TWAS hub - SPATA5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1280	0.0320	8.9e-11	0.050	0.094	0.104	0.080	0.091	9.5e-07	1.8e-11	1.3e-12	5.9e-10	3.5e-11
2	ROSMAP	Brain Pre-frontal Cortex	0.0459	0.0236	8.7e-03	0.010	0.009	0.003	0.011	0.001	1.5e-02	2.3e-02	1.1e-01	1.2e-02	2.3e-01
3	TCGA	Brain Lower Grade Glioma	0.1008	0.0433	3.3e-04	0.019	0.029	0.018	NA	0.037	2.9e-03	2.6e-04	3.7e-03	NA	4.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Allergy or Eczema	10.6	27.8	81.4	1.5	-9.0	-0.2
Hayfever/allergic rhinitis (self-reported)	10.0	13.3	21.3	2.9	-4.6	3.2
Hayfever, allergic rhinitis or eczema	8.9	19.3	55.1	1.7	-7.4	0.1
Allergy	7.3	16.8	44.1	-2.3	6.6	-0.9
Respiratory disease	6.0	13.4	35.0	2.3	-5.9	0.5
Heart disease (siblings)	5.0	6.1	7.3	-2.5	2.2	-2.7
Commuting to job workplace: Car/motor vehicle	4.3	5.0	6.4	-2.4	1.7	-2.5
Medication: Ventolin 100micrograms inhaler	4.0	5.2	13.6	0.7	-3.7	1.2
Chronic bronchitis/emphysema (mother)	3.6	4.2	7.5	1.6	-2.7	1.6
Crohns Disease (2017)	3.3	7.2	11.8	2.2	-3.4	2.3
Crohns Disease (2012)	3.3	5.3	7.4	2.7	-2.3	1.8
Blood Eosinophil Count	3.2	24.6	56.7	3.5	-7.5	2.1
Asthma (self-reported)	3.2	6.3	18.2	0.5	-4.3	-0.7
Handedness (chirality/laterality): Left-handed	3.0	3.6	6.4	-0.3	-2.5	2.1
Blood clot in the leg (DVT)	2.9	3.8	8.8	1.6	0.4	3.0
Wheeze or whistling in the chest in last year	2.9	5.3	9.1	2.4	-3.0	0.9
Lupus	2.8	4.3	5.6	-2.4	-1.5	-2.2
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	7.6	1.3	-0.6	2.8
Asthma	2.8	5.5	15.5	0.4	-3.9	-0.9
Townsend deprivation index at recruitment	2.6	3.6	6.4	2.5	-0.5	2.0
Shortness of breath walking on level ground	2.6	3.1	4.9	1.5	-1.4	2.2
Commuting to job workplace: Public transport	2.6	3.1	4.8	2.2	-1.3	1.6
Medication: Atorvastatin	2.6	3.2	5.7	-2.4	0.3	-1.9
Mean Putamen Volume	2.4	2.7	4.5	-2.1	-1.3	-1.4
Impedance of leg (right)	2.4	11.8	21.3	-4.6	1.2	-3.5
Eye problems/disorders: Cataract	2.4	2.8	4.8	-0.4	2.2	-1.9
Alcohol drinker status: Never	2.4	2.9	5.2	-1.8	0.5	-2.3
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	8.2	1.1	0.3	2.9
Irritable Bowel Disease (IBD)	2.3	5.4	13.0	1.5	-3.6	0.9
Supplements: Zinc	2.3	2.5	4.2	-2.1	-0.5	-1.7
Medication: Cholesterol lowering	2.3	3.5	5.3	-2.0	1.2	-2.3
Emphysema/chronic bronchitis	2.3	2.5	3.0	1.7	-1.5	1.6
Medication: Blood pressure	2.3	4.1	7.5	-2.7	1.0	-2.0
Angina	2.2	2.9	5.4	-1.4	1.1	-2.3
Medication: Metformin	2.2	3.1	7.1	-2.7	-0.1	-1.5
Heart attack	2.2	2.8	4.9	-1.9	-0.3	-2.2
Diabetes (self-reported)	2.2	3.3	7.0	-2.6	0.5	-1.7
Happiness	2.2	2.6	7.5	0.6	2.7	-0.2
Eye problems/disorders: Glaucoma	2.2	2.5	4.0	1.9	-0.4	2.0
Impedance of leg (left)	2.1	10.0	18.0	-4.2	1.1	-3.3
Glaucoma (self-reported)	2.1	2.5	4.1	2.0	-0.4	1.8
Medication: Ibuprofen	2.1	2.5	4.6	2.1	-0.1	1.7
