Hub : Genes

RGMB-AS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0930	0.0290	1.0e-07	0.065	NA	0.110	NA	0.114	5.1e-06	NA	2.6e-09	NA	1.4e-09
2	GTEx	Adipose Visceral Omentum	0.1020	0.0500	2.8e-03	0.016	NA	0.050	NA	0.041	5.0e-02	NA	1.4e-03	NA	3.4e-03
3	GTEx	Adrenal Gland	0.2967	0.1244	3.2e-03	0.042	NA	0.113	NA	0.034	1.2e-02	NA	7.5e-05	NA	2.2e-02
4	GTEx	Esophagus Gastroesophageal Junction	0.1270	0.0560	7.6e-03	0.085	NA	0.014	NA	0.062	5.5e-04	NA	9.6e-02	NA	2.8e-03
5	GTEx	Esophagus Mucosa	0.0800	0.0430	4.5e-03	0.030	NA	0.009	NA	0.015	4.2e-03	NA	8.0e-02	NA	3.4e-02
6	GTEx	Nerve Tibial	0.0780	0.0340	4.6e-04	0.093	NA	0.062	NA	0.062	4.3e-07	NA	3.4e-05	NA	3.5e-05
7	GTEx	Pancreas	0.2780	0.1360	2.8e-03	0.068	NA	0.034	NA	0.046	8.2e-04	NA	1.4e-02	NA	5.1e-03
8	GTEx	Testis	0.4440	0.0740	5.6e-17	0.500	NA	0.477	NA	0.292	3.6e-25	NA	1.2e-23	NA	1.9e-13
9	GTEx	Thyroid	0.1920	0.0530	3.1e-08	0.156	NA	0.156	NA	0.158	5.0e-12	NA	5.4e-12	NA	4.2e-12
10	ROSMAP	Brain Pre-frontal Cortex	0.0261	0.0146	9.9e-03	0.007	0.011	-0.001	0.009	0.002	4.2e-02	0.012	5.5e-01	0.02	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.6	0.9	2.9	-0.3	1.4	-1.7	-0.8	-0.8	-0.0	0.2	-0.7	-0.9	-1.2
Bipolar Disorder or Schizophrenia	1.0	2.4	7.4	-1.6	-0.4	-1.3	-2.2	-1.7	-0.5	-1.5	-1.0	-1.1	-2.7
Depressed Affect (Nagel 2018)	0.3	0.5	1.7	-0.3	-0.9	-0.1	0.9	-0.2	-1.3	-0.0	-0.8	-0.9	-0.7
Depression (Nagel 2018)	0.3	0.5	1.9	0.4	0.0	-1.1	-0.7	0.5	-1.4	0.4	-0.5	-0.3	-0.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.1	-0.2	-0.4	-1.2	0.8	-1.2	-1.5	-0.5	-1.0	-0.8	-1.4
Neuroticism (Nagel 2018)	0.2	0.4	1.1	-0.2	0.6	-1.0	1.0	-0.4	-0.6	-0.1	-0.5	-0.7	0.0
Schizophrenia (2018)	1.2	2.4	6.1	-1.8	-1.7	-0.0	-2.2	-1.5	-0.6	-2.1	-0.7	-0.7	-2.5
Schizophrenia vs Biploar Disorder	1.5	2.0	3.5	-1.5	-1.4	-0.5	-0.9	-1.2	-1.8	-1.9	-1.3	-1.1	-1.8
Worry (Nagel 2018)	0.2	0.4	1.1	-0.2	0.8	-0.9	1.1	-0.5	0.5	-0.4	0.1	-0.2	0.7
Alzheimer’s Disease (in mother)	0.7	0.8	1.7	-0.2	-1.2	-0.7	0.5	0.3	-0.4	-0.9	-1.2	-1.1	-1.3
Alzheimer’s Disease (in father)	0.6	0.7	2.4	0.8	-0.4	0.9	-1.6	0.7	0.7	0.6	0.8	0.9	0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	2.0	0.3	-0.6	0.8	-1.4	0.6	0.2	0.1	0.0	0.2	-0.7
Crohns Disease (2017)	0.4	0.8	4.6	-0.1	-2.1	-0.5	1.1	0.6	-0.7	-0.7	-0.6	-0.2	0.1
Irritable Bowel Disease (IBD)	0.6	1.4	7.2	-0.6	-2.7	0.0	-0.9	0.1	-1.4	-1.5	-0.7	0.2	-0.5
Ulcerative Colitis (UC)	0.7	1.3	5.3	-0.7	-1.7	0.3	-2.3	-0.0	-1.0	-1.3	-0.4	0.3	-1.0
Major Depression (MDD)	0.4	0.5	2.3	-1.5	-0.6	0.3	-0.7	-1.2	-0.2	-0.1	0.2	0.0	-0.1
Reaction Time	0.9	1.8	8.9	-0.2	-0.1	2.2	3.0	0.3	1.0	-0.2	1.3	0.5	0.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.6	-0.4	-1.3	-1.2	0.7	-0.6	-1.3	-0.8	-1.0	-0.8	-0.9
Breast Cancer	0.7	1.7	4.1	-1.2	0.4	-2.0	-0.4	-1.0	-0.5	-1.7	-1.5	-1.8	-1.3
Ovarian Cancer	0.5	0.6	2.3	-0.9	-1.5	0.7	-0.1	-0.9	0.6	-1.0	-0.2	-0.3	-0.4
Prostate Cancer	0.2	0.3	1.2	0.8	0.3	-0.3	-0.1	0.6	0.0	1.1	0.5	0.8	-0.1
Age at First Birth	0.5	0.7	2.4	-0.1	1.5	0.3	1.4	0.2	1.0	-0.1	0.1	-0.9	0.5
Bipolar Disorder (2011)	2.5	2.4	8.1	-2.9	-1.1	-1.1	0.1	-2.2	-0.6	-1.1	-1.3	-1.7	-1.7
Body Mass Index (BMI) (2010)	2.9	4.0	11.9	-3.5	-2.2	-0.3	-0.7	-3.2	-1.2	-2.6	-1.2	-1.4	0.2
Coronary Artery Disease (CAD)	1.8	2.2	5.2	-2.2	-1.4	-0.7	-0.6	-2.3	-1.4	-1.4	-0.9	-1.3	-1.5
Crohns Disease (2012)	0.4	0.6	2.5	-0.3	-1.1	-0.5	1.6	-0.1	-0.6	-0.2	-0.8	-0.7	-0.8
Mean Putamen Volume	0.4	0.4	1.0	0.9	0.3	1.0	0.2	0.8	0.1	0.6	0.7	0.8	-0.1
Fasting Glucose	0.3	0.3	1.3	0.5	-0.1	-0.6	0.2	0.7	0.6	0.5	0.5	0.3	1.1
HbA1C	2.5	2.8	5.6	-2.4	-2.1	-1.4	0.6	-2.0	-1.0	-2.3	-1.8	-0.8	-1.2
HDL Cholesterol	0.1	0.1	0.5	0.1	-0.4	0.1	0.5	-0.5	-0.7	0.3	0.2	-0.2	0.4
LDL Cholesterol	0.3	0.5	1.4	-1.2	-0.2	-0.4	-0.1	-1.0	-0.4	-0.8	-1.1	-0.6	-0.3
Lupus	0.5	0.7	1.8	0.5	-1.3	-0.5	-1.3	1.4	-0.2	0.3	-0.2	0.4	-1.1
Neuroticism (2016)	0.4	0.6	1.6	-0.6	0.7	-1.0	-1.3	-1.2	0.7	0.3	0.4	-0.5	0.6
