Best TWAS P=1.74e-37 · Best GWAS P=8.47e-46 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | -12.92 | -12.8 | 1.7e-37 | 0.95 | 0.06 | 0.94 | TRUE |
| 1 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | -11.92 | 11.9 | 1.1e-32 | -0.44 | 0.25 | 0.05 | TRUE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PTCH1 | 0.02 | 0.01 | blup | 54 | 0.02 | 1.1e-03 | -12.15 | 9.7 | 3.6e-22 | -0.19 | 0.06 | 0.03 | TRUE |
| 3 | GTEx | Spleen | PTCH1 | 0.33 | 0.08 | lasso | 8 | 0.18 | 1.9e-05 | 0.61 | -8.7 | 2.8e-18 | 0.64 | 0.04 | 0.80 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PTCH1 | 0.04 | 0.00 | blup | 56 | 0.02 | 1.6e-03 | -12.92 | -7.1 | 1.5e-12 | 0.73 | 0.02 | 0.31 | TRUE |
| 2 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | -14.01 | -11.6 | 5.5e-31 | 0.91 | 0.01 | 0.94 | FALSE |
| 4 | NTR | Blood | PTCH1 | 0.04 | 0.02 | blup | 433 | 0.02 | 4.1e-08 | -12.95 | -8.3 | 1.1e-16 | 0.65 | 0.01 | 0.99 | FALSE |