Medication: Seretide 50 evohaler	2.1	2.5	5.2	0.6	-1.4	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	6.7	-1.1	2.6	-2.3
Heart attack/myocardial infarction (self-reported)	2.1	2.7	4.7	-1.9	-0.2	-2.2
Type 2 Diabetes (T2D) (2018)	2.0	3.7	7.5	-2.7	-0.0	-1.9
Diabetes (mother)	2.0	2.5	4.9	-1.4	0.9	-2.2
Exposure to tobacco smoke at home	2.0	2.3	5.8	0.4	0.9	2.4
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	6.6	2.6	-0.2	1.8
Diabetes diagnosed by doctor	2.0	3.3	6.9	-2.6	-0.0	-1.7
Age at First Birth	1.9	2.7	7.7	0.3	-0.6	2.8
Triglycerides	1.9	3.1	4.7	-2.0	0.7	-2.2
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	3.9	1.9	0.0	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	4.1	0.4	1.3	2.0
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	5.6	-0.7	2.4	-1.5
Angina (self-reported)	1.8	2.4	5.0	-1.3	0.8	-2.2
Leg fat-free mass (right)	1.8	9.5	16.3	4.0	-0.5	3.4
Average weekly beer plus cider intake	1.8	2.5	5.4	2.3	1.1	1.0
Commuting to job workplace: Cycle	1.8	2.2	6.0	0.3	-2.4	0.8
Reaction Time	1.7	3.2	3.4	1.9	-1.8	1.7
Chronotype (morning person)	1.7	4.0	4.8	-2.2	2.1	-1.7
Taking other prescription medications	1.7	2.7	6.1	-0.0	-2.5	-1.4
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.6	-0.1	-1.5	1.9
Leg predicted mass (right)	1.7	9.3	16.3	4.0	-0.4	3.4
Alzheimer’s Disease (in father)	1.6	1.8	4.3	0.9	-0.3	2.1
Qualifications: CSEs or equivalent	1.6	2.1	3.7	1.4	0.7	1.9
Arm fat-free mass (right)	1.6	8.0	12.2	3.4	0.2	3.5
Arm predicted mass (right)	1.6	8.1	12.3	3.5	0.1	3.5
Ever had bowel cancer screening	1.6	1.9	5.0	0.6	2.2	-0.6
Whole body water mass	1.6	8.9	14.2	3.8	-0.2	3.5
Waist Hip Ratio (WHR)	1.5	6.8	19.4	-4.4	-0.1	-1.1
Leg fat-free mass (left)	1.5	7.8	12.8	3.6	-0.2	3.2
Leg predicted mass (left)	1.5	7.7	12.9	3.6	-0.2	3.2
Whole body fat-free mass	1.5	8.6	13.7	3.7	-0.2	3.5
Osteoarthritis (self-reported)	1.5	2.0	5.3	0.6	2.3	0.6
Arm predicted mass (left)	1.5	7.4	11.9	3.5	0.4	3.2
Alzheimer’s Disease (including proxy)	1.4	2.1	4.5	0.6	1.2	2.1
Falls in the last year	1.4	1.9	2.6	-1.4	1.0	-1.6
Medication: Aspirin	1.4	1.8	3.0	-1.0	1.1	-1.7
Basal metabolic rate	1.4	7.7	11.8	3.4	0.0	3.3
Arm fat-free mass (left)	1.4	6.9	10.9	3.3	0.3	3.1
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.3	-2.1	0.1	-0.6
Major Depression (MDD)	1.3	1.6	1.9	1.1	1.3	1.4
Lung FVC	1.3	6.4	12.5	-3.5	0.5	-2.5
Age when periods started (menarche)	1.3	3.2	4.9	1.2	-2.2	1.8
Trunk fat-free mass	1.3	7.5	11.6	3.3	-0.2	3.4
Trunk predicted mass	1.3	7.2	11.2	3.2	-0.1	3.3
Neck or shoulder pain in last month	1.3	1.9	4.6	-0.3	2.1	-0.9
Medication: Aspirin	1.3	1.7	2.5	-0.6	1.4	-1.6
Average weekly red wine intake	1.3	1.9	4.6	0.9	0.4	2.1
High cholesterol (Self-reported)	1.3	2.4	4.8	-1.5	2.2	-0.3
