[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr7:6,502,367-7,988,091

Best TWAS P=1.51e-17 · Best GWAS P=2.55e-15 conditioned to 0.00968

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Colon Transverse	C1GALT1	0.32	0.23	lasso	4	0.30	8.0e-15	-6.79	-8.5	1.5e-17	0.72	0.04	0.96	TRUE
18	GTEx	Nerve Tibial	C1GALT1	0.44	0.28	lasso	12	0.40	2.0e-30	-7.40	-8.5	2.1e-17	0.81	0.05	0.95	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C1GALT1	0.27	0.06	enet	22	0.10	8.1e-05	-6.88	-8.2	2.6e-16	0.70	0.01	0.96	FALSE
14	GTEx	Esophagus Muscularis	C1GALT1	0.36	0.16	lasso	8	0.27	1.9e-16	-6.82	-8.2	3.6e-16	0.79	0.11	0.89	FALSE
13	GTEx	Esophagus Mucosa	C1GALT1	0.33	0.19	lasso	6	0.18	2.8e-12	-7.60	-8.1	4.6e-16	0.63	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C1GALT1	0.26	0.15	enet	20	0.23	1.1e-27	-7.91	-8.0	1.5e-15	0.82	0.00	1.00	FALSE
20	GTEx	Pancreas	C1GALT1	0.44	0.11	enet	24	0.22	8.8e-10	-7.40	-8.0	1.8e-15	0.79	0.01	0.99	FALSE
25	GTEx	Thyroid	C1GALT1	0.30	0.27	lasso	3	0.31	3.9e-24	-7.40	-7.9	3.0e-15	0.89	0.03	0.97	FALSE
27	METSIM	Adipose	C1GALT1	0.22	0.16	lasso	9	0.23	5.1e-34	-5.56	-7.9	3.7e-15	0.78	0.14	0.86	FALSE
6	GTEx	Brain Frontal Cortex BA9	C1GALT1	0.38	0.28	enet	21	0.16	5.2e-05	-7.40	-7.8	5.0e-15	0.76	0.00	0.99	FALSE
26	GTEx	Uterus	C1GALT1	0.38	0.28	enet	8	0.32	2.0e-07	-6.79	-7.8	9.0e-15	0.56	0.19	0.59	FALSE
10	GTEx	Cells Transformed fibroblasts	C1GALT1	0.12	0.03	lasso	3	0.05	1.0e-04	-7.40	-7.6	3.9e-14	0.75	0.01	0.97	FALSE
2	GTEx	Adipose Subcutaneous	C1GALT1	0.20	0.14	enet	18	0.15	1.5e-12	-7.40	-7.5	5.2e-14	0.90	0.00	1.00	FALSE
19	GTEx	Ovary	C1GALT1	0.22	0.14	enet	11	0.15	1.8e-04	-7.10	-7.4	1.4e-13	0.58	0.07	0.73	FALSE
24	GTEx	Stomach	C1GALT1	0.24	0.07	enet	17	0.12	1.9e-06	-6.86	-7.4	1.5e-13	0.68	0.16	0.82	FALSE
16	GTEx	Lung	C1GALT1	0.18	0.13	lasso	3	0.15	1.1e-11	-6.82	-7.4	1.7e-13	0.77	0.22	0.78	FALSE
3	GTEx	Artery Tibial	C1GALT1	0.19	0.06	lasso	5	0.09	3.3e-07	-7.40	-7.3	2.1e-13	0.87	0.01	0.99	FALSE
4	GTEx	Brain Caudate basal ganglia	C1GALT1	0.27	0.18	enet	8	0.20	2.4e-06	-5.56	-7.2	4.7e-13	0.63	0.05	0.90	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1GALT1	0.02	0.01	lasso	4	0.01	1.7e-02	-7.91	-7.2	6.5e-13	0.93	0.00	0.98	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1GALT1	0.16	0.12	lasso	7	0.14	3.7e-08	-5.00	-7.0	3.4e-12	0.58	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	C1GALT1	0.05	0.01	lasso	2	0.01	3.8e-02	-5.63	-6.8	8.4e-12	0.56	0.02	0.75	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	C1GALT1	0.12	0.05	enet	10	0.13	9.9e-14	-7.91	-6.8	1.5e-11	0.80	0.00	1.00	FALSE
23	GTEx	Spleen	C1GALT1	0.56	0.29	lasso	6	0.46	3.2e-13	-6.86	-6.7	1.6e-11	0.72	0.09	0.88	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	C1GALT1	0.08	0.03	blup	112	0.06	2.5e-07	1.68	-6.7	2.1e-11	0.69	0.16	0.84	FALSE
5	GTEx	Brain Cerebellar Hemisphere	C1GALT1	0.33	0.24	lasso	4	0.20	6.1e-06	-7.16	-6.7	2.2e-11	0.42	0.04	0.91	FALSE
22	GTEx	Skin Sun Exposed Lower leg	C1GALT1	0.22	0.04	lasso	9	0.10	4.8e-09	-7.16	-6.5	8.1e-11	0.63	0.06	0.94	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1GALT1	0.22	0.11	enet	20	0.16	3.4e-18	-6.79	-6.3	3.4e-10	0.63	0.82	0.18	FALSE
29	YFS	Blood	C1GALT1	0.35	0.20	enet	45	0.32	4.3e-109	-6.82	-6.0	2.5e-09	0.73	0.80	0.20	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	C1GALT1	0.28	0.00	enet	28	0.01	1.8e-01	-5.56	-5.9	3.0e-09	0.54	0.02	0.82	FALSE
11	GTEx	Colon Sigmoid	C1GALT1	0.52	0.25	enet	38	0.31	1.0e-11	-5.56	-5.8	4.8e-09	0.55	0.71	0.28	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	C1GALT1	0.24	0.13	lasso	5	0.23	4.6e-29	1.18	-5.7	9.5e-09	0.71	0.56	0.44	FALSE
8	GTEx	Breast Mammary Tissue	C1GALT1	0.23	0.15	lasso	8	0.15	5.1e-08	-5.63	-5.7	1.6e-08	0.42	0.79	0.15	FALSE
9	GTEx	Breast Mammary Tissue (Male)	C1GALT1	0.00	0.03	lasso	1	0.09	4.0e-03	-5.63	-5.6	1.9e-08	0.37	0.04	0.10	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C1GALT1	0.04	0.00	blup	108	0.02	2.7e-03	-0.31	-5.6	2.0e-08	0.75	0.02	0.76	FALSE
17	GTEx	Muscle Skeletal	C1GALT1	0.12	0.10	lasso	7	0.13	2.2e-12	6.40	-5.4	5.7e-08	0.54	0.76	0.24	FALSE
15	GTEx	Heart Left Ventricle	C1GALT1	0.17	0.04	enet	23	0.05	1.5e-03	-7.60	-5.3	1.3e-07	0.31	0.08	0.77	FALSE
21	GTEx	Prostate	C1GALT1	0.38	-0.01	enet	18	0.08	4.6e-03	-7.67	-5.3	1.4e-07	0.79	0.01	0.92	FALSE