[Hub]/) : Traits : Lung FVC :

chr2:190,583,187-192,091,293

Best TWAS P=1.04e-10 · Best GWAS P=6.18e-09 conditioned to 0.0895

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cerebellar Hemisphere MFSD6 0.14 0.20 lasso 4 0.13 2.8e-04 -5.3 -5.3 1.1e-07 0.55 0.05 0.84 FALSE
2 GTEx Cells Transformed fibroblasts TMEM194B 0.13 0.12 enet 13 0.11 6.9e-09 4.8 -5.2 2.5e-07 0.47 0.21 0.78 FALSE
3 GTEx Thyroid MFSD6 0.12 0.01 lasso 5 0.05 2.0e-04 -3.7 -5.4 6.7e-08 0.56 0.09 0.90 FALSE
4 GTEx Whole Blood TMEM194B 0.04 0.00 lasso 2 0.01 5.7e-02 5.3 -5.5 3.3e-08 0.62 0.04 0.81 FALSE
5 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMEM194B 0.06 0.06 lasso 6 0.06 2.4e-07 -5.8 -5.7 9.9e-09 1.00 0.00 1.00 FALSE
6 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MFSD6 0.18 0.19 enet 11 0.20 1.1e-11 4.9 5.1 2.9e-07 -0.68 0.25 0.74 FALSE
7 The Cancer Genome Atlas Lung Adenocarcinoma TMEM194B 0.03 0.04 lasso 2 0.04 4.5e-05 -5.3 -5.3 1.3e-07 0.55 0.03 0.84 FALSE
8 The Cancer Genome Atlas Pancreatic Adenocarcinoma TMEM194B 0.09 0.02 blup 41 0.04 6.0e-03 5.0 -6.5 1.0e-10 0.72 0.02 0.72 TRUE
9 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM194B 0.04 0.01 blup 41 0.02 3.8e-03 -2.6 -5.3 1.0e-07 0.43 0.07 0.44 FALSE