TWAS
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Traits
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Traits
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Lung FEV1/FVC ratio
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chr11:61,697,904-63,110,149
Best TWAS P=9.4e-10 · Best GWAS P=4.22e-09 conditioned to 0.0071
61.8M
62M
62.2M
62.4M
62.6M
62.8M
63M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Rectum Adenocarcinoma
EML3
0.36
0.08
blup
27
0.19
3.7e-05
4.0
6.1
9.4e-10
-0.61
0.02
0.67
TRUE
1
GTEx
Nerve Tibial
GANAB
0.21
0.14
lasso
4
0.14
1.8e-10
-5.8
6.0
2.7e-09
-0.71
0.00
1.00
FALSE
2
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
EML3
0.04
0.05
blup
27
0.05
3.5e-06
4.0
5.5
4.9e-08
-0.42
0.68
0.23
FALSE
3
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
EEF1G
0.08
0.00
blup
27
0.04
1.3e-02
4.3
-5.5
4.9e-08
0.48
0.05
0.40
FALSE