[Hub]/) : Traits : Lung FVC : ← →

chr1:223,846,564-225,265,424

Best TWAS P=3.98e-09 · Best GWAS P=5.66e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CNIH4	0.24	0.16	enet	38	0.20	3.5e-16	5.4	-5.4	8.0e-08	-0.93	0.04	0.96	FALSE
2	GTEx	Adrenal Gland	CNIH4	0.21	0.05	lasso	6	0.13	2.5e-05	5.4	-5.5	4.7e-08	-0.93	0.02	0.97	FALSE
3	GTEx	Artery Tibial	CNIH4	0.15	0.14	lasso	4	0.16	1.1e-12	5.5	-5.6	1.8e-08	-1.00	0.02	0.98	FALSE
4	GTEx	Breast Mammary Tissue	CNIH4	0.25	0.19	lasso	5	0.22	1.6e-11	5.8	-5.9	4.0e-09	-0.99	0.01	0.99	TRUE
5	GTEx	Breast Mammary Tissue (Male)	CNIH4	0.26	0.16	lasso	4	0.11	2.0e-03	5.8	-5.7	1.3e-08	-1.00	0.02	0.91	FALSE
6	GTEx	Breast Mammary Tissue (Female)	CNIH4	0.12	0.16	lasso	4	0.14	7.8e-05	5.7	-5.7	1.3e-08	-1.00	0.01	0.95	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	CNIH4	0.21	0.13	lasso	5	0.11	9.8e-05	5.8	-5.8	7.5e-09	-0.99	0.01	0.98	FALSE
8	GTEx	Esophagus Mucosa	CNIH4	0.20	0.19	lasso	5	0.18	2.0e-12	5.5	-5.6	2.9e-08	-0.95	0.05	0.95	FALSE
9	GTEx	Esophagus Muscularis	CNIH4	0.23	0.22	lasso	4	0.24	8.0e-15	5.5	-5.7	1.2e-08	-0.99	0.02	0.98	FALSE
10	GTEx	Heart Atrial Appendage	CNIH4	0.20	0.11	lasso	6	0.07	3.3e-04	5.8	-5.7	1.6e-08	-1.00	0.02	0.97	FALSE
11	GTEx	Heart Left Ventricle	CNIH4	0.11	0.09	enet	12	0.09	2.0e-05	5.5	-5.6	2.3e-08	-0.99	0.03	0.96	FALSE
12	GTEx	Lung	CNIH4	0.25	0.20	lasso	15	0.25	1.9e-19	5.5	-5.7	1.4e-08	-0.95	0.04	0.96	FALSE
13	GTEx	Muscle Skeletal	CNIH4	0.13	0.16	lasso	7	0.16	4.5e-15	5.5	-5.5	3.9e-08	-0.99	0.04	0.96	FALSE
14	GTEx	Nerve Tibial	CNIH4	0.26	0.20	lasso	10	0.22	6.2e-16	5.8	-5.7	1.4e-08	-0.96	0.02	0.98	FALSE
15	GTEx	Pancreas	CNIH4	0.21	0.07	enet	23	0.08	4.0e-04	5.8	-5.7	1.1e-08	-0.89	0.02	0.98	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	CNIH4	0.22	0.22	lasso	4	0.21	7.4e-12	5.4	-5.5	4.3e-08	-0.99	0.05	0.95	FALSE
17	GTEx	Skin Sun Exposed Lower leg	CNIH4	0.28	0.26	lasso	8	0.26	8.6e-22	5.5	-5.6	2.0e-08	-0.98	0.04	0.96	FALSE
18	GTEx	Thyroid	CNIH4	0.20	0.23	lasso	3	0.25	8.4e-19	5.5	-5.6	1.9e-08	-0.99	0.03	0.97	FALSE
19	GTEx	Whole Blood	CNIH4	0.07	0.04	lasso	2	0.05	2.0e-05	5.5	-5.5	4.6e-08	-0.98	0.04	0.95	FALSE
20	METSIM	Adipose	CNIH4	0.16	0.20	lasso	2	0.20	2.4e-29	5.4	-5.3	9.0e-08	-0.98	0.03	0.97	FALSE
21	NTR	Blood	CNIH4	0.02	0.02	lasso	5	0.02	1.7e-06	5.4	-5.3	1.2e-07	-0.92	0.02	0.98	FALSE
22	YFS	Blood	CNIH4	0.12	0.13	bslmm	358	0.13	5.1e-40	5.5	-5.7	1.2e-08	-0.96	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	CNIH4	0.04	0.02	blup	33	0.03	1.1e-06	5.5	-5.3	1.5e-07	-0.85	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Esophageal Carcinoma	CNIH4	0.10	0.07	lasso	7	0.06	7.3e-03	5.8	-5.8	7.3e-09	-1.00	0.01	0.76	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CNIH4	0.04	0.04	blup	33	0.04	2.3e-05	5.4	-5.5	4.5e-08	-0.91	0.02	0.97	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CNIH4	0.07	0.06	enet	29	0.07	3.1e-08	5.7	-5.5	3.4e-08	-0.87	0.02	0.98	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	CNIH4	0.03	0.01	blup	33	0.01	6.1e-02	5.5	-5.6	1.9e-08	-0.97	0.02	0.95	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CNIH4	0.02	0.02	lasso	5	0.01	1.0e-02	5.8	-5.7	1.2e-08	-1.00	0.01	0.88	FALSE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CNIH4	0.19	0.22	lasso	15	0.20	7.3e-09	5.4	-5.4	7.3e-08	-0.98	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	CNIH4	0.08	0.14	enet	13	0.15	2.4e-15	5.8	-5.7	1.5e-08	-1.00	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	CNIH4	0.07	0.05	lasso	10	0.04	7.1e-04	5.5	-5.5	3.5e-08	-0.99	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	CNIH4	0.09	0.09	enet	10	0.09	3.7e-09	5.7	-5.7	1.5e-08	-0.90	0.01	0.99	FALSE