Hub : Genes

GPR135

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0850 0.0300 1.1e-04 0.092 NA 0.056 NA 0.068 6.0e-08 NA 2.3e-05 NA 3.2e-06
2 GTEx Artery Aorta 0.0960 0.0450 2.4e-03 0.014 NA 0.024 NA 0.019 5.3e-02 NA 1.8e-02 NA 2.9e-02
3 GTEx Artery Tibial 0.1024 0.0326 6.8e-07 0.059 NA 0.063 NA 0.074 2.1e-05 NA 1.1e-05 NA 1.8e-06
4 GTEx Brain Cerebellum 0.1210 0.0510 2.7e-03 0.016 NA 0.034 NA -0.008 1.1e-01 NA 3.6e-02 NA 6.6e-01
5 GTEx Breast Mammary Tissue 0.1220 0.0570 8.8e-03 0.011 NA 0.025 NA 0.035 8.1e-02 NA 1.8e-02 NA 6.5e-03
6 GTEx Breast Mammary Tissue (Male) 0.0389 0.0645 3.1e-01 -0.005 NA -0.006 NA 0.008 4.4e-01 NA 4.6e-01 NA 2.1e-01
7 GTEx Breast Mammary Tissue (Female) 0.0726 0.0591 1.3e-01 0.028 NA -0.009 NA 0.002 5.0e-02 NA 7.7e-01 NA 2.7e-01
8 GTEx Cells EBV-transformed lymphocytes 0.3320 0.0910 3.3e-04 0.038 NA 0.146 NA 0.093 2.1e-02 NA 1.7e-05 NA 5.9e-04
9 GTEx Cells Transformed fibroblasts 0.1120 0.0410 7.2e-05 0.127 NA 0.100 NA 0.119 9.6e-10 NA 5.9e-08 NA 3.2e-09
10 GTEx Colon Transverse 0.1530 0.0590 4.1e-04 0.170 NA 0.118 NA 0.108 1.7e-08 NA 3.1e-06 NA 7.9e-06
11 GTEx Esophagus Mucosa 0.1010 0.0390 2.0e-03 -0.002 NA 0.020 NA 0.015 5.0e-01 NA 1.6e-02 NA 3.0e-02
12 GTEx Esophagus Muscularis 0.1170 0.0450 9.1e-05 0.106 NA 0.053 NA 0.075 6.0e-07 NA 3.7e-04 NA 2.6e-05
13 GTEx Heart Atrial Appendage 0.1410 0.0490 6.0e-05 0.082 NA 0.070 NA 0.075 1.5e-04 NA 4.4e-04 NA 3.1e-04
14 GTEx Ovary 0.2350 0.0780 3.7e-04 0.176 NA 0.189 NA 0.194 4.2e-05 NA 2.1e-05 NA 1.7e-05
15 GTEx Pituitary 0.1780 0.0720 1.8e-03 0.135 NA 0.117 NA 0.117 3.0e-04 NA 7.3e-04 NA 7.3e-04
16 METSIM Adipose 0.0505 0.0192 8.9e-05 0.032 0.029 0.023 0.029 0.023 1.0e-05 3.2e-05 1.7e-04 3.3e-05 2.0e-04
17 TCGA Head and Neck Squamous Cell Carcinoma 0.0242 0.0131 6.0e-04 0.039 0.026 0.030 NA 0.033 2.9e-05 5.6e-04 2.4e-04 NA 1.1e-04
18 TCGA Brain Lower Grade Glioma 0.0679 0.0314 1.6e-08 0.087 0.076 0.076 NA 0.075 4.0e-10 5.3e-09 5.7e-09 NA 7.7e-09
19 TCGA Thyroid Carcinoma 0.0640 0.0340 2.8e-06 0.024 0.048 0.039 NA 0.041 1.9e-03 1.7e-05 9.9e-05 NA 6.6e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bipolar Disorder (2018) 3.5 5.6 10.2 2.5 1.3 3.2 2.8 2.0 -0.2 2.9 1.1 2.6 3.2 1.9 2.6 3.0 2.5 2.1 -1.3 -2.1 2.4 2.7
Bipolar Disorder or Schizophrenia 1.1 2.7 7.3 1.5 1.2 2.0 1.9 -1.5 0.3 -0.9 -2.7 1.2 1.1 -1.0 1.6 1.3 1.4 1.2 -2.1 -2.1 2.0 2.3
Depressed Affect (Nagel 2018) 1.4 2.9 7.7 2.3 0.2 2.0 1.4 0.5 2.1 0.5 0.4 1.7 1.3 1.1 2.8 1.6 1.8 2.6 -1.1 -1.6 2.1 2.0
Depression (Nagel 2018) 3.0 4.6 12.3 2.8 2.0 2.7 1.3 0.7 3.5 0.4 -0.9 2.7 1.3 1.4 3.1 2.0 2.3 2.5 -0.8 -2.2 2.5 2.0
Intelligence (Savage-Jansen 2018) 2.6 8.0 22.3 -2.8 -3.5 -2.9 -2.4 -2.9 -0.9 -4.7 -2.9 -3.5 -2.3 -2.3 -3.5 -3.3 -3.0 -2.4 1.6 2.6 -2.3 -1.6
Neuroticism (Nagel 2018) 2.5 5.9 12.2 3.0 2.1 3.2 2.4 0.4 2.2 0.7 -0.5 2.2 2.1 1.7 3.5 2.6 2.5 3.3 -1.9 -2.6 3.2 3.0
Schizophrenia (2018) 1.5 3.1 18.9 -0.1 0.5 -0.0 0.2 -3.6 0.6 -3.5 -4.3 -0.5 -1.1 -2.8 -0.0 -0.8 -0.3 -0.2 -1.6 -0.9 0.6 0.8
Schizophrenia vs Biploar Disorder 2.0 2.7 13.0 -0.3 1.3 -0.3 -0.2 -2.9 1.5 -3.2 -3.6 -0.4 -1.5 -2.6 -0.1 -1.5 -0.4 -0.1 -1.7 -1.0 0.2 0.3
Worry (Nagel 2018) 2.2 4.6 8.5 2.5 2.4 2.9 2.0 0.5 2.3 1.2 -1.0 2.0 1.8 0.8 2.7 2.4 2.2 2.2 -1.5 -2.4 2.9 2.8
Alzheimer’s Disease (in mother) 0.4 0.5 3.1 0.5 -0.3 0.1 0.0 -0.2 0.1 0.1 1.8 1.3 1.1 0.4 0.3 0.5 0.8 0.0 0.2 0.8 1.1 0.4
Alzheimer’s Disease (in father) 0.5 0.5 1.2 -0.7 -0.7 -0.7 -0.5 -1.1 0.1 -0.4 -0.1 -0.4 -1.0 -0.8 -0.6 -1.0 -0.7 -0.9 -0.5 -0.0 -0.9 -1.0
Alzheimer’s Disease (including proxy) 0.2 0.2 1.9 -0.4 -0.8 -0.5 -0.2 -0.3 -0.1 0.0 1.4 0.2 -0.2 -0.2 -0.5 -0.5 -0.2 -0.6 0.1 0.2 -0.0 -0.4
Crohns Disease (2017) 0.2 0.4 1.8 0.4 -0.9 -0.2 0.1 -0.4 -0.7 -0.4 1.4 0.4 1.0 0.4 0.0 0.3 0.6 -0.1 0.2 0.7 0.5 0.8
Irritable Bowel Disease (IBD) 0.1 0.3 2.3 0.4 -0.4 -0.0 0.6 0.2 -1.1 0.2 1.5 0.1 0.8 0.4 0.2 0.3 0.6 0.4 -0.0 0.0 0.4 0.8
Ulcerative Colitis (UC) 0.2 0.4 1.1 0.3 0.9 0.3 1.1 0.7 -1.0 0.7 0.9 -0.4 0.4 0.2 0.3 0.2 0.4 0.6 -0.1 -0.8 0.4 0.8
Major Depression (MDD) 1.1 1.4 7.9 -0.4 -1.5 -0.3 -1.1 -1.5 1.7 -2.2 -2.8 -0.9 -1.1 -0.4 -0.2 -0.5 -0.9 -0.5 0.9 0.5 -0.3 -0.4
Reaction Time 0.3 0.6 1.8 0.7 0.9 0.8 0.8 0.6 -1.3 0.6 0.2 0.6 1.2 0.4 0.5 1.1 0.9 0.8 0.0 0.0 1.0 1.1
Verbal and Numeric Reasoning (VNR) 1.0 2.4 8.1 -1.4 -1.7 -1.2 -1.5 -1.4 0.8 -2.9 -2.5 -2.1 -1.8 -1.3 -1.5 -1.3 -1.8 -1.2 0.7 1.1 -1.2 -0.8
Breast Cancer 0.4 0.9 5.1 0.5 0.4 0.1 0.6 -1.2 1.0 -0.7 -1.1 0.4 -0.7 -0.9 1.1 -0.6 0.3 0.8 -2.2 -1.7 0.3 0.3
Ovarian Cancer 0.9 1.2 3.3 1.3 0.5 0.9 1.5 -0.2 0.7 -0.1 0.7 0.7 0.8 0.1 1.1 1.3 1.2 1.4 -1.2 -1.8 1.1 1.8
Prostate Cancer 0.2 0.2 1.0 -0.1 0.9 0.1 -0.5 0.2 0.8 0.0 1.0 -0.3 0.2 -0.7 -0.4 -0.4 -0.2 -0.3 0.1 0.3 0.4 0.5
Age at First Birth 0.3 0.5 2.0 -0.7 -0.8 -0.9 -0.7 -1.4 0.1 -0.7 -0.7 0.2 -0.7 -0.8 -0.8 -0.6 -0.5 -0.7 0.3 0.3 -0.5 -1.0
Bipolar Disorder (2011) 2.1 2.0 5.1 1.6 -0.3 2.0 1.4 1.6 -0.2 1.8 0.1 1.0 2.2 1.7 1.5 1.2 1.7 1.3 -0.2 -0.8 1.7 1.7
Body Mass Index (BMI) (2010) 1.4 1.9 4.9 1.4 1.5 1.4 1.3 0.7 -0.3 2.2 1.3 1.5 1.8 0.9 1.6 1.8 1.5 1.2 -0.8 -0.8 1.4 1.4
Coronary Artery Disease (CAD) 0.5 0.6 2.3 -0.7 -1.5 -0.7 -0.7 -0.5 0.7 -1.0 -0.5 -0.9 -1.3 -0.7 -0.2 -0.7 -0.9 0.3 0.2 -0.0 -0.8 -0.8
Crohns Disease (2012) 0.3 0.4 3.5 0.1 -0.8 -0.3 -0.6 0.3 -0.4 0.0 1.9 0.8 0.6 0.7 0.0 -0.0 0.5 -0.4 0.4 1.2 0.2 -0.2
Mean Putamen Volume 1.6 1.8 3.8 -1.3 -1.6 -1.4 -1.5 -1.4 0.5 -1.6 -1.4 -1.2 -2.0 -1.0 -1.1 -1.5 -1.5 -1.5 1.5 0.9 -1.1 -1.1
Fasting Glucose 0.8 0.9 6.3 0.8 0.6 0.5 -0.3 -0.1 2.5 -0.9 -0.5 1.6 -0.1 0.2 1.3 0.2 0.8 1.4 -0.7 -0.6 1.0 0.1
HbA1C 0.4 0.4 3.6 0.1 1.9 -0.2 -0.3 0.7 0.5 0.6 0.6 0.6 0.3 0.5 0.2 -0.7 0.2 -0.2 -0.8 0.1 -0.4 -0.5
