[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr11:56,666,189-58,284,951

Best TWAS P=6.88e-14 · Best GWAS P=9.02e-12 conditioned to 0.647

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	YFS	Blood	SERPING1	0.04	0.04	lasso	6	0.04	1.2e-12	-6.8	-7.5	6.9e-14	0.93	0.00	1.00	TRUE
14	The Cancer Genome Atlas	Thyroid Carcinoma	SERPING1	0.06	0.03	blup	52	0.04	6.3e-05	-6.7	6.5	9.0e-11	-0.87	0.01	0.98	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	YPEL4	0.04	0.05	blup	33	0.04	2.6e-05	5.0	-6.4	1.6e-10	0.67	0.52	0.39	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMX2	0.01	0.01	enet	7	0.01	3.3e-03	6.2	-6.4	2.0e-10	0.52	0.01	0.94	FALSE
2	GTEx	Nerve Tibial	CTNND1	0.06	0.02	lasso	11	0.04	1.0e-03	6.2	6.3	2.4e-10	-0.42	0.23	0.69	FALSE
4	GTEx	Skin Sun Exposed Lower leg	YPEL4	0.09	0.07	lasso	10	0.07	3.2e-06	6.1	-6.2	7.2e-10	0.35	0.24	0.76	FALSE
13	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMX2	0.03	0.02	blup	29	0.02	3.7e-03	6.2	-6.1	9.9e-10	0.58	0.01	0.94	FALSE
3	GTEx	Skin Sun Exposed Lower leg	ZDHHC5	0.05	0.03	lasso	8	0.02	6.2e-03	-4.6	-6.1	1.4e-09	0.72	0.35	0.56	FALSE
7	ROSMAP	Brain Pre-frontal Cortex	ZDHHC5	0.05	0.02	blup	401	0.03	2.0e-04	-4.2	6.0	2.5e-09	-0.63	0.12	0.68	FALSE
5	GTEx	Testis	MED19	0.16	0.15	enet	12	0.15	3.0e-07	5.7	-5.8	5.8e-09	0.38	0.36	0.63	FALSE
6	NTR	Blood	SERPING1	0.01	0.00	blup	399	0.00	2.9e-02	6.3	-5.8	6.2e-09	0.57	0.19	0.43	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	AP000662.4	0.05	0.01	enet	17	0.02	3.8e-04	-3.2	5.8	8.3e-09	-0.54	0.48	0.44	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	YPEL4	0.02	0.03	lasso	3	0.02	5.4e-06	5.7	-5.7	1.0e-08	0.43	0.78	0.20	FALSE
1	GTEx	Lung	YPEL4	0.05	0.06	lasso	3	0.05	6.7e-05	5.0	-5.3	1.4e-07	0.42	0.41	0.57	FALSE