Best TWAS P=8.25e-10 · Best GWAS P=3.69e-12 conditioned to 0.00102
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | ADAM33 | 0.32 | 0.10 | lasso | 8 | 0.11 | 4.8e-09 | -6.9 | -6.0 | 2.4e-09 | 0.91 | 0 | 1.00 | FALSE |
| 2 | GTEx | Nerve Tibial | ADAM33 | 0.25 | 0.02 | enet | 17 | 0.06 | 3.3e-05 | -6.9 | -5.7 | 1.1e-08 | 0.72 | 0 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADAM33 | 0.07 | 0.03 | enet | 9 | 0.04 | 1.9e-05 | -6.9 | -6.1 | 8.3e-10 | 0.85 | 0 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ADAM33 | 0.06 | 0.02 | blup | 79 | 0.03 | 2.3e-04 | -4.0 | -5.3 | 1.0e-07 | 0.71 | 0 | 0.99 | FALSE |