[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr7:2,032,803-3,581,391

Best TWAS P=1.05e-17 · Best GWAS P=2.78e-16 conditioned to 0.0161

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Lung	GNA12	0.16	0.08	enet	21	0.12	1.2e-09	8.1	8.6	1.0e-17	0.78	0.01	0.99	TRUE
8	GTEx	Esophagus Muscularis	GNA12	0.32	0.31	lasso	3	0.34	2.1e-21	7.9	7.9	2.6e-15	0.94	0.03	0.97	FALSE
4	GTEx	Cells Transformed fibroblasts	GNA12	0.21	0.11	lasso	11	0.15	1.7e-11	7.9	7.9	3.5e-15	0.87	0.02	0.98	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	GNA12	0.46	0.51	lasso	5	0.50	7.9e-19	7.8	7.8	6.4e-15	0.91	0.08	0.92	FALSE
14	GTEx	Whole Blood	GNA12	0.09	0.01	enet	4	0.00	3.3e-01	8.0	7.8	8.2e-15	0.93	0.02	0.92	FALSE
7	GTEx	Esophagus Mucosa	GNA12	0.16	0.13	lasso	3	0.13	3.0e-09	8.0	7.7	1.7e-14	0.90	0.02	0.98	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	AMZ1	0.09	0.05	lasso	6	0.04	2.4e-06	7.9	-7.7	2.0e-14	-0.93	0.01	0.99	FALSE
11	GTEx	Skin Sun Exposed Lower leg	GNA12	0.17	0.16	lasso	3	0.18	1.3e-14	6.0	7.3	3.2e-13	0.86	0.19	0.81	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	GNA12	0.20	0.12	lasso	6	0.12	3.4e-05	5.9	7.2	4.4e-13	0.86	0.03	0.96	FALSE
10	GTEx	Nerve Tibial	GNA12	0.31	0.34	lasso	7	0.36	9.6e-27	5.7	7.1	1.2e-12	0.85	0.94	0.06	FALSE
2	GTEx	Artery Tibial	GNA12	0.24	0.13	enet	20	0.22	3.5e-17	7.9	6.8	7.9e-12	0.85	0.03	0.97	FALSE
5	GTEx	Colon Sigmoid	GNA12	0.14	0.05	lasso	3	0.03	3.6e-02	5.7	6.8	1.5e-11	0.85	0.04	0.87	FALSE
15	METSIM	Adipose	GNA12	0.07	0.05	lasso	3	0.05	3.3e-08	6.6	6.5	6.7e-11	0.74	0.17	0.83	FALSE
12	GTEx	Small Intestine Terminal Ileum	GNA12	0.34	0.20	lasso	5	0.16	2.4e-04	6.6	6.3	3.1e-10	0.73	0.07	0.76	FALSE
1	GTEx	Adipose Subcutaneous	GNA12	0.11	0.08	lasso	4	0.07	1.3e-06	5.9	6.1	1.1e-09	0.73	0.54	0.46	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	GNA12	0.03	0.01	enet	7	0.02	1.5e-03	-3.0	6.0	2.7e-09	0.76	0.05	0.79	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNA12	0.03	0.04	lasso	1	0.04	3.0e-05	5.9	5.9	4.6e-09	0.71	0.11	0.67	FALSE
13	GTEx	Stomach	GNA12	0.18	0.16	lasso	2	0.13	6.6e-07	5.7	5.8	5.0e-09	0.71	0.62	0.37	FALSE
16	NTR	Blood	GNA12	0.07	0.03	bslmm	597	0.06	1.3e-17	6.3	5.8	6.1e-09	0.62	0.96	0.04	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMZ1	0.08	0.01	blup	71	0.05	1.3e-05	5.9	-5.8	7.9e-09	-0.65	0.04	0.82	FALSE
18	The Cancer Genome Atlas	Esophageal Carcinoma	AMZ1	0.18	0.05	blup	69	0.05	1.4e-02	-4.3	5.4	7.5e-08	0.73	0.01	0.67	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	AMZ1	0.32	0.04	enet	19	0.20	3.3e-19	6.3	-5.3	1.1e-07	-0.59	0.17	0.83	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMZ1	0.04	0.04	lasso	3	0.02	1.3e-03	-4.3	-5.1	2.8e-07	-0.63	0.04	0.90	FALSE