Rheumatoid Arthritis	1.2	1.7	4.1	-0.3	0.9	-2.0
Chronic bronchitis/emphysema (father)	1.2	1.4	1.9	1.4	-1.2	0.9
Pulse rate	1.2	2.0	2.9	-1.6	0.8	-1.7
Lung cancer (father)	1.2	1.4	3.9	0.2	-0.5	-2.0
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.5	-1.9	-0.5	-0.8
Commuting to job workplace: Walk	1.2	1.3	3.3	0.7	-0.2	1.8
Medication for cholesterol	1.2	1.9	2.9	0.1	-1.7	-1.7
Alzheimer’s Disease (in mother)	1.1	1.2	3.0	-0.3	1.7	0.8
Schizophrenia (2014)	1.1	2.5	7.1	0.3	-2.7	0.5
Medication: Co-codamol	1.1	1.3	3.1	-0.8	1.8	-0.5
Loud music exposure frequency	1.1	1.2	2.7	1.6	-0.9	-0.1
Had major operations	1.1	1.2	2.3	-1.1	-1.5	-0.5
Hearing aid user	1.1	1.2	3.5	-0.3	-1.9	-0.1
Mother’s age at death	1.1	1.3	1.5	-1.1	1.2	-1.2
Diastolic blood pressure, automated reading	1.1	3.5	6.4	1.9	-2.5	0.8
Ever depressed for a whole week	1.1	1.4	3.0	-0.9	-0.6	-1.7
Fasting Glucose	1.0	1.2	3.0	-0.3	0.8	-1.7
Primary Biliary Cirrhosis	1.0	1.5	2.5	-1.1	-1.6	-0.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.8	-1.7	0.3	-0.6
Severe depression (siblings)	1.0	1.1	1.4	-0.9	-1.2	-1.1
Supplements: Glucosamine	1.0	1.4	3.7	-0.5	1.9	0.3
Number of live births	1.0	1.4	3.8	-0.5	2.0	-0.4
Noisy workplace	1.0	1.2	1.9	-1.0	-1.4	-0.9
Number of children fathered	1.0	1.1	2.5	-1.6	0.9	0.1
Average weekly champagne plus white wine intake	1.0	1.4	2.6	-1.2	0.1	-1.6
Wears glasses or contact lenses	1.0	1.2	2.1	0.9	1.5	0.9
Pack years of smoking	1.0	1.4	3.4	0.5	-0.8	1.9
Ulcerative Colitis	0.9	1.4	3.7	0.6	-1.9	-0.2
Average weekly spirits intake	0.9	1.1	3.1	0.5	1.8	-0.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.8	1.3	0.9	0.8
Diabetes (father)	0.9	1.1	1.7	-1.1	0.5	-1.3
Medication: Simvastatin	0.9	1.3	3.7	-0.3	1.9	-0.2
Father’s age at death	0.9	1.3	1.5	-1.2	-0.9	1.2
Mouth/teeth dental problems: Dentures	0.9	1.5	3.9	-2.0	-0.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	1.6	-1.3	-0.9	-1.2
Leg fat percentage (right)	0.9	3.3	7.2	-1.6	2.7	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.4	-0.1	-1.8	0.4
Number of self-reported non-cancer illnesses	0.9	1.5	2.0	-1.1	-1.4	-1.1
Financial situation satisfaction	0.9	1.1	1.4	-0.8	1.2	-1.2
Irritability	0.9	1.4	2.9	-1.2	0.3	-1.7
Fractured/broken bones in last 5 years	0.9	1.1	3.1	0.3	1.8	-0.4
Impedance of whole body	0.9	4.4	8.2	-2.9	0.1	-2.2
HDL Cholesterol	0.8	1.3	2.0	1.4	0.7	1.2
Height	0.8	15.6	24.5	5.0	-0.4	4.7
Lung FEV1/FVC ratio	0.8	3.9	7.0	-0.8	2.6	-2.1
Maternal smoking around birth	0.8	1.2	2.5	1.0	0.3	-1.6
Stomach or abdominal pain in last month	0.8	1.0	2.0	-1.0	1.4	-0.2
Number of incorrect matches in round	0.8	1.4	3.1	-1.8	0.7	-0.7
Weight	0.8	3.8	6.0	2.1	1.1	2.4
Time employed in main current job	0.8	0.9	1.4	0.8	1.2	0.8
Alcohol intake versus 10 years previously	0.8	1.2	2.0	1.4	0.1	1.2
