TWAS hub - KIAA1109

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0260	9.1e-08	0.083	0.068	0.064	0.078	0.072	2.4e-10	1.0e-08	2.7e-08	8.9e-10	3.7e-09
2	GTEx	Artery Aorta	0.1070	0.0430	1.7e-03	0.000	NA	0.008	NA	0.014	3.3e-01	NA	1.1e-01	NA	5.1e-02
3	GTEx	Artery Tibial	0.1591	0.0628	3.7e-04	0.072	NA	0.041	NA	0.053	2.5e-06	NA	3.4e-04	NA	5.1e-05
4	GTEx	Brain Nucleus accumbens basal ganglia	0.2210	0.0900	9.2e-03	0.066	NA	0.024	NA	0.028	7.5e-03	NA	7.5e-02	NA	5.9e-02
5	GTEx	Colon Transverse	0.2480	0.0810	6.2e-04	-0.006	NA	-0.002	NA	-0.002	9.0e-01	NA	4.0e-01	NA	4.4e-01
6	ROSMAP	Brain Pre-frontal Cortex	0.0812	0.0291	1.2e-05	0.078	0.043	0.057	0.068	0.070	3.2e-10	2.8e-06	7.3e-08	3.9e-09	2.5e-09
7	TCGA	Breast Invasive Carcinoma	0.0272	0.0168	1.1e-03	0.027	0.011	0.017	NA	0.023	2.1e-06	2.0e-03	1.4e-04	NA	1.2e-05
8	TCGA	Esophageal Carcinoma	0.3160	0.1240	3.4e-04	0.016	0.020	0.000	NA	0.018	9.7e-02	7.4e-02	3.2e-01	NA	8.9e-02
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0502	0.0287	3.2e-04	0.047	0.038	0.043	NA	0.041	4.8e-06	3.5e-05	1.3e-05	NA	1.8e-05
10	TCGA	Brain Lower Grade Glioma	0.0551	0.0349	1.2e-03	0.051	0.005	0.025	NA	0.035	1.9e-06	8.9e-02	6.5e-04	NA	7.1e-05
11	TCGA	Lung Adenocarcinoma	0.0382	0.0245	7.5e-03	0.011	0.014	0.014	NA	0.005	1.7e-02	7.1e-03	7.6e-03	NA	8.2e-02
12	TCGA	Thyroid Carcinoma	0.0470	0.0260	7.6e-04	0.041	0.043	0.054	NA	0.050	7.2e-05	4.8e-05	5.4e-06	NA	1.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Allergy or Eczema	49.5	130.3	207.4	-8.9	-10.4	-11.9	-12.0	-12.7	-12.0	-12.3	-14.4	-9.2	-12.6	-3.4	-13.1
Allergy	45.9	105.5	146.4	8.4	10.1	10.9	10.7	11.2	10.9	11.1	12.1	8.2	11.3	3.6	11.7
Hayfever, allergic rhinitis or eczema	45.8	99.5	153.8	-7.9	-9.3	-10.4	-10.5	-11.1	-10.5	-10.7	-12.4	-8.1	-11.0	-3.0	-11.4
Respiratory disease	25.5	56.7	88.7	-5.6	-7.8	-8.0	-8.2	-7.9	-7.7	-8.3	-9.4	-5.7	-8.7	-0.7	-8.1
Asthma	24.4	48.1	72.9	-5.4	-7.4	-7.2	-7.3	-7.4	-7.3	-7.6	-8.5	-5.1	-7.8	-1.2	-7.8
Asthma (self-reported)	23.0	45.7	71.0	-5.3	-7.2	-7.0	-7.2	-7.2	-7.1	-7.4	-8.4	-4.7	-7.6	-1.0	-7.6
Hayfever/allergic rhinitis (self-reported)	19.6	25.9	43.8	-4.0	-5.4	-5.1	-5.0	-5.7	-5.2	-5.2	-6.6	-3.8	-5.3	-2.2	-6.0
Irritable Bowel Disease (IBD)	14.1	33.6	45.3	-4.1	-5.4	-5.9	-6.2	-6.4	-5.8	-6.2	-6.7	-6.0	-6.6	-1.9	-6.7
Medication: Ventolin 100micrograms inhaler	13.2	16.9	28.1	-2.6	-4.8	-4.4	-4.4	-4.3	-4.0	-4.5	-5.3	-3.0	-4.8	0.9	-4.2
Ulcerative Colitis (UC)	11.5	21.6	31.4	-3.8	-4.3	-4.5	-5.0	-4.5	-4.7	-5.1	-5.6	-4.9	-5.2	-2.2	-5.1
Wheeze or whistling in the chest in last year	10.2	18.1	29.5	-3.2	-4.4	-4.6	-4.6	-4.2	-4.5	-4.7	-5.4	-3.3	-4.8	-1.1	-4.5
Blood Eosinophil Count	9.7	74.8	108.2	-5.4	-7.1	-9.2	-9.8	-10.4	-8.9	-9.7	-9.8	-7.6	-10.1	-0.4	-10.1
Crohns Disease (2017)	9.0	19.8	30.3	-2.7	-4.1	-4.7	-4.6	-5.5	-4.4	-4.7	-4.5	-4.7	-5.0	-0.9	-5.5
Ulcerative Colitis	9.0	13.0	28.1	-2.6	-2.8	-3.3	-3.9	-3.4	-3.5	-3.8	-5.3	-3.8	-4.0	-1.6	-4.0
Bipolar Disorder (2011)	7.4	7.2	10.1	-2.8	-2.8	-2.5	-2.8	-3.2	-2.8	-2.6	-1.9	-2.6	-2.6	-2.2	-3.2
Medication: Seretide 50 evohaler	6.5	7.5	14.4	-2.2	-3.7	-3.1	-2.9	-2.1	-3.0	-3.1	-3.8	-1.6	-3.0	-0.5	-2.4
Crohns Disease (2012)	6.3	10.2	16.5	-2.4	-2.4	-3.2	-3.4	-3.4	-3.4	-3.5	-3.5	-3.4	-3.7	-0.8	-4.1
Chronotype (morning person)	5.9	13.7	22.6	3.4	4.0	3.6	4.1	3.5	3.6	4.0	4.8	3.1	4.1	1.8	3.8
Hair/balding pattern: Pattern 2	5.9	7.5	10.4	2.4	3.2	2.9	3.0	2.6	3.0	3.0	3.1	2.2	2.8	1.3	2.8
Emphysema/chronic bronchitis	5.7	6.4	10.8	-2.4	-3.3	-3.0	-2.9	-2.1	-2.7	-2.8	-2.4	-2.0	-2.7	-1.0	-2.3
Osteoarthritis (self-reported)	5.7	7.3	10.4	2.0	2.9	2.9	2.9	2.9	2.5	2.8	2.4	3.1	3.0	1.5	3.2
Alcohol usually taken with meals	5.5	9.0	14.9	-2.5	-2.6	-2.7	-2.9	-3.4	-3.0	-2.9	-1.7	-3.9	-2.9	-3.2	-3.7
Long-standing illness, disability or infirmity	5.0	7.6	13.1	-1.3	-3.5	-2.8	-3.1	-3.3	-2.4	-2.8	-3.6	-2.3	-3.0	-0.0	-2.9
Number of self-reported non-cancer illnesses	4.5	7.9	15.1	-2.2	-3.9	-3.0	-3.3	-2.5	-2.8	-2.9	-3.6	-1.6	-2.8	-0.8	-2.8
Taking other prescription medications	4.4	6.8	11.4	-1.8	-3.4	-2.9	-2.9	-2.4	-2.7	-3.0	-2.9	-2.2	-3.0	-0.5	-2.5
Average weekly beer plus cider intake	4.4	6.3	11.1	2.6	1.6	2.0	2.4	3.1	2.7	2.6	1.0	2.9	2.5	2.5	3.3
Illnesses of father: High blood pressure	4.3	5.3	8.3	-2.2	-2.9	-2.5	-2.6	-1.4	-2.5	-2.7	-2.1	-2.4	-2.7	-0.9	-2.0
Bipolar Disorder (2018)	4.2	6.6	11.4	-2.9	-2.1	-2.4	-2.1	-3.2	-2.6	-2.2	-2.0	-2.3	-2.1	-3.0	-3.4
