Best TWAS P=3.29e-25 · Best GWAS P=7.67e-23 conditioned to 0.000202
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIAA1109 | 0.09 | 0.08 | bslmm | 390 | 0.08 | 8.9e-10 | 9.7 | -5.4 | 6.4e-08 | -0.80 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | KIAA1109 | 0.11 | 0.00 | lasso | 7 | 0.01 | 5.1e-02 | 9.7 | -7.1 | 1.5e-12 | -0.77 | 0.02 | 0.86 | FALSE |
| 3 | GTEx | Artery Tibial | KIAA1109 | 0.16 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | 9.7 | -9.2 | 3.8e-20 | -0.86 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | KIAA1109 | 0.22 | 0.07 | lasso | 7 | 0.03 | 5.9e-02 | 9.7 | -9.8 | 1.4e-22 | -0.83 | 0.02 | 0.72 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | BBS12 | 0.10 | 0.02 | lasso | 6 | 0.02 | 7.2e-03 | -6.7 | -7.0 | 2.7e-12 | -0.38 | 0.08 | 0.08 | FALSE |
| 6 | GTEx | Colon Transverse | KIAA1109 | 0.25 | -0.01 | enet | 16 | 0.00 | 4.1e-01 | 9.8 | -10.4 | 3.3e-25 | -0.91 | 0.02 | 0.72 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | KIAA1109 | 0.08 | 0.08 | lasso | 7 | 0.07 | 2.5e-09 | 9.7 | -8.9 | 8.0e-19 | -0.87 | 0.01 | 0.99 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | SPATA5 | 0.05 | 0.01 | bslmm | 485 | 0.01 | 1.2e-02 | 5.1 | -7.5 | 5.0e-14 | -0.15 | 0.17 | 0.04 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1109 | 0.03 | 0.03 | lasso | 1 | 0.02 | 1.2e-05 | 9.7 | -9.7 | 3.5e-22 | -0.87 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Esophageal Carcinoma | KIAA1109 | 0.32 | 0.02 | blup | 45 | 0.02 | 7.4e-02 | 9.8 | -9.8 | 1.3e-22 | -0.68 | 0.00 | 0.88 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA1109 | 0.05 | 0.05 | enet | 8 | 0.04 | 1.3e-05 | 9.7 | -7.6 | 3.4e-14 | -0.85 | 0.00 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA1109 | 0.06 | 0.05 | lasso | 2 | 0.03 | 7.1e-05 | 9.7 | -10.1 | 3.8e-24 | -0.87 | 0.00 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CETN4P | 0.05 | 0.02 | blup | 39 | 0.03 | 2.3e-03 | -3.7 | -5.7 | 1.6e-08 | -0.11 | 0.06 | 0.50 | TRUE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1109 | 0.05 | 0.04 | enet | 3 | 0.05 | 5.4e-06 | 9.8 | -10.1 | 4.0e-24 | -0.97 | 0.00 | 1.00 | FALSE |