Best TWAS P=2.47e-08 · Best GWAS P=3.3e-13 conditioned to 3.78e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | STAG3L2 | 0.18 | 0.18 | lasso | 6 | 0.16 | 3.0e-09 | 5.4 | -5.3 | 1.0e-07 | -0.07 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Coronary | STAG3L2 | 0.16 | 0.10 | lasso | 3 | 0.11 | 1.5e-04 | 5.4 | -5.2 | 1.8e-07 | -0.07 | 0.01 | 0.93 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | STAG3L2 | 0.14 | 0.08 | lasso | 2 | 0.11 | 4.0e-06 | 5.4 | -5.2 | 1.9e-07 | -0.07 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | STAG3L2 | 0.18 | 0.16 | lasso | 5 | 0.16 | 7.5e-12 | 5.4 | -5.2 | 1.6e-07 | -0.07 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Esophagus Mucosa | STAG3L2 | 0.23 | 0.16 | lasso | 3 | 0.16 | 1.0e-10 | 5.4 | -5.2 | 2.1e-07 | -0.08 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Nerve Tibial | GTF2IRD2 | 0.08 | 0.09 | lasso | 2 | 0.08 | 5.4e-06 | 5.4 | 5.3 | 9.1e-08 | 0.07 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | GTF2IRD2 | 0.07 | 0.04 | lasso | 2 | 0.05 | 5.2e-05 | 5.4 | 5.6 | 2.5e-08 | 0.06 | 0.01 | 0.96 | TRUE |
| 8 | GTEx | Testis | STAG3L2 | 0.26 | 0.13 | lasso | 4 | 0.22 | 4.0e-10 | 5.0 | -5.2 | 1.8e-07 | -0.08 | 0.02 | 0.98 | FALSE |
| 9 | GTEx | Thyroid | GTF2IRD2 | 0.08 | 0.07 | lasso | 1 | 0.04 | 2.4e-04 | 5.4 | 5.4 | 8.1e-08 | 0.07 | 0.01 | 0.94 | FALSE |