Primary Biliary Cirrhosis	1.3	1.8	4.8	-0.1	-2.2	-0.5	-0.8	-0.1	-1.4	-1.9	-1.6	-0.8	-1.9
Rheumatoid Arthritis	0.2	0.3	1.4	1.2	0.1	-0.5	-0.6	0.8	-0.2	0.6	-0.1	0.1	0.1
Schizophrenia (2014)	1.3	2.9	6.2	-1.7	-1.6	-0.9	-2.3	-1.4	-0.9	-2.3	-1.4	-1.0	-2.5
Triglycerides	1.4	2.3	5.2	-1.5	-0.2	-1.3	-1.0	-1.2	-1.6	-1.6	-1.8	-1.8	-2.3
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.3	-0.1	1.0	-1.5	-0.0	-0.3	-0.5	-0.6	-1.7	-1.6	-2.1
Ulcerative Colitis	1.0	1.5	5.1	-0.3	-2.0	-0.2	-2.2	0.2	-1.1	-1.5	-0.7	-0.1	-1.2
Blood Eosinophil Count	2.4	18.8	40.4	-6.4	-4.5	-1.2	0.0	-5.3	-4.2	-5.2	-3.8	-4.3	-4.5
Blood Platelet Count	0.4	4.8	14.3	2.5	3.8	0.9	2.9	1.1	0.5	2.4	2.1	1.1	2.4
Blood Red Count	0.4	3.5	7.6	2.7	1.0	0.3	-2.8	2.6	1.2	1.8	1.8	1.9	1.1
Blood White Count	0.1	0.4	1.6	1.1	1.3	0.2	0.5	0.6	-0.4	-0.2	0.1	0.5	0.3
Heel T-Score	0.8	6.6	26.8	-1.8	-1.7	-1.5	-5.2	-1.8	-2.6	-2.9	-1.9	-2.4	-1.8
BMI	0.3	1.8	4.8	-2.1	-2.2	0.1	-0.2	-1.9	-1.3	-1.2	-0.7	-1.2	-0.4
Height	0.3	6.1	18.3	-1.2	-1.9	-3.5	-4.3	-0.8	-1.6	-0.5	-2.4	-1.2	-3.9
Waist Hip Ratio (WHR)	0.6	2.5	6.9	1.9	0.9	-1.5	2.6	1.4	1.6	0.8	0.6	0.4	2.3
Systolic Blood Pressure	0.7	3.3	6.1	-0.5	2.3	-2.2	0.6	-1.2	-2.5	-0.7	-2.3	-2.2	-2.2
Smoking Status	0.2	0.6	3.6	0.4	-0.2	0.7	1.9	0.6	-0.1	0.2	0.4	0.7	0.7
Allergy or Eczema	1.3	3.6	7.2	2.2	-0.4	2.4	-0.6	2.6	1.2	2.1	1.9	2.7	0.9
Cardiovascular Disease	0.8	2.6	8.0	-1.5	1.3	-1.4	-0.4	-2.8	-2.4	-0.5	-0.7	-1.5	-1.8
Hypothyroidism (self reported)	0.6	1.5	8.4	-0.3	1.2	-1.1	2.9	-1.0	-0.6	-0.4	-0.4	-0.9	1.1
Respiratory disease	4.4	9.8	21.0	2.4	1.8	2.5	2.6	2.1	3.7	3.1	3.9	3.4	4.6
Type 2 Diabetes (T2D) (2018)	4.1	7.6	10.5	-2.6	-2.8	-3.0	0.0	-2.4	-3.0	-2.9	-3.2	-3.2	-2.9
Lung FEV1/FVC ratio	7.1	36.2	54.6	-7.4	-5.1	-4.4	-4.8	-6.1	-6.1	-6.4	-6.0	-6.1	-7.0
Lung FVC	1.8	8.9	18.4	-1.8	-3.4	-2.1	-2.2	-1.4	-2.7	-4.2	-4.3	-3.2	-3.0
Neuroticism	0.2	0.5	1.6	0.4	1.2	-0.9	0.7	-0.1	0.3	1.0	0.9	0.0	0.8
Chronotype (morning person)	0.6	1.3	8.6	-0.4	-1.3	0.4	-2.9	-0.7	-0.5	-0.8	-0.1	0.0	0.9
Hair Pigment	0.1	3.8	13.7	3.2	-0.0	-1.0	-2.9	3.7	0.2	1.1	0.3	1.8	-0.5
Tanning	0.1	1.6	4.3	0.3	0.3	1.6	-1.4	1.0	2.1	0.9	1.6	1.3	1.0
Hand grip strength (left)	0.9	2.3	4.8	0.8	0.8	1.7	-1.1	1.1	1.3	1.7	2.1	2.2	1.7
Number of treatments/medications taken	0.3	0.6	1.6	-0.8	-0.2	-0.3	0.6	-1.3	-0.6	-1.1	-0.1	-1.1	0.1
Average weekly spirits intake	0.2	0.3	1.1	0.1	-1.0	-0.3	0.7	0.6	0.2	-0.4	-0.3	-0.5	0.3
Sensitivity / hurt feelings	0.6	1.1	4.1	0.7	2.0	-1.7	1.2	0.2	0.0	1.2	-0.2	-0.6	-0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.1	0.4	-0.6	0.9	-0.4	-0.7	0.2	-0.1	-0.4	0.6
Hearing difficulty/problems: Yes	0.7	1.1	2.7	1.2	-0.0	-0.1	-1.6	0.9	1.1	1.6	1.1	0.7	0.1
Relative age of first facial hair	2.8	5.8	10.7	2.0	2.7	2.1	1.7	2.0	2.5	3.3	2.6	3.0	1.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	1.0	0.4	-0.5	-0.6	0.6	-0.6	-0.1	-0.3	-0.2	-0.3
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.4	-1.8	-1.7	-0.7	-0.5	-2.1	-1.1	-1.8	-1.4	-1.4	-0.2
Ever had hysterectomy (womb removed)	1.2	1.4	10.4	0.5	-0.3	-1.5	-3.2	-0.1	0.3	0.2	-0.4	0.3	-0.7
Systolic blood pressure, automated reading	0.1	0.4	1.2	0.3	1.1	-0.5	0.6	-0.0	-0.2	-0.0	-0.9	-0.7	-0.8
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	5.5	-1.4	-2.4	-1.0	1.1	-0.6	-0.6	-1.7	-1.8	-1.6	-1.9
Angina	1.3	1.7	5.2	-0.7	-1.8	-0.6	-1.7	-1.1	-1.5	-2.3	-1.1	-0.8	0.4
Medication for hormone replacement therapy	0.3	0.4	1.9	-0.2	-0.6	-0.3	-0.2	-0.3	-0.1	-1.4	-0.9	-0.7	-0.0
Vitamin and mineral supplements	0.5	0.6	2.6	0.9	-0.2	-0.5	-1.4	0.7	-1.6	-0.0	-0.5	-0.1	-0.1
Supplements: Zinc	0.9	1.0	3.4	0.9	0.2	1.8	1.3	0.9	1.3	0.1	0.7	0.6	1.0
Medication: Co-codamol	0.2	0.2	0.6	0.2	-0.2	-0.7	-0.8	0.2	0.3	0.1	0.5	0.6	-0.5
Medication: Metformin	4.5	6.3	11.0	-2.1	-2.1	-3.3	0.1	-1.8	-2.7	-2.2	-3.1	-3.1	-3.0
Diabetes (father)	4.7	5.9	10.8	-3.3	-1.9	-1.9	-1.4	-2.8	-1.9	-2.1	-2.4	-2.9	-2.9
Diabetes (mother)	0.8	1.1	2.7	-1.3	-0.8	-0.4	1.6	-0.9	-0.0	-1.2	-1.0	-1.4	-0.1
