1.0	1.4	1.1	1.0	1.6	1.0	1.2
Intelligence (Savage-Jansen 2018)	0.8	2.5	5.4	2.0	2.3	1.8	1.7	1.0	1.7	1.4	1.6	1.3	1.7	1.5
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.6	2.1	2.0	1.4	1.2	0.7	1.5	1.0	1.5	1.0	1.6	1.1
Fed-up feelings	0.8	1.4	3.2	-1.8	-1.6	-1.6	-1.2	-0.5	-1.6	-1.0	-1.2	-0.5	-1.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.4	-1.6	-1.3	-1.4	-0.9	-0.6	-1.1	-0.9	-1.1	-0.4	-1.1	-0.9
Chronic bronchitis/emphysema (father)	0.8	0.9	2.9	-0.9	-1.7	-1.5	-0.9	-0.5	-1.0	-0.7	-0.6	-0.9	-1.0	-0.6
Diabetes (self-reported)	0.8	1.2	2.7	1.0	1.1	1.2	1.2	1.5	0.8	1.0	1.0	0.5	1.2	1.6
Hair/balding pattern: Pattern 4	0.8	1.9	3.5	-1.6	-1.9	-1.6	-1.3	-1.1	-1.7	-1.3	-1.5	-1.3	-1.5	-1.0
Number of children fathered	0.8	0.9	1.6	0.7	1.2	1.1	0.8	1.0	0.8	1.2	1.0	1.3	0.7	0.8
Average weekly champagne plus white wine intake	0.8	1.1	2.7	1.6	1.3	1.0	1.0	0.5	1.2	1.0	0.9	1.1	1.2	0.6
LDL Cholesterol	0.7	1.1	3.3	-1.8	-1.0	-0.9	-1.3	-0.9	-1.3	-0.9	-1.0	-0.4	-1.3	-0.8
Neuroticism (2016)	0.7	1.0	2.1	-1.5	-1.1	-1.1	-1.2	-0.9	-1.0	-0.9	-0.9	-0.8	-1.3	-0.4
Relative age of first facial hair	0.7	1.5	4.0	-0.9	-1.0	-0.9	-1.4	-2.0	-0.6	-1.2	-1.3	-1.3	-1.3	-1.8
Medication: Metformin	0.7	0.9	2.2	0.8	0.9	1.1	1.1	1.5	0.7	0.9	0.9	0.7	1.2	1.0
Pack years adult smoking proportion	0.7	1.0	3.9	-1.2	-2.0	-1.2	-0.6	-0.1	-0.9	-0.9	-0.4	-1.3	-0.9	-0.6
High blood pressure	0.7	2.0	2.9	1.5	1.6	1.5	1.6	1.2	1.6	1.3	1.7	1.5	1.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.4	-1.5	-0.9	-1.3	-0.8	-0.7	-1.3	-0.7	-1.1	-0.7	-1.6	-0.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.9	-1.3	-1.2	-1.3	-1.9	-1.8	-1.4	-1.8	-1.5	-2.0	-1.6	-1.9
Impedance of arm (left)	0.7	3.1	6.7	-1.2	-1.1	-1.4	-2.2	-2.5	-1.2	-2.0	-1.8	-1.8	-1.6	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.2	-1.8	-1.1	-0.8	-0.7	-0.2	-1.6	-0.6	-1.2	-0.5	-1.4	-0.3
Health satisfaction	0.7	0.9	1.8	0.8	1.3	1.0	1.1	0.9	1.1	0.9	0.7	0.7	1.1	1.0
Medication: Seretide 50 evohaler	0.7	0.8	2.5	0.6	0.8	0.9	1.0	0.9	1.0	1.6	0.3	1.4	0.8	0.6
Number of full sisters	0.7	0.9	2.1	0.6	0.7	0.9	0.9	1.4	0.9	1.2	0.9	1.2	0.8	0.7
Ever smoked	0.7	1.2	2.1	0.3	0.8	0.8	1.4	1.4	1.1	1.4	0.9	1.5	1.0	1.3
Commuting to job workplace: Cycle	0.7	0.8	2.4	0.8	0.9	0.9	1.0	0.9	0.7	1.1	0.7	1.5	0.8	0.9
Impedance of whole body	0.7	3.5	7.4	-1.2	-1.3	-1.5	-2.1	-2.5	-1.4	-2.2	-2.0	-2.2	-1.7	-2.7
Depression (Nagel 2018)	0.6	0.9	2.3	-1.5	-1.4	-1.1	-0.7	0.0	-1.3	-0.6	-0.9	-0.5	-1.1	-0.4