HDL Cholesterol 1.0 1.7 8.2 -0.7 -2.5 -0.9 -0.3 -2.5 -1.0 -2.9 -0.8 -0.6 -0.6 -1.5 -0.5 -1.6 -0.4 -0.8 0.7 0.7 -0.7 -0.5
LDL Cholesterol 0.7 1.0 3.6 -1.0 0.9 -1.2 -1.1 0.6 -0.9 0.5 -1.9 -1.3 -0.3 0.1 -0.8 -1.3 -0.9 -1.5 0.0 1.2 -0.9 -1.0
Lupus 0.9 1.3 5.3 -1.3 -0.6 -0.8 -0.0 -1.3 -2.1 -0.3 -1.5 -2.3 -0.9 -1.0 -1.0 -1.2 -1.6 -0.9 0.1 0.6 -1.0 -0.1
Neuroticism (2016) 0.2 0.3 1.6 0.4 0.1 0.6 0.5 -0.6 -0.2 0.0 -1.3 -0.1 0.2 -0.6 0.6 -0.4 0.2 0.5 -0.8 -0.7 0.4 0.9
Primary Biliary Cirrhosis 1.8 2.6 10.2 1.3 2.2 1.4 1.9 -1.7 0.5 -1.3 -1.5 1.2 0.7 -1.3 1.3 0.4 1.3 1.2 -3.2 -2.6 1.3 1.6
Rheumatoid Arthritis 0.5 0.7 5.8 0.2 1.0 0.7 1.2 0.7 -2.4 0.6 -0.5 -0.8 1.1 0.2 -0.6 0.7 0.4 0.3 -0.1 -0.4 0.5 0.9
Schizophrenia (2014) 1.1 2.5 19.0 0.2 0.8 0.4 0.6 -2.8 0.7 -2.4 -4.4 -0.9 -0.8 -2.4 0.2 -0.5 -0.2 -0.3 -1.0 -1.2 1.0 1.5
Triglycerides 0.6 1.0 5.2 -0.4 0.8 -0.5 -0.4 2.3 -1.5 2.1 1.6 0.2 0.6 0.4 -0.8 -0.0 -0.2 -0.8 0.2 1.1 -0.5 -0.6
Type 2 Diabetes (T2D) (2012) 0.4 0.5 3.4 0.2 -1.0 -0.4 -0.8 0.6 0.3 0.3 1.9 0.6 0.2 0.7 -0.3 0.5 -0.1 0.1 1.0 1.0 0.2 -0.6
Ulcerative Colitis 0.3 0.4 2.8 0.1 1.1 0.2 0.8 0.8 -1.7 0.6 0.5 -0.6 0.5 0.5 -0.1 0.2 0.4 0.4 -0.6 -0.3 0.1 0.1
Blood Eosinophil Count 0.3 2.5 6.3 -1.8 -1.5 -1.5 -1.8 0.9 -1.6 1.5 1.2 -0.6 -0.1 0.5 -1.4 -1.6 -1.2 -2.0 2.0 2.5 -1.8 -2.2
Blood Platelet Count 0.4 5.2 12.9 2.8 1.7 2.0 1.2 0.2 2.8 0.2 3.6 2.4 2.3 1.6 3.0 2.5 2.5 2.7 -1.0 -0.8 3.2 2.6
Blood Red Count 0.4 4.1 9.3 -2.2 -2.6 -2.5 -2.8 -1.2 0.2 -1.6 1.1 -1.7 -1.6 -1.4 -1.8 -3.1 -2.1 -2.1 0.3 2.7 -2.3 -2.4
Blood White Count 0.1 0.5 6.1 -0.0 -0.9 -0.1 -0.3 0.9 -0.5 0.7 2.5 0.1 0.7 0.6 0.0 -0.2 0.2 0.4 0.2 0.8 -0.2 -0.2
Heel T-Score 0.4 3.1 14.4 0.2 -1.0 0.2 -0.4 3.6 0.8 2.7 2.9 0.1 0.4 3.8 -0.1 1.6 0.2 0.5 2.9 0.8 -0.4 -1.0
BMI 1.4 8.3 37.4 2.9 1.0 2.5 2.3 3.5 -0.3 3.8 6.1 3.6 3.5 3.2 2.6 2.6 3.1 2.1 -1.1 -1.2 2.1 1.5
Height 1.3 25.1 79.7 -5.2 -3.5 -4.0 -3.0 -7.0 -1.1 -6.4 -8.9 -5.0 -6.2 -6.2 -4.4 -6.1 -5.3 -4.0 -0.1 0.7 -4.9 -3.6
Waist Hip Ratio (WHR) 0.2 0.8 3.0 -0.7 0.1 -1.3 -0.5 -0.3 -1.6 -0.1 0.5 0.5 -0.1 -1.3 -0.3 -1.7 -0.2 -1.0 -0.9 1.2 -0.4 -1.1
Systolic Blood Pressure 0.2 1.2 8.3 0.1 -0.4 -0.5 0.3 -2.0 0.1 -2.9 0.3 -0.4 -0.5 -2.0 0.0 -0.8 0.0 -0.0 -1.4 -0.6 0.3 1.3
Smoking Status 2.4 5.8 13.0 3.1 1.9 3.0 2.5 -0.1 2.1 0.6 -0.3 2.4 2.5 2.2 3.6 2.7 3.0 2.3 -1.6 -2.4 3.0 2.9
Allergy or Eczema 0.3 0.8 7.7 -0.5 -0.9 -0.5 0.3 0.7 -2.8 0.9 1.6 -0.1 0.8 0.1 -0.6 0.2 -0.0 -0.6 0.2 1.0 -0.4 -0.2
Cardiovascular Disease 0.8 2.5 7.6 1.8 0.6 1.5 1.5 0.2 1.5 0.4 2.8 2.3 0.9 -0.2 2.1 1.3 1.6 0.9 -2.1 -1.9 1.7 1.9
Hypothyroidism (self reported) 0.1 0.3 1.0 -0.3 0.4 0.0 -0.4 1.0 0.6 0.9 -0.7 -0.5 -0.7 0.5 -0.5 0.1 -0.8 -0.4 0.2 -0.1 -0.6 -0.8
Respiratory disease 0.5 1.1 2.9 -1.2 -1.0 -1.4 -0.9 -0.4 -1.4 -0.8 -0.3 -0.7 -0.6 -0.6 -1.3 -1.6 -0.9 -0.9 0.2 1.0 -1.7 -1.5
Type 2 Diabetes (T2D) (2018) 0.2 0.3 2.4 -0.1 -1.6 -0.2 -0.6 0.4 0.3 0.1 0.4 0.5 0.1 0.2 -0.3 -0.3 0.1 0.2 0.6 0.6 -0.1 -0.8
Lung FEV1/FVC ratio 0.7 3.7 7.8 -2.1 -2.6 -2.3 -2.8 -0.4 0.4 0.4 -1.6 -1.3 -2.3 -1.0 -1.8 -1.7 -2.3 -2.2 1.7 2.0 -2.2 -2.7
Lung FVC 3.4 17.5 28.4 5.1 5.2 4.9 4.9 0.9 1.7 1.3 2.9 4.4 4.4 2.1 4.1 5.3 4.9 4.0 -4.0 -4.2 5.3 5.2
Neuroticism 2.9 6.9 12.4 3.2 2.5 3.0 2.9 1.0 2.2 1.4 -0.3 2.4 2.0 1.1 3.5 2.8 2.8 3.4 -2.4 -3.1 3.5 3.2
Chronotype (morning person) 0.4 0.9 2.5 -1.4 -0.3 -1.0 -0.7 -0.2 -0.2 -0.0 0.3 -1.0 -1.6 -0.8 -0.7 -1.5 -1.4 -0.6 0.1 0.0 -1.4 -1.4
Hair Pigment 0.1 2.9 10.9 -1.9 -0.4 -2.0 -1.1 -1.9 0.4 -1.3 -1.1 -1.4 -2.6 -3.3 -1.7 -2.4 -1.9 -1.3 -0.6 0.1 -1.8 -1.3
Tanning 0.2 1.9 5.5 1.4 0.9 1.4 1.8 0.3 -1.9 0.8 1.0 1.0 2.3 1.2 0.7 1.3 1.8 1.2 0.2 -0.2 1.8 2.0
Hand grip strength (left) 0.1 0.4 2.4 -0.2 0.3 0.3 0.3 -1.5 -0.6 -1.1 -1.6 -0.1 0.1 -0.0 -0.3 -0.4 0.0 -0.1 0.3 -0.1 -0.1 0.1
Number of treatments/medications taken 0.4 0.7 2.7 -0.9 -1.1 -0.7 -1.3 0.9 0.1 0.8 -0.0 -0.2 -0.3 0.1 -0.7 -0.7 -0.9 -0.5 0.6 1.0 -1.6 -1.4
Average weekly spirits intake 1.3 1.6 7.0 0.0 0.4 0.1 -0.4 2.3 -1.6 2.1 2.6 1.1 1.4 1.5 -0.4 0.7 0.4 -0.5 1.2 1.7 -0.2 -0.7
Sensitivity / hurt feelings 1.6 2.7 6.2 1.9 1.8 2.0 1.8 1.1 1.3 0.4 -0.3 1.2 1.3 2.1 1.7 2.0 1.5 2.5 -0.8 -1.9 2.1 1.6
Frequency of depressed mood in last 2 weeks 3.3 4.6 8.5 2.8 2.2 2.9 1.5 0.5 2.4 0.1 -1.8 2.3 1.8 1.2 2.4 2.5 2.4 2.9 -0.4 -1.7 2.9 2.5
Hearing difficulty/problems: Yes 0.5 0.8 2.8 0.7 1.5 0.3 0.6 -0.4 1.4 -0.9 -1.7 0.8 -0.1 -0.2 0.8 0.7 0.6 1.2 -1.1 -1.1 0.7 0.3
Relative age of first facial hair 0.1 0.3 1.5 -0.4 1.2 0.1 -0.2 -0.4 -0.5 0.3 -1.2 -0.4 -0.3 -0.8 -0.0 0.1 -0.4 -0.6 0.0 0.1 -0.3 -0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 5.9 -0.8 0.4 -0.3 0.4 -0.7 -2.4 -0.8 -0.4 0.0 -0.1 -1.6 -0.7 -0.4 -0.4 -0.9 -1.2 -0.1 -0.7 -0.1
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.9 -0.7 -1.5 -0.6 -0.8 -1.5 0.0 -2.0 -1.3 -0.9 -0.9 -0.0 -0.8 -0.4 -0.9 -0.2 1.1 0.5 -0.6 -0.6
Ever had hysterectomy (womb removed) 0.9 1.0 2.3 1.0 0.7 1.2 1.3 0.8 -1.1 0.6 1.0 0.6 1.5 0.7 0.7 1.0 1.1 0.9 -0.3 -0.3 1.4 1.5
Systolic blood pressure, automated reading 0.2 0.5 2.9 0.1 -1.0 -0.4 -0.2 -0.9 -0.2 -1.7 1.7 -0.4 0.0 -0.5 0.4 -0.5 0.2 0.1 -0.4 0.3 0.3 0.8
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.8 -0.5 -0.3 -0.9 -0.6 -0.9 0.2 -1.4 0.1 -0.5 -1.4 -0.9 -0.5 -0.6 -0.8 -0.4 -0.0 -0.2 -0.6 -0.4
Angina 1.8 2.4 5.1 1.9 1.6 1.6 1.6 1.0 1.6 0.8 0.9 1.8 0.8 0.7 1.9 2.0 1.6 1.8 -1.1 -2.2 1.7 1.5
Medication for hormone replacement therapy 1.2 1.3 2.7 -1.3 -0.8 -1.4 -1.5 0.2 0.2 0.2 -0.9 -1.2 -1.2 0.7 -1.0 -0.4 -1.3 -1.3 1.5 1.3 -1.5 -1.7
Vitamin and mineral supplements 1.1 1.5 5.0 -1.2 -0.2 -1.2 -1.3 -0.6 0.0 -1.0 -1.5 -1.8 -1.3 -0.8 -1.4 -0.6 -1.5 -2.2 1.0 1.2 -1.0 -0.9