Severe depression (siblings)	2.3	2.6	8.0	-2.0	-2.8	-0.8	0.1	-1.7	-1.7	-1.7	-1.0	-1.7	-0.8
Pack years adult smoking proportion	1.4	2.2	4.2	2.0	0.7	0.2	-0.8	1.8	1.3	1.8	1.6	1.7	1.6
Impedance of leg (right)	2.3	11.2	20.6	3.7	4.5	1.1	-1.2	3.1	4.3	3.7	3.5	3.8	2.6
Leg fat-free mass (left)	1.1	6.0	16.9	-2.9	-4.1	-1.3	-1.0	-2.1	-2.6	-2.1	-2.2	-2.4	-2.4
Trunk fat percentage	0.2	0.7	3.7	-0.6	-0.4	-1.9	-0.1	-0.4	0.0	0.0	-0.7	-1.1	-0.7
Hand grip strength (right)	0.7	2.0	4.6	0.6	0.1	1.2	-1.4	1.0	1.6	1.5	2.0	2.1	1.3
Townsend deprivation index at recruitment	0.3	0.4	1.5	-0.7	-0.2	1.2	-0.5	0.1	0.5	0.2	1.0	0.4	0.8
Current tobacco smoking	0.3	0.5	0.9	0.4	1.0	0.5	0.8	0.5	0.5	0.3	0.9	0.9	0.8
Average weekly fortified wine intake	0.4	0.4	1.4	-0.7	0.1	-0.8	-1.2	-0.7	-0.9	-0.5	-0.1	-0.1	0.2
Maternal smoking around birth	0.6	0.8	1.7	1.3	0.3	0.4	-0.6	1.0	0.9	0.9	0.7	1.3	1.0
Fed-up feelings	0.2	0.3	1.6	0.3	-0.8	0.5	1.3	0.1	-0.3	0.2	-0.4	-0.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	0.3	-0.1	-1.2	-0.3	0.7	-1.3	-0.2	-0.7	-0.3	-0.6
Relative age voice broke	2.2	3.3	6.4	1.0	2.5	1.3	2.5	0.9	1.5	2.5	2.0	1.7	1.3
Taking other prescription medications	0.1	0.2	0.9	-0.1	-0.9	-0.3	0.1	-0.2	-0.1	-0.7	-0.1	-0.2	0.5
Age when periods started (menarche)	0.2	0.4	2.5	-0.1	1.6	0.4	0.4	-0.1	0.9	0.2	0.5	0.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	4.8	0.0	0.1	-1.7	-2.2	-0.4	0.4	1.0	-0.0	0.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.8	-0.9	-0.8	-0.9	-1.9	-0.9	-1.5	-1.0	-1.5	-1.5	-1.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	4.1	0.9	2.0	0.5	-0.5	1.1	0.7	0.4	0.2	0.2	0.1
Qualifications: CSEs or equivalent	4.2	5.5	12.5	2.9	3.5	0.5	-0.2	2.2	2.4	2.8	2.2	2.3	2.4
Serious illness, injury or assault to yourself	0.4	0.5	2.2	0.8	-0.3	-1.5	-0.9	0.6	0.2	0.6	-0.2	0.0	-0.5
High blood pressure	0.6	1.7	4.5	-0.7	2.1	-1.3	0.9	-1.6	-1.5	-0.2	-0.6	-1.4	-1.7
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.1	2.0	-0.4	2.5	-0.3	2.2	1.1	1.8	1.8	2.4	1.1
Multivitamins +/- minerals	0.4	0.6	3.1	-0.6	-0.8	0.4	1.8	-0.0	1.2	-0.1	0.0	-0.2	-0.1
Stomach or abdominal pain in last month	0.3	0.4	1.4	-0.4	0.0	-0.3	0.4	-1.2	-1.0	-0.4	-0.4	-0.9	-0.3
Supplements: Glucosamine	0.3	0.3	3.2	0.2	0.0	0.2	1.8	-0.3	-0.1	-0.0	-0.2	-0.2	0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.5	0.5	-0.3	0.1	0.2	-0.0	0.4	-0.1	-0.2	0.2
Medication: Atenolol	3.3	4.2	7.2	-1.6	-0.2	-1.6	-1.8	-1.8	-2.5	-2.1	-2.4	-2.6	-2.7
Medication: Levothyroxine sodium	0.5	0.9	2.3	1.0	1.1	-1.5	0.7	0.0	-1.5	-0.1	-1.0	-0.7	-0.2
Sitting height	0.1	0.6	2.0	0.8	-0.1	-0.1	-0.7	0.9	-0.4	1.2	0.1	0.3	-1.4
Chronic bronchitis/emphysema (father)	1.1	1.3	3.4	1.1	0.3	1.4	-0.4	1.1	1.4	0.7	1.6	1.8	0.4
High blood pressure (mother)	0.4	0.6	2.3	-0.2	-0.1	1.5	0.2	-0.5	-0.9	0.3	1.3	0.3	-0.4
Body mass index (BMI)	0.3	1.3	5.1	-1.4	-2.3	-0.9	-0.6	-1.0	-1.1	-0.8	-0.7	-1.0	-0.8
Impedance of leg (left)	2.3	11.2	25.1	3.6	5.0	0.7	-1.0	3.1	4.1	3.8	3.5	3.5	2.7
Leg predicted mass (left)	1.1	5.8	16.9	-2.8	-4.1	-1.3	-0.9	-2.1	-2.6	-2.1	-2.1	-2.3	-2.3
Trunk fat mass	0.4	1.7	4.6	-1.4	-1.6	-2.1	-0.8	-1.0	-0.7	-0.6	-1.2	-1.5	-1.3
Waist circumference	0.2	0.7	2.7	-0.8	-1.6	-1.4	-0.0	-0.8	-0.6	-0.5	-0.3	-0.8	-0.2
Number of incorrect matches in round	0.1	0.2	0.7	0.1	0.1	0.9	0.8	-0.0	0.1	-0.0	0.0	-0.2	0.7
Past tobacco smoking	0.3	0.6	2.0	0.1	0.4	0.4	-1.4	0.1	0.5	0.4	0.9	0.5	1.4
Alcohol usually taken with meals	0.3	0.6	1.9	1.1	0.5	-0.2	-1.1	0.6	-0.5	-0.0	-0.7	-0.2	-1.4
Nervous feelings	0.8	1.6	3.7	-1.1	0.7	-1.9	0.6	-1.4	-0.5	-1.5	-1.4	-1.9	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.6	-1.3	-0.2	-0.7	-0.0	-1.1	-0.4	-0.6	-0.5	-1.0	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	1.0	-0.4	0.7	0.3	-1.0	-0.9	-0.1	0.3	0.3	0.0	-0.4
Hair/balding pattern: Pattern 2	0.4	0.5	2.2	-0.8	-0.6	-0.2	0.1	-0.6	-1.5	-0.4	-0.3	-0.7	-0.3
