Best TWAS P=5.28e-08 · Best GWAS P=3.77e-08 conditioned to 0.00406
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | GPR135 | 0.10 | 0.01 | enet | 16 | 0.02 | 1.8e-02 | -4.8 | 5.2 | 1.5e-07 | -0.69 | 0.05 | 0.84 | FALSE |
| 2 | GTEx | Artery Coronary | L3HYPDH | 0.22 | 0.07 | enet | 35 | 0.04 | 1.8e-02 | -4.0 | 5.2 | 2.2e-07 | -0.36 | 0.22 | 0.54 | FALSE |
| 3 | GTEx | Artery Tibial | DAAM1 | 0.07 | 0.01 | enet | 8 | 0.00 | 1.4e-01 | 3.6 | 5.4 | 5.3e-08 | -0.58 | 0.15 | 0.55 | TRUE |
| 4 | GTEx | Brain Caudate basal ganglia | L3HYPDH | 0.29 | 0.28 | enet | 20 | 0.31 | 1.5e-09 | -5.0 | 5.1 | 2.9e-07 | -0.75 | 0.05 | 0.94 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | GPR135 | 0.14 | 0.08 | lasso | 9 | 0.07 | 3.1e-04 | -5.5 | 5.3 | 1.5e-07 | -0.92 | 0.02 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GPR135 | 0.07 | 0.09 | blup | 69 | 0.08 | 5.3e-09 | -4.9 | 5.3 | 9.9e-08 | -0.90 | 0.01 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | GPR135 | 0.06 | 0.02 | blup | 69 | 0.05 | 1.7e-05 | -4.1 | 5.2 | 2.4e-07 | -0.81 | 0.03 | 0.96 | FALSE |