[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr2:24,021,231-25,889,403

Best TWAS P=9.67e-14 · Best GWAS P=1.78e-12 conditioned to 0.623

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	6.3	-7.5	9.7e-14	-0.92	0.02	0.98	TRUE
13	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	6.5	7.3	3.9e-13	0.94	0.02	0.98	FALSE
12	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	6.9	7.2	5.1e-13	0.96	0.02	0.98	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	6.9	-7.0	1.9e-12	-0.95	0.02	0.98	FALSE
10	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	6.3	-7.0	2.5e-12	-0.86	0.03	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	6.8	-6.7	2.4e-11	-0.83	0.03	0.97	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	6.7	-6.7	2.8e-11	-0.94	0.04	0.90	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	3.7	-6.6	3.2e-11	-0.51	0.50	0.22	FALSE
4	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	6.3	6.6	4.5e-11	0.78	0.31	0.69	FALSE
11	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	6.5	6.5	7.3e-11	0.91	0.04	0.96	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	6.7	6.0	2.7e-09	0.95	0.02	0.98	FALSE
5	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	6.3	5.9	3.6e-09	0.61	0.07	0.92	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	4.6	-5.8	8.9e-09	-0.92	0.03	0.94	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	6.7	-5.7	9.7e-09	-0.87	0.05	0.94	FALSE
8	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	3.2	5.4	7.8e-08	0.27	0.52	0.02	FALSE