Had menopause	0.5	0.6	1.9	-0.4	-1.4	-0.4	-0.8	-0.6	-1.1	-0.4	-1.0	-0.7	-0.4
Had other major operations	0.3	0.3	0.7	0.8	-0.5	-0.6	-0.9	0.5	0.3	0.6	0.5	0.5	0.4
Forced vital capacity (FVC)	1.5	5.8	10.1	-2.5	-3.0	-1.4	-1.1	-1.4	-2.2	-3.1	-3.2	-2.3	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	7.8	-1.2	-1.3	-0.6	-2.8	-1.0	-1.6	-1.5	-1.3	-1.3	-1.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.2	-0.5	-1.8	-1.7	-0.0	0.2	-0.6	-1.4	-1.3	-1.0	-0.9
Qualifications: None of the above	0.5	1.1	5.2	-0.2	-0.3	-0.2	0.3	-0.2	2.3	-0.3	0.9	0.3	2.2
Financial difficulties in last 2 years	0.3	0.4	1.8	0.6	1.3	-0.0	0.1	0.4	-0.5	1.0	0.1	-0.4	-0.7
Mouth/teeth dental problems	0.2	0.4	2.2	-0.1	0.2	-0.1	0.9	0.6	1.5	0.3	0.2	-0.2	-0.2
Heart attack	1.2	1.6	4.3	-1.3	-1.5	0.6	-2.1	-1.2	-1.2	-2.0	-0.6	-0.4	0.0
Allergy	2.3	5.4	9.6	-2.6	-0.5	-2.7	-0.1	-2.4	-2.2	-2.4	-2.7	-3.1	-2.5
Pain all over the body in last month	0.1	0.1	0.4	0.6	0.2	-0.3	0.5	0.4	0.3	-0.1	0.1	0.2	0.2
Diabetes (self-reported)	2.0	3.1	5.2	-1.2	-2.3	-2.0	0.3	-0.7	-1.6	-1.6	-2.2	-2.1	-2.3
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	6.6	1.8	0.5	2.4	0.4	2.1	1.5	1.8	2.1	2.6	1.4
Medication: Ramipril	1.2	1.5	2.7	-1.5	-0.5	0.0	0.2	-1.6	-1.6	-1.5	-1.3	-1.6	-1.1
Medication: Simvastatin	3.1	4.6	11.2	-2.0	-1.3	-1.4	-0.4	-2.6	-3.3	-1.9	-2.4	-2.5	-2.0
Fluid intelligence score	0.2	0.4	1.6	0.4	-0.3	-0.4	1.0	0.1	-0.6	0.3	-0.4	0.0	-1.3
Illnesses of siblings	0.4	0.6	1.8	0.2	-1.1	0.8	-0.2	0.8	1.3	-0.4	0.5	0.9	-0.1
Neuroticism score	0.4	0.8	2.8	0.2	1.7	-0.2	1.5	-0.4	0.5	1.0	0.8	-0.1	1.1
Weight	0.6	2.9	9.5	-1.9	-3.1	-1.4	-1.4	-1.3	-1.4	-1.1	-1.3	-1.4	-1.8
Impedance of arm (right)	0.3	1.5	9.9	0.5	3.1	-0.7	1.0	0.1	1.5	0.6	-0.3	-0.3	-0.5
Arm fat percentage (right)	0.4	1.4	3.1	-1.4	-1.1	-1.7	0.4	-1.1	-0.5	-0.7	-1.3	-1.7	-1.2
Trunk fat-free mass	0.8	4.5	17.6	-2.3	-4.2	-0.7	-2.2	-1.7	-2.1	-1.5	-1.2	-1.1	-2.2
Hip circumference	0.6	2.6	6.5	-1.9	-2.5	-0.9	-2.2	-1.5	-1.7	-1.0	-0.8	-1.2	-1.4
Time employed in main current job	0.7	0.8	2.4	-0.6	-0.6	-0.9	-1.1	-0.2	-0.2	-1.2	-1.6	-0.9	-1.0
Alcohol intake versus 10 years previously	0.4	0.6	2.7	-0.4	0.6	0.5	1.6	-0.3	0.6	-1.0	-0.5	-0.9	0.8
Father’s age at death	0.2	0.2	1.5	0.1	-1.2	0.0	0.2	0.1	0.2	0.3	0.4	0.4	0.2
Worrier / anxious feelings	0.6	1.2	3.8	1.1	2.0	-0.4	1.1	0.6	0.6	1.1	0.7	0.5	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	2.5	0.1	-0.1	0.4	-1.6	0.4	-0.5	0.3	0.8	0.4	-0.2
Falls in the last year	0.3	0.4	1.3	-0.7	-1.1	-0.3	0.1	-0.1	-0.5	-0.7	-0.5	-0.8	-0.8
Hair/balding pattern: Pattern 3	0.2	0.3	1.2	0.1	-0.2	0.8	0.5	-0.2	1.1	-0.9	-0.3	-0.0	0.6
Number of live births	0.5	0.7	4.5	0.0	-2.1	-0.4	-1.0	-0.0	-0.8	-0.5	-0.3	0.2	0.0
Forced expiratory volume in 1-second (FEV1)	3.2	10.9	17.3	-3.7	-4.0	-1.8	-2.6	-2.3	-3.2	-4.2	-3.9	-2.8	-3.7
Pulse rate	0.8	1.3	3.1	0.8	1.2	0.7	-0.7	0.9	1.1	1.2	1.6	1.8	0.9
Happiness	3.4	4.2	7.6	-2.7	-2.1	-0.2	1.5	-2.6	-1.9	-2.4	-2.0	-2.4	-1.1
Noisy workplace	4.0	5.0	9.3	2.3	2.4	1.8	0.2	2.0	2.6	3.0	2.6	2.3	1.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.8	0.4	0.8	0.1	2.0	-0.2	-0.4	-0.1	-0.8	-0.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	5.7	0.5	-0.4	2.4	0.2	0.2	0.4	0.8	1.5	1.3	1.6
Mouth/teeth dental problems: Dentures	0.2	0.3	1.3	0.8	0.6	0.3	-0.7	-0.2	-1.1	-0.2	0.0	0.2	0.2
Asthma	2.7	5.3	12.1	2.1	1.0	2.2	1.9	1.9	2.8	2.0	2.5	2.2	3.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	9.5	0.1	-1.7	0.4	-3.1	0.2	-0.6	-1.1	-0.2	0.2	-0.2
Medication: Cholesterol lowering	0.9	1.4	3.4	-0.7	-0.9	-0.8	-0.7	-1.0	-1.8	-1.3	-1.7	-1.6	-0.7
Depression (self-reported)	0.2	0.3	1.0	-0.2	0.4	1.0	0.4	-0.5	-0.1	0.6	0.5	0.5	-0.2
Medication: Lansoprazole	1.1	1.2	6.4	-0.1	0.6	-2.5	-0.8	-1.1	-0.1	-0.7	-1.3	-1.3	-0.2
Prospective memory result	3.0	3.7	7.5	2.2	1.2	1.3	-0.5	2.0	2.7	1.7	2.0	2.0	2.5
Lung cancer (father)	1.1	1.2	3.7	0.7	1.9	-0.8	0.3	1.2	1.8	1.3	0.5	0.8	0.5