Supplements: Zinc 0.5 0.6 5.5 -0.2 -0.5 -0.4 -0.9 -0.1 2.3 -0.2 -0.3 0.0 -1.5 -0.6 0.3 -0.6 -0.3 -0.4 0.4 -0.1 -0.5 -0.6
Medication: Co-codamol 0.9 1.1 3.2 -0.9 -1.3 -1.0 -0.8 -0.6 -1.3 -0.9 -1.5 -1.7 -0.3 -0.0 -1.1 -0.4 -1.0 -0.7 1.8 1.3 -0.7 -0.5
Medication: Metformin 1.4 2.0 5.4 1.7 0.9 1.5 1.1 2.3 0.0 1.4 1.2 1.1 1.8 2.2 1.2 1.9 1.5 1.6 0.2 -0.6 1.3 1.0
Diabetes (father) 0.8 1.0 2.4 0.8 1.0 0.8 1.5 0.7 -1.2 0.7 0.5 1.0 1.3 -0.5 0.7 0.4 1.1 0.8 -1.5 -1.2 1.0 1.5
Diabetes (mother) 0.2 0.3 1.5 0.4 -0.5 0.3 0.6 -0.6 0.1 -0.3 -0.8 -0.4 -0.1 -0.1 0.6 -0.5 0.1 0.8 -0.8 -1.2 0.2 0.6
Severe depression (siblings) 0.9 1.0 2.8 1.0 1.2 1.0 0.9 -0.4 0.6 -1.0 -1.7 0.7 0.8 0.7 1.0 0.6 0.9 1.7 -0.6 -0.8 1.3 1.1
Pack years adult smoking proportion 0.4 0.6 3.3 -0.1 -1.8 -0.4 -0.2 -1.3 -0.6 -1.6 -1.0 -0.8 -0.2 -0.3 -0.5 -0.7 -0.2 0.0 0.7 0.5 -0.3 -0.1
Impedance of leg (right) 0.4 1.9 16.9 -0.1 0.5 -0.1 -1.0 -1.4 4.1 -1.1 -1.5 0.3 -2.0 -1.8 0.5 -0.6 -0.5 -0.6 -2.0 -0.9 -0.2 -0.1
Leg fat-free mass (left) 0.2 1.2 9.1 0.4 0.2 0.7 1.5 0.9 -3.0 1.7 1.0 0.5 1.6 0.6 -0.2 0.3 0.9 1.0 -0.4 -0.5 0.1 0.4
Trunk fat percentage 0.6 2.6 19.0 1.1 -0.1 0.7 1.0 2.5 -0.3 2.9 4.4 1.4 1.6 1.6 0.8 0.7 1.4 0.9 -1.2 -0.4 0.4 0.6
Hand grip strength (right) 0.2 0.5 2.0 0.3 -0.2 0.9 0.8 -0.9 -1.4 -0.1 -1.3 0.2 1.1 0.9 0.3 -0.3 0.6 0.8 0.2 -0.1 0.3 0.6
Townsend deprivation index at recruitment 0.9 1.3 3.8 0.9 1.0 1.5 1.1 1.9 -0.2 1.0 1.9 1.4 1.1 -0.2 0.9 0.5 1.0 1.3 -1.0 -0.8 1.2 1.2
Current tobacco smoking 1.6 2.6 5.4 1.9 1.1 2.3 2.2 -0.3 0.1 0.5 -0.9 1.5 1.8 0.5 2.0 0.8 2.0 1.9 -1.6 -2.0 1.9 2.3
Average weekly fortified wine intake 0.2 0.2 1.0 -0.5 -1.0 -0.2 -0.6 0.1 -0.2 0.2 -0.0 -0.7 0.2 0.1 -0.5 -0.4 -0.7 -0.2 0.2 0.7 -0.3 -0.3
Maternal smoking around birth 0.4 0.5 5.4 0.2 1.2 0.9 0.2 -0.7 0.7 0.3 -2.3 -0.1 -0.1 -0.3 -0.1 0.5 0.1 0.1 -0.8 -0.4 0.4 0.4
Fed-up feelings 1.6 3.0 6.9 2.1 1.3 2.2 1.7 0.4 1.4 0.8 -0.5 1.4 1.6 0.7 2.5 1.6 1.7 2.6 -2.2 -1.8 1.8 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 8.0 1.9 1.4 2.1 0.9 1.7 2.8 1.3 -0.9 1.7 0.6 0.8 1.9 1.8 1.5 2.4 -1.4 -1.9 1.5 1.1
Relative age voice broke 1.1 1.8 3.6 1.9 1.6 1.8 1.2 0.6 1.3 0.8 -0.9 1.1 1.2 1.2 1.5 1.5 1.5 1.2 0.0 -1.2 1.6 1.4
Taking other prescription medications 1.1 1.7 4.1 -1.4 -0.6 -1.2 -1.7 1.2 -1.0 0.6 0.7 -1.4 -0.7 0.4 -1.6 -0.7 -1.4 -1.2 1.9 2.0 -1.7 -1.7
Age when periods started (menarche) 0.1 0.3 1.1 0.2 0.3 0.7 -0.2 0.3 0.5 1.0 -0.5 -0.3 0.7 0.6 -0.1 1.1 0.2 -0.1 1.0 0.6 0.7 0.6
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.2 0.7 -0.1 0.7 0.4 -0.4 0.4 -0.4 0.1 1.1 0.6 -0.1 0.1 0.2 1.1 1.0 -0.5 -0.0 0.9 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 4.2 -0.9 -1.7 -0.8 -0.7 0.5 -0.9 -0.0 0.2 -0.8 -0.6 0.7 -1.1 -0.2 -0.8 -1.0 2.1 1.2 -1.0 -1.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.5 0.7 0.3 0.1 0.7 -0.3 0.3 -1.2 0.1 0.2 -0.1 0.8 0.9 0.7 0.4 0.8 -0.5 -1.0 0.5 0.6
Qualifications: CSEs or equivalent 0.5 0.6 3.2 0.7 1.3 0.5 1.0 0.3 0.1 0.1 1.8 -0.2 0.2 0.2 0.7 0.5 0.6 0.2 -1.1 -1.0 0.7 1.2
Serious illness, injury or assault to yourself 0.5 0.6 3.8 0.2 1.0 0.0 -0.4 1.9 0.2 1.2 1.2 1.0 0.5 0.5 0.8 -0.1 0.4 -0.1 -0.3 0.7 -0.3 -0.8
High blood pressure 1.1 3.0 9.3 1.8 0.4 1.5 2.1 0.5 0.3 1.0 2.7 1.9 1.2 -0.2 2.1 1.6 1.8 1.5 -3.1 -2.3 1.4 2.1
Hayfever, allergic rhinitis or eczema 0.3 0.6 5.3 0.0 -0.7 0.2 0.7 0.9 -2.3 0.9 1.1 0.3 0.9 0.7 -0.2 0.6 0.3 0.1 -0.1 0.3 0.0 0.2
Multivitamins +/- minerals 1.0 1.2 3.5 1.1 0.4 0.8 1.0 1.0 0.4 0.9 1.7 1.8 0.9 0.4 1.2 0.6 1.4 1.9 -1.2 -1.1 0.8 0.8
Stomach or abdominal pain in last month 0.4 0.6 3.0 0.2 1.4 0.9 -0.1 1.7 0.4 1.5 0.3 0.3 0.3 0.7 0.5 1.0 0.2 0.3 -0.1 0.0 0.1 -0.3
Supplements: Glucosamine 0.2 0.3 2.0 0.4 0.1 -0.3 -0.3 0.1 0.9 -0.1 0.6 1.4 0.1 0.1 0.1 0.8 0.5 0.3 0.7 0.6 0.4 -0.4
Diverticular disease/diverticulitis (self-reported) 3.7 4.4 9.5 -2.4 -1.9 -2.1 -2.1 0.4 -1.4 0.1 -1.2 -3.0 -1.7 0.8 -2.4 -1.8 -2.7 -1.7 3.1 2.3 -2.6 -2.8
Medication: Atenolol 1.3 1.6 4.8 1.5 -0.7 0.8 0.8 0.9 1.5 0.3 2.2 1.8 0.6 0.8 1.9 1.3 1.3 1.9 -0.8 -1.4 0.8 0.6
Medication: Levothyroxine sodium 0.2 0.3 1.8 0.3 0.6 0.4 -0.6 0.1 1.4 -0.0 -0.9 0.1 -0.2 1.0 0.5 0.4 -0.2 0.0 -0.2 0.1 -0.1 -0.6
Sitting height 0.5 3.3 8.4 -1.7 -1.9 -1.3 -1.1 -2.5 -1.1 -2.6 -2.9 -2.2 -1.7 -1.2 -2.3 -2.1 -1.7 -1.1 0.7 0.8 -1.9 -1.3
Chronic bronchitis/emphysema (father) 0.5 0.6 2.4 -0.3 -0.1 -0.9 -0.4 -1.4 -1.1 -1.6 -0.5 0.2 0.0 -1.5 -0.1 -1.3 -0.1 -0.2 -0.5 0.7 -0.1 -0.3
High blood pressure (mother) 0.5 0.7 1.7 -1.0 -1.3 -1.0 -0.8 -0.4 0.1 -0.1 -0.7 -0.4 -0.9 -1.2 -0.9 -0.6 -1.1 -1.1 0.7 0.4 -0.9 -1.0
Body mass index (BMI) 1.6 6.8 30.0 2.4 1.2 2.0 2.4 3.4 -1.6 3.5 5.5 2.6 3.5 2.6 1.7 2.6 2.8 2.1 -0.6 -0.9 1.9 1.8
Impedance of leg (left) 0.4 2.0 14.6 -0.5 -0.1 -0.5 -1.3 -1.4 3.8 -1.4 -1.9 -0.3 -2.3 -1.8 0.0 -1.0 -0.9 -1.1 -1.5 -0.5 -0.6 -0.5
Leg predicted mass (left) 0.2 1.1 9.4 0.3 0.2 0.6 1.4 1.0 -3.1 1.7 1.0 0.4 1.6 0.6 -0.3 0.2 0.8 0.9 -0.3 -0.4 0.1 0.4
Trunk fat mass 0.6 2.4 15.3 1.0 0.0 0.8 1.3 2.2 -0.9 2.8 3.9 1.4 1.7 1.3 0.7 0.7 1.4 1.1 -1.3 -0.6 0.3 0.6
Waist circumference 0.8 3.0 15.2 1.4 0.6 1.0 1.6 2.1 -1.7 2.1 3.9 2.2 2.4 1.5 1.1 1.2 2.0 1.2 -1.0 -0.4 1.0 0.7
Number of incorrect matches in round 0.6 1.0 2.8 0.9 0.5 1.2 1.4 -0.3 -1.2 -0.2 -0.6 0.3 1.5 0.6 0.9 0.7 1.0 1.5 -0.7 -0.6 1.5 1.7
Past tobacco smoking 0.3 0.6 2.5 -0.9 -0.4 -0.2 -0.1 0.7 -1.2 1.2 -0.4 -0.1 -0.4 -1.6 -0.9 -1.3 -0.8 -0.4 -0.2 -0.1 -0.8 -0.3
Alcohol usually taken with meals 0.3 0.6 2.7 -0.8 -1.1 -0.7 -0.1 -0.1 -1.6 -0.7 -0.7 -0.5 -0.5 -0.6 -0.7 -1.3 -0.6 -0.4 0.0 0.4 -0.6 -0.7
Nervous feelings 2.1 4.0 9.0 2.4 2.5 2.3 2.3 -0.1 1.5 0.6 -0.8 1.4 1.8 0.6 2.7 1.9 2.1 2.0 -1.7 -2.4 3.0 3.0
