Best TWAS P=3.33e-14 · Best GWAS P=1.91e-23 conditioned to 8.13e-19
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | DAP | 0.31 | 0.07 | enet | 28 | 0.20 | 2.8e-15 | 6.1 | -5.8 | 8.0e-09 | 0.09 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | DAP | 0.34 | 0.14 | lasso | 8 | 0.26 | 6.5e-09 | 5.8 | -6.2 | 6.4e-10 | 0.01 | 0.89 | 0.01 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | DAP | 0.31 | 0.19 | lasso | 5 | 0.26 | 1.4e-19 | 5.4 | -5.4 | 7.4e-08 | 0.08 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Colon Transverse | DAP | 0.35 | 0.16 | lasso | 6 | 0.18 | 4.5e-09 | 6.1 | -5.8 | 6.5e-09 | 0.01 | 0.85 | 0.01 | FALSE |
| 5 | GTEx | Esophagus Muscularis | DAP | 0.27 | 0.15 | lasso | 8 | 0.24 | 5.6e-15 | 6.1 | -5.4 | 5.9e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | DAP | 0.26 | 0.08 | lasso | 4 | 0.17 | 4.0e-08 | -2.3 | -5.3 | 8.9e-08 | 0.05 | 0.51 | 0.02 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | DAP | 0.21 | 0.11 | lasso | 5 | 0.16 | 3.9e-13 | 6.1 | -5.9 | 4.1e-09 | 0.05 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Thyroid | DAP | 0.24 | 0.11 | lasso | 7 | 0.13 | 3.3e-10 | 6.1 | -6.0 | 2.3e-09 | 0.03 | 1.00 | 0.00 | FALSE |
| 9 | NTR | Blood | DAP | 0.03 | 0.01 | enet | 19 | 0.02 | 2.2e-06 | 5.8 | -6.9 | 4.6e-12 | -0.07 | 0.97 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DAP | 0.06 | 0.00 | blup | 105 | 0.02 | 1.3e-02 | 5.4 | -7.6 | 3.3e-14 | -0.16 | 0.04 | 0.11 | TRUE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DAP | 0.07 | 0.04 | blup | 105 | 0.04 | 3.4e-05 | 5.8 | -5.5 | 2.8e-08 | -0.05 | 0.54 | 0.02 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DAP | 0.06 | 0.05 | lasso | 3 | 0.04 | 1.7e-05 | 6.1 | -6.3 | 3.0e-10 | -0.02 | 0.63 | 0.01 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DAP | 0.05 | 0.04 | blup | 105 | 0.03 | 7.9e-05 | 5.4 | 6.7 | 2.9e-11 | 0.08 | 0.70 | 0.01 | FALSE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DAP | 0.07 | 0.10 | lasso | 1 | 0.07 | 8.0e-04 | 6.1 | -6.1 | 1.2e-09 | 0.00 | 0.14 | 0.09 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DAP | 0.08 | 0.07 | lasso | 4 | 0.06 | 2.7e-07 | 5.4 | -5.3 | 9.0e-08 | 0.06 | 0.98 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | DAP | 0.07 | 0.07 | lasso | 1 | 0.06 | 1.9e-06 | 5.4 | -5.4 | 8.0e-08 | 0.06 | 0.87 | 0.02 | FALSE |