TWAS
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Traits
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Traits
:
Lung FEV1/FVC ratio
:
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chr2:17,368,202-19,236,850
Best TWAS P=2.15e-25 · Best GWAS P=9.13e-47 conditioned to 9.1e-26
17.5M
18M
18.5M
19M
0
10
20
30
40
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Muscularis
KCNS3
0.20
0.06
enet
20
0.08
1.0e-05
7.8
10.4
2.1e-25
0.52
0.13
0.79
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
KCNS3
0.09
0.06
lasso
7
0.05
1.3e-06
6.7
6.3
2.2e-10
0.38
1.00
0.00
FALSE
2
GTEx
Pancreas
KCNS3
0.47
0.18
enet
41
0.28
2.5e-12
-1.2
6.2
4.9e-10
0.27
0.84
0.13
FALSE