Best TWAS P=1.67e-16 · Best GWAS P=1.11e-17 conditioned to 0.0109
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RGMB-AS1 | 0.09 | 0.07 | lasso | 5 | 0.11 | 1.4e-09 | -4.9 | -6.4 | 2.0e-10 | 0.77 | 0.16 | 0.84 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CTD-2007H13.3 | 0.08 | 0.01 | enet | 17 | 0.03 | 8.8e-03 | -7.1 | -6.6 | 3.4e-11 | 0.81 | 0.04 | 0.82 | FALSE |
| 3 | GTEx | Artery Tibial | CTD-2007H13.3 | 0.05 | 0.03 | lasso | 4 | 0.03 | 3.2e-03 | -7.4 | -6.8 | 9.8e-12 | 0.80 | 0.09 | 0.75 | FALSE |
| 4 | GTEx | Esophagus Mucosa | CHD1 | 0.18 | 0.07 | enet | 23 | 0.06 | 4.6e-05 | -7.4 | 5.4 | 7.9e-08 | -0.59 | 0.09 | 0.77 | FALSE |
| 5 | GTEx | Esophagus Mucosa | RGMB-AS1 | 0.08 | 0.03 | lasso | 6 | 0.01 | 3.4e-02 | -5.0 | -5.3 | 1.3e-07 | 0.69 | 0.38 | 0.07 | FALSE |
| 6 | GTEx | Lung | CTD-2007H13.3 | 0.05 | 0.04 | lasso | 2 | 0.03 | 3.9e-03 | -8.6 | -8.0 | 1.5e-15 | 0.94 | 0.01 | 0.97 | FALSE |
| 7 | GTEx | Pancreas | RGMB-AS1 | 0.28 | 0.07 | lasso | 6 | 0.05 | 5.1e-03 | -4.7 | -5.2 | 1.8e-07 | 0.59 | 0.06 | 0.65 | FALSE |
| 8 | GTEx | Testis | CHD1 | 0.15 | 0.08 | lasso | 4 | 0.08 | 1.4e-04 | -7.4 | 7.0 | 2.7e-12 | -0.80 | 0.04 | 0.93 | FALSE |
| 9 | GTEx | Whole Blood | CTD-2007H13.3 | 0.04 | 0.03 | lasso | 4 | 0.02 | 1.1e-02 | -8.4 | -8.2 | 1.7e-16 | 0.91 | 0.02 | 0.96 | TRUE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | CHD1 | 0.05 | 0.02 | bslmm | 366 | 0.03 | 7.7e-05 | -7.3 | 6.3 | 2.6e-10 | -0.68 | 0.03 | 0.93 | FALSE |
| 11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHD1 | 0.04 | 0.01 | blup | 40 | 0.02 | 6.2e-03 | -5.9 | 6.9 | 6.0e-12 | -0.80 | 0.04 | 0.59 | FALSE |