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.8 8.8 2.4 0.8 3.0 1.9 1.8 1.1 1.9 -0.2 1.5 2.2 2.3 2.1 2.5 1.9 2.8 -0.7 -1.4 2.4 2.1
Hearing difficulty/problems with background noise 0.8 1.3 2.7 1.1 1.6 1.2 1.2 -0.3 1.3 -0.5 -1.4 1.0 0.2 -0.6 1.2 1.3 1.0 1.0 -1.5 -1.6 1.2 1.3
Hair/balding pattern: Pattern 2 0.8 1.0 4.1 -0.5 -1.0 -0.8 -0.3 -2.0 0.1 -1.7 -1.5 -1.1 -0.9 -0.9 -0.3 -1.6 -0.8 0.5 -1.2 -0.2 -0.6 -0.2
Had menopause 0.9 1.1 3.5 1.3 0.2 1.5 1.3 -0.7 0.1 -0.4 0.1 0.9 1.0 0.1 1.4 1.3 1.2 0.8 -0.6 -1.3 1.4 1.9
Had other major operations 0.5 0.6 1.8 0.6 -0.1 1.0 1.1 0.4 -1.3 0.4 1.0 1.2 1.3 0.6 0.7 0.8 0.9 0.6 -0.3 -0.3 0.5 0.5
Forced vital capacity (FVC) 1.4 5.4 11.3 2.5 3.4 2.8 2.9 -1.5 0.6 -0.7 -1.5 1.9 1.9 -0.1 2.2 1.9 2.4 2.1 -3.3 -2.9 2.9 3.2
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 5.8 -1.7 -2.4 -1.5 -1.2 -0.3 -1.2 -0.4 -0.0 -1.6 -1.4 -0.6 -1.7 -1.1 -1.7 -1.8 1.7 1.7 -1.6 -1.5
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.6 -0.8 0.2 -0.6 -0.6 -0.8 0.3 -0.9 -1.6 -0.3 -0.8 -1.3 -0.9 -0.7 -0.6 -0.3 0.1 0.5 -0.4 -0.6
Qualifications: None of the above 0.4 0.9 3.6 -0.5 -1.2 -0.7 -0.8 1.3 -1.0 1.8 1.9 -0.2 0.1 0.2 -0.7 -0.4 -0.2 -0.2 1.0 1.4 -0.8 -0.8
Financial difficulties in last 2 years 0.1 0.2 1.1 0.4 0.3 0.2 0.1 0.4 -0.1 -0.1 0.1 -0.1 0.4 0.6 -0.3 0.6 0.4 0.6 1.0 0.5 0.4 0.1
Mouth/teeth dental problems 0.5 0.7 2.3 0.9 -0.4 1.1 1.2 -0.5 -0.6 -0.8 -0.1 0.3 1.2 0.8 0.5 1.0 0.8 0.9 0.2 -0.4 1.2 1.5
Heart attack 0.5 0.6 2.7 0.8 1.3 0.7 0.1 0.5 1.6 -0.0 0.5 1.4 0.3 -0.1 0.8 0.7 0.8 0.6 -0.2 -0.6 0.8 0.3
Allergy 0.7 1.5 7.3 1.3 2.3 1.1 0.5 -0.4 2.7 -0.2 -0.9 0.7 0.2 -0.2 1.5 0.5 0.9 1.0 -1.5 -1.3 1.4 1.1
Pain all over the body in last month 2.3 2.5 5.3 1.9 2.3 1.1 1.4 0.9 1.9 1.0 0.4 2.0 1.0 0.2 1.7 0.9 1.8 2.0 -2.1 -2.0 1.7 1.5
Diabetes (self-reported) 0.2 0.2 1.3 -0.5 -1.1 -0.5 -0.2 0.0 -0.3 -0.3 0.1 -0.3 -0.4 -0.2 -0.5 -0.6 -0.5 0.1 0.8 0.2 -0.4 -0.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 4.3 -0.3 0.1 0.3 -0.7 2.1 -0.6 2.0 0.6 0.5 0.4 1.5 -0.3 0.7 -0.1 -0.3 1.9 1.2 -0.6 -1.3
Medication: Ramipril 1.3 1.6 3.7 -1.5 -1.2 -1.9 -1.8 -0.3 0.4 -0.6 0.9 -1.1 -1.5 -0.7 -1.5 -1.2 -1.5 -1.5 0.5 1.5 -1.5 -1.6
Medication: Simvastatin 0.4 0.6 2.0 1.1 0.3 0.9 0.4 0.2 0.8 0.1 0.5 1.4 0.9 0.3 1.2 0.8 0.9 0.6 -0.2 -0.5 0.8 0.9
Fluid intelligence score 1.3 2.6 5.1 -1.5 -2.2 -1.5 -1.6 -0.7 1.2 -2.0 -2.3 -1.3 -2.1 -1.5 -1.6 -1.5 -1.8 -1.7 0.8 0.8 -1.8 -1.6
Illnesses of siblings 0.6 0.8 2.5 -0.9 -0.2 -0.4 -1.0 0.9 -0.5 1.3 0.1 -1.1 0.2 1.4 -0.8 0.1 -0.7 -1.0 1.4 1.6 -0.8 -0.6
Neuroticism score 1.7 3.5 7.2 2.2 1.8 2.2 1.9 0.7 1.9 1.1 -0.6 1.7 1.3 0.8 2.5 2.1 1.8 2.7 -1.9 -2.2 2.2 2.1
Weight 0.3 1.6 6.9 0.8 -0.0 0.8 1.5 1.4 -2.0 2.0 2.6 1.1 1.7 0.9 0.2 0.6 1.3 1.1 -0.8 -0.5 0.3 0.6
Impedance of arm (right) 0.9 4.4 9.2 -2.2 -2.6 -2.2 -2.4 -2.1 1.3 -2.1 -2.2 -2.0 -3.0 -1.3 -1.8 -2.5 -2.5 -2.0 0.6 1.5 -2.2 -2.1
Arm fat percentage (right) 0.8 3.3 25.0 1.3 0.0 0.8 1.4 2.5 -1.3 2.6 5.0 1.6 2.1 1.9 0.7 1.3 1.7 1.2 -0.7 -0.1 0.6 0.7
Trunk fat-free mass 0.1 0.5 4.9 -0.2 0.1 0.3 1.0 -0.7 -2.2 -0.1 -0.6 -0.0 0.4 -1.0 -0.8 -0.3 0.3 0.4 -0.5 -0.6 -0.3 0.1
Hip circumference 0.5 2.1 9.3 1.4 0.3 1.2 1.6 1.8 -1.3 1.5 3.1 1.7 2.0 1.5 0.7 1.3 1.7 1.3 -0.4 -0.6 0.9 0.9
Time employed in main current job 2.8 3.3 6.4 -2.1 -2.1 -2.5 -2.5 -1.0 0.2 -1.3 0.0 -1.9 -1.9 -1.0 -1.8 -1.7 -2.0 -1.8 1.2 2.3 -2.2 -2.2
Alcohol intake versus 10 years previously 1.8 2.7 7.3 2.0 0.6 1.7 2.1 0.8 0.0 0.7 1.4 1.8 1.6 1.3 2.0 2.1 2.1 2.7 -0.9 -1.6 1.7 1.7
Father’s age at death 0.4 0.6 2.3 -0.8 -0.5 -0.6 -0.3 0.3 -1.5 0.6 1.2 -0.9 0.1 -0.1 -1.1 -0.1 -0.6 -0.9 1.0 1.0 -0.5 -0.4
Worrier / anxious feelings 0.9 1.7 3.5 1.6 0.6 1.5 0.8 1.4 1.6 1.4 -0.1 1.9 1.2 1.1 1.9 1.5 1.4 1.5 -0.6 -0.7 1.5 0.8
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 7.4 1.7 1.9 1.3 0.4 0.3 2.7 0.1 -0.8 1.5 0.7 1.1 2.3 1.1 1.2 2.3 -0.9 -1.2 1.4 0.8
Falls in the last year 1.3 1.7 5.2 -1.2 -0.5 -1.4 -1.7 1.4 -0.4 0.8 1.4 -0.5 -0.5 0.1 -1.5 -0.3 -1.0 -1.9 2.3 2.2 -1.2 -1.8
Hair/balding pattern: Pattern 3 0.6 0.8 3.7 -0.6 -1.2 -0.4 -0.9 -0.1 1.9 -0.6 -1.8 -0.6 -1.4 -0.8 -0.5 -0.5 -0.7 -0.7 0.7 -0.1 -0.7 -0.7
Number of live births 0.2 0.3 2.2 0.0 0.4 0.0 0.4 0.6 -1.5 1.1 0.9 -0.5 0.8 0.3 0.2 0.5 -0.0 -0.3 0.4 0.1 0.2 0.5
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 5.3 1.7 2.1 2.0 1.9 -1.1 0.2 -0.1 -1.4 1.6 1.3 -0.4 1.2 1.2 1.7 1.2 -2.3 -1.8 2.0 2.2
Pulse rate 0.4 0.8 4.5 -0.3 -1.3 -0.6 -0.3 -0.0 -1.7 0.5 2.1 0.2 0.7 0.6 -0.7 -0.1 0.1 -0.8 0.4 1.2 -0.5 -0.8
Happiness 1.5 1.8 5.2 1.1 2.0 1.7 1.3 0.0 1.3 -0.4 -1.5 1.0 0.7 -0.2 1.2 0.8 1.0 1.8 -2.3 -1.7 1.5 1.6
Noisy workplace 0.3 0.4 2.8 -0.0 0.8 0.1 -0.1 1.0 -0.5 1.7 1.0 -0.2 0.5 0.6 -0.1 0.1 -0.1 -0.0 -0.5 0.4 -0.3 0.0
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.1 0.7 0.3 1.1 1.0 -0.5 -0.3 -0.9 -0.6 1.5 0.9 0.2 0.4 0.4 1.0 0.6 -0.9 -0.7 1.1 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.9 0.4 0.5 0.6 0.5 -0.1 1.3 -0.5 -0.3 0.9 -0.3 -1.3 1.0 0.4 0.4 0.3 -1.0 -1.4 0.5 0.6
Mouth/teeth dental problems: Dentures 0.8 1.3 3.2 -1.4 -0.4 -1.3 -1.5 0.6 -0.1 0.3 0.3 -0.5 -1.4 -1.4 -1.2 -1.3 -1.3 -1.6 0.3 0.8 -1.8 -1.4
Asthma 1.3 2.5 7.0 -2.0 -1.7 -1.8 -1.1 -0.5 -2.6 -0.7 -0.1 -1.5 -0.9 -0.9 -2.1 -2.0 -1.7 -1.6 1.1 1.5 -2.3 -1.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 2.9 -0.4 -0.3 0.1 0.8 0.0 -1.7 0.8 0.2 -0.4 0.3 -0.3 -1.0 0.3 -0.2 0.2 -0.7 -0.3 -0.4 0.1
Medication: Cholesterol lowering 0.7 1.1 6.8 1.3 0.1 0.6 0.4 -0.2 2.6 -0.1 1.2 1.7 0.2 0.1 1.7 0.5 1.0 0.8 -0.6 -1.3 0.9 0.7
Depression (self-reported) 1.9 2.2 6.9 -1.4 -2.0 -1.4 -1.9 -1.6 0.1 -2.6 -0.5 -1.7 -1.0 -0.7 -1.3 -1.7 -1.5 -0.9 1.3 1.9 -1.2 -1.3
