Best TWAS P=1.02e-53 · Best GWAS P=1.68e-51 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NADKD1 | 0.08 | 0.06 | bslmm | 563 | 0.05 | 1.3e-06 | -2.3 | -7.0 | 1.7e-12 | 0.30 | 0.97 | 0.00 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | SPEF2 | 0.39 | 0.23 | enet | 27 | 0.22 | 1.8e-06 | -5.4 | -6.3 | 3.4e-10 | 0.49 | 0.81 | 0.02 | FALSE |
| 3 | GTEx | Brain Nucleus accumbens basal ganglia | SPEF2 | 0.31 | 0.24 | lasso | 6 | 0.19 | 9.2e-06 | -5.4 | -5.3 | 9.8e-08 | 0.39 | 0.40 | 0.17 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | SPEF2 | 0.26 | 0.01 | enet | 56 | 0.04 | 2.6e-04 | -1.3 | -6.0 | 1.9e-09 | 0.34 | 0.17 | 0.58 | FALSE |
| 5 | METSIM | Adipose | SPEF2 | 0.06 | 0.01 | blup | 522 | 0.03 | 4.0e-05 | 3.1 | -6.7 | 1.5e-11 | 0.37 | 0.74 | 0.02 | FALSE |
| 6 | YFS | Blood | IL7R | 0.03 | 0.01 | bslmm | 467 | 0.01 | 8.1e-05 | 5.9 | 7.1 | 1.4e-12 | -0.39 | 0.82 | 0.05 | FALSE |
| 7 | YFS | Blood | SKP2 | 0.03 | 0.02 | enet | 16 | 0.03 | 4.9e-10 | 5.8 | 6.2 | 6.6e-10 | -0.19 | 0.97 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | SPEF2 | 0.16 | 0.00 | blup | 136 | 0.08 | 1.9e-03 | -6.3 | -6.5 | 7.6e-11 | 0.47 | 0.09 | 0.36 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SPEF2 | 0.09 | 0.00 | blup | 135 | 0.01 | 8.1e-02 | 1.3 | 5.3 | 1.2e-07 | -0.37 | 0.11 | 0.05 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPEF2 | 0.03 | 0.04 | lasso | 5 | 0.02 | 8.4e-04 | -5.4 | -5.4 | 7.5e-08 | 0.39 | 0.38 | 0.09 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL7R | 0.04 | 0.03 | lasso | 3 | 0.02 | 9.8e-04 | -15.0 | -15.4 | 1.0e-53 | 0.96 | 0.00 | 0.99 | TRUE |