Best TWAS P=2.21e-14 · Best GWAS P=7.64e-14 conditioned to 0.147
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | UBXN2A | 0.06 | 0.04 | lasso | 5 | 0.04 | 5.2e-04 | -7.4 | -7.4 | 1.8e-13 | 0.95 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Visceral Omentum | UBXN2A | 0.10 | 0.08 | enet | 29 | 0.03 | 9.8e-03 | -6.2 | -6.5 | 1.1e-10 | 0.69 | 0.03 | 0.96 | FALSE |
3 | GTEx | Artery Aorta | UBXN2A | 0.20 | 0.09 | lasso | 6 | 0.08 | 4.1e-05 | -5.3 | -6.2 | 6.8e-10 | 0.70 | 0.37 | 0.62 | FALSE |
4 | GTEx | Artery Tibial | UBXN2A | 0.12 | 0.06 | enet | 24 | 0.09 | 1.5e-07 | -5.3 | -7.1 | 1.4e-12 | 0.84 | 0.03 | 0.97 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | UBXN2A | 0.12 | 0.07 | enet | 12 | 0.12 | 4.7e-09 | -6.9 | -6.0 | 2.3e-09 | 0.75 | 0.04 | 0.96 | FALSE |
6 | GTEx | Colon Transverse | UBXN2A | 0.11 | 0.01 | enet | 8 | 0.03 | 8.7e-03 | -7.4 | -7.5 | 6.4e-14 | 0.93 | 0.01 | 0.94 | FALSE |
7 | GTEx | Esophagus Mucosa | UBXN2A | 0.12 | 0.06 | lasso | 6 | 0.05 | 1.9e-04 | -5.6 | -5.3 | 1.4e-07 | 0.57 | 0.67 | 0.08 | FALSE |
8 | GTEx | Esophagus Muscularis | UBXN2A | 0.08 | 0.07 | lasso | 6 | 0.06 | 2.4e-04 | -5.6 | -5.5 | 3.3e-08 | 0.58 | 0.61 | 0.07 | FALSE |
9 | GTEx | Lung | UBXN2A | 0.09 | 0.06 | enet | 7 | 0.07 | 6.1e-06 | -5.6 | -7.4 | 1.7e-13 | 0.88 | 0.02 | 0.98 | FALSE |
10 | GTEx | Muscle Skeletal | UBXN2A | 0.10 | 0.04 | lasso | 7 | 0.03 | 5.5e-04 | -5.6 | -6.6 | 3.5e-11 | 0.73 | 0.15 | 0.85 | FALSE |
11 | GTEx | Prostate | FAM228B | 0.16 | 0.02 | enet | 31 | 0.07 | 9.6e-03 | -6.1 | 5.9 | 2.9e-09 | -0.74 | 0.11 | 0.36 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | UBXN2A | 0.08 | 0.04 | enet | 17 | 0.03 | 1.3e-03 | -7.5 | -7.6 | 2.2e-14 | 0.89 | 0.01 | 0.99 | TRUE |
13 | GTEx | Small Intestine Terminal Ileum | UBXN2A | 0.18 | 0.08 | enet | 33 | 0.16 | 2.5e-04 | -6.1 | -6.1 | 9.0e-10 | 0.78 | 0.04 | 0.85 | FALSE |
14 | GTEx | Spleen | UBXN2A | 0.31 | 0.11 | enet | 19 | 0.17 | 4.1e-05 | 6.4 | -7.1 | 1.3e-12 | 0.72 | 0.06 | 0.88 | FALSE |
15 | GTEx | Stomach | UBXN2A | 0.13 | 0.14 | enet | 5 | 0.14 | 3.6e-07 | -5.3 | -6.7 | 1.9e-11 | 0.80 | 0.07 | 0.92 | FALSE |
16 | GTEx | Whole Blood | UBXN2A | 0.17 | 0.07 | lasso | 8 | 0.09 | 2.1e-08 | -5.6 | -7.5 | 4.8e-14 | 0.83 | 0.02 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UBXN2A | 0.03 | 0.02 | blup | 46 | 0.03 | 5.7e-04 | -5.7 | -6.4 | 1.8e-10 | 0.68 | 0.17 | 0.60 | FALSE |