Peak expiratory flow (PEF)	0.8	1.8	4.0	-0.3	1.1	-2.0
Pulse wave reflection index	0.8	1.0	2.2	0.4	1.5	-0.8
Knee pain experienced in last month	0.8	1.2	3.3	1.8	0.2	0.5
Long-standing illness, disability or infirmity	0.8	1.2	2.4	0.9	-1.6	0.5
Medication: Bendroflumethiazide	0.8	1.2	2.0	1.4	1.0	0.9
Leg fat percentage (left)	0.8	2.9	7.2	-1.2	2.7	-0.1
Risk taking	0.8	1.1	2.3	-1.0	-0.1	-1.5
Unable to work because of sickness or disability	0.8	1.0	2.7	-0.5	-1.6	-0.2
Schizophrenia vs Biploar Disorder	0.7	0.9	2.3	-0.4	1.5	-0.5
Sensitivity / hurt feelings	0.7	1.2	3.4	-1.9	0.0	0.1
Pack years adult smoking proportion	0.7	1.1	2.6	0.4	-0.7	1.6
Sitting height	0.7	4.7	7.2	2.7	-1.2	2.3
High blood pressure (mother)	0.7	1.0	1.8	0.1	1.3	-1.1
Illnesses of siblings	0.7	1.0	1.5	1.2	1.0	0.8
Impedance of arm (right)	0.7	3.3	5.3	-2.3	-0.5	-2.1
Prospective memory result	0.7	0.9	2.5	-1.6	-0.3	0.3
Standing height	0.7	7.4	10.8	3.2	-1.0	3.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	2.4	0.0	-1.4	-1.6
Medication: Omeprazole	0.7	0.8	1.8	-0.7	-1.4	-0.3
Mean time to correctly identify matches	0.7	1.2	2.2	0.9	-0.8	1.5
Family relationship satisfaction	0.7	0.9	1.7	1.3	0.6	-0.7
Qualifications: nursing, teaching	0.7	1.1	1.7	-0.1	1.3	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	1.9	-0.8	1.4	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.9	-1.4	0.1	-0.8
Back pain experienced in last month	0.7	1.0	1.3	1.2	1.1	0.6
Vascular/heart problems diagnosed by doctor	0.7	1.9	2.0	1.4	-1.4	1.4
Alcohol drinker status: Previous	0.7	0.8	1.3	-1.1	-0.4	0.9
Ulcerative Colitis (UC)	0.6	1.1	2.7	0.3	-1.6	-0.8
Multivitamins +/- minerals	0.6	0.7	1.7	1.3	0.3	0.6
Hearing difficulty/problems with background noise	0.6	1.0	1.8	-0.8	-1.3	-0.7
Had menopause	0.6	0.7	2.1	-0.2	1.5	-0.2
Fluid intelligence score	0.6	1.2	2.7	-0.5	0.8	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-1.2	0.6	-0.6
Medication: Allopurinol	0.6	0.8	1.2	-0.4	-1.1	-1.1
Supplements: Vitamin C	0.6	0.7	1.9	-0.2	0.5	-1.4
Illnesses of father: High blood pressure	0.6	0.7	1.1	-0.8	1.0	0.6
Age started oral contraceptive pill	0.6	0.8	1.2	1.0	1.1	0.4
Cholesterol lowering medication	0.6	0.9	1.6	0.2	1.3	1.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.4	-0.7	0.1	-1.2
Number of treatments/medications taken	0.5	0.8	1.3	-1.0	0.4	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.0	-1.0	0.3	-1.0
Ever had hysterectomy (womb removed)	0.5	0.5	1.5	-0.0	-0.2	1.2
Fed-up feelings	0.5	0.9	1.9	0.1	1.4	-0.8
Relative age voice broke	0.5	0.8	2.1	-0.3	1.4	0.4
Medication: Levothyroxine sodium	0.5	0.8	2.2	-0.0	0.3	-1.5
Past tobacco smoking	0.5	0.9	1.7	-0.1	1.3	-1.0
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	-0.3	-0.7	-1.2
