Best TWAS P=8.89e-11 · Best GWAS P=1.39e-08 conditioned to 0.428
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | ZFP82 | 0.15 | 0.04 | enet | 9 | 0.10 | 4.8e-06 | 5.0 | -5.2 | 2.6e-07 | -0.75 | 0.02 | 0.97 | FALSE |
2 | GTEx | Artery Aorta | LINC00665 | 0.20 | 0.10 | lasso | 7 | 0.10 | 2.8e-06 | 5.6 | -5.4 | 7.3e-08 | -0.87 | 0.01 | 0.99 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | LINC00665 | 0.18 | 0.08 | lasso | 8 | 0.12 | 1.7e-09 | 5.6 | -5.2 | 2.3e-07 | -0.73 | 0.01 | 0.99 | FALSE |
4 | GTEx | Esophagus Muscularis | ZFP82 | 0.11 | 0.07 | lasso | 4 | 0.06 | 1.9e-04 | 5.6 | -5.7 | 1.0e-08 | -0.98 | 0.01 | 0.99 | FALSE |
5 | GTEx | Lung | LINC00665 | 0.10 | 0.08 | lasso | 4 | 0.05 | 9.9e-05 | 5.6 | -5.2 | 1.7e-07 | -0.81 | 0.01 | 0.98 | FALSE |
6 | GTEx | Nerve Tibial | ZFP14 | 0.08 | 0.00 | lasso | 7 | 0.00 | 4.8e-01 | 5.6 | -5.6 | 2.2e-08 | -0.94 | 0.01 | 0.93 | FALSE |
7 | GTEx | Nerve Tibial | ZFP82 | 0.09 | 0.11 | lasso | 3 | 0.09 | 5.6e-07 | 5.6 | -5.6 | 2.7e-08 | -0.88 | 0.01 | 0.99 | FALSE |
8 | GTEx | Testis | ZFP82 | 0.28 | 0.14 | lasso | 5 | 0.11 | 1.3e-05 | 5.0 | -5.6 | 2.8e-08 | -0.85 | 0.04 | 0.96 | FALSE |
9 | YFS | Blood | ZFP14 | 0.37 | 0.43 | bslmm | 301 | 0.44 | 1.2e-160 | 5.6 | 5.2 | 2.1e-07 | 0.85 | 0.01 | 0.99 | FALSE |
10 | YFS | Blood | ZFP82 | 0.23 | 0.24 | bslmm | 300 | 0.25 | 4.0e-81 | 5.0 | -5.7 | 1.5e-08 | -0.82 | 0.09 | 0.91 | FALSE |
11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ZFP14 | 0.09 | 0.08 | lasso | 2 | 0.07 | 8.1e-07 | 5.3 | -5.3 | 9.0e-08 | -0.87 | 0.00 | 1.00 | FALSE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZFP14 | 0.06 | 0.03 | lasso | 2 | 0.03 | 4.5e-04 | 5.6 | -5.6 | 2.4e-08 | -0.89 | 0.00 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZFP82 | 0.06 | 0.02 | blup | 31 | 0.02 | 8.5e-04 | 5.3 | -6.0 | 1.8e-09 | -0.82 | 0.00 | 0.93 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ZFP82 | 0.13 | 0.07 | lasso | 1 | 0.05 | 5.0e-04 | 5.3 | -5.3 | 9.0e-08 | -0.87 | 0.00 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZFP82 | 0.06 | 0.01 | lasso | 2 | 0.02 | 6.5e-04 | 5.3 | -5.7 | 1.0e-08 | -0.82 | 0.00 | 0.94 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF565 | 0.08 | 0.04 | blup | 48 | 0.04 | 3.8e-05 | 5.6 | 5.9 | 4.2e-09 | 0.90 | 0.00 | 0.99 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZFP14 | 0.13 | 0.09 | lasso | 2 | 0.09 | 1.3e-09 | 5.3 | -5.3 | 9.1e-08 | -0.87 | 0.00 | 1.00 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZFP82 | 0.08 | 0.02 | blup | 31 | 0.03 | 5.4e-04 | -3.9 | -5.3 | 1.3e-07 | -0.61 | 0.01 | 0.68 | FALSE |
19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF565 | 0.05 | 0.01 | blup | 47 | 0.03 | 8.8e-04 | -3.2 | 5.5 | 3.5e-08 | 0.75 | 0.01 | 0.92 | FALSE |
20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ZFP14 | 0.22 | 0.08 | enet | 8 | 0.13 | 2.4e-05 | 5.0 | -6.5 | 8.9e-11 | -0.80 | 0.00 | 0.78 | TRUE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | ZFP82 | 0.11 | 0.03 | enet | 6 | 0.04 | 4.7e-05 | 5.0 | -5.9 | 3.5e-09 | -0.73 | 0.01 | 0.97 | FALSE |