Illnesses of mother	0.1	0.2	0.5	-0.2	0.3	-0.5	-0.0	0.0	0.7	-0.1	-0.4	0.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	3.2	10.3	19.4	-3.3	-3.6	-1.8	-2.4	-2.2	-3.3	-4.4	-3.9	-2.9	-3.3
Pulse wave Arterial Stiffness index	0.2	0.2	1.5	0.3	1.2	0.1	0.2	-0.1	-0.4	-0.0	-0.4	0.1	-0.3
Impedance of arm (left)	0.2	1.0	5.6	0.8	2.4	-0.6	0.1	0.5	1.6	0.6	-0.2	0.0	-0.3
Arm fat mass (right)	0.5	1.9	4.1	-1.6	-2.0	-1.6	-0.8	-1.2	-1.0	-0.9	-1.3	-1.5	-1.4
Trunk predicted mass	0.8	4.8	18.5	-2.4	-4.3	-0.8	-2.2	-1.8	-2.2	-1.6	-1.3	-1.1	-2.3
Standing height	0.3	2.7	5.9	-1.5	-2.3	-1.7	-2.4	-0.8	-1.0	-0.8	-1.4	-1.1	-2.4
Length of working week for main job	0.1	0.2	0.4	-0.1	0.1	-0.0	-0.5	-0.3	-0.2	-0.6	-0.7	-0.3	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.3	-0.4	0.8	0.5	-0.0	-0.5	-0.8	0.5	-0.1	0.2
Breastfed as a baby	0.4	0.5	2.5	0.6	-1.6	0.9	-0.2	0.3	-0.2	-0.0	0.2	0.8	0.3
Tense / ‘highly strung’	0.6	1.1	2.9	-1.0	0.5	-1.2	1.7	-1.5	-0.2	-0.9	-0.5	-1.0	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	-0.4	-0.8	-0.7	1.0	-0.4	-0.5	-0.7	-0.6	-1.2	-0.1
Hair/balding pattern: Pattern 4	0.7	1.8	4.6	0.6	0.2	2.2	0.7	1.0	0.5	1.5	2.0	1.7	1.4
Birth weight of first child	1.7	3.1	6.1	-2.5	-1.5	-2.0	-0.3	-2.3	-1.3	-1.6	-1.9	-1.9	-1.4
Peak expiratory flow (PEF)	0.4	1.0	3.1	-0.6	-1.3	0.4	-1.8	-0.1	-0.7	-1.0	-1.1	-0.1	-1.5
Pulse wave reflection index	0.5	0.7	2.9	0.3	0.4	-0.8	0.6	-0.3	-1.7	-0.4	-1.2	-0.8	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.5	0.1	0.4	0.2	-0.3	-0.4	-0.7	-0.5	-0.5	-0.5
Loud music exposure frequency	0.5	0.6	2.2	-0.2	1.5	0.5	0.8	-0.7	0.7	0.8	0.9	0.3	0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.7	0.7	-0.9	-0.0	0.0	-0.8	-0.1	-0.7	0.0	-0.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.3	-1.4	-1.2	-1.1	-0.6	-1.5	-1.5	-0.8	-1.1	-1.3	-1.1
Blood clot in the leg (DVT)	0.4	0.6	1.1	1.1	-0.3	0.7	-1.0	1.1	-0.4	0.8	-0.1	1.1	0.2
Medication: Paracetamol	2.3	3.8	10.0	2.2	0.8	0.8	-0.8	1.7	2.3	1.8	2.1	2.2	3.2
Headache pain in last month	0.3	0.5	2.0	0.8	0.1	-0.6	0.4	1.2	0.6	0.3	0.1	-0.1	1.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.9	1.0	0.5	0.6	0.2	1.6	2.0	1.3	1.5	1.3	0.7
Glaucoma (self-reported)	1.2	1.4	4.1	0.9	0.9	2.0	0.3	0.5	-0.1	1.4	1.7	1.7	0.7
Gout (self-reported)	1.3	1.7	6.1	0.5	0.4	2.0	1.5	-0.0	1.0	0.5	1.5	1.0	2.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.7	0.6	1.3	-0.8	1.0	-0.1	-0.5	0.5	0.5	0.2	1.0
Medication: Amlodipine	1.8	2.6	4.4	-1.2	1.3	-2.1	1.4	-1.6	-1.8	-0.7	-1.7	-2.1	-1.6
Medication: Ventolin 100micrograms inhaler	6.3	8.1	14.0	3.5	2.2	3.3	1.5	3.1	2.7	2.2	2.8	2.7	3.7
Birth weight	0.1	0.3	1.1	0.1	-0.7	-0.6	-0.4	0.3	0.4	0.8	0.2	-0.0	1.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.2	0.9	1.2	-1.2	1.5	0.5	-0.3	0.5	-0.4	-0.7	0.2
High blood pressure (siblings)	1.1	1.6	3.6	-1.2	0.2	-1.5	-1.2	-1.5	-1.9	-0.5	-1.1	-1.6	-1.0
Forced vital capacity (FVC), Best measure	1.1	4.0	9.2	-1.7	-2.6	-0.8	-1.3	-0.8	-2.1	-3.0	-2.7	-1.7	-1.9
Body fat percentage	0.1	0.3	2.2	-0.3	-0.4	-1.5	-0.2	-0.1	0.2	0.2	-0.4	-0.7	-0.4
Leg fat percentage (right)	0.2	0.5	1.2	0.4	0.1	-0.7	-1.1	0.6	1.1	1.1	0.8	0.5	0.3
Arm fat-free mass (right)	0.7	3.7	17.8	-1.8	-4.2	-0.6	-2.6	-1.0	-1.9	-1.1	-0.7	-0.6	-1.5
Exposure to tobacco smoke outside home	0.3	0.4	2.3	0.4	-1.5	0.3	0.3	0.8	0.3	-0.3	-0.1	-0.2	-0.0
Comparative body size at age 10	1.8	5.1	9.8	-1.4	-1.6	-2.0	1.3	-2.0	-3.0	-1.8	-3.0	-3.1	-2.3
Number of full brothers	1.8	2.3	4.9	0.1	-1.2	-2.1	-1.5	0.1	-1.7	-1.4	-1.9	-1.2	-2.2
Worry too long after embarrassment	0.5	0.8	2.3	-0.6	1.5	-0.9	-0.2	-1.4	-0.7	-0.4	-0.6	-1.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.5	-1.1	-0.4	0.2	-0.9	-0.9	-0.3	0.2	-0.4	0.8
Wheeze or whistling in the chest in last year	4.3	7.7	13.0	3.0	2.6	2.1	0.2	2.1	3.1	2.8	3.6	3.0	3.6
Number of children fathered	0.3	0.3	1.4	-0.5	0.4	-0.4	-0.6	-0.4	-0.4	0.5	-0.6	0.0	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	-0.1	-0.6	0.9	-0.9	-0.6	0.1	-0.1	0.3	-0.0	0.4
