[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr11:56,666,189-58,284,951

Best TWAS P=6.88e-14 · Best GWAS P=9.02e-12 conditioned to 0.647

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Lung YPEL4 0.05 0.06 lasso 3 0.05 6.7e-05 5.0 -5.3 1.4e-07 0.42 0.41 0.57 FALSE
2 GTEx Nerve Tibial CTNND1 0.06 0.02 lasso 11 0.04 1.0e-03 6.2 6.3 2.4e-10 -0.42 0.23 0.69 FALSE
3 GTEx Skin Sun Exposed Lower leg ZDHHC5 0.05 0.03 lasso 8 0.02 6.2e-03 -4.6 -6.1 1.4e-09 0.72 0.35 0.56 FALSE
4 GTEx Skin Sun Exposed Lower leg YPEL4 0.09 0.07 lasso 10 0.07 3.2e-06 6.1 -6.2 7.2e-10 0.35 0.24 0.76 FALSE
5 GTEx Testis MED19 0.16 0.15 enet 12 0.15 3.0e-07 5.7 -5.8 5.8e-09 0.38 0.36 0.63 FALSE
6 NTR Blood SERPING1 0.01 0.00 blup 399 0.00 2.9e-02 6.3 -5.8 6.2e-09 0.57 0.19 0.43 FALSE
7 ROSMAP Brain Pre-frontal Cortex ZDHHC5 0.05 0.02 blup 401 0.03 2.0e-04 -4.2 6.0 2.5e-09 -0.63 0.12 0.68 FALSE
8 ROSMAP Brain Pre-frontal Cortex AP000662.4 0.05 0.01 enet 17 0.02 3.8e-04 -3.2 5.8 8.3e-09 -0.54 0.48 0.44 FALSE
9 YFS Blood SERPING1 0.04 0.04 lasso 6 0.04 1.2e-12 -6.8 -7.5 6.9e-14 0.93 0.00 1.00 TRUE
10 The Cancer Genome Atlas Breast Invasive Carcinoma TMX2 0.01 0.01 enet 7 0.01 3.3e-03 6.2 -6.4 2.0e-10 0.52 0.01 0.94 FALSE
11 The Cancer Genome Atlas Breast Invasive Carcinoma YPEL4 0.02 0.03 lasso 3 0.02 5.4e-06 5.7 -5.7 1.0e-08 0.43 0.78 0.20 FALSE
12 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma YPEL4 0.04 0.05 blup 33 0.04 2.6e-05 5.0 -6.4 1.6e-10 0.67 0.52 0.39 FALSE
13 The Cancer Genome Atlas Prostate Adenocarcinoma TMX2 0.03 0.02 blup 29 0.02 3.7e-03 6.2 -6.1 9.9e-10 0.58 0.01 0.94 FALSE
14 The Cancer Genome Atlas Thyroid Carcinoma SERPING1 0.06 0.03 blup 52 0.04 6.3e-05 -6.7 6.5 9.0e-11 -0.87 0.01 0.98 FALSE