Medication: Lansoprazole 0.4 0.5 1.2 0.6 0.4 1.1 0.3 0.8 0.3 0.4 -0.3 1.1 1.0 0.6 0.8 0.6 0.6 0.7 0.6 -0.5 0.9 0.8
Prospective memory result 1.1 1.4 5.3 1.0 2.3 1.1 0.3 1.3 1.0 1.9 1.9 1.3 1.0 1.2 0.7 1.0 1.0 0.4 0.3 -0.1 1.2 0.5
Lung cancer (father) 0.2 0.2 1.0 0.4 -0.7 0.2 0.2 -0.6 -0.2 -1.0 0.1 -0.2 0.6 0.8 0.7 0.2 0.4 0.4 0.2 0.2 0.2 0.4
Illnesses of mother 2.6 3.3 6.5 2.2 2.5 2.3 1.9 1.0 0.2 1.1 0.0 1.6 2.0 1.8 2.0 1.4 2.2 2.4 -1.3 -1.7 2.0 2.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 3.2 1.1 1.6 1.5 1.5 -1.0 -0.2 -0.4 -1.8 1.0 0.9 -0.5 0.5 0.7 1.1 0.7 -1.7 -1.4 1.4 1.5
Pulse wave Arterial Stiffness index 2.6 3.1 8.5 1.9 2.3 2.0 2.0 0.7 0.8 1.4 0.1 1.9 1.1 -0.0 2.4 1.3 1.7 1.2 -2.9 -2.5 1.6 1.9
Impedance of arm (left) 0.6 2.7 5.9 -1.7 -1.8 -1.6 -1.9 -1.4 1.4 -1.2 -2.2 -1.8 -2.4 -0.8 -1.1 -2.1 -2.0 -1.7 0.2 0.9 -1.7 -1.6
Arm fat mass (right) 0.7 2.9 18.9 1.2 0.2 0.9 1.5 2.3 -1.6 2.5 4.3 1.4 2.2 1.6 0.6 1.3 1.6 1.2 -0.8 -0.4 0.6 0.8
Trunk predicted mass 0.1 0.5 4.8 -0.2 0.2 0.3 1.0 -0.8 -2.2 -0.1 -0.7 -0.0 0.4 -1.1 -0.8 -0.2 0.3 0.5 -0.6 -0.7 -0.3 0.2
Standing height 0.9 8.6 33.4 -3.0 -2.4 -2.1 -1.6 -4.1 -1.0 -3.0 -5.8 -3.1 -3.3 -3.4 -2.9 -4.0 -2.9 -1.8 -0.5 0.3 -3.0 -2.1
Length of working week for main job 1.5 1.7 3.3 1.2 0.7 1.5 1.4 1.5 -0.2 1.8 1.0 1.6 1.2 0.6 1.4 1.4 1.4 1.8 -1.2 -1.4 0.9 1.2
Exposure to tobacco smoke at home 0.4 0.4 3.5 0.1 1.2 -0.0 -0.5 0.5 1.9 -0.1 0.6 0.7 -0.3 -0.8 0.4 -0.3 0.0 -0.0 -0.8 0.1 -0.0 -0.4
Breastfed as a baby 0.2 0.2 1.0 -0.3 -0.4 -0.8 -0.4 -0.4 0.0 -0.3 1.0 0.4 -0.1 -0.3 -0.3 -0.8 0.1 -0.4 0.0 0.3 -0.2 -0.4
Tense / ‘highly strung’ 2.5 4.2 8.0 2.4 2.2 2.8 2.3 1.5 0.8 1.3 -0.2 1.6 2.3 1.7 2.3 2.7 2.2 2.2 -0.8 -1.9 2.6 2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 3.5 0.1 -1.2 0.2 -1.2 -0.3 1.7 -1.9 -0.9 -0.3 -0.4 0.5 0.5 0.0 -0.4 0.4 1.1 0.7 0.0 -0.3
Hair/balding pattern: Pattern 4 0.5 1.2 3.0 1.1 1.0 0.8 0.8 1.2 0.6 1.7 1.7 1.6 1.2 0.7 0.9 1.1 1.3 1.1 -1.2 -0.7 1.0 0.6
Birth weight of first child 1.2 2.2 5.6 1.4 2.4 1.7 1.9 0.5 0.5 0.8 -1.8 1.3 0.8 -0.5 1.1 1.1 1.4 2.2 -1.7 -2.2 1.6 1.5
Peak expiratory flow (PEF) 0.1 0.3 0.9 0.6 -0.5 0.7 0.2 -0.2 -0.2 0.2 -0.5 0.5 0.7 1.0 0.7 0.2 0.4 0.5 0.6 0.2 0.6 0.4
Pulse wave reflection index 1.4 1.8 4.1 1.4 2.0 1.5 0.9 1.7 1.5 2.0 0.3 1.2 0.5 0.6 1.6 1.6 1.0 0.9 -1.5 -1.5 0.9 1.2
Ever highly irritable/argumentative for 2 days 1.9 2.3 5.2 -1.6 -1.0 -1.6 -1.6 -1.4 0.7 -1.5 -2.0 -1.0 -1.8 -2.1 -1.3 -2.3 -1.7 -1.3 -0.4 0.8 -1.5 -1.7
Loud music exposure frequency 0.9 1.0 2.2 -0.9 -0.8 -0.8 -1.1 0.7 0.3 0.4 -1.2 -1.5 -1.2 0.8 -0.8 -0.4 -1.2 -1.1 1.5 0.8 -1.1 -1.1
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 6.7 0.5 -1.0 0.4 0.5 -1.4 0.9 -2.6 -1.2 0.1 -0.2 0.6 0.9 -0.5 0.5 0.9 0.1 -0.9 1.0 0.8
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 1.5 -0.1 0.2 -0.0 -0.5 -0.3 1.2 0.8 -0.5 -0.1 -0.3 0.3 0.2 -0.0 -0.2 0.2 -0.4 0.2 -0.2 -0.6
Blood clot in the leg (DVT) 1.5 1.9 3.7 -1.8 -1.8 -1.6 -1.3 -0.6 0.0 -1.2 -0.1 -1.0 -1.9 -1.4 -1.6 -1.8 -1.6 -0.9 0.7 0.7 -1.8 -1.9
Medication: Paracetamol 0.1 0.2 2.3 -0.2 0.2 -0.3 -0.3 0.0 0.5 0.4 -1.5 -0.6 -0.5 0.3 0.0 -0.3 -0.6 0.3 -0.4 -0.3 -0.5 -0.2
Headache pain in last month 0.4 0.6 3.9 0.3 0.9 0.5 -0.2 1.3 0.6 2.0 1.2 0.7 0.6 1.0 0.4 0.9 0.5 0.5 -0.3 0.2 0.0 -0.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.5 -1.0 -0.3 -0.5 -0.5 -0.2 -1.9 0.0 -1.4 -1.2 -0.2 0.1 -1.5 -0.3 -0.7 -0.8 1.3 1.2 -0.7 -0.9
Glaucoma (self-reported) 1.4 1.7 5.9 -1.2 -1.8 -0.8 -1.9 0.8 0.0 0.8 0.2 -0.9 -0.5 0.8 -1.0 -0.4 -1.2 -1.5 2.4 2.2 -1.2 -1.6
Gout (self-reported) 2.2 3.0 9.2 -1.7 0.0 -2.3 -1.6 -2.3 1.0 -3.0 -2.2 -1.8 -2.4 -2.2 -1.0 -1.7 -1.8 -1.6 0.4 0.7 -1.0 -0.8
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.8 -0.3 0.7 0.0 -0.5 0.1 0.6 0.4 -0.8 -0.6 -0.7 0.4 -0.1 0.3 -0.9 -0.4 -0.3 -0.1 -0.6 -0.8
Medication: Amlodipine 3.3 4.6 7.5 2.2 2.1 2.1 2.4 2.4 -0.9 2.7 2.4 1.9 2.6 1.8 2.2 1.8 2.7 2.2 -1.7 -1.7 2.0 2.2
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.9 -0.3 -0.9 -0.6 -0.1 -0.0 -0.1 -0.7 -0.4 0.2 -0.6 0.2 -0.6 -0.8 -0.1 0.1 0.1 -0.3 -0.9 -0.9
Birth weight 0.4 0.9 3.9 0.5 1.4 0.4 1.3 -1.3 -1.6 -0.9 0.7 0.4 0.7 -0.9 0.5 -0.0 0.7 0.5 -2.0 -0.8 0.6 1.0
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.8 -1.1 -0.2 -0.9 -1.0 -0.1 0.3 -0.2 -0.5 -1.1 -1.4 -0.5 -0.6 -0.9 -1.0 -0.8 0.1 0.2 -1.4 -1.1
High blood pressure (siblings) 1.7 2.4 7.9 1.4 1.4 1.3 2.0 -1.4 -0.1 -1.4 -0.8 1.5 1.0 -1.4 1.1 0.9 1.3 1.7 -2.8 -2.3 1.6 1.9
Forced vital capacity (FVC), Best measure 0.8 2.8 6.6 1.6 2.6 2.2 2.2 -1.4 -0.2 -1.2 -1.9 1.2 1.3 -0.4 1.0 1.1 1.6 1.2 -2.3 -2.1 2.0 2.2
Body fat percentage 1.1 4.3 25.6 1.8 0.4 1.3 1.6 2.9 -0.3 3.2 5.1 2.2 2.3 1.8 1.4 1.5 2.1 1.6 -1.5 -0.8 1.1 1.1
Leg fat percentage (right) 1.9 6.8 28.8 2.6 1.7 2.1 2.3 2.9 0.3 3.2 5.4 3.2 2.9 1.8 2.2 2.7 3.0 2.3 -2.0 -1.5 2.0 1.8
Arm fat-free mass (right) 0.2 1.2 5.2 0.8 0.7 1.1 1.7 0.5 -2.3 1.3 0.7 0.8 1.7 0.0 0.3 0.4 1.2 1.2 -1.1 -0.9 0.6 0.9
Exposure to tobacco smoke outside home 0.2 0.3 1.1 0.5 0.3 0.3 0.2 -0.0 -0.4 0.0 0.7 0.6 1.0 0.0 0.7 0.6 0.6 0.4 0.4 0.5 0.9 0.7
Comparative body size at age 10 0.3 0.9 6.8 0.2 1.2 -0.0 0.8 -1.1 -0.1 -0.5 0.3 1.4 -0.1 -1.4 0.6 -0.5 0.6 0.2 -2.6 -1.4 0.0 0.1
Number of full brothers 0.3 0.4 2.0 0.4 -0.1 -0.1 0.9 -0.9 -0.3 -1.4 -0.9 0.1 -0.2 -0.8 -0.4 -0.5 0.6 0.5 -0.1 -0.9 0.4 0.5
Worry too long after embarrassment 2.6 4.3 10.5 2.2 2.9 2.2 2.4 -0.4 1.1 -0.3 -0.4 1.5 1.5 0.2 2.3 1.8 1.9 2.8 -3.2 -2.7 2.5 2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.6 0.4 -0.7 0.3 -0.5 1.0 1.3 -0.1 0.6 -0.1 0.1 0.5 0.6 0.5 0.2 0.3 1.2 0.4 0.3 0.1
Wheeze or whistling in the chest in last year 0.4 0.7 5.0 0.1 -0.4 -0.2 -0.2 1.3 -0.4 0.6 2.2 0.2 0.8 1.3 -0.3 -0.1 0.4 0.7 1.2 0.7 -0.3 -0.3