Age at first live birth	1.0	1.8	6.4	1.7	2.5	0.7	0.2	1.5	0.5	1.7	1.0	1.1	0.6
Pulse wave peak to peak time	0.2	0.3	1.8	-0.3	-1.3	-0.3	-0.6	-0.1	0.3	-0.1	0.2	-0.2	0.0
Health satisfaction	2.4	3.1	5.8	-2.0	-0.9	-0.2	0.4	-2.4	-2.3	-2.3	-1.7	-2.0	-1.7
Shortness of breath walking on level ground	0.3	0.3	1.0	-0.1	0.8	0.0	-1.0	-0.3	-0.8	0.5	0.3	0.3	-0.6
Qualifications: College or University degree	0.4	1.1	4.4	-0.4	0.3	-0.2	1.9	0.1	-0.5	-0.3	-1.1	-1.2	-2.1
Eye problems/disorders: None of the above	0.3	0.3	1.0	0.8	1.0	0.6	0.4	0.4	0.6	0.0	0.0	0.2	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	1.3	-0.8	0.8	-0.2	1.1	-0.4	0.1	0.2	0.7	-0.1
Emphysema/chronic bronchitis	6.4	7.2	13.0	2.7	2.2	2.0	1.8	2.0	3.4	3.0	3.6	2.9	2.6
Medication for pain relief, constipation, heartburn	0.7	1.2	5.4	0.2	1.3	-0.8	2.3	-0.1	-0.8	0.7	-0.5	-0.6	-1.5
Neck or shoulder pain in last month	0.3	0.4	2.3	0.1	-0.3	-1.5	-1.2	-0.0	0.1	0.1	-0.4	-0.2	0.3
Medication: Blood pressure	2.0	3.4	6.7	-1.8	-0.3	-1.4	0.1	-2.5	-2.6	-2.0	-2.2	-2.4	-1.3
Angina (self-reported)	1.7	2.2	6.6	-0.8	-1.9	-0.7	-1.8	-1.2	-1.7	-2.6	-1.4	-1.1	0.2
Migraine (self-reported)	2.0	2.5	5.3	0.8	0.6	2.1	1.7	1.4	1.7	1.4	1.6	1.5	2.3
Medication: Ibuprofen	1.4	1.7	7.2	-0.3	-2.3	0.4	-2.7	-0.3	-1.1	-1.4	-0.6	-0.4	-0.4
Medication: Allopurinol	0.5	0.6	2.5	-0.6	-0.4	0.8	0.7	-1.3	-0.3	-0.3	0.6	0.1	1.6
Medication: Omeprazole	0.7	0.8	6.6	-0.4	-0.5	0.5	-2.6	-0.3	0.1	-0.4	0.4	0.3	0.5
Medication: Seretide 50 evohaler	3.3	3.8	8.2	2.9	0.8	1.6	1.2	2.8	1.6	2.1	1.8	1.8	2.0
Mean time to correctly identify matches	0.7	1.3	4.9	0.2	-0.8	2.1	2.2	0.8	1.1	-0.0	1.1	0.7	0.4
Heart disease (mother)	0.1	0.1	0.3	0.1	-0.3	-0.1	0.2	0.5	-0.4	0.3	0.1	-0.3	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.7	7.5	1.5	2.7	1.4	1.8	1.5	1.1	2.2	1.2	0.9	1.1
Whole body fat mass	0.2	0.9	2.4	-0.8	-1.5	-1.6	-1.0	-0.5	-0.5	-0.3	-0.7	-0.9	-1.0
Leg fat mass (right)	0.1	0.6	2.1	-0.7	-1.4	-1.0	-1.2	-0.3	-0.1	-0.0	-0.1	-0.4	-0.6
Arm predicted mass (right)	0.6	3.3	16.6	-1.9	-4.1	-0.6	-2.1	-1.1	-1.9	-1.1	-0.7	-0.7	-1.3
Pulse rate, automated reading	2.3	7.3	12.4	3.5	3.3	1.6	0.7	2.5	2.4	2.9	3.2	2.9	2.9
Alcohol intake frequency.	0.2	0.4	2.1	0.3	0.4	-1.5	-0.3	0.3	0.0	-0.9	-0.3	-0.5	-0.2
Comparative height size at age 10	0.7	4.0	8.6	-2.0	-2.8	-2.4	-2.9	-1.2	-1.1	-1.2	-1.8	-1.2	-2.2
Number of full sisters	0.5	0.6	1.5	1.2	1.2	-0.1	-0.1	0.5	0.9	0.7	0.3	0.5	0.9
Suffer from ‘nerves’	0.5	0.8	2.6	-0.6	1.0	-1.6	-0.3	-1.3	-0.6	-0.5	-0.1	-0.8	0.8
Overall health rating	1.0	2.0	4.4	-1.1	-1.2	-2.1	-1.3	-1.3	-2.0	-1.0	-1.1	-1.2	-1.5
Chest pain or discomfort	0.6	0.9	5.5	0.4	-0.9	-1.0	-2.3	0.7	0.6	0.3	0.2	0.3	-0.4
Had major operations	0.5	0.6	1.4	1.2	-0.1	1.0	-0.7	0.9	-0.5	0.7	0.6	1.0	-0.2
Age at last live birth	1.0	1.4	3.5	1.6	1.9	1.0	0.3	1.6	0.5	1.3	1.0	0.9	0.9
Family relationship satisfaction	0.6	0.8	1.8	-0.1	-1.3	0.1	0.6	-0.2	-1.3	-1.3	-1.2	-1.0	-0.6
Leg pain on walking	0.6	0.8	3.4	0.2	0.5	-1.4	-1.8	-0.2	-0.6	0.3	-0.5	-0.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	2.2	-1.5	-0.2	0.8	0.0	-0.6	-0.2	0.2	0.3	-0.0	-0.5
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.5	1.5	-0.4	1.1	-1.4	1.0	0.3	0.8	1.8	2.1	0.9
Illness, injury, bereavement, stress in last 2 years	2.5	3.1	6.0	-2.4	-0.5	-2.0	0.1	-1.7	-0.8	-2.0	-2.2	-1.7	-2.3
Medication: Aspirin	4.6	6.0	15.0	-3.2	-2.6	-1.0	0.0	-2.6	-2.4	-3.9	-2.6	-2.7	-1.1
Supplements: Vitamin C	0.3	0.3	1.3	-0.1	0.4	0.4	0.4	-0.2	1.1	0.1	0.8	0.4	0.7
Knee pain experienced in last month	0.4	0.6	2.5	-0.5	0.5	-1.6	-0.9	-0.2	-0.7	1.0	0.4	-0.0	-0.9
Hypertension (Self-reported)	0.6	1.6	3.3	-0.9	1.7	-1.4	1.0	-1.8	-1.5	-0.2	-0.5	-1.4	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	0.5	0.3	0.6	-0.9	-0.1	-0.2	0.7	0.9	0.6	0.9
Illnesses of father: Heart disease	0.4	0.6	2.7	-0.5	-0.2	-1.7	-0.3	-0.3	-1.1	-0.0	-1.1	-0.7	-0.2