Arm fat mass (right)	0.5	2.1	3.3	0.9	1.8	1.5
High blood pressure (siblings)	0.5	0.8	1.3	-1.1	-1.0	-0.2
Body fat percentage	0.5	1.8	4.5	-1.0	2.1	0.1
Exposure to tobacco smoke outside home	0.5	0.6	0.9	-0.9	0.9	-0.5
Pulse rate, automated reading	0.5	1.7	3.4	-1.8	-1.1	-0.5
Age at last live birth	0.5	0.7	1.8	-1.3	-0.5	0.1
Leg pain on walking	0.5	0.6	1.3	0.7	-1.1	0.3
Hypertension (Self-reported)	0.5	1.3	1.4	-1.2	1.1	-1.1
Smoking status: Previous	0.5	0.7	2.0	-0.3	-1.4	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	1.2	-0.2	0.7
Arm fat mass (left)	0.5	2.0	2.8	0.7	1.7	1.7
Medication: Blood pressure	0.5	0.9	2.3	0.2	1.5	0.6
Medication: Paracetamol	0.5	0.8	1.7	-1.3	-0.0	-0.8
Medication: Lisinopril	0.5	0.7	1.5	-1.2	-0.1	-0.7
Bipolar Disorder (2018)	0.4	0.6	1.7	0.1	-0.1	1.3
Depressed Affect (Nagel 2018)	0.4	0.9	2.4	0.1	1.6	-0.6
Schizophrenia (2018)	0.4	0.9	2.2	0.3	-1.5	-0.6
Breast Cancer	0.4	0.9	1.6	-1.0	0.1	-1.2
Ovarian Cancer	0.4	0.6	0.8	0.8	-0.9	0.5
Cardiovascular Disease	0.4	1.5	3.2	-1.8	0.6	-0.9
Systolic blood pressure, automated reading	0.4	1.0	2.8	0.6	-1.7	-0.1
Trunk fat percentage	0.4	1.4	3.7	-0.6	1.9	0.4
Serious illness, injury or assault to yourself	0.4	0.5	0.6	-0.6	-0.8	-0.8
Body mass index (BMI)	0.4	1.5	3.1	0.6	1.8	1.0
Trunk fat mass	0.4	1.6	3.2	0.2	1.8	1.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	0.1	0.6	1.0
Arm fat percentage (right)	0.4	1.6	4.3	-0.5	2.1	0.3
Hip circumference	0.4	1.9	3.0	1.4	0.9	1.7
Medication: Lansoprazole	0.4	0.5	1.0	0.6	-1.0	-0.5
Impedance of arm (left)	0.4	1.9	3.3	-1.8	-0.3	-1.5
Tense / ‘highly strung’	0.4	0.7	1.9	-0.3	-0.3	-1.4
Headache pain in last month	0.4	0.7	1.2	-0.7	1.1	0.6
Gout (self-reported)	0.4	0.5	1.3	1.1	-0.5	-0.3
Pulse wave peak to peak time	0.4	0.5	1.0	-0.1	-1.0	0.7
Qualifications: College or University degree	0.4	1.2	2.0	-0.4	-1.3	-1.4
Whole body fat mass	0.4	1.5	3.5	0.1	1.9	1.0
Leg fat mass (right)	0.4	1.7	4.6	-0.6	2.1	0.4
Overall health rating	0.4	1.0	2.8	-0.1	-1.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	0.3	-1.2	-0.1
Arm fat percentage (left)	0.4	1.5	3.8	-0.2	2.0	0.9
Loneliness, isolation	0.4	0.6	0.9	0.2	1.0	-0.9
Friendships satisfaction	0.4	0.5	0.9	-0.2	1.0	-0.7
Guilty feelings	0.4	0.6	1.6	-1.3	0.2	0.0
Ever taken oral contraceptive pill	0.4	0.4	0.6	0.7	-0.5	0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	-0.2	0.8	0.9
Ever smoked	0.4	0.7	1.3	-0.6	-1.1	0.8
Myopia	0.4	0.5	1.5	0.0	0.4	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	-0.4	-1.2	-0.2
Pain experienced in last month	0.4	0.6	1.3	0.4	-1.2	0.6
Leg fat mass (left)	0.4	1.7	4.5	-0.3	2.1	0.6
Depression (Nagel 2018)	0.3	0.4	1.0	-0.1	1.0	0.5
Worry (Nagel 2018)	0.3	0.5	0.6	-0.8	-0.7	0.7
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	-0.5	0.9	-0.3