Number of children fathered 0.5 0.5 2.6 0.4 1.2 0.8 0.2 1.0 1.1 1.6 0.4 0.3 -0.1 0.6 0.7 0.8 0.2 0.0 -0.5 -0.9 0.1 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 3.3 1.8 1.6 1.7 1.5 -0.5 1.1 -0.7 0.7 1.8 1.4 1.4 1.7 1.7 1.7 1.6 -0.9 -1.5 1.8 1.4
Age at first live birth 0.4 0.7 5.2 0.3 -0.3 -0.0 -0.2 -0.9 2.3 -1.2 -1.5 -0.4 -0.7 0.4 0.1 0.3 -0.4 0.3 -0.3 -1.3 0.2 0.5
Pulse wave peak to peak time 2.7 3.2 8.5 -1.9 -2.4 -2.0 -2.0 -0.9 -0.8 -1.6 -0.5 -2.1 -1.2 -0.0 -2.4 -1.4 -1.8 -1.1 2.9 2.5 -1.6 -1.9
Health satisfaction 0.1 0.1 0.6 -0.0 -0.5 0.0 0.0 0.7 -0.1 0.4 0.2 0.0 -0.1 -0.0 -0.3 -0.1 -0.1 0.4 -0.8 0.1 -0.3 -0.3
Shortness of breath walking on level ground 0.2 0.3 1.2 -0.3 -1.1 -0.3 -0.1 -0.0 -0.9 -0.2 0.8 0.3 -0.2 0.2 -0.7 -0.3 -0.1 0.3 0.4 0.4 -0.5 -0.9
Qualifications: College or University degree 0.1 0.4 2.4 0.2 -0.1 0.5 0.0 -1.2 0.2 -1.4 -1.6 0.3 0.4 0.2 0.2 0.1 0.1 -0.2 0.4 0.1 0.6 0.3
Eye problems/disorders: None of the above 2.1 2.5 5.4 1.9 2.3 2.0 2.0 0.3 0.1 0.7 -1.1 1.2 1.7 0.8 1.4 1.4 1.8 1.4 -1.9 -1.6 1.9 1.9
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.8 -0.7 -0.1 -0.6 -0.7 -1.2 0.1 -1.1 -0.7 -0.5 -0.9 -1.3 -1.0 -0.5 -0.7 -0.9 -0.2 0.7 -0.6 -0.9
Emphysema/chronic bronchitis 0.3 0.3 1.9 0.4 -1.4 0.1 0.2 -0.4 0.3 -0.6 0.2 -0.1 0.2 0.6 0.2 -0.1 0.5 0.6 1.1 0.0 0.5 0.7
Medication for pain relief, constipation, heartburn 0.2 0.4 1.6 0.3 0.1 0.5 -0.3 -0.3 0.8 -0.6 -1.1 -0.3 0.2 1.1 0.2 0.3 0.1 -0.5 1.3 0.7 0.6 -0.1
Neck or shoulder pain in last month 0.9 1.3 2.7 1.1 1.4 1.6 1.6 0.6 -0.4 0.6 0.0 0.2 1.1 1.0 0.9 1.5 1.0 1.1 -1.2 -1.5 1.1 1.5
Medication: Blood pressure 0.8 1.5 5.7 1.2 0.5 0.8 0.8 1.2 1.3 0.9 2.4 1.3 0.8 0.2 1.7 1.2 1.0 0.9 -1.8 -1.2 0.8 1.2
Angina (self-reported) 2.0 2.6 4.9 2.0 1.6 1.7 1.5 1.2 1.8 1.1 1.2 1.9 0.9 0.7 2.0 2.0 1.7 1.9 -1.0 -2.2 1.8 1.6
Migraine (self-reported) 0.3 0.4 1.5 -0.0 0.6 0.1 0.7 -0.8 -0.6 -1.1 -0.9 -0.1 0.1 -1.2 -0.2 -0.1 0.2 0.5 -1.2 -0.6 0.2 0.4
Medication: Ibuprofen 0.2 0.3 1.2 0.1 0.3 0.5 0.8 0.7 -0.7 1.1 0.6 -0.2 0.3 0.3 -0.4 0.6 -0.1 0.3 -0.4 -0.6 -0.2 0.2
Medication: Allopurinol 0.5 0.7 2.8 -0.7 -0.5 -1.1 -0.7 -0.7 1.0 -1.7 -0.9 -1.2 -1.1 -0.5 -0.2 -0.5 -1.0 -0.7 1.1 0.3 -0.2 -0.0
Medication: Omeprazole 2.8 3.4 6.8 -2.3 -2.0 -2.3 -1.9 -0.7 -1.8 -0.9 -0.3 -1.6 -1.6 -1.6 -2.0 -2.6 -1.9 -1.6 0.4 2.0 -2.5 -2.6
Medication: Seretide 50 evohaler 0.2 0.2 1.1 0.2 -0.1 0.6 0.5 0.2 0.0 0.7 -0.1 0.8 0.2 -0.1 0.2 0.5 0.2 1.1 -0.7 -0.7 0.0 0.1
Mean time to correctly identify matches 0.3 0.5 2.5 0.5 1.6 0.6 0.5 0.0 -1.3 -0.1 0.3 0.4 1.1 0.5 0.3 1.0 0.6 0.7 -0.1 0.3 0.8 0.8
Heart disease (mother) 1.2 1.5 5.0 -1.4 -2.2 -0.9 -0.8 -0.5 -0.9 -1.5 -0.4 -1.1 -1.3 -1.0 -1.4 -0.6 -1.5 -1.4 1.1 0.9 -1.5 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.7 -0.1 -0.7 -0.4 -0.5 -1.3 0.4 -1.3 0.6 0.3 0.0 -0.4 0.2 -0.6 0.1 0.2 -0.1 0.4 -0.1 -0.1
Whole body fat mass 1.0 4.0 20.3 1.7 0.6 1.4 1.8 2.6 -1.0 3.3 4.5 2.0 2.5 1.8 1.2 1.5 2.1 1.6 -1.5 -0.9 1.0 1.1
Leg fat mass (right) 1.4 5.6 23.1 2.2 1.4 1.9 2.2 2.8 -0.8 3.5 4.8 2.7 2.9 1.9 1.7 2.2 2.6 2.0 -1.8 -1.2 1.5 1.4
Arm predicted mass (right) 0.2 1.2 5.5 0.7 0.7 1.2 1.7 0.6 -2.3 1.5 0.6 0.7 1.7 0.0 0.2 0.4 1.2 1.1 -1.0 -1.0 0.5 0.9
Pulse rate, automated reading 0.2 0.7 2.4 -1.0 -0.1 -1.1 -0.5 -0.8 -1.6 -0.3 0.6 -0.7 -0.1 -0.8 -0.8 -1.0 -0.7 -1.4 0.1 0.8 -0.9 -0.7
Alcohol intake frequency. 0.6 1.3 10.7 0.1 -0.6 0.1 -0.6 1.9 1.3 2.3 3.3 1.0 -0.0 0.1 0.7 0.7 0.2 0.2 -0.1 0.2 -0.3 -0.5
Comparative height size at age 10 0.3 1.6 7.3 -1.1 -1.0 -0.9 -0.1 -1.0 -0.4 -0.3 -2.7 -1.1 -1.4 -2.1 -1.0 -2.1 -1.0 -0.5 -1.4 -0.7 -1.4 -0.5
Number of full sisters 0.8 1.0 3.1 1.1 1.1 1.3 1.3 -0.3 -0.1 -0.6 0.6 0.8 0.8 0.3 0.7 0.8 1.1 1.4 -1.2 -1.8 0.8 0.9
Suffer from ‘nerves’ 0.7 1.1 2.4 1.2 1.5 1.5 0.9 0.7 0.3 0.4 -0.7 0.1 1.1 0.9 1.1 1.4 0.8 1.1 -0.4 -0.5 1.5 1.5
Overall health rating 1.5 3.2 5.6 1.9 1.6 2.2 2.4 1.3 -0.6 2.0 0.5 1.8 2.0 0.5 1.8 1.9 2.0 2.2 -2.0 -1.8 1.7 2.0
Chest pain or discomfort 0.1 0.2 0.7 -0.1 -0.5 -0.1 -0.7 0.7 0.7 0.3 -0.3 -0.1 -0.3 0.8 -0.2 0.2 -0.2 0.2 0.5 0.4 -0.2 -0.8
Had major operations 0.3 0.4 2.2 -0.0 -1.0 -0.2 -0.3 0.3 -0.0 -0.5 0.1 -0.8 0.0 1.0 -0.8 0.5 -0.3 0.2 1.5 0.8 -0.3 -0.3
Age at last live birth 0.4 0.6 1.9 0.7 0.6 0.4 0.8 -1.0 0.5 -0.9 -0.8 -0.3 0.4 0.3 0.5 0.7 0.3 0.8 -0.5 -1.4 0.8 1.4
Family relationship satisfaction 1.1 1.4 5.7 0.7 1.5 0.9 0.7 -0.1 2.1 -0.5 -1.3 1.1 -0.5 -1.4 1.2 0.1 0.8 0.5 -2.4 -1.9 0.7 0.8
Leg pain on walking 1.2 1.6 2.9 1.4 0.9 1.3 1.1 1.1 1.0 1.7 0.9 1.3 1.3 1.2 1.2 1.3 1.2 1.6 -0.9 -1.0 1.4 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 5.5 -0.7 0.9 -0.8 0.3 0.5 -0.3 0.4 -0.2 -1.0 -1.0 -1.7 -0.2 -1.5 -0.8 -0.3 -2.3 -0.9 -0.9 -0.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 4.8 -0.5 1.2 -0.5 -0.6 -1.9 1.2 -0.9 -2.2 -0.7 -1.2 -0.7 -0.4 -0.0 -0.7 -0.5 -0.9 -0.3 -0.5 -0.4
Illness, injury, bereavement, stress in last 2 years 2.0 2.4 5.8 -1.8 -1.8 -1.7 -0.9 -1.2 -2.0 -1.8 -0.7 -2.1 -1.1 -0.8 -2.4 -1.3 -1.7 -1.8 1.5 1.4 -1.3 -0.8
Medication: Aspirin 0.8 1.0 2.3 1.0 1.5 0.6 1.1 0.3 0.3 -0.1 1.5 1.5 0.6 -0.3 1.5 0.5 1.1 1.0 -1.4 -1.3 0.8 0.9
Supplements: Vitamin C 1.9 2.2 5.6 1.7 0.7 1.9 0.9 1.3 1.0 1.6 1.9 2.4 1.8 1.5 1.6 1.3 2.1 1.4 -0.2 -0.9 1.4 0.9
Knee pain experienced in last month 0.6 1.0 4.2 0.1 0.5 0.6 -0.4 2.0 -0.0 2.0 1.3 0.3 1.1 2.0 0.1 1.1 0.2 0.3 0.9 1.1 0.0 -0.4
Hypertension (Self-reported) 1.0 2.9 8.1 1.7 0.3 1.6 2.1 1.0 0.2 1.3 2.9 1.8 1.3 0.0 2.0 1.6 1.7 1.4 -2.5 -2.3 1.2 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.6 0.8 0.7 0.5 -0.1 0.6 0.7 0.3 0.7 0.8 0.7 1.3 0.8 1.2 0.6 0.5 0.3 0.3 0.4 -0.1