Illnesses of siblings: Diabetes	0.3	0.4	1.2	0.2	0.1	0.3	0.6	0.3	0.9	0.4	0.7	0.5	1.1
Smoking status: Previous	0.7	1.0	4.0	-0.9	-0.7	-0.6	0.4	-0.8	-1.0	-0.8	-1.2	-1.0	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.1	-0.7	0.5	0.3	-1.4	-0.7	-0.1	-0.0	-0.1	0.3	-0.8
Whole body fat-free mass	0.9	4.9	17.6	-2.5	-4.2	-1.0	-1.8	-1.8	-2.3	-1.7	-1.5	-1.5	-2.2
Leg fat-free mass (right)	1.2	6.4	15.8	-3.0	-4.0	-1.5	-0.8	-2.1	-2.9	-2.2	-2.3	-2.6	-2.6
Arm fat percentage (left)	0.4	1.5	2.8	-1.3	-1.6	-1.6	0.0	-1.0	-0.6	-0.9	-1.4	-1.7	-1.1
Average weekly red wine intake	2.0	3.0	8.6	-1.5	-1.5	-1.3	-1.7	-1.0	-1.6	-1.1	-2.0	-1.8	-2.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-0.7	0.1	-0.5	-0.6	-1.0	-0.8	-0.5	-0.7	-0.8	-1.1
Mood swings	0.4	0.7	3.3	0.1	0.5	-0.3	1.8	-0.0	0.3	0.5	0.4	-0.4	1.5
Loneliness, isolation	0.4	0.6	1.6	-0.7	0.7	-0.1	1.2	-0.9	-1.3	-0.2	-0.3	-0.7	-0.3
Long-standing illness, disability or infirmity	0.8	1.2	3.6	0.5	0.1	-1.9	0.3	0.2	-1.3	-0.9	-1.6	-1.6	-0.8
Ever had bowel cancer screening	0.1	0.1	0.4	0.6	-0.1	0.4	0.3	0.4	0.1	-0.0	-0.1	-0.3	0.6
Diabetes diagnosed by doctor	2.7	4.5	7.0	-1.7	-2.6	-2.6	0.3	-1.5	-2.0	-2.2	-2.4	-2.4	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.8	-0.3	0.4	0.4	-0.6	-0.4	-0.4	0.1	-0.3	0.1
Friendships satisfaction	3.6	4.4	8.6	-1.8	-2.0	-1.1	-0.7	-2.2	-2.4	-2.9	-2.5	-2.4	-2.1
Qualifications: nursing, teaching	0.3	0.5	1.4	1.2	1.0	-0.5	-0.1	0.9	0.0	0.8	0.0	-0.1	-0.8
Commuting to job workplace: Walk	0.4	0.5	1.4	-0.3	1.2	-0.4	0.5	-0.5	-0.3	1.0	-0.3	-1.1	0.3
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.3	-0.7	-0.7	-0.8	-0.3	-0.8	-0.2	-0.2	-0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	5.6	0.9	0.9	0.8	-0.2	1.2	1.2	1.1	1.5	1.8	2.4
Medication for cholesterol	2.9	4.4	7.1	2.4	0.9	1.7	0.1	2.5	2.7	2.6	1.8	2.7	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	2.9	0.1	0.6	-1.7	-0.7	-0.1	-0.0	0.5	-0.5	-0.3	-0.1
Back pain experienced in last month	0.8	1.2	2.6	-1.1	-0.2	-1.2	0.1	-0.8	-0.9	-0.9	-1.5	-1.4	-1.6
Mineral and other dietary supplements	0.3	0.4	1.8	0.5	0.7	-0.1	-1.4	0.5	-0.1	0.8	0.5	0.6	0.3
Breast cancer (self-reported)	0.3	0.3	1.0	1.0	0.8	-0.2	-0.4	0.4	0.5	0.7	-0.1	-0.1	0.6
Asthma (self-reported)	2.9	5.7	12.2	2.1	1.0	2.4	1.9	2.0	2.8	2.2	2.7	2.5	3.5
Osteoporosis (self-reported)	1.4	1.8	9.8	1.3	-0.8	-1.1	-3.1	1.0	-1.1	-0.1	-0.4	0.1	-1.4
Osteoarthritis (self-reported)	0.1	0.1	0.6	-0.0	0.4	0.4	-0.7	-0.2	-0.2	0.2	-0.0	0.5	-0.4
Medication: Aspirin	3.7	4.9	11.9	-2.8	-2.7	-1.1	-0.3	-2.3	-2.1	-3.5	-2.1	-2.4	-0.8
Medication: Gliclazide	0.7	0.8	2.6	0.5	-0.6	-0.5	1.2	0.7	-0.9	-0.6	-1.0	-0.6	-1.6
Illnesses of father: None of the above (group 1)	0.9	1.1	1.8	1.1	1.3	1.4	1.0	0.9	1.0	0.4	1.1	1.2	0.9
Smoking status: Current	0.4	0.6	1.2	0.5	0.8	0.7	1.1	0.6	0.5	0.2	0.9	1.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.7	7.9	15.8	-2.6	-3.2	-2.1	-1.9	-1.3	-2.2	-4.0	-3.9	-2.8	-2.9
Whole body water mass	0.9	5.0	17.1	-2.6	-4.1	-1.0	-1.8	-1.9	-2.4	-1.7	-1.6	-1.6	-2.3
Leg predicted mass (right)	1.2	6.5	16.3	-2.9	-4.0	-1.6	-0.8	-2.1	-2.9	-2.3	-2.4	-2.6	-2.5
Arm fat mass (left)	0.4	1.8	4.4	-1.3	-2.1	-1.8	-0.8	-1.1	-1.1	-0.8	-1.3	-1.5	-1.2
Number of self-reported non-cancer illnesses	0.5	0.8	2.2	1.4	1.1	-0.3	0.2	0.5	-0.4	1.5	0.9	0.7	1.1
Average weekly champagne plus white wine intake	0.4	0.6	2.5	0.9	0.8	1.6	-0.8	0.5	-0.8	0.2	0.1	0.2	-0.6
Miserableness	0.3	0.5	2.2	0.7	0.5	0.9	1.5	0.6	0.5	0.5	-0.0	0.0	0.7
Guilty feelings	0.4	0.5	2.5	0.3	0.9	-0.2	1.6	-0.1	-0.0	0.4	0.3	-0.2	1.2
Wears glasses or contact lenses	1.1	1.3	3.1	-1.4	-0.7	-0.6	-0.1	-0.8	-1.0	-1.2	-1.8	-1.5	-1.4
Ever taken oral contraceptive pill	0.9	1.0	2.6	1.2	1.6	0.9	0.6	1.0	0.5	1.0	1.2	1.0	0.5
Hearing aid user	0.4	0.4	2.3	-0.5	-0.5	0.6	-1.5	-0.5	-0.0	-0.4	-0.1	-0.1	-0.9
Mother’s age at death	0.1	0.2	0.4	0.4	0.6	-0.3	-0.7	-0.2	-0.5	0.3	0.2	0.2	0.2
