Best TWAS P=4.59e-18 · Best GWAS P=2.94e-14 conditioned to 0.531
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | TSTD2 | 0.12 | 0.00 | lasso | 6 | 0.02 | 2.8e-02 | 6.1 | 6.6 | 4.7e-11 | -0.01 | 0.05 | 0.68 | FALSE |
| 2 | GTEx | Adrenal Gland | TSTD2 | 0.24 | 0.11 | lasso | 4 | 0.07 | 1.2e-03 | 6.8 | 6.3 | 3.0e-10 | -0.03 | 0.01 | 0.96 | TRUE |
| 3 | GTEx | Artery Tibial | TSTD2 | 0.08 | 0.04 | lasso | 2 | 0.05 | 4.3e-05 | 6.8 | 6.1 | 1.4e-09 | -0.03 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | COL15A1 | 0.09 | 0.06 | enet | 22 | 0.05 | 1.2e-04 | 2.1 | 6.2 | 4.9e-10 | -0.35 | 0.19 | 0.78 | FALSE |
| 5 | GTEx | Lung | COL15A1 | 0.08 | 0.05 | lasso | 1 | 0.03 | 1.1e-03 | 6.6 | 6.6 | 3.1e-11 | -0.24 | 0.08 | 0.58 | FALSE |
| 6 | GTEx | Muscle Skeletal | XPA | 0.07 | 0.04 | enet | 10 | 0.04 | 1.4e-04 | 6.7 | 6.7 | 1.6e-11 | -0.02 | 0.01 | 0.99 | TRUE |
| 7 | GTEx | Ovary | C9orf156 | 0.39 | 0.23 | enet | 15 | 0.18 | 3.9e-05 | -3.3 | -5.3 | 1.3e-07 | 0.02 | 0.27 | 0.07 | TRUE |
| 8 | GTEx | Thyroid | COL15A1 | 0.10 | 0.06 | lasso | 5 | 0.04 | 2.2e-04 | 6.6 | 7.5 | 5.8e-14 | -0.32 | 0.06 | 0.92 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | COL15A1 | 0.05 | 0.04 | lasso | 3 | 0.04 | 3.8e-04 | 7.2 | 7.2 | 5.8e-13 | -0.23 | 0.05 | 0.88 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | COL15A1 | 0.12 | 0.12 | enet | 19 | 0.13 | 3.9e-25 | 7.2 | 7.8 | 7.7e-15 | -0.45 | 0.03 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | COL15A1 | 0.20 | 0.07 | blup | 115 | 0.09 | 8.3e-06 | 6.6 | 5.7 | 1.0e-08 | -0.25 | 0.07 | 0.86 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | COL15A1 | 0.05 | 0.05 | lasso | 1 | 0.04 | 1.7e-05 | 7.2 | 7.2 | 8.3e-13 | -0.24 | 0.04 | 0.96 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | COL15A1 | 0.06 | 0.06 | enet | 10 | 0.06 | 5.5e-07 | 7.1 | 7.0 | 1.9e-12 | -0.30 | 0.05 | 0.95 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | XPA | 0.03 | 0.01 | blup | 43 | 0.03 | 2.0e-04 | 6.2 | 5.7 | 1.3e-08 | -0.03 | 0.03 | 0.82 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | COL15A1 | 0.17 | 0.10 | blup | 114 | 0.11 | 9.3e-13 | 7.1 | 6.4 | 1.2e-10 | -0.38 | 0.04 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | COL15A1 | 0.12 | 0.14 | enet | 12 | 0.13 | 1.9e-14 | 7.2 | 8.3 | 7.3e-17 | -0.44 | 0.04 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | COL15A1 | 0.07 | 0.01 | enet | 8 | 0.02 | 1.2e-02 | 7.1 | 8.7 | 4.6e-18 | -0.68 | 0.02 | 0.79 | TRUE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | COL15A1 | 0.18 | 0.06 | blup | 115 | 0.08 | 4.7e-04 | 6.9 | 7.4 | 1.0e-13 | -0.54 | 0.02 | 0.90 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NCBP1 | 0.16 | 0.02 | blup | 40 | 0.06 | 1.5e-03 | -2.1 | -5.4 | 8.5e-08 | 0.01 | 0.02 | 0.44 | TRUE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | COL15A1 | 0.05 | 0.04 | enet | 13 | 0.03 | 6.1e-04 | 6.8 | 7.7 | 2.1e-14 | -0.38 | 0.09 | 0.75 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | COL15A1 | 0.05 | 0.00 | enet | 7 | 0.02 | 2.0e-02 | 7.1 | 8.3 | 9.1e-17 | -0.46 | 0.05 | 0.58 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | COL15A1 | 0.07 | 0.01 | blup | 115 | 0.03 | 2.8e-04 | 3.6 | 6.7 | 3.0e-11 | -0.45 | 0.04 | 0.87 | FALSE |
| 23 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | XPA | 0.12 | 0.14 | lasso | 1 | 0.11 | 5.2e-04 | 6.2 | -6.2 | 4.8e-10 | 0.01 | 0.04 | 0.45 | TRUE |