Illnesses of father: Heart disease 0.8 1.1 2.9 -1.0 -1.4 -1.3 -1.5 -0.0 1.3 0.1 0.3 -0.7 -1.7 -0.5 -0.5 -0.6 -1.2 -1.4 0.6 1.0 -0.9 -1.3
Illnesses of siblings: Diabetes 2.1 2.6 7.8 -1.2 -2.4 -1.9 -0.6 -1.9 0.1 -2.1 -1.6 -1.1 -2.8 -2.8 -1.0 -1.9 -1.4 -0.5 -0.4 -0.9 -1.6 -1.3
Smoking status: Previous 0.3 0.4 1.8 0.4 -0.1 -0.4 -0.4 -0.9 1.3 -1.2 0.3 -0.1 -0.2 1.1 0.4 0.8 0.3 0.1 0.5 0.5 0.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.0 5.8 -2.2 -1.4 -1.6 -1.3 -1.1 -2.4 -0.8 -1.7 -2.2 -1.0 -1.2 -2.3 -2.4 -2.0 -2.1 0.7 1.7 -2.1 -1.4
Whole body fat-free mass 0.1 0.6 7.8 -0.1 -0.0 0.3 1.2 0.0 -2.8 0.6 -0.1 0.0 0.8 -0.5 -0.8 -0.2 0.4 0.5 -0.4 -0.5 -0.3 0.2
Leg fat-free mass (right) 0.2 0.9 11.8 -0.2 -0.4 0.2 1.0 0.6 -3.4 1.2 0.3 -0.2 1.2 0.4 -0.8 -0.3 0.3 0.4 0.2 0.0 -0.4 -0.1
Arm fat percentage (left) 1.2 4.6 26.6 1.8 0.6 1.3 1.8 3.0 -1.3 3.1 5.2 1.8 2.7 2.4 1.3 1.7 2.1 1.6 -1.0 -0.5 1.1 1.2
Average weekly red wine intake 2.3 3.4 5.8 2.3 2.0 2.0 2.0 1.1 0.7 1.4 -0.2 2.1 2.0 2.1 2.3 2.1 2.1 1.7 -0.8 -2.0 2.4 1.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 3.4 0.5 1.1 -0.1 0.6 -1.2 0.8 -1.9 -0.7 -0.5 -0.2 0.1 0.5 -0.1 0.3 0.6 0.0 -1.0 0.9 0.8
Mood swings 0.2 0.4 1.6 0.6 0.5 0.6 0.7 0.6 0.4 0.6 0.3 -0.1 0.3 0.0 1.0 0.6 0.3 0.9 -1.3 -0.5 0.5 0.7
Loneliness, isolation 0.5 0.6 1.5 1.1 0.1 0.8 0.3 1.1 0.6 1.1 0.1 0.4 0.9 1.1 0.8 0.7 0.7 1.2 0.2 0.0 1.2 1.0
Long-standing illness, disability or infirmity 0.5 0.7 3.0 -0.9 -1.7 -0.8 -0.8 -0.0 -0.7 -1.1 0.1 -0.9 -0.4 -0.2 -0.7 -0.5 -0.9 0.2 1.2 0.9 -1.1 -0.9
Ever had bowel cancer screening 2.4 2.8 4.8 2.0 1.5 1.9 1.4 1.6 1.6 0.7 2.0 2.2 1.3 1.3 2.0 1.7 1.6 2.1 -1.3 -1.7 1.8 1.6
Diabetes diagnosed by doctor 0.2 0.4 1.5 -0.5 -1.2 -0.9 -0.2 0.2 -0.9 -0.5 0.6 -0.3 -0.3 -0.4 -0.7 -0.8 -0.3 0.1 0.6 0.4 -0.4 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 4.8 0.7 0.2 0.3 -0.1 -1.1 1.7 -0.6 -2.2 0.1 0.0 1.3 0.7 0.9 0.4 0.4 0.9 -0.4 0.2 0.1
Friendships satisfaction 2.8 3.5 8.8 2.0 2.5 2.1 1.9 -0.2 2.1 -0.2 -1.5 1.6 1.0 -0.1 2.3 1.3 1.4 1.8 -3.0 -2.1 2.5 2.5
Qualifications: nursing, teaching 0.4 0.6 2.2 -0.4 -1.5 -0.3 -0.5 -1.3 0.3 -1.1 -1.1 0.2 -0.5 -0.6 -0.1 -0.8 -0.3 -1.1 0.9 0.3 0.1 -0.3
Commuting to job workplace: Walk 0.2 0.3 0.8 0.5 -0.3 0.3 0.2 0.9 -0.2 0.1 0.6 0.5 0.9 0.4 0.6 -0.1 0.4 0.8 -0.4 0.2 0.8 0.6
Eye problems/disorders: Cataract 1.6 1.9 5.9 -1.8 -2.4 -1.3 -1.0 -0.0 -1.1 -0.6 1.0 -1.3 -1.4 -1.1 -1.7 -1.3 -1.6 -1.3 1.4 1.0 -1.8 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 2.2 0.5 0.0 0.1 0.1 1.5 -0.2 0.5 1.5 0.8 0.4 0.3 0.4 0.3 0.6 0.1 0.3 0.1 0.5 0.0
Medication for cholesterol 0.2 0.3 1.0 0.5 1.0 0.8 0.5 0.1 0.7 0.3 -0.7 0.2 0.1 0.2 0.6 0.5 0.3 0.2 -0.7 -0.9 0.6 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.4 6.2 1.9 0.1 1.7 2.1 -0.3 0.3 -0.1 0.1 1.1 1.5 0.5 2.0 1.3 1.9 2.2 -1.0 -2.3 1.7 2.5
Back pain experienced in last month 0.1 0.2 1.1 -0.0 0.7 0.2 0.3 -0.1 -0.2 0.3 -0.8 0.2 0.2 -0.0 -0.1 -0.3 0.0 0.9 -1.0 -0.2 -0.1 -0.3
Mineral and other dietary supplements 0.4 0.6 1.8 0.5 0.6 1.0 1.0 -1.0 -0.3 -1.2 -0.9 -0.8 0.4 -0.0 0.2 0.3 0.2 0.5 -0.3 -1.1 0.7 1.4
Breast cancer (self-reported) 0.8 0.9 3.1 0.8 0.6 1.1 0.9 0.6 -0.0 0.7 1.6 0.9 1.0 0.2 0.5 1.0 1.0 1.0 -1.8 -1.0 0.7 0.9
Asthma (self-reported) 1.0 1.9 5.9 -1.7 -1.2 -1.6 -1.0 -0.2 -2.4 -0.4 -0.2 -1.2 -0.7 -0.6 -1.8 -1.6 -1.5 -1.5 0.9 1.4 -2.1 -1.7
Osteoporosis (self-reported) 1.1 1.4 4.2 1.2 0.4 1.4 1.2 1.7 -0.4 2.1 0.9 1.3 1.6 1.7 0.7 0.9 1.5 1.1 -0.8 -0.9 0.6 0.7
Osteoarthritis (self-reported) 0.5 0.6 4.3 -0.5 -1.4 -0.5 -0.3 0.3 -2.1 -0.3 0.8 -0.7 0.6 0.6 -0.6 -0.4 -0.4 -0.1 0.7 1.5 -0.4 -0.1
Medication: Aspirin 1.5 1.9 4.1 1.4 1.7 1.0 1.7 0.1 0.4 -0.5 1.4 2.0 0.9 -0.5 1.8 0.7 1.5 1.5 -2.0 -2.0 1.3 1.5
Medication: Gliclazide 0.7 0.8 2.6 0.8 -0.5 0.5 -0.1 1.3 1.2 0.7 1.3 0.2 0.7 1.6 1.0 0.8 0.6 0.7 1.5 0.0 0.9 0.8
Illnesses of father: None of the above (group 1) 0.7 0.9 3.6 0.8 0.5 1.0 0.2 1.6 1.2 1.4 0.7 0.3 0.5 1.9 0.6 1.3 0.6 0.6 1.4 -0.3 0.5 0.3
Smoking status: Current 1.4 2.3 4.9 1.8 1.1 2.2 1.9 -0.2 0.3 0.5 -0.7 1.5 1.7 0.6 2.0 0.9 1.9 1.7 -1.4 -1.8 1.8 2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 6.7 2.3 1.7 2.4 1.7 -0.2 1.4 0.2 0.6 2.6 2.1 0.7 1.9 2.2 2.3 1.5 -1.7 -1.4 2.6 2.2
Whole body water mass 0.1 0.6 7.5 -0.2 -0.1 0.2 0.9 0.1 -2.7 0.7 -0.0 -0.1 0.7 -0.5 -0.9 -0.3 0.3 0.3 -0.2 -0.3 -0.5 -0.0
Leg predicted mass (right) 0.2 0.9 11.2 -0.1 -0.4 0.2 1.1 0.8 -3.3 1.3 0.4 -0.1 1.2 0.5 -0.8 -0.2 0.4 0.5 0.2 -0.0 -0.4 -0.0
Arm fat mass (left) 0.9 3.7 19.3 1.5 0.7 1.3 1.8 2.6 -1.8 3.0 4.4 1.6 2.6 2.0 0.9 1.6 1.9 1.5 -0.9 -0.6 0.9 1.1
Number of self-reported non-cancer illnesses 0.2 0.4 1.9 -0.5 -1.4 -0.5 -0.8 0.3 -0.5 -0.2 0.4 -0.1 -0.1 0.4 -0.0 -0.3 -0.6 0.0 0.1 1.0 -1.0 -1.0
Average weekly champagne plus white wine intake 1.0 1.4 4.6 -1.2 -1.1 -1.1 -1.6 0.4 -0.0 0.1 -0.4 -0.5 -1.2 0.1 -0.8 -0.9 -1.3 -1.2 2.1 1.5 -1.6 -2.1
Miserableness 0.3 0.5 1.4 0.6 0.8 0.7 0.9 -0.6 -0.0 -0.6 -1.0 0.1 0.3 -0.1 0.8 0.4 0.5 1.0 -1.2 -0.9 0.6 0.9
Guilty feelings 1.0 1.4 3.7 1.3 1.7 1.3 0.4 1.2 1.3 1.2 0.3 0.9 0.8 1.3 1.9 1.4 0.9 1.4 -1.3 -0.5 1.3 1.0
Wears glasses or contact lenses 5.6 6.5 12.2 -2.7 -3.5 -3.1 -2.9 -1.5 -0.5 -1.9 -1.1 -2.7 -2.7 -1.2 -2.6 -2.8 -3.0 -2.8 2.9 2.5 -2.8 -2.8
Ever taken oral contraceptive pill 1.0 1.2 3.9 0.7 1.5 0.3 0.7 -1.0 1.7 -1.8 -0.4 0.4 -0.6 -1.5 0.4 -0.1 0.4 0.8 -2.0 -1.5 0.8 0.9
Hearing aid user 0.3 0.3 1.4 -0.1 -0.2 -0.1 -0.2 -0.1 -1.1 0.0 1.2 0.2 0.4 1.1 -0.2 -0.1 0.0 0.4 0.3 0.8 0.1 -0.5
Mother’s age at death 3.0 3.8 9.3 -2.3 -3.0 -2.2 -1.5 -0.6 -2.4 -1.0 -0.8 -2.7 -1.2 -0.1 -2.0 -2.0 -2.1 -2.2 1.5 2.4 -2.3 -1.9