Alzheimer’s Disease (in father)	0.6	0.6	2.4	0.4	-0.1	0.3	0.8	1.5	0.2	0.9	1.1	1.1	0.5	1.0
Blood Red Count	0.6	5.5	10.6	1.9	1.9	1.9	2.2	2.7	2.2	2.3	3.0	2.8	2.2	3.2
Neuroticism	0.6	1.4	3.2	-1.8	-1.0	-1.4	-1.3	-0.8	-1.4	-0.9	-1.3	-0.5	-1.6	-0.9
Supplements: Zinc	0.6	0.6	1.3	-0.8	-1.1	-1.1	-0.4	-0.6	-0.6	-1.0	-0.5	-1.1	-0.5	-0.9
Townsend deprivation index at recruitment	0.6	0.9	2.0	0.7	1.2	1.2	1.4	1.0	0.9	1.0	0.6	0.7	0.7	1.2
Trunk fat mass	0.6	2.7	4.3	1.8	1.4	1.6	1.7	1.7	2.0	1.7	1.8	2.1	1.8	1.2
Hip circumference	0.6	2.7	5.0	1.5	1.4	1.6	1.9	1.6	1.9	2.0	1.5	2.2	1.8	1.2
Peak expiratory flow (PEF)	0.6	1.3	2.6	0.7	1.4	1.3	1.1	1.2	0.8	1.5	1.0	1.6	0.7	1.3
Exposure to tobacco smoke outside home	0.6	0.8	2.8	0.4	0.4	0.7	1.2	1.7	0.6	1.1	1.0	0.7	0.7	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	1.1	1.3	1.1	0.8	0.2	1.1	0.5	0.3	0.6	1.3	0.4
Emphysema/chronic bronchitis	0.6	0.7	1.6	1.3	0.9	0.6	1.2	0.4	1.1	0.6	0.7	0.4	1.1	0.2
Medication: Ibuprofen	0.6	0.7	1.6	1.3	0.7	0.6	1.1	0.5	0.9	0.9	0.8	0.8	1.0	0.4
Family relationship satisfaction	0.6	0.7	1.8	-0.5	-0.5	-0.7	-1.0	-1.4	-0.6	-0.9	-0.8	-0.5	-1.0	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.5	1.2	0.7	0.5	0.7	0.7	0.8	0.3	1.2	0.6	1.0	1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.6	1.2	1.2	1.3	1.2	1.1	0.7	1.1	0.8	0.5	0.9	0.5
Ovarian Cancer	0.5	0.7	1.4	-0.2	-1.2	-1.2	-0.6	-0.6	-0.8	-1.0	-0.2	-0.8	-0.8	-1.2
HDL Cholesterol	0.5	0.9	1.8	-0.6	-0.9	-1.1	-1.2	-1.0	-0.8	-1.1	-1.0	-0.9	-1.0	-1.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	0.5	0.6	0.7	0.5	0.6	0.8	0.7	0.9	0.8	1.0	1.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.2	1.1	0.8	0.9	0.8	0.8	1.0	0.5	1.1	0.5	1.0	0.8
Stomach or abdominal pain in last month	0.5	0.6	2.1	0.2	0.8	0.9	0.7	1.0	0.4	0.9	0.5	0.9	0.3	1.5
Medication: Ramipril	0.5	0.7	1.4	0.7	0.4	0.5	1.1	1.2	0.9	0.7	0.9	0.8	1.1	0.8
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	-0.8	-1.0	-0.7	-0.7	-0.5	-1.1	-1.1	-0.7	-1.3	-0.8	-0.7
Happiness	0.5	0.6	1.2	-0.6	-0.2	-0.8	-1.1	-0.7	-0.7	-1.1	-0.8	-0.8	-0.8	-0.9
Asthma	0.5	0.9	2.2	-0.9	-1.5	-1.3	-0.6	-0.6	-0.9	-0.6	-1.0	-0.8	-1.0	-1.2
Depression (self-reported)	0.5	0.6	2.2	-1.5	-0.7	-0.6	-0.7	-0.3	-0.8	-0.4	-1.0	-0.1	-1.1	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.0	1.7	0.8	1.2	0.7	-0.2	1.3	0.3	0.6	-0.3	1.1	-0.0
Wheeze or whistling in the chest in last year	0.5	0.8	2.6	1.4	-0.1	0.1	1.6	1.2	0.9	0.7	1.0	0.0	1.1	0.8
