Best TWAS P=1.04e-10 · Best GWAS P=6.18e-09 conditioned to 0.0895
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | MFSD6 | 0.14 | 0.20 | lasso | 4 | 0.13 | 2.8e-04 | -5.3 | -5.3 | 1.1e-07 | 0.55 | 0.05 | 0.84 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | TMEM194B | 0.13 | 0.12 | enet | 13 | 0.11 | 6.9e-09 | 4.8 | -5.2 | 2.5e-07 | 0.47 | 0.21 | 0.78 | FALSE |
| 3 | GTEx | Thyroid | MFSD6 | 0.12 | 0.01 | lasso | 5 | 0.05 | 2.0e-04 | -3.7 | -5.4 | 6.7e-08 | 0.56 | 0.09 | 0.90 | FALSE |
| 4 | GTEx | Whole Blood | TMEM194B | 0.04 | 0.00 | lasso | 2 | 0.01 | 5.7e-02 | 5.3 | -5.5 | 3.3e-08 | 0.62 | 0.04 | 0.81 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM194B | 0.06 | 0.06 | lasso | 6 | 0.06 | 2.4e-07 | -5.8 | -5.7 | 9.9e-09 | 1.00 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MFSD6 | 0.18 | 0.19 | enet | 11 | 0.20 | 1.1e-11 | 4.9 | 5.1 | 2.9e-07 | -0.68 | 0.25 | 0.74 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | TMEM194B | 0.03 | 0.04 | lasso | 2 | 0.04 | 4.5e-05 | -5.3 | -5.3 | 1.3e-07 | 0.55 | 0.03 | 0.84 | FALSE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TMEM194B | 0.09 | 0.02 | blup | 41 | 0.04 | 6.0e-03 | 5.0 | -6.5 | 1.0e-10 | 0.72 | 0.02 | 0.72 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM194B | 0.04 | 0.01 | blup | 41 | 0.02 | 3.8e-03 | -2.6 | -5.3 | 1.0e-07 | 0.43 | 0.07 | 0.44 | FALSE |