Coronary Artery Disease (CAD)	0.3	0.4	0.8	-0.5	0.1	-0.9
HbA1C	0.3	0.4	1.0	-0.2	0.3	-1.0
Smoking Status	0.3	0.7	1.7	-0.5	-0.3	1.3
Hypothyroidism (self reported)	0.3	0.6	1.0	0.4	-1.0	-0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.8	-0.6	-0.5
Medication for hormone replacement therapy	0.3	0.3	0.7	0.1	-0.5	0.9
High blood pressure	0.3	1.0	1.5	-0.9	1.2	-0.8
Waist circumference	0.3	1.1	1.5	-0.9	1.2	0.9
Nervous feelings	0.3	0.5	1.1	-1.0	-0.7	0.0
Mouth/teeth dental problems	0.3	0.4	0.8	0.5	-0.5	0.9
Pain all over the body in last month	0.3	0.4	0.9	-0.4	-0.9	0.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	0.7	0.7	-0.3
Birth weight	0.3	0.6	0.9	-0.8	-0.2	0.9
Comparative body size at age 10	0.3	0.9	2.3	-0.6	1.5	-0.2
Suffer from ‘nerves’	0.3	0.4	0.7	-0.9	-0.4	0.6
Chest pain or discomfort	0.3	0.5	0.7	0.9	0.4	0.7
Illnesses of father: Heart disease	0.3	0.4	0.9	-1.0	-0.2	-0.3
Mineral and other dietary supplements	0.3	0.5	1.2	-0.3	-1.1	0.4
Osteoporosis (self-reported)	0.3	0.3	0.7	0.0	-0.5	-0.8
Medication: Gliclazide	0.3	0.3	0.8	-0.9	0.1	-0.4
Smoking status: Current	0.3	0.5	1.3	-0.2	-0.4	1.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.2	0.3	1.0
Supplements: Calcium	0.3	0.3	0.6	-0.6	-0.8	-0.2
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.6	-0.2	0.8
Bipolar Disorder or Schizophrenia	0.2	0.6	1.5	0.3	-1.2	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	-1.0	-0.6	-0.6
Prostate Cancer	0.2	0.3	0.9	0.1	0.9	-0.3
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.1	0.5	0.7
Neuroticism (2016)	0.2	0.3	0.5	-0.7	0.6	0.2
Blood Red Count	0.2	1.6	2.0	1.0	1.4	1.4
BMI	0.2	1.2	2.6	0.4	1.6	0.8
Systolic Blood Pressure	0.2	1.0	2.4	-0.7	-1.6	-0.2
Hair Pigment	0.2	4.4	8.7	1.6	-1.4	3.0
Vitamin and mineral supplements	0.2	0.2	0.3	-0.4	0.3	0.6
Current tobacco smoking	0.2	0.3	0.4	-0.6	-0.2	0.6
Average weekly fortified wine intake	0.2	0.2	0.3	0.5	0.5	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	0.2	0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	-1.0	0.4	-0.6
Medication: Atenolol	0.2	0.3	0.8	-0.2	0.9	-0.2
Had other major operations	0.2	0.2	0.3	0.3	0.6	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.9	0.1	0.5	-1.4
Depression (self-reported)	0.2	0.3	0.8	-0.9	0.1	0.2
Illnesses of mother	0.2	0.3	0.5	0.4	-0.7	0.3
Length of working week for main job	0.2	0.2	0.5	0.3	0.7	0.2
Medication: Paracetamol	0.2	0.4	0.7	-0.8	0.7	-0.0
Age at first live birth	0.2	0.3	0.9	-0.9	-0.2	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	-0.7	0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.3	-0.8	-0.3
Comparative height size at age 10	0.2	0.9	1.3	1.0	-0.5	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.8	0.9	0.1	-0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	0.8	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	1.1	0.2	0.1