Leg pain on walking	0.5	0.6	1.1	0.3	0.8	0.8	0.7	1.0	0.7	0.9	0.8	1.0	0.8	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.9	0.0	0.4	0.8	0.5	1.2	0.7	0.6	0.5	0.3	0.6	1.7
Knee pain experienced in last month	0.5	0.7	2.0	0.3	0.7	0.6	0.7	1.4	0.4	1.0	1.0	1.3	0.4	1.0
Unable to work because of sickness or disability	0.5	0.6	1.6	-1.0	-1.0	-0.9	-0.5	-0.6	-0.8	-0.9	-0.6	-1.2	-0.9	-0.3
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	-1.4	-1.1	-1.3	-0.8	0.0	-1.2	-0.3	-0.8	0.1	-1.2	-0.5
Worry (Nagel 2018)	0.4	0.9	2.1	-1.3	-0.8	-0.9	-1.1	-0.9	-0.9	-0.9	-0.8	-0.7	-1.4	-1.0
Fasting Glucose	0.4	0.5	1.9	0.4	0.3	0.5	0.6	1.0	0.4	0.5	1.1	0.7	0.2	1.4
Lung FEV1/FVC ratio	0.4	1.9	2.6	1.4	1.3	1.3	1.4	1.6	1.2	1.4	1.5	1.4	1.4	1.5
Relative age voice broke	0.4	0.6	2.4	-0.8	-0.3	-0.0	-0.8	-1.5	-0.1	-0.7	-1.0	-1.0	-0.9	-0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.4	-0.4	-0.9	-0.8	-0.4	-0.7	-0.6	-0.8	-0.5	-1.2	-0.6	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.7	0.5	1.2	0.9	0.6	0.6	0.5	0.6	0.3	1.3	0.7	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.0	1.7	1.2	1.1	0.8	-0.4	1.4	0.5	0.3	0.4	1.2	-0.2
Prospective memory result	0.4	0.5	1.9	-1.4	-0.8	-0.4	-0.7	-0.1	-0.7	-0.2	-0.5	-0.3	-1.2	-0.4
Length of working week for main job	0.4	0.4	1.0	-0.5	-0.7	-0.5	-0.7	-0.5	-0.5	-0.8	-0.9	-1.0	-0.4	-0.8
Qualifications: College or University degree	0.4	1.1	2.6	-0.4	-0.6	-0.9	-1.1	-1.6	-1.2	-1.1	-1.2	-0.9	-1.0	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.2	-0.8	-1.1	-1.1	-0.4	-0.3	-0.8	-0.4	-0.7	-0.1	-0.7	-0.4
Alcohol intake frequency.	0.4	0.9	2.5	-1.6	-1.5	-1.5	-0.9	-0.1	-1.1	-0.5	-0.9	-0.6	-0.9	-0.2
Ever taken oral contraceptive pill	0.4	0.5	0.9	0.7	1.0	0.9	0.7	0.4	0.8	0.6	0.4	0.9	0.8	0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	0.2	0.1	0.5	0.7	1.3	0.2	1.0	0.7	0.6	0.4	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	0.5	0.7	1.1	0.8	0.8	0.6	0.7	0.5	0.7	0.8	0.9
Lung FVC	0.3	1.6	4.5	-1.3	-1.2	-1.0	-1.5	-1.3	-1.1	-1.4	-0.8	-2.1	-1.4	-0.9
Hand grip strength (left)	0.3	0.8	1.2	-0.7	-1.1	-0.7	-1.1	-1.0	-0.9	-1.1	-0.7	-1.0	-1.0	-0.9
Hearing difficulty/problems: Yes	0.3	0.5	1.3	1.1	0.7	0.5	0.6	0.8	0.4	0.4	1.1	0.9	0.7	0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	0.5	0.2	0.2	0.5	0.5	0.5	0.8	0.6	1.0	0.4	0.7
Diabetes (mother)	0.3	0.4	1.5	-0.3	0.2	0.2	0.7	1.2	0.0	0.8	0.4	0.2	0.2	1.2
Nervous feelings	0.3	0.5	0.9	-0.8	-0.8	-0.9	-0.7	-0.5	-0.6	-0.9	-0.4	-0.7	-0.9	-0.4