Type 2 Diabetes (T2D) (2012)	3.2	3.7	6.2	-1.5	-1.9	-2.3	-1.5	-2.2	-2.1	-2.1	-1.8	-1.6	-2.0	-0.8	-2.5
Handedness (chirality/laterality): Left-handed	3.2	3.8	6.8	-1.2	-1.7	-2.1	-1.7	-2.6	-1.9	-2.0	-2.3	-1.8	-2.3	-0.6	-2.5
Bipolar Disorder or Schizophrenia	2.9	7.2	13.3	-3.2	-2.1	-2.2	-2.1	-3.5	-2.8	-2.4	-1.9	-2.4	-2.3	-2.8	-3.6
Serious illness, injury or assault to yourself	2.9	3.5	4.8	1.7	1.9	2.1	1.8	1.6	2.1	2.1	0.9	2.2	2.0	1.9	2.0
Birth weight of first child	2.7	5.0	7.5	-2.7	-2.5	-2.1	-2.2	-2.1	-2.2	-2.1	-1.3	-2.3	-2.1	-2.5	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.7	3.2	6.6	2.6	1.7	1.6	1.8	0.5	2.0	1.8	-0.2	2.0	1.6	2.5	1.5
Medication: Blood pressure	2.7	5.2	10.0	-2.2	-3.2	-2.5	-2.6	-1.6	-2.4	-2.5	-1.7	-2.1	-2.3	-1.4	-2.1
Hypothyroidism/myxoedema (self-reported)	2.6	5.2	18.4	-0.3	-2.0	-1.7	-2.7	-2.4	-1.2	-2.2	-4.3	-2.1	-2.7	1.4	-1.7
Sitting height	2.5	18.0	34.5	-5.9	-5.1	-4.0	-4.4	-2.4	-4.2	-4.2	-3.2	-4.2	-3.9	-4.8	-3.7
Vitamin and mineral supplements	2.4	3.2	4.9	1.5	1.7	2.2	2.2	1.9	1.9	2.1	0.6	2.2	2.1	-0.1	1.6
Schizophrenia vs Biploar Disorder	2.3	3.0	9.0	1.1	1.3	1.7	1.5	1.9	1.4	1.6	3.0	1.7	1.8	0.5	2.0
Chest pain or discomfort	2.3	3.3	4.8	-1.9	-1.9	-1.9	-2.2	-1.7	-1.9	-2.0	-1.7	-1.6	-2.1	-0.4	-1.7
Eye problems/disorders: Cataract	2.2	2.6	5.5	-1.2	-1.5	-1.5	-1.3	-2.3	-1.8	-1.5	-1.6	-0.9	-1.4	-1.7	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	3.9	-1.9	-2.0	-1.9	-1.6	-1.7	-1.8	-1.7	-0.7	-0.9	-1.6	-1.0	-1.9
Hair/balding pattern: Pattern 4	1.9	4.7	6.0	-1.6	-1.7	-2.4	-2.2	-2.4	-2.2	-2.3	-1.9	-2.3	-2.3	-1.9	-2.5
Hearing aid user	1.9	2.1	3.0	-1.0	-1.1	-1.4	-1.6	-1.5	-1.6	-1.6	-1.7	-1.3	-1.6	-1.3	-1.5
Angina	1.8	2.4	3.1	-1.7	-1.6	-1.5	-1.6	-1.5	-1.7	-1.8	-1.3	-1.5	-1.8	-1.1	-1.5
High blood pressure (mother)	1.8	2.6	7.3	-2.1	-2.7	-1.7	-1.7	-0.4	-1.4	-1.6	-1.4	-1.4	-1.6	-1.0	-1.1
Fractured/broken bones in last 5 years	1.8	2.4	4.0	1.3	1.6	1.6	1.5	2.0	1.5	1.6	0.8	1.9	1.6	1.1	1.6
Alcohol drinker status: Previous	1.8	2.1	3.3	-1.3	-1.3	-1.7	-1.4	-1.8	-1.3	-1.4	-1.5	-1.4	-1.5	-0.7	-1.8
Prostate Cancer	1.7	2.4	3.7	1.2	1.4	1.6	1.3	1.9	1.6	1.6	0.9	1.7	1.5	1.9	1.5
Hearing difficulty/problems with background noise	1.7	2.7	7.0	1.1	1.2	1.2	1.2	2.6	1.6	1.4	-0.6	2.1	1.4	2.1	2.1
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	7.1	1.5	1.4	0.9	1.3	1.5	1.3	1.2	0.9	1.6	1.1	2.7	1.7
High blood pressure (siblings)	1.7	2.5	4.1	-1.4	-2.0	-1.8	-2.0	-1.2	-1.5	-1.7	-1.9	-1.2	-1.7	-0.6	-1.5
Mood swings	1.7	3.0	9.3	1.1	0.5	1.4	0.8	3.0	1.6	1.2	0.3	2.0	1.2	2.2	2.9
Smoking Status	1.6	3.9	7.2	1.9	1.2	1.8	1.5	2.1	2.2	2.0	1.3	2.6	1.9	2.0	2.7
Hypothyroidism (self reported)	1.6	3.7	17.6	0.3	-1.4	-1.0	-2.2	-1.9	-0.5	-1.6	-4.2	-1.6	-2.2	2.0	-1.2
Relative age voice broke	1.6	2.4	4.7	-1.5	-0.8	-1.6	-1.1	-1.8	-1.6	-1.4	-0.6	-1.9	-1.4	-2.2	-1.9
Happiness	1.6	2.0	4.0	0.7	0.5	1.7	1.2	1.9	1.5	1.4	0.5	1.6	1.4	1.5	2.0
Illnesses of father: None of the above (group 1)	1.6	2.0	3.3	1.8	1.4	1.4	1.5	0.7	1.5	1.4	1.2	1.5	1.4	1.6	1.4
Commuting to job workplace: Cycle	1.6	2.0	2.8	-1.5	-1.7	-1.4	-1.7	-1.4	-1.5	-1.5	-1.1	-1.2	-1.5	-0.4	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.0	-2.0	-1.9	-1.7	-1.7	-0.5	-1.5	-1.4	-0.3	-1.5	-1.2	-1.2	-1.1
Supplements: Calcium	1.6	1.7	4.0	-0.9	-1.3	-1.6	-1.3	-2.0	-1.3	-1.2	-0.8	-1.3	-1.3	-0.5	-1.6
Blood Platelet Count	1.5	17.8	33.4	-5.2	-5.8	-4.9	-5.5	-2.0	-4.7	-4.9	-3.1	-2.2	-4.7	-1.2	-3.5
Height	1.5	28.9	62.1	-6.7	-7.9	-5.5	-5.8	-3.3	-5.0	-5.4	-3.6	-5.9	-5.3	-4.1	-4.2
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.3	-1.6	-1.8	-1.5	-1.2	-1.3	-1.4	-1.2	-0.3	-1.4	-1.1	-1.7	-1.4
Supplements: Zinc	1.4	1.6	4.2	-1.5	-1.3	-1.6	-1.2	-0.5	-1.5	-1.2	0.2	-1.0	-0.9	-2.1	-0.9
Medication: Levothyroxine sodium	1.4	2.4	6.7	-0.1	-1.9	-1.0	-2.0	-1.5	-0.6	-1.4	-2.6	-1.6	-1.8	1.3	-1.0
Hip circumference	1.4	5.9	14.1	-3.8	-3.2	-2.4	-2.0	-0.7	-2.6	-2.3	-0.9	-1.9	-1.9	-3.6	-1.7
Time employed in main current job	1.4	1.6	4.7	0.9	0.6	1.4	0.9	2.2	1.6	1.3	0.2	1.0	1.2	0.9	1.7
Ever had bowel cancer screening	1.4	1.6	4.5	-1.4	-1.8	-1.1	-0.8	-0.6	-1.2	-1.0	-1.4	-1.3	-0.9	-2.1	-1.0
Heart attack/myocardial infarction (self-reported)	1.4	1.8	2.9	-1.1	-0.9	-1.3	-1.3	-1.7	-1.3	-1.5	-1.2	-1.6	-1.6	-0.6	-1.4
Number of treatments/medications taken	1.3	2.4	5.8	-1.2	-2.4	-1.9	-2.0	-1.3	-1.8	-1.8	-0.8	-0.7	-1.7	0.1	-1.2
