Best TWAS P=5.06e-11 · Best GWAS P=1.05e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | FCHO2 | 0.27 | 0.10 | lasso | 5 | 0.06 | 6.2e-04 | -6.2 | -6.6 | 5.1e-11 | 0.95 | 0.01 | 0.98 | TRUE |
2 | GTEx | Adrenal Gland | FCHO2 | 0.11 | 0.03 | lasso | 3 | 0.01 | 1.2e-01 | -6.2 | -5.7 | 1.4e-08 | 0.96 | 0.03 | 0.84 | FALSE |
3 | GTEx | Artery Aorta | FCHO2 | 0.07 | 0.04 | lasso | 2 | 0.03 | 5.2e-03 | -6.1 | -5.8 | 6.3e-09 | 0.95 | 0.02 | 0.93 | FALSE |
4 | GTEx | Artery Tibial | FCHO2 | 0.14 | 0.03 | enet | 59 | 0.02 | 5.9e-03 | -3.9 | -5.2 | 1.5e-07 | 0.59 | 0.09 | 0.80 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | FCHO2 | 0.10 | 0.04 | lasso | 10 | 0.05 | 6.0e-05 | -6.1 | -5.4 | 7.4e-08 | 0.89 | 0.02 | 0.98 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | FCHO2 | 0.16 | -0.01 | enet | 24 | -0.01 | 7.5e-01 | -3.1 | -5.2 | 1.9e-07 | 0.64 | 0.04 | 0.51 | FALSE |
7 | GTEx | Esophagus Mucosa | FCHO2 | 0.15 | 0.07 | lasso | 2 | 0.09 | 1.1e-06 | -6.1 | 6.0 | 1.4e-09 | -0.95 | 0.06 | 0.94 | FALSE |
8 | GTEx | Nerve Tibial | FCHO2 | 0.10 | 0.08 | enet | 17 | 0.05 | 3.4e-04 | -6.2 | -5.7 | 1.3e-08 | 0.91 | 0.01 | 0.99 | FALSE |
9 | GTEx | Pancreas | FCHO2 | 0.11 | 0.04 | enet | 7 | 0.03 | 1.8e-02 | -3.5 | -5.9 | 3.1e-09 | 0.80 | 0.03 | 0.90 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | FCHO2 | 0.06 | 0.03 | enet | 20 | 0.03 | 2.6e-03 | -6.2 | -5.9 | 4.0e-09 | 0.81 | 0.04 | 0.88 | FALSE |
11 | METSIM | Adipose | FCHO2 | 0.06 | 0.08 | lasso | 5 | 0.08 | 1.9e-11 | -6.1 | -5.8 | 6.1e-09 | 0.96 | 0.01 | 0.99 | FALSE |
12 | NTR | Blood | FCHO2 | 0.04 | 0.03 | lasso | 4 | 0.03 | 2.4e-11 | -6.1 | -5.2 | 1.6e-07 | 0.89 | 0.04 | 0.96 | FALSE |
13 | YFS | Blood | FCHO2 | 0.23 | 0.24 | lasso | 6 | 0.29 | 2.8e-97 | -6.6 | -5.5 | 3.3e-08 | 0.92 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FCHO2 | 0.05 | 0.04 | blup | 84 | 0.04 | 1.9e-09 | -6.3 | -6.5 | 7.9e-11 | 0.94 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Colon Adenocarcinoma | FCHO2 | 0.10 | 0.08 | blup | 84 | 0.08 | 3.6e-05 | -6.3 | -5.2 | 1.6e-07 | 0.93 | 0.01 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FCHO2 | 0.08 | 0.00 | blup | 84 | 0.03 | 1.0e-02 | -3.0 | -5.6 | 1.9e-08 | 0.77 | 0.02 | 0.58 | FALSE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FCHO2 | 0.05 | 0.04 | lasso | 4 | 0.03 | 9.8e-05 | -6.3 | -6.3 | 3.1e-10 | 0.97 | 0.01 | 0.99 | FALSE |
18 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FCHO2 | 0.32 | 0.16 | blup | 84 | 0.21 | 1.0e-05 | -5.8 | -6.0 | 2.1e-09 | 0.85 | 0.05 | 0.90 | FALSE |
19 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FCHO2 | 0.06 | 0.04 | blup | 84 | 0.05 | 8.9e-04 | -5.8 | -5.9 | 4.1e-09 | 0.89 | 0.06 | 0.88 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | FCHO2 | 0.05 | 0.03 | blup | 84 | 0.01 | 1.2e-02 | -4.1 | -5.6 | 2.2e-08 | 0.86 | 0.01 | 0.93 | FALSE |