Weight	0.3	1.7	4.0	1.2	0.9	1.1	1.4	1.5	1.4	1.4	1.4	2.0	1.4	1.1
Worrier / anxious feelings	0.3	0.5	1.3	-1.0	-0.2	-0.5	-0.8	-0.9	-0.5	-0.4	-1.1	-0.1	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.0	-0.7	-0.7	-0.6	-1.1	-1.0	-0.9	-1.0	-0.6	-1.4	-1.1	-1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	-0.6	0.3	0.4	0.6	1.2	0.5	1.2	0.3	1.1	0.2	1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	-0.5	-1.2	-0.8	-0.5	-0.3	-0.9	-0.7	-0.5	-0.7	-0.4	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.6	-0.9	-0.5	-0.7	-0.3	-0.8	-0.5	-0.6	-0.5	-0.6	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.6	1.7	-0.4	-0.3	-0.5	-1.0	-1.1	-0.4	-0.9	-0.8	-0.9	-0.6	-1.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	-0.8	-0.7	-0.4	-0.4	-0.2	-0.8	-0.4	-0.8	-0.6	-0.9	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	-0.4	-0.3	-0.4	-0.6	-1.1	-0.6	-0.9	-0.6	-0.5	-0.6	-0.7
Asthma (self-reported)	0.3	0.5	1.6	-0.7	-1.3	-1.1	-0.4	-0.3	-0.7	-0.4	-0.8	-0.4	-0.8	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	0.4	0.4	0.4	0.6	0.9	0.7	0.5	1.2	0.6	0.4	1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.7	0.5	0.3	0.2	0.5	0.5	0.8	0.5	0.6	0.5	0.5	0.3
Major Depression (MDD)	0.2	0.3	2.5	0.0	0.0	0.0	0.0	0.0	0.0	0.8	0.3	0.4	-0.2	1.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	-0.4	-0.6	-0.5	-0.3	-0.4	-0.7	-0.6	-0.7	-0.7	-0.3	-0.6
Primary Biliary Cirrhosis	0.2	0.3	1.2	0.5	0.2	0.4	0.7	0.5	0.5	0.5	0.7	0.3	0.5	1.1
Triglycerides	0.2	0.4	1.0	-1.0	-0.8	-0.6	-0.5	-0.1	-0.9	-0.3	-0.5	-0.5	-0.8	0.2
Smoking Status	0.2	0.5	1.3	0.5	0.2	0.3	0.9	1.2	0.7	0.9	0.7	0.7	0.7	1.0
Allergy or Eczema	0.2	0.4	0.9	0.8	0.8	0.3	0.7	1.0	0.4	0.6	0.8	0.7	0.7	0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.7	-0.6	-0.5	-0.1	0.1	-0.5	-0.1	-0.4	-0.5	-0.5	0.0
Severe depression (siblings)	0.2	0.2	0.6	0.7	0.1	0.5	0.6	0.4	0.5	0.5	0.3	0.3	0.5	-0.2
Impedance of leg (right)	0.2	1.0	2.7	-0.4	-0.7	-0.8	-1.0	-1.4	-0.6	-1.3	-1.1	-1.3	-0.6	-1.6
Maternal smoking around birth	0.2	0.3	1.0	-0.8	-1.0	-0.7	-0.7	-0.0	-0.9	-0.3	-0.6	-0.1	-0.6	0.2
Impedance of leg (left)	0.2	1.0	2.8	-0.4	-0.5	-0.6	-1.0	-1.4	-0.5	-1.2	-1.2	-1.4	-0.7	-1.7
Number of incorrect matches in round	0.2	0.3	0.7	0.5	0.8	0.9	0.8	0.6	0.5	0.6	0.5	0.2	0.3	0.5
Pain all over the body in last month	0.2	0.2	0.4	0.3	0.1	0.6	0.7	0.6	0.3	0.4	0.2	0.0	0.4	0.5
