Best TWAS P=2.62e-08 · Best GWAS P=2.36e-07 conditioned to 0.0918
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | RP11-977G19.11 | 0.12 | 0.06 | lasso | 2 | 0.10 | 2.2e-06 | 3.4 | -5.2 | 2.2e-07 | -0.71 | 0.05 | 0.88 | FALSE |
| 2 | GTEx | Heart Atrial Appendage | SUOX | 0.09 | 0.10 | enet | 8 | 0.09 | 1.1e-04 | -4.9 | 5.3 | 1.4e-07 | 0.19 | 0.02 | 0.91 | FALSE |
| 3 | GTEx | Muscle Skeletal | SUOX | 0.11 | 0.04 | lasso | 7 | 0.04 | 4.4e-05 | -4.9 | 5.4 | 8.3e-08 | 0.23 | 0.02 | 0.97 | TRUE |
| 4 | YFS | Blood | SPRYD4 | 0.39 | 0.34 | lasso | 5 | 0.36 | 3.7e-126 | 5.1 | 5.4 | 8.0e-08 | 0.97 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SPRYD4 | 0.07 | 0.06 | blup | 34 | 0.05 | 2.2e-06 | 5.1 | 5.6 | 2.6e-08 | 0.85 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SPRYD4 | 0.07 | 0.05 | lasso | 3 | 0.03 | 2.0e-03 | 5.1 | 5.1 | 2.8e-07 | 0.96 | 0.00 | 0.97 | FALSE |