Heart attack	1.3	1.7	3.2	-1.0	-0.9	-1.3	-1.3	-1.8	-1.3	-1.5	-1.1	-1.6	-1.6	-0.5	-1.4
Breastfed as a baby	1.3	1.7	2.6	-1.6	-0.6	-1.2	-1.5	-0.9	-1.6	-1.5	0.1	-1.3	-1.4	-1.4	-1.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	2.7	-1.0	-0.9	-1.4	-1.3	-1.2	-1.5	-1.5	-1.7	-1.1	-1.5	-0.3	-1.6
Angina (self-reported)	1.3	1.7	2.3	-1.5	-1.2	-1.3	-1.4	-1.2	-1.5	-1.5	-1.0	-1.2	-1.5	-0.9	-1.2
Vascular/heart problems diagnosed by doctor	1.3	3.5	6.8	2.2	2.6	2.1	2.3	0.7	2.1	2.1	0.6	1.8	1.8	1.7	1.4
Rheumatoid Arthritis	1.2	1.7	12.0	0.8	-1.0	-0.0	-1.0	-0.2	0.0	-0.5	-3.5	-0.2	-0.7	2.1	0.1
Leg fat-free mass (left)	1.2	6.2	16.3	-4.0	-3.6	-2.5	-2.4	-0.1	-2.5	-2.2	-1.1	-1.8	-1.8	-3.6	-1.2
Leg predicted mass (left)	1.2	6.5	16.9	-4.1	-3.6	-2.5	-2.4	-0.3	-2.5	-2.3	-1.1	-1.9	-1.9	-3.6	-1.3
Waist circumference	1.2	4.5	8.7	-2.5	-3.0	-2.4	-2.1	-0.9	-2.3	-2.2	-1.2	-1.9	-2.0	-2.5	-1.5
Weight	1.2	5.8	14.6	-3.8	-3.5	-2.4	-2.1	0.0	-2.5	-2.2	-0.9	-1.8	-1.7	-3.7	-1.2
Noisy workplace	1.2	1.5	3.6	0.7	1.6	0.9	0.9	1.9	0.9	0.9	1.6	1.3	1.0	0.8	1.5
Arm fat mass (right)	1.2	4.9	10.2	-3.1	-3.0	-2.3	-2.0	-0.5	-2.4	-2.2	-1.1	-1.7	-1.8	-3.2	-1.3
Standing height	1.2	12.1	24.1	-4.9	-4.4	-3.4	-3.7	-1.9	-3.4	-3.4	-2.3	-3.7	-3.2	-3.6	-2.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.4	1.8	1.5	1.0	1.2	1.0	1.4	1.0	-0.2	0.7	0.7	1.6	1.2
Friendships satisfaction	1.2	1.4	2.6	-0.9	-1.3	-0.7	-1.1	-1.6	-0.8	-1.1	-1.5	-1.3	-1.2	-1.1	-1.4
Ever taken oral contraceptive pill	1.2	1.3	3.7	1.2	1.9	1.2	0.9	1.3	1.5	1.2	0.3	0.6	1.0	0.8	1.2
Trunk fat percentage	1.1	4.2	7.3	-2.4	-2.7	-2.3	-2.1	-1.3	-2.2	-2.2	-1.1	-2.0	-2.0	-2.3	-1.5
Multivitamins +/- minerals	1.1	1.4	2.6	-0.9	-1.3	-1.4	-1.3	-1.4	-1.2	-1.4	0.3	-1.6	-1.4	0.1	-1.0
Trunk fat mass	1.1	4.8	9.9	-2.9	-3.1	-2.4	-2.2	-0.8	-2.3	-2.2	-1.0	-1.9	-1.9	-2.9	-1.3
Impedance of arm (right)	1.1	5.1	12.8	-0.6	-0.8	-2.0	-2.4	-3.6	-1.9	-2.3	-2.2	-2.8	-2.7	0.2	-3.0
Gout (self-reported)	1.1	1.6	2.6	1.3	1.0	1.4	1.2	0.7	1.5	1.4	-0.0	1.6	1.3	1.4	1.3
Exposure to tobacco smoke outside home	1.1	1.5	6.5	0.7	-0.5	1.1	-0.1	2.5	1.3	0.8	-0.5	1.2	0.8	1.0	1.9
Whole body fat mass	1.1	4.4	9.8	-2.9	-2.9	-2.2	-1.9	-0.6	-2.2	-2.1	-0.9	-1.8	-1.7	-3.1	-1.2
Leg fat-free mass (right)	1.1	6.1	16.2	-4.0	-3.5	-2.5	-2.3	-0.2	-2.5	-2.2	-1.1	-1.8	-1.7	-3.6	-1.3
Leg predicted mass (right)	1.1	6.0	16.2	-4.0	-3.5	-2.4	-2.3	-0.1	-2.5	-2.2	-1.0	-1.7	-1.7	-3.7	-1.2
Basal cell carcinoma (self-reported)	1.1	1.3	2.4	1.6	1.4	1.3	1.1	0.5	1.2	1.1	1.2	0.5	0.9	1.5	1.0
Alzheimer’s Disease (in father)	1.0	1.0	3.1	-1.2	-1.0	-1.1	-1.2	0.5	-1.0	-1.0	-1.8	-0.2	-1.0	-0.7	-0.8
HbA1C	1.0	1.1	1.7	1.3	0.8	1.3	1.3	1.1	1.3	1.0	0.6	0.7	0.9	0.8	1.2
Diabetes (father)	1.0	1.2	3.2	0.5	0.4	0.8	0.8	1.5	0.8	1.1	1.4	1.8	1.3	0.8	1.0
Current tobacco smoking	1.0	1.6	4.9	1.3	1.0	0.9	0.7	1.5	1.3	0.9	0.5	1.5	0.8	2.2	1.7
High blood pressure	1.0	2.9	6.4	-2.0	-2.5	-1.8	-2.1	-0.5	-1.8	-1.8	-0.6	-1.6	-1.5	-1.6	-1.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.3	1.8	1.7	0.7	1.1	0.1	1.1	1.1	0.2	0.5	0.9	1.5	1.0
Medication: Omeprazole	1.0	1.3	2.8	-1.5	-1.7	-1.4	-1.2	-0.4	-1.1	-1.0	0.4	-1.3	-0.9	-1.0	-0.7
Medication for cholesterol	1.0	1.5	3.5	1.5	1.9	1.4	1.4	0.4	1.4	1.3	0.1	1.1	1.2	1.0	1.2
Smoking status: Current	1.0	1.6	4.4	1.2	1.0	0.9	0.7	1.4	1.3	1.0	0.4	1.6	0.9	2.1	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	9.2	-0.5	0.8	0.8	1.6	1.6	0.6	1.2	3.0	1.2	1.6	-1.5	1.2
Arm fat mass (left)	1.0	4.0	8.9	-2.9	-3.0	-2.1	-1.9	-0.3	-2.2	-2.0	-0.9	-1.4	-1.6	-2.7	-1.0
Basal metabolic rate	1.0	5.5	15.8	-4.0	-3.5	-2.2	-2.0	0.3	-2.3	-2.0	-0.7	-1.6	-1.5	-3.7	-0.9
Schizophrenia (2018)	0.9	1.9	4.0	-1.7	-1.0	-0.8	-1.0	-2.0	-1.5	-1.3	-0.8	-1.2	-1.3	-1.2	-2.0
Alzheimer’s Disease (in mother)	0.9	1.1	4.7	-1.6	-0.6	-0.9	-0.6	0.1	-1.3	-0.8	0.9	-0.6	-0.4	-2.2	-0.6
Medication for hormone replacement therapy	0.9	1.0	2.0	0.6	0.2	1.1	0.5	1.3	1.1	1.0	1.4	1.0	1.0	1.0	1.1
Pulse rate	0.9	1.5	3.1	1.3	1.1	1.2	0.8	0.7	1.3	1.3	1.0	1.8	1.3	1.4	1.2
Blood clot in the leg (DVT)	0.9	1.2	2.3	-1.1	-1.5	-1.2	-0.8	-1.2	-1.0	-0.9	-0.1	-1.2	-0.9	-1.4	-1.1
Birth weight	0.9	2.0	3.3	-1.7	-1.3	-1.3	-1.3	-1.0	-1.2	-1.3	-1.7	-1.3	-1.4	-1.8	-1.4
Number of full brothers	0.9	1.1	1.9	-0.8	-1.2	-1.0	-1.4	-1.1	-0.7	-0.9	1.2	-1.0	-1.1	1.3	-0.5
Family relationship satisfaction	0.9	1.1	2.4	-1.1	-1.6	-1.1	-1.2	-1.1	-0.7	-1.1	-0.8	-1.2	-1.3	0.3	-0.7