Alcohol intake versus 10 years previously	0.2	0.3	1.0	-0.5	-0.9	-0.8	-0.2	0.1	-0.6	-0.5	-0.4	-1.0	-0.2	-0.5
Falls in the last year	0.2	0.2	0.5	0.3	0.3	0.4	0.7	0.6	0.3	0.6	0.2	0.6	0.3	0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.4	-0.6	-0.6	-0.4	-0.4	-0.4	-0.6	-0.2	-0.2	-0.4	-0.4
High blood pressure (siblings)	0.2	0.3	1.3	0.3	0.5	0.6	0.4	0.3	0.4	0.5	0.4	1.2	0.5	0.5
Suffer from ‘nerves’	0.2	0.3	1.4	-0.5	-0.2	0.1	0.0	0.8	-0.4	0.2	0.5	-0.1	-0.5	1.2
High cholesterol (Self-reported)	0.2	0.3	1.0	-0.1	0.3	0.2	0.6	0.9	0.2	0.8	-0.0	1.0	0.3	1.0
Medication: Atorvastatin	0.2	0.2	0.9	-1.0	-0.4	-0.4	-0.3	0.5	-0.2	0.1	-0.5	0.4	-0.3	0.7
Irritability	0.2	0.4	1.6	-0.3	-0.3	-0.6	-0.5	-0.6	-0.8	-0.8	-0.7	-0.4	-0.5	-1.3
Supplements: Calcium	0.2	0.2	0.4	0.3	0.4	0.6	0.6	0.5	0.5	0.4	0.2	0.1	0.6	0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.5	0.1	-0.1	-0.8	-0.7	-0.5	-0.3	-0.7	0.0	-0.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.5	0.4	0.3	0.5	0.6	0.5	0.4	0.4	0.8	0.6	0.0
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.1	-0.3	-0.2	0.2	0.6	-0.2	-0.2	0.6	-0.6	0.1	0.7
Prostate Cancer	0.1	0.1	0.3	-0.2	0.4	0.1	-0.4	-0.6	0.2	-0.3	-0.2	-0.2	-0.3	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.2	0.4	0.4	0.2	0.3	0.6	0.3	0.2	0.2	0.4	0.3
Heel T-Score	0.1	0.7	1.4	1.1	1.0	1.2	0.8	0.5	1.2	0.8	1.1	0.5	0.7	0.6
Waist Hip Ratio (WHR)	0.1	0.6	2.4	0.8	0.9	0.6	0.4	0.4	0.9	0.1	0.7	0.5	0.9	1.5
Hypothyroidism (self reported)	0.1	0.3	1.1	-0.6	0.1	0.0	0.3	0.6	0.5	0.9	0.1	1.1	0.0	0.6
Respiratory disease	0.1	0.1	0.6	0.2	-0.1	-0.0	0.4	0.6	0.1	0.5	0.2	0.7	0.0	0.2
Chronotype (morning person)	0.1	0.2	0.8	-0.3	0.4	0.2	-0.3	-0.3	0.0	-0.2	-0.4	-0.9	-0.4	-0.5
Tanning	0.1	0.8	1.6	-0.6	-1.0	-1.1	-1.0	-1.1	-0.7	-0.9	-0.8	-1.2	-0.8	-0.9
Age when periods started (menarche)	0.1	0.2	0.8	-0.4	-0.3	-0.4	-0.6	-0.4	-0.2	-0.4	-0.3	0.0	-0.2	-0.9
Serious illness, injury or assault to yourself	0.1	0.1	0.5	-0.5	-0.5	-0.7	-0.2	0.2	-0.4	-0.2	-0.3	-0.1	-0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.9	0.1	-0.0	0.1	0.3	0.9	0.0	0.2	0.4	0.2	0.3	0.4
Had menopause	0.1	0.2	0.6	0.3	0.6	0.6	0.1	0.1	0.6	0.4	0.3	0.7	0.4	0.1
Mouth/teeth dental problems	0.1	0.2	0.6	-0.8	-0.3	-0.5	-0.5	-0.3	-0.5	-0.1	-0.5	0.1	-0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.6	-0.5	-0.6	-0.1	0.0	-0.6	-0.3	-0.4	-0.2	-0.6	0.4
