TWAS
hub
About
Usage
Models
Genes
Traits
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Traits
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Lung FEV1/FVC ratio
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chr20:2,961,408-4,359,816
Best TWAS P=8.25e-10 · Best GWAS P=3.69e-12 conditioned to 0.00102
3M
3.2M
3.4M
3.6M
3.8M
4M
4.2M
4.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
ADAM33
0.07
0.03
enet
9
0.04
1.9e-05
-6.9
-6.1
8.3e-10
0.85
0
1.00
TRUE
1
GTEx
Artery Tibial
ADAM33
0.32
0.10
lasso
8
0.11
4.8e-09
-6.9
-6.0
2.4e-09
0.91
0
1.00
FALSE
2
GTEx
Nerve Tibial
ADAM33
0.25
0.02
enet
17
0.06
3.3e-05
-6.9
-5.7
1.1e-08
0.72
0
0.99
FALSE
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
ADAM33
0.06
0.02
blup
79
0.03
2.3e-04
-4.0
-5.3
1.0e-07
0.71
0
0.99
FALSE