TWAS
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Traits
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Lung FEV1/FVC ratio
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chr7:19,674,247-21,151,172
Best TWAS P=9.9e-10 · Best GWAS P=2.6e-12 conditioned to 0.000601
19.6M
19.8M
20M
20.2M
20.4M
20.6M
20.8M
21M
21.2M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Pancreas
CTA-293F17.1
0.45
0.40
enet
10
0.40
3.3e-18
5.9
6.1
9.9e-10
0.85
0.44
0.56
TRUE
1
GTEx
Pancreas
ITGB8
0.26
0.14
lasso
6
0.14
2.5e-06
5.9
6.0
2.4e-09
0.87
0.39
0.60
FALSE