Pulse rate	0.1	0.1	0.6	-0.2	-0.2	-0.0	-0.4	-0.8	-0.2	-0.6	-0.5	-0.3	0.0	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.6	0.0	-0.6	-0.4	-0.0	-0.3	0.1	-0.4	0.0	-0.8	-0.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.4	0.2	0.2	0.3	0.1	0.2	0.4	0.1	0.4	0.3	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.0	0.0	0.2	0.5	0.4	0.3	0.3	-0.2	-0.2	0.4	0.1
Pulse wave reflection index	0.1	0.1	0.2	-0.2	0.1	-0.1	0.1	0.3	0.2	0.3	0.3	0.4	-0.2	0.5
Blood clot in the leg (DVT)	0.1	0.2	0.7	-0.0	0.1	0.1	0.2	0.6	0.4	0.2	0.9	0.4	-0.0	0.8
Medication: Amlodipine	0.1	0.1	0.5	-0.5	0.3	0.4	0.1	0.7	0.0	0.5	0.1	0.5	-0.2	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.4	-0.3	-0.0	0.1	0.2	-0.5	0.0	-0.4	0.1	-0.3	0.3
Age at first live birth	0.1	0.1	0.6	0.7	-0.1	-0.0	0.4	-0.1	0.1	-0.1	0.0	-0.8	0.5	-0.3
Shortness of breath walking on level ground	0.1	0.1	0.3	0.1	-0.2	0.1	0.1	0.4	0.3	0.2	0.3	0.5	0.2	0.5
Migraine (self-reported)	0.1	0.2	0.5	0.4	-0.7	-0.5	0.4	0.5	0.3	0.3	0.3	-0.2	0.4	0.2
Medication: Omeprazole	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.2	0.3	-0.4	-0.3	0.2	0.1	-0.3	0.4
Heart disease (mother)	0.1	0.1	0.5	-0.1	0.5	0.3	0.1	0.6	-0.0	0.5	-0.1	0.7	0.0	0.3
Chest pain or discomfort	0.1	0.1	0.4	-0.5	-0.6	-0.4	0.1	0.4	-0.5	0.2	-0.6	0.0	-0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.1	0.3	-0.1	-0.1	0.6	0.0	0.2	0.5	0.2	0.2	0.6
Loneliness, isolation	0.1	0.2	0.4	-0.7	-0.2	-0.1	0.2	0.6	-0.3	0.5	-0.1	0.6	-0.3	0.6
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.4	-0.2	0.2	0.3	0.3	0.5	0.1	0.6	0.3	0.2	-0.0
Miserableness	0.1	0.2	0.7	-0.8	-0.3	-0.3	-0.2	0.4	-0.6	0.1	-0.4	0.4	-0.4	-0.1
Hearing aid user	0.1	0.1	0.8	0.4	0.2	-0.0	0.5	0.3	0.0	0.2	0.9	0.3	0.2	0.4
Financial situation satisfaction	0.1	0.1	0.4	0.2	0.5	0.5	0.1	0.1	0.1	0.1	0.5	0.1	-0.1	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.3	-0.2	0.4	0.4	0.3	0.3	0.2	0.3	0.5	0.5	-0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.3	-0.0	0.1	0.0	0.1	-0.3	-0.1	-0.4	-0.3	-0.2	0.5
Age started oral contraceptive pill	0.1	0.2	1.1	0.2	-0.3	-0.3	0.1	-0.4	-0.2	-0.1	-0.5	0.0	-0.2	-1.0
Ever depressed for a whole week	0.1	0.1	0.3	0.0	0.3	0.3	-0.2	-0.0	0.1	-0.1	-0.2	0.4	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.2	-0.1	0.3	0.1	0.5	-0.2	-0.0	0.4	0.2	0.0	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.4	2.8	1.0	1.5	1.4	1.2	1.5	0.8	1.1	1.1	0.8	1.1	1.7
Leg fat-free mass (left)	0.0	0.1	0.5	-0.1	-0.3	-0.2	0.1	0.5	-0.0	0.3	0.3	0.7	0.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.2	-0.3	0.0	-0.4	-0.2	-0.1	-0.1	0.0	-0.2	0.4	-0.2	-0.2
