[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr9:97,520,168-98,975,128

Best TWAS P=1.74e-37 · Best GWAS P=8.47e-46 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial RP11-435O5.5 0.09 0.04 lasso 2 0.02 7.3e-03 -11.92 11.9 1.1e-32 -0.44 0.25 0.05 TRUE
2 GTEx Liver PTCH1 0.25 0.06 enet 11 0.03 4.9e-02 -14.01 -11.6 5.5e-31 0.91 0.01 0.94 FALSE
3 GTEx Spleen PTCH1 0.33 0.08 lasso 8 0.18 1.9e-05 0.61 -8.7 2.8e-18 0.64 0.04 0.80 TRUE
4 NTR Blood PTCH1 0.04 0.02 blup 433 0.02 4.1e-08 -12.95 -8.3 1.1e-16 0.65 0.01 0.99 FALSE
5 YFS Blood PTCH1 0.09 0.05 lasso 8 0.05 1.2e-15 -12.92 -12.8 1.7e-37 0.95 0.06 0.94 TRUE
6 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PTCH1 0.04 0.00 blup 56 0.02 1.6e-03 -12.92 -7.1 1.5e-12 0.73 0.02 0.31 TRUE
7 The Cancer Genome Atlas Prostate Adenocarcinoma PTCH1 0.02 0.01 blup 54 0.02 1.1e-03 -12.15 9.7 3.6e-22 -0.19 0.06 0.03 TRUE