[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr2:28,235,763-29,792,216

Best TWAS P=1.56e-08 · Best GWAS P=3.67e-08 conditioned to 0.232

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Artery Coronary	TRMT61B	0.21	0.16	lasso	3	0.17	2.8e-06	-5.2	-5.7	1.6e-08	-0.87	0.04	0.96	TRUE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TRMT61B	0.20	0.12	enet	12	0.18	3.2e-08	-5.3	-5.6	1.7e-08	-0.89	0.03	0.97	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	PPP1CB	0.05	0.02	blup	39	0.03	4.7e-03	-5.0	5.6	2.0e-08	0.86	0.05	0.78	FALSE
16	GTEx	Thyroid	PPP1CB	0.07	0.00	enet	7	0.00	3.4e-01	-5.3	5.6	2.3e-08	0.93	0.03	0.92	FALSE
30	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPDYA	0.05	0.03	blup	49	0.05	6.0e-03	-4.4	-5.5	3.2e-08	-0.92	0.02	0.60	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRMT61B	0.12	0.15	lasso	4	0.16	1.7e-17	-5.0	-5.5	3.6e-08	-0.91	0.04	0.96	FALSE
14	GTEx	Pancreas	TRMT61B	0.17	0.14	lasso	2	0.12	7.5e-06	5.4	-5.5	4.1e-08	-0.98	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRMT61B	0.30	0.30	enet	18	0.30	2.6e-12	-5.1	-5.5	4.4e-08	-0.89	0.05	0.95	FALSE
27	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRMT61B	0.12	0.18	lasso	4	0.18	1.8e-10	-5.2	-5.5	4.8e-08	-0.89	0.05	0.95	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPP1CB	0.04	0.04	lasso	1	0.03	9.8e-05	5.4	5.4	5.5e-08	0.99	0.01	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PPP1CB	0.12	0.08	blup	574	0.10	3.3e-12	-5.0	5.4	5.9e-08	0.83	0.03	0.97	FALSE
19	METSIM	Adipose	TRMT61B	0.06	0.08	enet	12	0.09	8.5e-13	-5.3	-5.4	6.0e-08	-0.76	0.08	0.92	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	TRMT61B	0.35	0.22	lasso	3	0.22	2.1e-07	-5.2	-5.4	6.3e-08	-0.88	0.04	0.96	FALSE
17	GTEx	Thyroid	AC097724.3	0.07	0.03	lasso	4	0.03	4.1e-03	5.5	5.4	6.6e-08	0.99	0.02	0.95	FALSE
18	METSIM	Adipose	PPP1CB	0.07	0.08	lasso	3	0.08	1.1e-11	5.5	5.4	6.9e-08	0.99	0.02	0.98	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	TRMT61B	0.15	0.11	lasso	8	0.10	3.7e-13	-5.2	-5.4	8.1e-08	-0.82	0.08	0.91	FALSE
32	The Cancer Genome Atlas	Stomach Adenocarcinoma	TRMT61B	0.13	0.14	enet	11	0.15	5.5e-11	-5.0	-5.3	9.4e-08	-0.85	0.08	0.92	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	TRMT61B	0.29	0.37	lasso	4	0.38	1.5e-38	-5.1	-5.3	1.1e-07	-0.81	0.08	0.92	FALSE
6	GTEx	Brain Caudate basal ganglia	TRMT61B	0.22	0.01	enet	5	0.04	2.5e-02	-5.3	-5.3	1.3e-07	-0.80	0.06	0.83	FALSE
34	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRMT61B	0.26	0.15	lasso	7	0.14	1.0e-04	-5.3	-5.3	1.3e-07	-0.82	0.03	0.82	FALSE
8	GTEx	Breast Mammary Tissue	TRMT61B	0.32	0.17	lasso	7	0.20	8.2e-11	-5.0	-5.2	1.7e-07	-0.83	0.08	0.92	FALSE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRMT61B	0.14	0.17	lasso	2	0.16	1.9e-13	-5.1	-5.2	1.7e-07	-0.82	0.07	0.93	FALSE
13	GTEx	Lung	TRMT61B	0.20	0.24	lasso	9	0.24	4.2e-18	-5.0	-5.2	1.8e-07	-0.88	0.14	0.86	FALSE
3	GTEx	Artery Aorta	TRMT61B	0.26	0.29	enet	16	0.29	4.0e-16	-5.1	-5.2	2.1e-07	-0.84	0.10	0.89	FALSE
9	GTEx	Esophagus Mucosa	TRMT61B	0.18	0.22	lasso	3	0.22	1.7e-14	-5.1	-5.2	2.1e-07	-0.83	0.09	0.91	FALSE
28	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TRMT61B	0.08	0.09	lasso	1	0.07	3.4e-04	-5.2	-5.2	2.2e-07	-0.81	0.05	0.84	FALSE
5	GTEx	Artery Tibial	TRMT61B	0.29	0.27	lasso	4	0.28	1.1e-21	-5.0	-5.2	2.3e-07	-0.83	0.12	0.88	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRMT61B	0.10	0.17	lasso	2	0.17	1.2e-33	-5.1	-5.2	2.3e-07	-0.82	0.05	0.95	FALSE
2	GTEx	Adrenal Gland	PPP1CB	0.16	0.07	lasso	6	0.07	1.6e-03	-5.0	5.2	2.6e-07	0.82	0.05	0.84	FALSE
15	GTEx	Thyroid	TRMT61B	0.18	0.23	lasso	6	0.22	1.0e-16	-5.1	-5.1	2.7e-07	-0.82	0.09	0.91	FALSE
12	GTEx	Heart Left Ventricle	TRMT61B	0.21	0.17	lasso	3	0.15	1.9e-08	-5.1	-5.1	2.8e-07	-0.81	0.11	0.89	FALSE
10	GTEx	Esophagus Muscularis	TRMT61B	0.27	0.34	lasso	3	0.33	1.0e-20	-5.1	-5.1	2.9e-07	-0.82	0.09	0.91	FALSE
7	GTEx	Brain Putamen basal ganglia	TRMT61B	0.27	0.12	enet	11	0.20	1.3e-05	-5.1	-5.1	3.0e-07	-0.71	0.09	0.85	FALSE
11	GTEx	Heart Atrial Appendage	TRMT61B	0.38	0.27	lasso	4	0.24	5.5e-11	-5.1	-5.1	3.1e-07	-0.81	0.09	0.91	FALSE