Hypertension (Self-reported)	0.9	2.6	6.0	-1.8	-2.5	-1.8	-2.1	-0.5	-1.8	-1.7	-0.8	-1.4	-1.5	-1.4	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.3	-1.5	-1.1	-1.1	-0.8	-0.1	-1.5	-0.9	0.3	-0.4	-0.6	-1.5	-0.8
Whole body fat-free mass	0.9	4.9	15.2	-3.9	-3.3	-2.0	-1.9	0.5	-2.1	-1.8	-0.5	-1.5	-1.3	-3.6	-0.7
Whole body water mass	0.9	5.0	15.7	-4.0	-3.4	-2.0	-1.9	0.5	-2.1	-1.8	-0.6	-1.4	-1.3	-3.6	-0.7
Commuting to job workplace: Public transport	0.9	1.1	2.1	-1.1	-0.9	-0.8	-1.2	-1.1	-1.1	-1.1	-1.5	-0.8	-1.1	-0.6	-1.1
Average weekly spirits intake	0.8	0.9	2.6	0.9	0.7	1.1	0.7	1.6	0.9	0.8	0.9	0.7	0.9	0.1	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	9.1	-1.6	-1.2	-1.1	-0.4	-1.4	-1.3	-0.8	0.7	-0.9	-0.6	-3.0	-1.5
Neuroticism score	0.8	1.6	6.8	0.4	-0.4	0.6	-0.0	1.9	0.8	0.4	0.3	1.6	0.5	2.6	2.0
Arm fat percentage (right)	0.8	3.1	5.4	-2.2	-2.3	-1.9	-1.7	-0.8	-2.0	-1.9	-1.0	-1.6	-1.7	-2.2	-1.2
Trunk fat-free mass	0.8	4.6	15.1	-3.9	-3.3	-1.8	-1.7	0.7	-1.9	-1.6	-0.4	-1.4	-1.1	-3.5	-0.5
Hair/balding pattern: Pattern 3	0.8	1.1	2.3	1.4	1.1	1.2	1.5	0.1	1.3	1.3	-0.3	1.1	1.1	0.7	0.7
Medication: Lansoprazole	0.8	1.0	2.5	-0.3	-0.7	-1.1	-0.8	-1.6	-1.1	-1.0	-0.8	-0.8	-1.1	0.4	-1.3
Lung cancer (father)	0.8	0.9	2.1	1.5	0.8	0.8	1.0	0.8	1.3	1.1	0.3	0.7	1.0	0.8	1.0
Trunk predicted mass	0.8	4.6	15.2	-3.9	-3.3	-1.8	-1.7	0.8	-1.9	-1.6	-0.3	-1.4	-1.1	-3.6	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	7.1	0.6	-0.3	0.1	-0.0	1.0	0.8	0.5	1.1	1.2	0.5	2.7	1.4
Overall health rating	0.8	1.8	3.7	1.2	-0.0	1.0	0.9	1.7	1.6	1.2	-0.6	1.8	1.2	1.4	1.9
Diabetes diagnosed by doctor	0.8	1.4	2.4	-1.2	-1.1	-1.5	-1.5	-0.5	-1.2	-1.3	-1.5	-0.8	-1.2	-0.7	-0.8
Breast cancer (self-reported)	0.8	1.0	3.4	-0.4	-0.9	-0.4	-0.2	-1.9	-0.3	-0.2	-1.1	-1.0	-0.3	-1.7	-1.3
Ever smoked	0.8	1.4	2.6	1.3	1.1	1.1	0.8	1.2	1.2	1.2	1.5	1.0	1.2	0.5	1.6
Arm fat-free mass (left)	0.8	4.0	13.2	-3.6	-3.1	-1.7	-1.6	0.7	-1.9	-1.6	-0.3	-1.1	-1.1	-3.3	-0.5
Worry (Nagel 2018)	0.7	1.5	3.0	-1.7	-1.4	-1.3	-1.6	-0.5	-1.6	-1.6	-0.1	-0.4	-1.4	0.2	-0.9
Type 2 Diabetes (T2D) (2018)	0.7	1.2	2.7	-0.7	-0.8	-1.4	-1.4	-0.6	-1.0	-1.3	-1.6	-1.1	-1.4	0.6	-0.8
Frequency of depressed mood in last 2 weeks	0.7	0.9	4.6	0.2	-1.3	0.3	-0.5	1.1	0.4	0.1	0.6	0.9	0.2	2.1	1.4
Average weekly fortified wine intake	0.7	0.8	2.2	-0.6	-1.5	-0.6	-1.2	-0.3	-0.5	-0.8	-1.4	-0.9	-0.9	-0.3	-0.6
Fed-up feelings	0.7	1.3	4.8	0.3	-1.1	0.4	-0.4	1.8	0.7	0.1	0.2	0.7	0.1	2.0	2.2
Illnesses of mother	0.7	0.8	2.2	1.1	1.5	1.1	0.9	-0.6	1.1	1.2	0.4	0.5	1.0	0.1	0.3
Impedance of arm (left)	0.7	3.1	9.6	-0.1	-0.3	-1.4	-1.8	-3.1	-1.3	-1.7	-1.9	-2.0	-2.1	0.9	-2.3
Body fat percentage	0.7	2.7	4.9	-2.0	-2.2	-1.9	-1.6	-0.8	-1.8	-1.7	-0.6	-1.5	-1.5	-2.2	-1.1
Medication: Allopurinol	0.7	1.0	1.5	0.7	0.3	1.2	0.6	0.8	1.1	1.0	1.0	1.2	1.0	1.2	1.2
Alcohol intake frequency.	0.7	1.7	2.9	-1.0	-1.5	-1.6	-1.6	-1.0	-1.1	-1.5	-1.0	-1.7	-1.7	0.3	-1.0
Medication: Aspirin	0.7	1.0	2.6	-1.1	-0.9	-1.2	-0.6	-0.7	-1.0	-0.7	0.8	-1.0	-0.6	-1.6	-0.8
Supplements: Vitamin C	0.7	0.8	1.9	-0.9	-0.3	-1.0	-0.8	-1.4	-1.0	-0.9	0.2	-1.1	-0.9	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.7	-1.9	-1.0	-1.3	-1.2	-0.7	-1.3	-1.2	-1.3	-1.0	-1.0	-1.6	-0.9
Arm fat percentage (left)	0.7	2.7	5.2	-2.1	-2.3	-1.8	-1.6	-0.7	-1.9	-1.8	-0.8	-1.3	-1.5	-2.1	-1.0
High cholesterol (Self-reported)	0.7	1.3	2.2	0.8	1.1	0.9	1.2	1.5	1.0	1.3	1.1	1.1	1.5	-0.7	1.1
Medication: Atorvastatin	0.7	0.9	2.0	-1.4	-1.1	-1.0	-0.9	-0.5	-1.0	-0.8	-0.4	-0.7	-0.8	-1.3	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.1	-0.9	-0.6	-0.0	-0.0	1.8	-0.1	0.2	1.6	0.0	0.5	-1.1	1.0
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.4	-0.6	-1.5	-1.2	-1.3	-1.8	-1.0	-1.2	-1.1	-1.6	-1.4	-0.9	-1.5
Major Depression (MDD)	0.6	0.7	2.2	-0.9	-1.5	-1.2	-1.0	-0.0	-0.6	-0.8	0.0	-1.0	-0.8	-0.6	-0.1
Mean Putamen Volume	0.6	0.6	2.3	0.8	1.5	0.2	0.9	0.5	0.4	0.2	1.1	0.0	0.0	1.4	0.5
Ever had hysterectomy (womb removed)	0.6	0.6	2.9	-0.6	-1.7	-0.8	-1.1	-0.6	-0.5	-0.6	-0.3	-0.9	-0.7	-0.1	-0.4
Stomach or abdominal pain in last month	0.6	0.7	2.4	-1.1	-1.6	-0.9	-0.8	-0.3	-0.9	-0.9	0.3	-0.9	-0.8	-0.3	-0.2
Supplements: Glucosamine	0.6	0.7	2.2	-0.3	0.0	0.4	0.6	1.3	0.4	0.6	1.5	1.2	0.7	0.8	1.2
Had other major operations	0.6	0.8	3.0	1.2	-0.5	0.3	-0.1	0.6	0.9	0.4	-1.6	0.6	0.1	1.7	0.6
Diabetes (self-reported)	0.6	0.9	2.9	-0.8	-0.9	-1.3	-1.2	-0.3	-1.0	-1.1	-1.7	-0.4	-1.0	-0.5	-0.5
