Best TWAS P=3.84e-11 · Best GWAS P=4.84e-17 conditioned to 1.51e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CALML6 | 0.19 | 0.16 | lasso | 4 | 0.18 | 1.5e-14 | 6.3 | 6.4 | 2.0e-10 | -0.08 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CALML6 | 0.13 | 0.03 | lasso | 5 | 0.03 | 1.6e-02 | 6.3 | 6.5 | 1.1e-10 | -0.11 | 0.22 | 0.04 | FALSE |
| 3 | GTEx | Artery Coronary | AL645728.2 | 0.18 | 0.03 | lasso | 3 | 0.00 | 4.2e-01 | 6.0 | 6.5 | 1.1e-10 | -0.12 | 0.02 | 0.46 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | CALML6 | 0.27 | 0.06 | enet | 11 | 0.15 | 3.5e-08 | 6.0 | 6.6 | 5.0e-11 | -0.10 | 0.99 | 0.00 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | CALML6 | 0.28 | 0.04 | enet | 15 | 0.04 | 3.0e-02 | 6.0 | 6.6 | 3.8e-11 | -0.12 | 0.17 | 0.04 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | CALML6 | 0.11 | 0.02 | lasso | 2 | 0.03 | 3.3e-03 | 6.3 | 5.8 | 6.5e-09 | -0.05 | 0.26 | 0.13 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RP1-283E3.4 | 0.53 | 0.12 | enet | 20 | 0.22 | 4.1e-15 | 3.1 | 5.5 | 4.2e-08 | 0.00 | 0.99 | 0.00 | TRUE |
| 8 | GTEx | Esophagus Muscularis | RP1-283E3.4 | 0.46 | 0.14 | enet | 23 | 0.24 | 1.6e-14 | 3.1 | 5.5 | 4.8e-08 | 0.00 | 0.96 | 0.00 | FALSE |
| 9 | GTEx | Lung | CALML6 | 0.10 | 0.02 | lasso | 2 | 0.01 | 5.0e-02 | 6.3 | 6.3 | 2.3e-10 | -0.08 | 0.34 | 0.03 | FALSE |
| 10 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | 3.8 | -5.2 | 1.7e-07 | 0.13 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Nerve Tibial | CALML6 | 0.13 | 0.12 | lasso | 2 | 0.11 | 4.4e-08 | 6.3 | 6.4 | 1.9e-10 | -0.10 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Pancreas | CALML6 | 0.21 | 0.08 | lasso | 4 | 0.06 | 2.2e-03 | 6.3 | 6.3 | 4.0e-10 | -0.11 | 0.48 | 0.03 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | RP1-283E3.4 | 0.48 | 0.12 | lasso | 5 | 0.31 | 1.1e-17 | 3.1 | 5.3 | 1.0e-07 | -0.02 | 0.48 | 0.05 | FALSE |
| 14 | GTEx | Spleen | TMEM52 | 0.47 | 0.21 | lasso | 5 | 0.22 | 2.3e-06 | 6.0 | 6.5 | 5.8e-11 | -0.07 | 0.38 | 0.03 | FALSE |
| 15 | GTEx | Thyroid | CALML6 | 0.24 | 0.13 | lasso | 4 | 0.18 | 9.2e-14 | 6.3 | 5.9 | 3.9e-09 | -0.06 | 1.00 | 0.00 | FALSE |
| 16 | METSIM | Adipose | CALML6 | 0.09 | 0.04 | enet | 10 | 0.08 | 2.8e-12 | -2.5 | 5.2 | 2.5e-07 | -0.06 | 1.00 | 0.00 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | C1orf222 | 0.11 | 0.14 | enet | 18 | 0.14 | 1.8e-17 | 6.3 | -5.7 | 9.0e-09 | 0.12 | 1.00 | 0.00 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | CALML6 | 0.07 | 0.02 | lasso | 2 | 0.04 | 4.3e-06 | -2.7 | 5.4 | 5.4e-08 | -0.07 | 0.89 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CALML6 | 0.04 | 0.02 | blup | 37 | 0.03 | 2.0e-06 | 6.4 | 6.6 | 4.6e-11 | -0.08 | 0.00 | 1.00 | FALSE |