Financial situation satisfaction	2.8	3.5	5.3	2.3	2.2	1.6	1.0	2.0	1.6	2.0	1.9	2.0	1.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.1	1.5	0.6	1.1	0.3	1.2	1.2	1.7	1.2	1.3	1.2
Commuting to job workplace: Public transport	0.2	0.3	0.9	-0.9	-0.9	-0.2	0.1	-0.5	0.2	-0.1	-0.4	-0.5	-0.4
Eye problems/disorders: Glaucoma	0.7	0.8	2.2	0.1	-0.1	1.4	0.1	-0.0	-0.7	0.9	1.4	1.5	0.7
Medication: Blood pressure	2.7	5.2	8.9	-2.3	-0.0	-2.2	1.2	-2.6	-2.8	-2.3	-2.2	-3.0	-2.6
Pain type(s) experienced in last month: Hip pain	1.0	1.3	6.8	1.3	1.0	-0.3	-2.6	0.6	-0.2	1.3	0.5	0.7	0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.4	-0.7	-1.4	-0.2	1.5	-0.4	-0.1	-1.2	-0.9	-0.7	-0.3
High cholesterol (Self-reported)	1.6	2.8	7.6	-1.2	-0.6	-1.4	-1.2	-1.8	-2.8	-1.3	-1.4	-2.1	-1.9
Medication: Bendroflumethiazide	1.3	2.0	3.7	-1.9	-1.0	-0.9	0.9	-1.8	-1.3	-1.5	-1.2	-1.7	-1.5
Medication: Paracetamol	0.6	1.0	3.6	0.8	0.5	0.0	-0.4	0.4	1.4	0.8	1.1	1.0	1.9
Medication: Lisinopril	0.4	0.5	2.4	0.8	0.3	-1.5	0.2	0.8	-0.1	0.6	-0.4	-0.1	-0.8
Medication: Atorvastatin	0.7	0.9	2.4	0.1	0.5	-1.5	-0.4	-0.1	-0.9	-1.0	-1.4	-1.3	-0.8
Illnesses of father: High blood pressure	0.4	0.4	1.8	-0.9	0.1	-1.3	-0.1	-0.3	-0.6	0.2	-0.6	-0.8	0.7
Alcohol drinker status: Never	0.9	1.0	1.8	-0.6	-1.3	-0.8	-0.8	-0.6	-1.3	-1.2	-1.1	-1.1	-0.9
Ever smoked	0.3	0.5	3.2	0.8	0.5	-0.1	1.8	0.8	-0.1	0.2	-0.4	-0.1	-0.7
Basal metabolic rate	0.8	4.5	14.4	-2.4	-3.8	-1.2	-1.7	-1.8	-2.3	-1.6	-1.6	-1.6	-2.2
Leg fat percentage (left)	0.2	0.6	1.5	0.4	0.3	-1.1	-1.0	0.5	0.9	1.2	0.8	0.4	0.4
Arm fat-free mass (left)	0.5	2.5	11.3	-1.6	-3.4	-0.8	-1.8	-1.1	-1.7	-0.6	-0.5	-0.6	-1.3
Number of operations (self-reported)	2.4	3.6	9.5	3.1	0.7	0.9	-1.1	2.4	0.6	2.4	2.1	2.4	1.4
Average weekly beer plus cider intake	0.7	1.0	3.3	-1.6	-1.8	-0.4	-0.0	-1.3	-0.5	-0.7	-0.9	-0.9	-0.1
Irritability	0.5	0.9	3.7	0.3	1.9	-0.4	1.6	-0.1	0.4	0.5	0.2	-0.4	1.4
Risk taking	2.7	3.9	7.9	1.8	0.5	1.0	-0.4	2.1	2.5	2.2	2.5	2.3	2.8
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.3	1.0	-0.2	0.6	1.1	1.0	0.2	0.9	0.5	0.5	0.3
Fractured/broken bones in last 5 years	0.8	1.1	2.5	1.1	0.6	0.5	-0.1	1.2	1.4	0.6	1.2	1.6	1.1
Age started oral contraceptive pill	1.7	2.2	4.7	1.5	1.5	0.0	0.8	1.6	1.8	2.2	1.6	1.4	1.5
Diastolic blood pressure, automated reading	0.5	1.5	4.3	1.5	2.1	0.8	-0.5	0.5	0.3	1.9	1.4	1.0	0.6
Ever depressed for a whole week	0.6	0.7	2.1	-0.8	-1.4	-0.3	0.3	-0.3	-0.4	-1.3	-0.9	-1.2	-0.2
Unable to work because of sickness or disability	3.2	4.1	7.3	-2.3	-0.7	-2.0	0.1	-2.6	-1.8	-2.7	-2.5	-2.5	-1.1
Commuting to job workplace: Cycle	1.5	1.8	7.9	0.3	-0.2	2.8	2.1	0.7	1.2	0.0	1.0	0.3	1.4
Myopia	0.6	0.8	2.3	-0.8	-0.5	-0.6	-0.1	-0.9	-0.4	-0.3	-1.3	-1.3	-1.5
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.3	0.9	-1.3	1.2	-0.2	1.8	1.8	0.5	0.7	1.3	1.6
Cholesterol lowering medication	3.2	4.7	8.0	-2.4	-1.1	-1.5	-0.9	-2.7	-2.7	-2.3	-2.2	-2.8	-2.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	4.6	0.3	-0.5	1.8	-2.1	0.1	0.6	0.2	1.3	1.5	1.3
Pain experienced in last month	0.5	0.8	4.2	0.1	-0.0	2.0	1.3	-0.0	0.6	0.1	0.6	0.9	0.4
Supplements: Calcium	0.2	0.2	0.7	0.4	0.4	0.5	-0.8	-0.4	0.1	0.3	0.5	0.3	0.7
Basal cell carcinoma (self-reported)	0.6	0.7	2.5	0.0	-1.6	1.1	-0.8	0.5	0.2	0.4	0.6	1.2	-0.4
Heart attack/myocardial infarction (self-reported)	1.2	1.6	4.7	-1.2	-1.4	0.5	-2.0	-1.2	-1.1	-2.2	-0.7	-0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.8	1.6	-0.1	0.8	-1.0	1.7	0.1	0.9	0.2	1.4	0.5
Heart disease (siblings)	0.4	0.5	1.3	0.5	-0.5	-0.7	1.1	0.5	-0.6	0.2	-0.9	-1.0	0.1
Alcohol drinker status: Previous	0.5	0.6	2.8	0.5	1.4	-1.7	0.5	0.1	-0.1	0.5	0.2	0.3	-0.2
Pack years of smoking	1.7	2.5	5.4	2.3	0.9	0.5	-0.7	1.9	1.3	2.0	1.6	1.9	1.6
Impedance of whole body	1.0	4.9	16.3	2.4	4.0	-0.0	0.1	2.1	2.9	2.4	1.7	1.7	1.4
Leg fat mass (left)	0.2	0.7	2.2	-0.8	-1.5	-1.2	-1.3	-0.4	-0.3	-0.0	-0.2	-0.5	-0.6
Arm predicted mass (left)	0.6	3.0	11.2	-1.8	-3.4	-1.0	-1.8	-1.2	-2.0	-0.9	-0.9	-0.9	-1.8