Worrier / anxious feelings	0.6	1.2	3.8	-2.0	-1.6	-1.1	-1.3	-0.2	-1.4	-1.1	-0.6	0.5	-0.9	0.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.2	0.1	-0.7	0.4	-0.1	1.8	0.7	0.2	0.1	0.7	0.2	1.7	1.8
Headache pain in last month	0.6	1.1	3.8	-1.9	-1.4	-1.3	-1.1	0.9	-1.0	-1.0	0.3	-0.4	-0.7	-0.5	0.1
Pulse wave peak to peak time	0.6	0.7	1.5	-0.7	-0.8	-1.0	-0.8	-1.2	-0.9	-0.8	0.5	-0.7	-0.8	-0.5	-1.2
Health satisfaction	0.6	0.8	1.6	0.7	0.1	0.9	0.7	1.0	1.0	1.0	-0.2	1.0	0.9	0.9	1.3
Migraine (self-reported)	0.6	0.8	2.0	-1.4	-0.9	-1.1	-0.8	-0.2	-1.0	-0.9	0.4	-0.3	-0.7	-1.4	-0.7
Leg fat mass (right)	0.6	2.3	8.2	-2.2	-2.1	-1.5	-1.1	0.3	-1.6	-1.3	-0.1	-1.0	-0.9	-2.9	-0.4
Leg pain on walking	0.6	0.7	4.4	1.2	0.7	0.6	0.5	0.4	0.8	0.4	-0.1	-0.0	0.1	2.1	0.8
Mother’s age at death	0.6	0.8	1.6	-1.2	-0.3	-0.9	-0.7	-0.5	-1.2	-1.0	-0.3	-0.7	-0.8	-1.3	-1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.9	0.9	0.5	0.8	0.7	1.0	0.9	0.9	0.7	0.8	1.0	0.2	1.4
Medication: Lisinopril	0.6	0.7	1.2	-0.9	-0.9	-1.1	-1.1	-0.5	-0.8	-1.0	-0.4	-0.9	-1.0	-0.7	-0.7
Irritability	0.6	1.0	3.0	0.0	-0.7	0.7	-0.0	1.7	0.7	0.5	0.4	1.6	0.6	1.2	1.7
Arm predicted mass (left)	0.6	3.1	10.8	-3.3	-2.9	-1.3	-1.2	1.1	-1.5	-1.1	-0.0	-0.7	-0.6	-3.0	-0.1
Depressed Affect (Nagel 2018)	0.5	1.1	3.9	-0.1	-0.9	0.1	-0.7	2.0	0.3	-0.2	-0.3	0.9	-0.1	1.8	1.9
Age at First Birth	0.5	0.7	1.9	0.7	0.1	1.4	0.7	0.3	1.0	1.1	0.6	1.1	1.2	-0.2	0.6
Primary Biliary Cirrhosis	0.5	0.7	1.5	1.2	0.9	1.2	0.9	0.1	1.0	0.7	-1.0	-0.1	0.5	1.1	0.4
Triglycerides	0.5	0.8	1.9	-0.9	-0.4	-1.4	-1.2	0.1	-1.1	-1.2	0.5	-0.7	-1.1	0.3	-0.5
Heel T-Score	0.5	3.6	7.5	1.4	1.9	1.9	1.8	2.5	1.8	2.0	1.3	2.7	2.2	0.4	1.9
Waist Hip Ratio (WHR)	0.5	2.4	5.4	1.5	-0.7	-1.3	-1.8	-2.3	-0.7	-1.5	-1.7	-1.5	-1.9	1.6	-1.0
Relative age of first facial hair	0.5	0.9	1.5	-0.8	-0.7	-1.2	-0.7	-0.8	-0.9	-1.0	-0.8	-1.2	-1.1	-1.0	-1.1
Medication: Co-codamol	0.5	0.6	1.9	-0.5	-1.4	-0.8	-0.8	-0.7	-0.6	-0.8	-0.7	-0.6	-0.7	-0.5	-0.4
Medication: Atenolol	0.5	0.6	1.3	0.5	0.6	0.6	1.1	1.1	0.7	0.8	0.1	0.9	0.9	-0.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.2	-0.8	-0.9	-0.2	-0.7	1.5	-0.4	-0.4	1.1	0.7	-0.1	1.0	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	7.3	-1.5	-0.7	-0.8	-0.2	-0.6	-1.0	-0.5	0.4	-0.5	-0.3	-2.7	-1.0
Financial difficulties in last 2 years	0.5	0.6	3.4	0.5	0.7	0.2	0.6	0.6	0.4	0.3	0.4	1.1	0.3	1.8	0.9
Pain all over the body in last month	0.5	0.6	1.2	0.7	-0.0	1.0	0.1	1.0	0.9	0.7	-0.0	0.8	0.6	1.1	1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.3	-0.1	0.9	1.3	1.5	1.8	1.0	1.5	1.7	1.1	1.8	-0.9	1.3
Glaucoma (self-reported)	0.5	0.6	1.0	0.7	-0.4	0.9	0.5	0.3	1.0	0.9	1.0	0.9	0.9	0.8	0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.8	0.7	-1.0	-0.2	-0.4	-0.9	0.1	-0.3	-1.3	-0.4	-0.6	1.3	-0.4
Arm fat-free mass (right)	0.5	2.7	9.5	-3.1	-2.5	-1.1	-0.9	1.3	-1.3	-0.9	0.3	-0.5	-0.3	-3.1	0.2
Worry too long after embarrassment	0.5	0.9	2.0	0.5	-0.1	0.8	0.6	1.3	1.0	0.9	0.7	1.3	0.9	1.0	1.4
Medication: Ibuprofen	0.5	0.6	3.5	0.9	0.5	0.2	0.6	0.4	0.6	0.5	-0.0	0.8	0.4	1.9	0.7
Number of full sisters	0.5	0.6	3.3	1.0	1.8	0.5	0.7	0.2	0.5	0.4	0.1	0.4	0.4	0.9	0.5
Average weekly red wine intake	0.5	0.7	1.9	-0.6	-0.7	-0.3	-0.4	-0.9	-0.7	-0.5	-1.4	-0.4	-0.5	-1.4	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.1	-1.4	-0.9	-1.2	-0.9	-0.3	-1.1	-0.9	0.7	-0.6	-0.7	-0.8	-0.7
Osteoporosis (self-reported)	0.5	0.6	1.0	-0.7	-0.8	-0.8	-1.0	-0.9	-0.9	-0.9	-0.8	-0.2	-0.8	0.1	-0.9
Miserableness	0.5	0.8	2.2	-0.6	-1.4	-0.3	-1.1	1.5	-0.4	-0.7	-0.3	0.4	-0.4	0.9	1.4
Leg fat mass (left)	0.5	1.9	7.7	-2.1	-1.9	-1.3	-0.9	0.6	-1.4	-1.1	-0.0	-0.8	-0.7	-2.8	-0.2
Neuroticism (Nagel 2018)	0.4	1.0	2.4	-1.1	-1.6	-0.6	-1.3	1.1	-0.8	-1.0	-0.2	0.5	-0.8	1.2	0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	3.1	-0.4	0.6	0.1	0.4	1.8	-0.1	0.2	0.7	0.6	0.6	-1.2	0.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.3	1.5	0.6	1.5	1.0	0.7	1.2	1.1	0.6	0.5	1.0	0.5	0.9
Fasting Glucose	0.4	0.5	0.9	-0.6	-0.9	-0.6	-0.7	-0.4	-0.4	-0.8	-0.7	-0.9	-0.9	0.4	-0.5
Lupus	0.4	0.7	3.7	0.7	-0.2	0.2	-0.4	0.3	0.2	-0.3	-1.7	0.2	-0.5	1.9	-0.3
Schizophrenia (2014)	0.4	0.8	2.4	-1.1	-0.6	-0.5	-0.6	-1.5	-0.8	-0.7	-0.9	-0.6	-0.7	-0.6	-1.5
Blood White Count	0.4	2.7	8.8	3.0	2.6	1.6	1.6	0.5	1.9	1.4	0.3	1.0	1.1	1.4	1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	-0.6	-1.0	-0.7	-1.2	-0.3	-0.9	-0.8	-0.5	-0.4	-0.7	-0.4	-0.6