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.2	0.4	-0.1	-0.0	0.3	-0.1	0.0	-0.0	-0.0	0.1	-0.2
Leg predicted mass (left)	0.0	0.1	0.5	-0.1	-0.3	-0.2	0.1	0.5	0.0	0.3	0.2	0.7	0.1	0.2
Heart attack	0.0	0.1	0.2	0.2	0.0	-0.1	0.2	0.4	0.2	0.1	0.2	0.5	0.3	-0.1
Allergy	0.0	0.1	0.5	-0.1	-0.1	0.1	-0.4	-0.7	-0.0	-0.3	-0.3	-0.3	-0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	0.3	-0.2	-0.3	0.1	0.3	-0.1	-0.0	0.2	-0.0	0.3	0.2
Trunk fat-free mass	0.0	0.3	0.9	-0.8	-1.0	-0.8	-0.4	0.0	-0.6	-0.2	-0.2	0.4	-0.4	-0.4
Time employed in main current job	0.0	0.0	0.1	-0.0	0.1	0.1	-0.0	0.1	-0.0	0.3	-0.1	0.1	-0.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.2	0.2	0.1	0.0	-0.4	0.0	-0.0	-0.3	0.4	0.2	0.1	-0.4
Trunk predicted mass	0.0	0.2	0.8	-0.7	-0.9	-0.8	-0.4	0.0	-0.6	-0.2	-0.2	0.4	-0.3	-0.4
Tense / ‘highly strung’	0.0	0.0	0.1	-0.2	-0.0	-0.3	-0.2	-0.1	-0.1	-0.2	0.1	0.1	-0.2	-0.2
Arm fat-free mass (right)	0.0	0.1	0.5	-0.1	-0.3	-0.1	0.3	0.6	0.0	0.4	0.3	0.7	0.3	0.2
Comparative body size at age 10	0.0	0.0	0.1	0.4	0.3	0.3	0.1	0.0	0.3	0.2	0.2	0.2	0.2	-0.0
Pulse wave peak to peak time	0.0	0.1	0.2	0.3	0.3	0.4	0.2	0.2	0.2	0.3	0.0	-0.0	0.2	0.0
Arm predicted mass (right)	0.0	0.1	0.4	-0.2	-0.5	-0.2	0.1	0.5	-0.1	0.3	0.1	0.6	0.2	-0.0
Pulse rate, automated reading	0.0	0.1	0.2	0.5	-0.3	0.3	0.3	0.1	0.1	-0.5	0.3	-0.3	0.4	0.3
Whole body fat-free mass	0.0	0.1	0.4	-0.5	-0.7	-0.5	-0.2	0.3	-0.4	0.1	-0.0	0.6	-0.1	-0.1
Leg fat-free mass (right)	0.0	0.1	0.3	-0.5	-0.6	-0.5	-0.3	0.1	-0.4	-0.1	-0.2	0.4	-0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.2	0.1	0.3	-0.1	-0.1	-0.4	-0.1	-0.2	0.0	-0.4	-0.2	0.1
Osteoporosis (self-reported)	0.0	0.0	0.2	-0.3	-0.2	-0.2	0.1	0.3	-0.4	0.3	-0.2	0.2	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.4	-0.3	0.6	0.4	-0.1	-0.1	-0.1	0.1	-0.1	-0.0	-0.3	0.3
Whole body water mass	0.0	0.1	0.5	-0.5	-0.7	-0.5	-0.1	0.3	-0.4	0.1	-0.0	0.6	-0.1	-0.0
Leg predicted mass (right)	0.0	0.1	0.3	-0.5	-0.5	-0.5	-0.2	0.2	-0.4	0.0	-0.1	0.4	-0.3	-0.1
Basal metabolic rate	0.0	0.1	0.9	-0.1	-0.3	-0.1	0.2	0.6	0.1	0.4	0.3	1.0	0.3	0.2
Arm fat-free mass (left)	0.0	0.1	0.8	0.1	-0.3	-0.1	0.3	0.6	0.1	0.4	0.2	0.9	0.3	0.2
Average weekly beer plus cider intake	0.0	0.1	0.2	-0.4	-0.4	-0.1	-0.1	0.5	-0.1	0.3	0.0	0.2	-0.2	0.0
Arm predicted mass (left)	0.0	0.2	0.7	0.0	-0.3	-0.1	0.4	0.7	0.1	0.5	0.4	0.9	0.4	0.2

Hub : Genes

GRPEL1

Models

Trait associations