TWAS
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Traits
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Traits
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Lung FEV1/FVC ratio
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chr9:37,222,681-38,765,310
Best TWAS P=2.15e-09 · Best GWAS P=3.06e-11 conditioned to 0.000343
37.2M
37.4M
37.6M
37.8M
38M
38.2M
38.4M
38.6M
38.8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Thyroid
SHB
0.07
0.05
lasso
5
0.04
4.3e-04
-5.9
-6.0
2.1e-09
0.66
0.09
0.90
TRUE
4
ROSMAP
Brain Pre-frontal Cortex
SHB
0.09
0.07
enet
13
0.09
1.5e-11
-6.2
-5.9
3.5e-09
0.63
0.02
0.98
FALSE
2
GTEx
Testis
SHB
0.15
0.04
lasso
5
0.07
3.6e-04
4.8
-5.7
1.2e-08
0.47
0.16
0.81
FALSE
1
CommonMind
Brain Pre-frontal Cortex
SHB
0.07
0.03
bslmm
587
0.04
1.1e-05
2.7
-5.5
4.4e-08
0.63
0.07
0.93
FALSE