Forced vital capacity (FVC)	0.4	1.5	2.7	-0.1	0.8	1.3	1.3	1.5	0.9	1.4	1.4	1.4	1.6	-0.5	1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	0.3	0.2	0.5	0.5	0.8	0.9	0.6	1.2	-0.2	0.5	0.5	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.6	-0.6	0.5	0.8	0.9	1.6	0.6	0.9	1.9	0.3	1.2	-1.6	0.9
Loud music exposure frequency	0.4	0.4	1.5	0.0	-0.6	-0.7	-1.0	-0.5	-0.3	-0.6	0.5	-0.7	-0.7	1.2	-0.1
Medication: Amlodipine	0.4	0.5	1.3	0.8	0.7	0.6	0.1	1.0	0.5	0.5	0.7	0.6	0.5	1.2	0.8
Qualifications: College or University degree	0.4	1.3	4.0	-0.5	0.4	-0.6	-0.7	-1.8	-1.3	-1.0	-0.7	-1.1	-0.9	-1.6	-2.0
Arm predicted mass (right)	0.4	2.1	7.5	-2.7	-2.3	-0.8	-0.6	1.4	-0.9	-0.6	0.4	-0.3	-0.0	-2.7	0.5
Loneliness, isolation	0.4	0.5	2.5	-0.5	-0.6	-0.2	-1.0	0.4	-0.2	-0.5	-0.9	0.5	-0.6	1.6	0.6
Back pain experienced in last month	0.4	0.6	2.4	-1.2	-1.0	-0.6	-0.5	1.1	-0.7	-0.4	0.4	0.1	0.0	-1.5	0.6
Medication: Aspirin	0.4	0.6	1.4	-0.5	-0.7	-1.0	-0.4	-0.8	-0.7	-0.5	0.7	-0.9	-0.5	-1.2	-0.8
Guilty feelings	0.4	0.6	2.9	-0.1	-1.3	-0.4	-0.9	0.2	-0.4	-0.7	-0.1	0.1	-0.7	1.7	0.4
Medication: Bendroflumethiazide	0.4	0.6	2.4	-0.6	-1.6	-0.7	-1.0	-0.2	-0.6	-0.6	-1.2	-0.2	-0.5	0.4	-0.2
Pain experienced in last month	0.4	0.6	1.9	1.4	0.5	0.3	0.1	-1.4	0.4	0.2	-1.3	-0.3	-0.1	0.6	-0.8
Depression (Nagel 2018)	0.3	0.5	1.7	0.0	-1.0	-0.2	-0.7	0.8	-0.0	-0.3	0.5	0.5	-0.2	1.3	1.0
Breast Cancer	0.3	0.8	1.8	-0.4	-1.4	-1.1	-1.1	-0.4	-0.5	-0.8	-0.7	-0.9	-1.0	0.9	-0.6
Ovarian Cancer	0.3	0.4	0.9	0.1	-0.8	-0.4	-0.8	-0.5	-0.3	-0.7	-0.2	-0.9	-0.8	0.9	-0.4
Body Mass Index (BMI) (2010)	0.3	0.3	1.2	-1.0	-0.6	-0.4	-0.4	1.1	-0.3	-0.4	-0.8	0.2	-0.3	-0.5	0.4
Lung FVC	0.3	1.7	4.0	0.4	1.4	1.6	1.7	0.8	0.6	1.3	1.5	2.0	1.7	-0.4	0.6
Neuroticism	0.3	0.8	4.8	-0.2	-1.2	-0.1	-0.8	1.0	0.0	-0.4	0.2	0.5	-0.4	2.2	1.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.3	-0.7	-0.1	-0.7	-0.1	-0.4	-0.7	-0.5	1.1	-0.4	-0.5	-0.1	-0.3
Diabetes (mother)	0.3	0.4	1.3	0.5	0.2	0.3	0.4	0.6	0.6	0.5	1.1	0.2	0.5	0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.5	-0.6	-1.2	-0.2	-0.6	0.8	0.0	-0.3	0.8	0.2	-0.2	0.8	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.1	-1.1	-1.0	-0.8	-0.6	0.4	-0.6	-0.5	0.1	0.0	-0.3	0.0	-0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.5	0.1	0.6	0.2	0.6	0.8	0.6	0.4	0.4	0.5	0.5	0.8
Qualifications: CSEs or equivalent	0.3	0.4	2.1	0.2	-0.5	0.3	0.0	0.3	0.3	0.3	1.5	0.4	0.4	0.7	0.9
Body mass index (BMI)	0.3	1.2	5.3	-1.8	-1.6	-0.9	-0.5	0.9	-1.0	-0.7	0.2	-0.1	-0.3	-2.3	0.1
Impedance of leg (left)	0.3	1.4	4.4	2.1	1.9	0.9	0.9	-0.4	1.0	0.9	0.4	0.2	0.5	2.0	0.3
Alcohol intake versus 10 years previously	0.3	0.5	1.9	-0.3	-0.9	-0.7	-0.5	1.2	-0.1	-0.2	1.4	-0.6	-0.1	0.1	0.9
Falls in the last year	0.3	0.4	1.5	-1.0	-0.8	-0.4	-0.4	0.3	-0.6	-0.3	0.6	-0.1	-0.2	-1.2	0.0
Number of live births	0.3	0.5	1.0	0.6	0.6	0.9	1.0	-0.0	0.7	0.9	0.1	1.0	0.8	0.2	0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	0.3	0.4	0.7	0.5	1.0	0.7	0.6	-0.6	0.4	0.6	0.2	1.0
Exposure to tobacco smoke at home	0.3	0.3	1.4	-0.0	-0.5	0.3	-0.5	0.7	0.2	-0.1	-0.6	0.7	-0.2	1.2	0.5
Number of children fathered	0.3	0.4	1.3	0.7	-0.1	0.4	0.2	0.8	0.4	0.5	-0.3	0.9	0.5	1.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.5	-0.6	-0.2	-0.2	0.2	-0.3	-0.6	-0.3	1.2	-0.2	-0.2	-1.2	-0.5
Shortness of breath walking on level ground	0.3	0.4	1.2	-0.7	-0.7	-0.7	-0.8	-0.5	-0.3	-0.5	-1.1	-0.4	-0.6	-0.4	-0.4
Comparative height size at age 10	0.3	1.6	7.0	-2.6	-1.8	-0.9	-0.8	0.6	-1.0	-0.9	-0.6	-1.1	-0.6	-1.8	-0.2
Had major operations	0.3	0.4	1.9	-0.8	-0.3	-0.7	-0.6	-0.1	-0.5	-0.5	0.1	-0.8	-0.5	-1.4	-0.4
Age at last live birth	0.3	0.4	1.0	-0.2	-0.9	-0.4	-0.5	-1.0	-0.5	-0.5	-0.7	-0.1	-0.6	-0.3	-1.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	0.2	-0.0	0.2	-0.2	-0.6	-0.1	-0.2	-0.8	-1.0	-0.3	-1.2	-0.8
Commuting to job workplace: Walk	0.3	0.4	0.8	-0.5	-0.9	-0.5	-0.6	-0.9	-0.8	-0.7	-0.0	-0.4	-0.7	0.2	-0.4
Mineral and other dietary supplements	0.3	0.4	0.9	0.5	0.7	0.9	0.6	0.6	0.7	0.7	-0.8	0.9	0.6	-0.1	0.1
Medication: Gliclazide	0.3	0.4	0.9	0.7	0.5	0.7	0.2	0.4	0.6	0.6	0.3	0.7	0.5	0.9	0.6
Average weekly champagne plus white wine intake	0.3	0.5	1.5	-0.8	-0.5	-0.1	-0.5	-0.7	-0.5	-0.5	1.2	-1.0	-0.4	-0.7	-0.5
Financial situation satisfaction	0.3	0.3	1.2	0.3	0.2	0.4	0.4	0.2	0.7	0.5	0.5	0.6	0.4	1.1	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	-0.2	-0.7	-0.9	-0.8	-0.7	-0.8	-0.9	-0.2	-0.6	-0.8	0.4	-0.3
