[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr2:24,021,231-25,889,403

Best TWAS P=9.67e-14 · Best GWAS P=1.78e-12 conditioned to 0.623

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADCY3 0.16 0.12 lasso 10 0.14 3.2e-17 6.8 -6.7 2.4e-11 -0.83 0.03 0.97 FALSE
2 CommonMind Brain Pre-frontal Cortex CENPO 0.07 0.03 bslmm 322 0.03 7.0e-05 3.7 -6.6 3.2e-11 -0.51 0.50 0.22 FALSE
3 GTEx Adipose Subcutaneous ADCY3 0.07 0.04 lasso 6 0.01 3.2e-02 6.7 6.0 2.7e-09 0.95 0.02 0.98 FALSE
4 GTEx Artery Tibial ADCY3 0.21 0.14 lasso 6 0.15 4.3e-12 6.3 6.6 4.5e-11 0.78 0.31 0.69 FALSE
5 GTEx Artery Tibial RP11-443B20.1 0.17 0.08 enet 40 0.09 8.2e-08 6.3 5.9 3.6e-09 0.61 0.07 0.92 FALSE
6 GTEx Cells EBV-transformed lymphocytes ADCY3 0.25 0.23 enet 10 0.12 9.2e-05 6.7 -5.7 9.7e-09 -0.87 0.05 0.94 FALSE
7 GTEx Cells EBV-transformed lymphocytes RP11-443B20.1 0.13 0.13 enet 9 0.05 9.2e-03 6.7 -6.7 2.8e-11 -0.94 0.04 0.90 FALSE
8 GTEx Lung NCOA1 0.12 0.04 lasso 7 0.06 1.9e-05 3.2 5.4 7.8e-08 0.27 0.52 0.02 FALSE
9 GTEx Nerve Tibial ADCY3 0.09 0.05 enet 6 0.03 2.2e-03 6.3 -7.5 9.7e-14 -0.92 0.02 0.98 TRUE
10 GTEx Nerve Tibial RP11-443B20.1 0.07 0.03 enet 6 0.02 1.1e-02 6.3 -7.0 2.5e-12 -0.86 0.03 0.96 FALSE
11 GTEx Whole Blood DNAJC27 0.08 0.10 lasso 1 0.10 2.2e-09 6.5 6.5 7.3e-11 0.91 0.04 0.96 FALSE
12 GTEx Whole Blood ADCY3 0.23 0.24 enet 24 0.27 5.5e-25 6.9 7.2 5.1e-13 0.96 0.02 0.98 FALSE
13 GTEx Whole Blood RP11-443B20.1 0.21 0.17 enet 32 0.20 1.8e-18 6.5 7.3 3.9e-13 0.94 0.02 0.98 FALSE
14 ROSMAP Brain Pre-frontal Cortex ADCY3 0.17 0.26 enet 32 0.26 6.8e-33 6.9 -7.0 1.9e-12 -0.95 0.02 0.98 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY3 0.03 0.02 blup 81 0.02 7.1e-04 4.6 -5.8 8.9e-09 -0.92 0.03 0.94 FALSE