Best TWAS P=2.15e-09 · Best GWAS P=3.06e-11 conditioned to 0.000343
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SHB | 0.07 | 0.03 | bslmm | 587 | 0.04 | 1.1e-05 | 2.7 | -5.5 | 4.4e-08 | 0.63 | 0.07 | 0.93 | FALSE |
| 2 | GTEx | Testis | SHB | 0.15 | 0.04 | lasso | 5 | 0.07 | 3.6e-04 | 4.8 | -5.7 | 1.2e-08 | 0.47 | 0.16 | 0.81 | FALSE |
| 3 | GTEx | Thyroid | SHB | 0.07 | 0.05 | lasso | 5 | 0.04 | 4.3e-04 | -5.9 | -6.0 | 2.1e-09 | 0.66 | 0.09 | 0.90 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | SHB | 0.09 | 0.07 | enet | 13 | 0.09 | 1.5e-11 | -6.2 | -5.9 | 3.5e-09 | 0.63 | 0.02 | 0.98 | FALSE |