Number of operations (self-reported)	0.3	0.4	1.0	-0.5	-0.8	-0.9	-0.7	-0.3	-0.6	-0.5	-0.7	-0.5	-0.5	-1.0	-0.6
Risk taking	0.3	0.4	1.5	-0.7	0.9	0.0	0.1	0.7	-0.4	0.0	1.0	0.3	0.4	-1.2	-0.3
Ever depressed for a whole week	0.3	0.4	2.2	-0.7	0.2	-0.1	0.4	-0.6	-0.1	0.1	1.0	-0.8	0.1	-1.5	-0.2
Impedance of whole body	0.3	1.5	5.6	0.9	0.6	-0.5	-0.9	-2.4	-0.4	-0.8	-1.1	-1.3	-1.2	1.7	-1.5
Reaction Time	0.2	0.4	2.2	-0.5	0.1	-0.7	-0.6	-0.6	-0.5	-0.5	-1.5	0.1	-0.5	0.8	-0.6
HDL Cholesterol	0.2	0.4	1.0	0.2	0.3	1.0	0.8	0.7	0.7	0.7	0.0	0.6	0.8	-0.6	0.5
LDL Cholesterol	0.2	0.3	1.3	-0.7	0.1	0.1	-0.2	1.0	-0.4	-0.1	1.1	0.5	0.2	-0.8	0.1
Neuroticism (2016)	0.2	0.3	1.5	0.2	-0.7	0.4	-0.1	0.6	0.5	0.1	0.6	0.0	0.0	1.2	1.0
BMI	0.2	1.0	3.7	-1.6	-1.1	-0.6	-0.5	1.5	-0.7	-0.5	0.2	0.1	-0.1	-1.9	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.4	0.4	-0.8	-0.4	-0.1	-1.2	-0.0	-0.1	-0.9	-0.0	-0.2	0.4	-0.6
Systolic blood pressure, automated reading	0.2	0.6	1.5	-0.9	-1.1	-1.0	-0.6	-0.4	-1.2	-0.9	-0.1	-0.7	-0.7	-0.9	-0.7
Impedance of leg (right)	0.2	1.1	4.1	1.9	1.6	0.9	0.7	-0.6	0.9	0.7	0.5	-0.0	0.3	2.0	0.1
Townsend deprivation index at recruitment	0.2	0.3	1.3	0.3	-0.3	0.1	-0.4	0.5	0.7	0.3	0.8	0.3	0.2	1.2	0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	0.6	0.4	0.3	0.4	-0.2	0.5	0.5	-0.9	0.4	0.4	0.2	0.2
Past tobacco smoking	0.2	0.4	1.1	-0.6	-0.1	-0.6	-0.5	-0.2	-0.6	-0.8	-1.0	-0.7	-0.9	0.8	-0.8
Qualifications: None of the above	0.2	0.4	1.2	0.0	-0.0	0.3	0.3	1.1	0.5	0.5	0.7	0.8	0.5	-0.2	1.1
Mouth/teeth dental problems	0.2	0.4	0.9	-0.0	0.3	1.0	0.6	0.5	0.6	0.7	0.4	0.4	0.8	-0.8	0.3
Illnesses of siblings	0.2	0.3	1.1	0.1	1.1	0.5	0.7	-0.1	0.2	0.4	0.8	0.1	0.4	-0.3	0.0
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	0.3	-0.5	-0.9	-0.6	-0.6	-0.4	-0.7	-1.1	-0.3	-0.7	0.6	-0.3
Depression (self-reported)	0.2	0.3	0.9	0.0	0.5	0.2	0.2	0.9	0.3	0.4	0.6	0.8	0.5	0.6	0.7
Prospective memory result	0.2	0.2	0.9	0.1	-0.3	-0.1	-0.1	-0.9	-0.1	-0.2	-0.9	-0.3	-0.4	0.5	-0.4
Tense / ‘highly strung’	0.2	0.4	1.7	-0.2	0.4	0.4	0.1	0.7	0.2	0.2	0.7	1.0	0.3	1.3	0.5
Pulse wave reflection index	0.2	0.2	1.0	-0.5	-0.3	0.2	0.1	0.8	0.1	0.2	-1.0	0.3	0.2	-0.6	0.5
Medication: Paracetamol	0.2	0.4	1.3	0.4	0.5	-0.2	0.2	0.9	0.1	0.2	0.3	1.2	0.4	0.4	1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	0.6	0.4	0.5	0.6	-0.3	0.3	0.2	-1.0	0.2	0.1	0.7	-0.4
Leg fat percentage (right)	0.2	0.7	2.8	-1.1	-1.3	-0.9	-0.4	0.3	-0.9	-0.7	0.3	-0.5	-0.4	-1.7	-0.0
Comparative body size at age 10	0.2	0.5	1.8	0.6	1.1	0.8	0.5	1.3	0.6	0.5	-0.1	0.6	0.6	-0.3	0.9
Age at first live birth	0.2	0.3	1.1	1.1	0.5	0.5	0.7	-0.6	0.6	0.5	-0.9	0.2	0.3	-0.2	-0.3
Eye problems/disorders: None of the above	0.2	0.2	1.1	0.2	0.5	0.2	0.3	1.1	0.2	0.2	-0.4	-0.3	0.2	-0.1	0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	2.1	0.3	0.3	0.7	0.3	-0.6	0.4	0.2	-1.5	-0.6	-0.0	-0.3	-0.5
Medication: Blood pressure	0.2	0.4	0.8	-0.9	-0.9	-0.6	-0.8	0.2	-0.6	-0.5	0.4	-0.2	-0.4	-0.8	0.0
Mean time to correctly identify matches	0.2	0.4	2.3	-0.4	-0.1	-0.5	-0.4	-0.7	-0.4	-0.4	-1.5	-0.1	-0.4	0.3	-0.7
Heart disease (mother)	0.2	0.2	1.7	-0.1	-0.0	-0.1	0.1	0.4	-0.2	0.2	1.3	0.5	0.4	-0.0	0.2
Suffer from ‘nerves’	0.2	0.4	1.4	-0.3	-0.2	-0.1	-0.4	1.2	0.1	-0.1	1.1	0.7	0.1	0.8	0.8
Knee pain experienced in last month	0.2	0.3	2.2	-0.8	-0.1	-0.5	0.1	0.3	-0.5	-0.3	1.5	0.2	-0.2	0.2	0.5
Smoking status: Previous	0.2	0.2	1.2	0.3	-0.2	0.2	0.3	-0.2	0.3	0.5	0.8	0.2	0.6	-1.1	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	-0.4	-0.2	-0.2	-0.1	-0.6	-0.2	-0.2	0.9	-0.4	-0.1	-0.6	-0.2
Qualifications: nursing, teaching	0.2	0.3	1.0	0.6	0.5	0.5	0.3	-0.8	0.2	0.3	-1.0	0.3	0.2	0.0	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.3	0.4	0.4	0.3	-0.2	-0.3	0.2	-0.1	-1.1	-0.0	-0.3	0.9	-0.1
Eye problems/disorders: Glaucoma	0.2	0.3	1.9	-0.0	-0.7	0.3	-0.2	-0.3	0.2	0.3	1.4	0.5	0.3	0.1	0.2
Medication: Paracetamol	0.2	0.3	1.4	0.0	0.2	-0.3	0.2	0.9	0.1	0.2	0.1	1.2	0.4	0.2	1.0
Age started oral contraceptive pill	0.2	0.2	0.4	0.5	0.2	0.3	0.6	-0.5	0.3	0.5	-0.3	0.5	0.5	-0.6	-0.5
Heart disease (siblings)	0.2	0.2	1.1	0.2	-0.9	-0.1	-0.4	0.1	0.2	-0.1	0.5	-0.4	-0.3	1.0	0.4
Blood Red Count	0.1	0.6	2.4	-0.8	-1.6	-0.1	-0.4	1.3	-0.1	0.0	-0.5	-0.4	0.2	-1.5	0.2
Systolic Blood Pressure	0.1	0.6	1.6	-0.7	-1.2	-0.9	-0.5	-0.7	-1.1	-0.7	0.5	-0.5	-0.5	-0.6	-0.6
