Best TWAS P=3.38e-19 · Best GWAS P=1.59e-25 conditioned to 3.06e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | C10orf11 | 0.35 | 0.27 | lasso | 4 | 0.25 | 9.8e-08 | 8.2 | -8.3 | 1.5e-16 | -0.73 | 0.58 | 0.37 | FALSE |
| 2 | GTEx | Brain Cortex | C10orf11 | 0.32 | 0.15 | lasso | 8 | 0.21 | 1.4e-06 | 8.4 | -9.0 | 3.4e-19 | -0.78 | 0.47 | 0.47 | TRUE |
| 3 | GTEx | Brain Frontal Cortex BA9 | C10orf11 | 0.33 | 0.18 | enet | 11 | 0.19 | 9.3e-06 | 8.2 | -8.0 | 1.5e-15 | -0.71 | 0.46 | 0.39 | FALSE |
| 4 | GTEx | Muscle Skeletal | C10orf11 | 0.11 | 0.13 | lasso | 3 | 0.12 | 5.1e-12 | 8.4 | -8.7 | 2.7e-18 | -0.74 | 1.00 | 0.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | C10orf11 | 0.20 | 0.23 | lasso | 4 | 0.23 | 1.1e-29 | 8.4 | -8.6 | 6.1e-18 | -0.71 | 1.00 | 0.00 | FALSE |