Best TWAS P=1.44e-18 · Best GWAS P=2.4e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | ZCCHC6 | 0.13 | 0.11 | lasso | 6 | 0.09 | 1.6e-07 | -7.8 | -7.6 | 3.5e-14 | -0.69 | 0.62 | 0.38 | FALSE |
| 2 | GTEx | Esophagus Muscularis | ZCCHC6 | 0.16 | 0.08 | enet | 12 | 0.09 | 3.5e-06 | -7.8 | -7.2 | 5.6e-13 | -0.67 | 0.43 | 0.53 | FALSE |
| 3 | METSIM | Adipose | ISCA1 | 0.06 | 0.03 | blup | 385 | 0.04 | 8.2e-07 | 8.3 | 5.6 | 2.4e-08 | 0.80 | 0.01 | 0.99 | FALSE |
| 4 | YFS | Blood | ISCA1 | 0.02 | 0.01 | lasso | 5 | 0.01 | 1.3e-05 | -7.8 | 8.6 | 8.4e-18 | 0.89 | 0.02 | 0.98 | FALSE |
| 5 | YFS | Blood | ZCCHC6 | 0.06 | 0.06 | lasso | 7 | 0.06 | 1.3e-17 | 8.5 | -8.4 | 4.3e-17 | -0.99 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ISCA1 | 0.04 | 0.01 | blup | 42 | 0.02 | 4.0e-03 | 8.2 | 5.9 | 3.7e-09 | 0.89 | 0.01 | 0.91 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf153 | 0.12 | 0.04 | blup | 43 | 0.05 | 7.6e-04 | -7.5 | 5.5 | 4.4e-08 | 0.63 | 0.04 | 0.55 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ISCA1 | 0.13 | 0.13 | lasso | 3 | 0.13 | 3.3e-05 | 8.5 | 8.8 | 1.4e-18 | 0.98 | 0.01 | 0.96 | TRUE |