Cardiovascular Disease	0.1	0.4	1.3	-0.5	-0.7	-0.1	-0.4	1.2	-0.1	0.1	1.0	0.3	0.4	-0.8	0.6
Lung FEV1/FVC ratio	0.1	0.7	2.5	-0.6	-0.7	0.1	0.5	0.8	0.4	0.6	1.6	-0.5	0.7	-1.3	0.8
Hair Pigment	0.1	1.7	2.9	1.5	1.3	1.3	1.6	0.5	1.4	1.4	1.7	0.8	1.4	0.9	1.2
Hand grip strength (left)	0.1	0.2	0.7	-0.1	0.4	-0.2	-0.1	0.1	-0.6	-0.4	-0.9	0.1	-0.3	-0.5	-0.5
Sensitivity / hurt feelings	0.1	0.2	0.9	-0.9	-1.0	-0.4	-0.4	0.3	-0.5	-0.3	-0.1	0.5	-0.1	-0.4	-0.0
Hearing difficulty/problems: Yes	0.1	0.1	0.9	-0.4	0.1	-0.3	0.1	-0.1	-0.3	-0.1	-0.5	-0.2	-0.1	-1.0	-0.5
Medication: Metformin	0.1	0.2	0.7	0.0	-0.3	-0.6	-0.1	-0.4	-0.3	-0.3	-0.9	-0.1	-0.2	-0.6	-0.2
Severe depression (siblings)	0.1	0.1	0.4	0.3	0.5	-0.1	0.5	-0.7	0.1	0.3	0.5	0.2	0.3	0.2	-0.2
Pack years adult smoking proportion	0.1	0.2	0.7	0.3	0.7	0.2	-0.1	0.6	0.1	0.1	0.2	0.5	0.1	0.8	0.5
Hand grip strength (right)	0.1	0.3	1.9	-0.3	-0.1	-0.3	-0.3	0.0	-0.7	-0.6	-1.4	0.0	-0.4	-0.2	-0.6
Maternal smoking around birth	0.1	0.2	0.8	0.4	-0.3	0.4	0.4	-0.2	0.4	0.5	0.9	0.2	0.4	-0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.6	-0.2	-0.5	0.3	0.3	-0.2	-0.0	0.2	0.8	0.3	0.3	-0.2	0.1
Number of incorrect matches in round	0.1	0.2	0.7	0.3	0.1	0.3	0.6	-0.8	0.4	0.5	0.1	0.2	0.5	-0.3	-0.1
Nervous feelings	0.1	0.2	1.6	0.2	-0.1	0.0	-0.1	0.0	-0.2	-0.3	-0.3	0.8	-0.3	1.3	-0.2
Had menopause	0.1	0.1	0.3	0.5	-0.4	0.4	-0.2	0.2	0.4	0.4	0.0	0.3	0.3	0.5	0.2
Medication: Ramipril	0.1	0.1	0.3	-0.4	-0.4	-0.3	-0.0	0.4	-0.2	0.1	0.4	0.4	0.3	-0.5	0.2
Medication: Simvastatin	0.1	0.2	1.4	0.1	0.0	-0.2	0.3	-0.0	0.0	0.2	0.3	0.1	0.4	-1.2	0.2
Fluid intelligence score	0.1	0.1	0.4	0.6	-0.2	0.6	0.1	-0.1	0.4	0.3	-0.4	0.4	0.2	-0.0	0.1
Father’s age at death	0.1	0.1	0.3	-0.2	0.3	-0.3	-0.0	0.1	-0.5	-0.6	-0.1	-0.2	-0.5	-0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.1	-0.8	0.3	0.2	-0.3	-0.2	-0.4	-0.2	0.4	-0.6	-0.1	-1.0	-0.5
Medication: Cholesterol lowering	0.1	0.2	0.8	0.2	0.4	-0.1	0.1	-0.0	-0.0	0.2	0.9	0.1	0.3	-0.7	0.5
Length of working week for main job	0.1	0.2	0.8	-0.0	-0.4	0.2	-0.2	0.4	0.1	0.2	0.9	0.6	0.3	0.2	0.3
Peak expiratory flow (PEF)	0.1	0.3	1.5	-0.7	-0.8	-0.1	0.1	-0.3	-0.1	0.2	-0.5	-0.2	0.2	-1.2	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.7	-0.4	-0.9	-0.2	-0.3	-0.1	-0.0	-0.4	-0.5	-0.2	-0.5	0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.6	-0.4	-0.4	-0.5	0.7	-0.2	-0.3	0.5	-0.5	-0.2	-0.4	0.1
Forced vital capacity (FVC), Best measure	0.1	0.5	1.8	-0.9	0.0	0.4	0.3	1.0	0.1	0.5	1.1	0.4	0.7	-1.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.6	-0.6	-0.2	-0.4	-0.0	-0.2	-0.2	0.1	0.2	-0.2	-0.0	-0.2
Neck or shoulder pain in last month	0.1	0.2	0.6	0.1	0.8	0.1	0.5	0.4	0.3	0.3	0.5	0.0	0.4	0.4	0.6
Pulse rate, automated reading	0.1	0.4	1.5	0.7	0.5	0.6	-0.2	0.4	0.3	0.3	0.0	1.1	0.3	1.2	0.7
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	-0.1	0.5	-0.1	0.1	0.5	-0.1	-0.0	-0.3	0.2	0.0	-0.7	-0.0
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.0	0.3	-0.2	-0.2	0.6	-0.1	-0.1	-0.4	0.5	-0.1	-0.1	0.3
Wears glasses or contact lenses	0.1	0.1	0.2	0.4	0.2	0.2	0.3	0.3	0.1	0.2	0.4	0.0	0.3	-0.4	-0.1
Alcohol drinker status: Never	0.1	0.2	0.4	0.3	0.5	0.0	0.3	0.6	0.3	0.4	0.6	0.1	0.4	0.5	0.5
Leg fat percentage (left)	0.1	0.5	2.4	-0.9	-1.0	-0.7	-0.2	0.8	-0.7	-0.4	0.5	-0.2	-0.1	-1.6	0.3
Diastolic blood pressure, automated reading	0.1	0.2	1.0	-0.7	-1.0	-0.4	-0.4	0.8	-0.3	-0.3	-0.4	-0.1	-0.2	-0.2	0.2
Unable to work because of sickness or disability	0.1	0.1	0.4	0.7	-0.0	0.2	-0.1	-0.3	0.3	0.2	-0.1	0.2	0.1	0.6	0.3
Myopia	0.1	0.2	0.7	-0.4	-0.0	-0.4	-0.4	0.2	-0.2	-0.4	-0.8	-0.6	-0.4	-0.5	-0.4
Coronary Artery Disease (CAD)	0.0	0.0	0.2	-0.1	-0.0	-0.2	-0.0	0.1	-0.4	-0.2	-0.4	-0.1	-0.1	-0.2	-0.0
Tanning	0.0	0.5	2.0	-0.8	1.0	0.1	0.5	0.2	-0.1	0.3	1.2	0.2	0.5	-1.4	-0.0
Age when periods started (menarche)	0.0	0.1	0.6	0.2	0.3	0.2	-0.1	0.8	-0.0	0.1	0.1	0.2	0.2	-0.3	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.2	0.4	0.0	-0.0	0.2	-0.2	0.2	0.1	-0.0	-0.2	-0.1	0.5	0.1
Illnesses of father: Heart disease	0.0	0.0	0.2	-0.2	0.4	0.1	-0.1	0.1	0.1	-0.1	0.4	-0.4	-0.2	0.0	-0.1
Cholesterol lowering medication	0.0	0.1	0.5	0.1	-0.2	0.0	0.3	0.1	0.1	0.1	-0.7	0.2	0.1	-0.4	-0.2
Pack years of smoking	0.0	0.0	0.1	-0.1	0.4	-0.0	-0.3	0.2	-0.3	-0.2	0.1	0.1	-0.1	0.1	0.2

Hub : Genes

KIAA1109

Models

Trait associations