Mood swings	0.2	0.4	0.6	-0.4	0.8	-0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.6	0.5	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.2	0.7	-0.0
LDL Cholesterol	0.1	0.1	0.3	0.5	0.1	0.3
Blood Platelet Count	0.1	1.6	3.0	-0.6	-1.3	1.7
Heel T-Score	0.1	1.1	3.1	-1.8	0.3	-0.3
Neuroticism	0.1	0.2	0.6	-0.0	0.2	0.8
Tanning	0.1	1.5	2.9	1.0	0.8	1.7
Hand grip strength (left)	0.1	0.4	0.7	-0.6	0.8	-0.2
Relative age of first facial hair	0.1	0.2	0.3	-0.3	0.5	0.4
Hand grip strength (right)	0.1	0.1	0.3	-0.4	0.6	0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.1	-0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.2	-0.3	0.5
Alcohol usually taken with meals	0.1	0.1	0.4	-0.6	0.3	0.0
Forced vital capacity (FVC)	0.1	0.4	0.9	0.2	-0.6	-0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.1	0.5	-0.0
Qualifications: None of the above	0.1	0.3	0.8	-0.3	-0.0	0.9
Financial difficulties in last 2 years	0.1	0.2	0.5	0.0	0.7	0.0
Medication: Ramipril	0.1	0.2	0.4	0.3	0.1	0.6
Neuroticism score	0.1	0.2	0.4	-0.6	0.1	-0.4
Worrier / anxious feelings	0.1	0.1	0.4	-0.6	0.0	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.3	0.7	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.2	-0.5	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	0.6	0.7	-0.3
Breastfed as a baby	0.1	0.1	0.2	0.1	-0.5	-0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.1	-0.2	-0.8
Birth weight of first child	0.1	0.2	0.4	-0.2	0.6	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.2	0.5	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.7	-0.1	-0.2
Medication: Amlodipine	0.1	0.1	0.3	-0.5	0.2	-0.1
Number of full brothers	0.1	0.1	0.2	-0.1	-0.4	-0.4
Worry too long after embarrassment	0.1	0.1	0.3	-0.5	0.1	-0.0
Eye problems/disorders: None of the above	0.1	0.2	0.5	0.0	-0.7	0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.6	-0.1	0.1
Migraine (self-reported)	0.1	0.1	0.3	0.4	-0.5	0.0
Heart disease (mother)	0.1	0.1	0.2	-0.4	-0.2	0.2
Alcohol intake frequency.	0.1	0.3	0.4	-0.6	0.5	0.6
Number of full sisters	0.1	0.1	0.2	-0.1	0.2	0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.5	0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	0.3	0.3	-0.6
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	-0.4	0.3
Blood White Count	0.0	0.2	0.5	0.2	-0.7	-0.2
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.2	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.1	0.2	0.0
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	0.3	-0.1	-0.1
Health satisfaction	0.0	0.1	0.1	0.2	-0.2	-0.3
Breast cancer (self-reported)	0.0	0.1	0.1	0.3	-0.1	0.3
Miserableness	0.0	0.1	0.1	0.3	0.3	-0.1

Hub : Genes

SPATA5

Models

Trait associations