Financial situation satisfaction 0.6 0.7 3.6 0.9 0.4 0.8 0.2 0.9 1.3 1.2 -0.3 0.5 0.5 1.9 0.6 1.3 0.6 0.6 0.2 0.1 0.7 -0.2
Tinnitus: Yes, now most or all of the time 0.2 0.3 1.0 0.4 0.1 0.5 0.6 -0.5 0.6 0.1 -0.6 0.9 -0.1 -0.3 0.3 0.3 0.2 0.7 -0.9 -1.0 0.4 0.3
Commuting to job workplace: Public transport 0.8 0.9 2.0 -1.0 -1.4 -0.7 -0.7 0.6 -0.8 -0.1 1.4 -0.1 -0.4 -0.5 -1.3 -1.2 -0.5 -1.2 1.0 1.3 -1.0 -1.2
Eye problems/disorders: Glaucoma 1.5 1.7 4.6 -1.2 -1.7 -0.6 -1.9 1.3 1.0 1.6 -0.3 -1.2 -1.3 0.6 -0.9 -0.4 -1.3 -1.4 2.1 1.4 -1.5 -1.6
Medication: Blood pressure 0.3 0.5 3.7 -0.2 -1.6 -0.4 0.1 -0.1 -1.4 -0.4 1.9 -0.3 0.1 -0.6 -0.4 -0.6 -0.1 0.1 -0.2 0.3 -0.3 0.1
Pain type(s) experienced in last month: Hip pain 0.8 1.0 6.2 -1.0 -0.7 -0.9 -0.1 0.4 -2.5 0.1 0.1 -2.0 -0.2 -0.1 -1.3 -0.6 -1.0 -0.6 0.6 0.9 -1.1 -0.4
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.8 0.3 -0.3 0.0 -0.3 1.1 0.8 0.9 -0.0 1.3 -0.1 0.4 0.9 0.3 0.4 0.3 -0.2 0.1 -0.0 -0.7
High cholesterol (Self-reported) 0.9 1.6 4.4 1.3 0.7 1.1 0.3 1.9 2.1 1.4 1.5 1.9 0.6 1.3 1.6 1.4 1.0 0.8 0.4 -1.0 1.0 0.5
Medication: Bendroflumethiazide 0.6 0.9 6.3 -0.6 -2.5 -0.7 -0.5 -0.3 -1.5 -0.8 1.0 -0.3 -0.1 -0.4 -0.5 -1.2 -0.6 -0.2 -0.2 0.8 -1.1 -0.7
Medication: Paracetamol 0.2 0.3 1.0 -0.1 0.1 -0.2 -0.4 0.7 0.8 1.0 -0.7 -0.3 -0.6 1.0 0.1 -0.1 -0.5 0.2 0.4 -0.2 -0.5 -0.5
Medication: Lisinopril 0.2 0.2 2.0 0.0 -1.4 -0.5 -0.0 -0.2 -0.8 -0.0 0.6 0.2 0.3 -0.2 -0.1 -0.1 0.1 -0.3 0.1 0.8 -0.2 -0.1
Medication: Atorvastatin 0.6 0.8 3.0 0.9 0.3 0.6 1.0 1.4 -0.1 0.2 1.7 0.4 0.9 1.0 0.8 0.9 0.8 1.2 0.5 -0.7 0.9 0.7
Illnesses of father: High blood pressure 0.1 0.2 0.7 0.2 0.0 0.3 0.2 -0.1 0.2 -0.1 -0.6 0.7 0.5 -0.3 0.6 -0.3 0.4 0.8 -0.6 -0.4 0.3 0.3
Alcohol drinker status: Never 0.4 0.5 2.6 -0.0 -0.3 0.1 -0.5 1.4 1.0 1.1 1.6 0.2 -0.2 0.7 0.3 0.4 -0.3 -0.1 -0.2 0.2 -0.4 -0.7
Ever smoked 1.0 1.8 3.6 1.8 1.2 1.3 1.3 -0.6 0.8 -0.8 0.9 0.9 1.5 1.8 1.6 1.9 1.8 1.3 -1.0 -0.8 1.8 1.4
Basal metabolic rate 0.1 0.7 7.4 0.1 0.0 0.4 1.2 0.4 -2.7 1.1 0.6 0.2 1.0 -0.2 -0.6 -0.1 0.6 0.6 -0.5 -0.4 -0.2 0.2
Leg fat percentage (left) 1.5 5.4 26.3 2.3 1.3 1.8 1.9 2.8 0.1 3.0 5.1 2.8 2.7 1.7 1.8 2.3 2.6 1.8 -1.6 -1.1 1.6 1.5
Arm fat-free mass (left) 0.1 0.7 5.6 0.2 0.3 0.6 1.3 0.2 -2.4 0.8 0.6 0.5 1.1 -0.5 -0.4 0.1 0.7 0.7 -0.7 -0.7 0.0 0.5
Number of operations (self-reported) 0.3 0.5 1.2 0.7 -0.5 1.1 1.0 0.9 -0.2 0.5 0.8 1.0 0.8 0.9 0.1 0.5 0.9 0.7 -0.0 -0.7 0.3 0.2
Average weekly beer plus cider intake 0.5 0.7 2.7 -0.4 -0.0 -0.3 0.7 -0.9 -1.1 0.2 -1.6 -1.2 -0.6 -1.5 -0.2 -0.6 -0.4 -0.0 -1.4 -1.0 -0.3 0.5
Irritability 0.2 0.4 1.1 0.5 0.7 0.5 0.6 -1.1 -0.2 -0.9 -1.0 0.8 0.4 0.2 0.4 0.4 0.7 0.6 -0.5 -0.3 0.8 0.2
Risk taking 0.5 0.8 2.4 0.8 1.3 1.3 1.0 0.7 0.6 1.2 -0.8 0.9 0.1 0.1 0.9 0.8 0.6 0.5 -0.9 -1.5 0.5 0.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 5.8 0.6 -1.5 1.0 -0.0 0.8 2.4 0.7 -1.5 0.4 -0.4 0.8 0.5 0.6 -0.1 1.3 0.5 -1.1 0.2 -0.0
Fractured/broken bones in last 5 years 0.2 0.2 1.1 0.2 -0.3 -0.1 -0.1 -0.4 0.7 -0.3 -0.8 0.5 -0.3 -1.1 -0.1 0.2 0.2 0.0 -0.6 -0.6 -0.1 0.3
Age started oral contraceptive pill 1.2 1.5 4.5 1.6 1.5 1.1 1.6 0.2 0.5 0.1 -0.1 1.0 1.0 0.2 1.5 1.2 1.4 2.1 -0.8 -1.7 1.5 1.6
Diastolic blood pressure, automated reading 0.9 2.9 11.5 1.5 1.4 1.2 2.2 -0.8 -0.1 -0.3 1.5 2.0 1.1 -0.7 1.9 0.8 2.0 1.8 -3.4 -2.6 1.4 2.0
Ever depressed for a whole week 0.2 0.3 1.5 -0.1 -0.3 0.0 -0.6 -0.3 0.9 -1.1 -0.8 0.2 -0.4 0.0 -0.0 0.3 -0.0 0.4 1.2 0.5 0.1 -0.2
Unable to work because of sickness or disability 0.2 0.3 1.1 -0.2 -0.0 -0.5 -0.6 0.9 1.0 1.1 0.9 0.4 -0.3 -0.2 0.1 0.0 -0.1 0.2 0.4 0.1 -0.2 -0.6
Commuting to job workplace: Cycle 0.2 0.2 0.9 0.2 0.7 0.2 0.1 0.5 -0.2 0.1 -0.0 -0.2 0.8 1.0 -0.2 0.5 0.1 0.3 0.4 0.5 0.8 0.7
Myopia 1.9 2.7 5.6 -1.9 -2.4 -2.0 -1.4 -1.1 -1.2 -1.5 -0.8 -2.1 -1.6 -1.8 -2.1 -1.4 -1.9 -1.8 1.3 1.4 -1.6 -0.9
Vascular/heart problems diagnosed by doctor 1.1 2.9 8.2 -1.8 -0.4 -1.4 -1.9 -0.6 -0.9 -0.6 -2.9 -2.1 -1.0 0.6 -2.1 -1.4 -1.7 -1.6 2.8 2.4 -1.4 -2.0
Cholesterol lowering medication 0.1 0.1 1.1 0.2 0.0 0.4 0.0 1.0 -0.3 -0.0 0.1 0.3 0.3 0.2 0.0 0.4 0.1 0.2 0.6 0.2 0.2 0.1
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 5.0 -1.8 -1.9 -1.8 -1.6 -0.5 -2.0 -0.8 0.1 -0.8 -0.9 -1.3 -1.7 -2.0 -1.3 -1.1 0.5 1.9 -2.0 -2.2
Pain experienced in last month 1.8 3.0 10.6 -1.5 -1.5 -1.7 -1.3 -2.6 0.3 -3.3 -2.1 -1.1 -2.0 -2.3 -1.3 -1.8 -1.6 -1.9 0.8 0.4 -1.3 -0.7
Supplements: Calcium 0.3 0.3 3.6 0.1 0.2 -0.3 -0.4 0.2 1.1 0.2 1.9 0.6 0.1 0.2 0.1 -0.3 0.4 0.2 -0.7 0.2 0.0 -0.1
Basal cell carcinoma (self-reported) 0.6 0.7 3.2 1.1 -0.1 1.1 0.7 -0.4 0.7 -0.6 -0.2 0.7 0.5 0.5 0.9 0.6 0.9 1.8 -0.6 -0.8 1.1 1.1
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.9 0.8 1.2 0.7 0.2 0.3 1.4 -0.2 0.4 1.3 0.4 -0.2 0.8 0.7 0.7 0.7 -0.1 -0.6 0.8 0.4
Deep venous thrombosis (DVT) (self-reported) 2.1 2.8 5.0 -2.1 -2.2 -2.0 -1.7 -0.9 -0.2 -1.5 -0.3 -1.3 -2.0 -1.5 -1.9 -2.1 -1.9 -1.2 1.0 1.2 -2.1 -2.2
Heart disease (siblings) 0.7 0.8 2.3 1.1 0.8 0.5 0.7 0.1 1.2 -1.5 0.4 0.7 0.1 -0.1 1.2 -0.0 0.9 1.4 -0.3 -1.1 1.4 1.1
Alcohol drinker status: Previous 0.2 0.2 1.4 0.3 -0.1 0.5 -0.5 -0.1 1.2 -0.0 0.1 0.5 0.1 -0.1 0.6 0.1 0.2 0.1 -0.1 0.4 0.6 0.3
Pack years of smoking 0.4 0.6 3.4 -0.2 -1.8 -0.4 -0.1 -1.3 -0.8 -1.8 -0.8 -0.8 -0.3 -0.4 -0.5 -0.8 -0.3 -0.0 0.7 0.4 -0.3 0.0
Impedance of whole body 0.4 2.3 7.6 -1.2 -1.2 -1.1 -1.8 -1.5 2.8 -1.4 -2.1 -1.1 -2.5 -1.3 -0.5 -1.8 -1.6 -1.4 -0.7 0.3 -1.2 -1.0
Leg fat mass (left) 1.2 4.8 20.7 2.0 1.2 1.7 2.1 2.7 -1.0 3.3 4.6 2.5 2.8 1.8 1.4 2.0 2.5 1.8 -1.6 -1.1 1.3 1.3
Arm predicted mass (left) 0.1 0.5 5.3 0.0 -0.0 0.3 0.9 0.2 -2.3 0.8 0.6 0.4 0.8 -0.6 -0.6 -0.1 0.6 0.6 -0.6 -0.4 -0.2 0.1