[Hub]/) : Traits : Lung FVC : ← →

chr4:2,233,366-4,219,590

Best TWAS P=1.12e-14 · Best GWAS P=3.81e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	LRPAP1	0.16	0.04	lasso	4	0.04	1.6e-04	7.3	-7.5	5.9e-14	-0.92	0.00	0.99	FALSE
2	GTEx	Artery Aorta	LRPAP1	0.20	0.13	lasso	3	0.13	1.7e-07	6.6	-7.3	2.1e-13	-0.98	0.00	1.00	TRUE
3	GTEx	Artery Coronary	LRPAP1	0.24	0.13	lasso	2	0.07	2.1e-03	6.7	-6.7	2.1e-11	-0.95	0.02	0.96	FALSE
4	GTEx	Artery Tibial	LRPAP1	0.36	0.21	lasso	7	0.21	3.5e-16	6.7	-7.4	1.2e-13	-0.94	0.04	0.96	FALSE
5	GTEx	Brain Cerebellar Hemisphere	LRPAP1	0.53	0.04	lasso	11	0.17	4.1e-05	-4.9	-7.5	4.9e-14	-0.42	0.08	0.27	FALSE
6	GTEx	Breast Mammary Tissue (Female)	GRK4	0.23	0.24	lasso	3	0.24	1.1e-07	5.3	-5.2	2.3e-07	-0.01	0.97	0.01	FALSE
7	GTEx	Cells Transformed fibroblasts	GRK4	0.32	0.35	lasso	7	0.37	3.1e-29	5.3	-5.1	2.9e-07	-0.01	1.00	0.00	FALSE
8	GTEx	Cells Transformed fibroblasts	LRPAP1	0.35	0.20	lasso	4	0.26	2.3e-19	5.9	-6.9	6.5e-12	-0.93	0.00	1.00	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	GRK4	0.37	0.23	lasso	9	0.22	2.2e-08	5.1	-5.1	3.0e-07	0.01	0.98	0.00	FALSE
10	GTEx	Esophagus Mucosa	LRPAP1	0.31	0.11	lasso	6	0.19	1.4e-12	-4.3	-6.3	3.0e-10	-0.79	0.01	0.99	FALSE
11	GTEx	Esophagus Muscularis	LRPAP1	0.22	0.03	lasso	7	0.02	1.1e-02	7.3	-7.5	8.2e-14	-0.97	0.00	1.00	FALSE
12	GTEx	Muscle Skeletal	LRPAP1	0.16	0.04	enet	23	0.09	4.4e-09	7.3	-7.0	2.7e-12	-0.67	0.00	1.00	FALSE
13	GTEx	Nerve Tibial	LRPAP1	0.29	0.11	enet	16	0.14	7.6e-10	6.6	-7.2	4.4e-13	-0.83	0.01	0.99	FALSE
14	GTEx	Pituitary	GRK4	0.17	0.00	enet	6	-0.01	5.6e-01	5.1	-5.2	2.5e-07	0.00	0.10	0.06	FALSE
15	GTEx	Skin Sun Exposed Lower leg	LRPAP1	0.13	0.03	enet	12	0.08	3.6e-07	-4.3	-7.7	1.1e-14	-0.47	0.27	0.66	TRUE
16	GTEx	Stomach	GRK4	0.22	0.19	lasso	7	0.19	2.6e-09	5.1	-5.5	3.0e-08	-0.03	1.00	0.00	TRUE
17	GTEx	Thyroid	NOP14	0.09	0.04	lasso	5	0.03	4.5e-03	5.0	-5.2	2.2e-07	-0.06	0.07	0.91	FALSE
18	GTEx	Thyroid	MFSD10	0.15	0.11	lasso	8	0.13	3.6e-10	5.5	-5.3	1.3e-07	0.01	0.03	0.97	FALSE
19	GTEx	Thyroid	LRPAP1	0.28	0.07	lasso	8	0.15	2.6e-11	6.7	-7.4	1.1e-13	-0.83	0.02	0.98	FALSE
20	GTEx	Thyroid	NOP14-AS1	0.18	0.09	lasso	8	0.11	1.3e-08	5.3	-5.5	4.1e-08	-0.05	0.03	0.97	FALSE
21	GTEx	Uterus	GRK4	0.31	0.24	enet	29	0.32	2.5e-07	5.1	-5.3	8.8e-08	-0.06	0.37	0.04	FALSE
22	GTEx	Vagina	GRK4	0.27	0.12	lasso	4	0.11	1.6e-03	4.6	-5.3	1.4e-07	-0.01	0.18	0.06	FALSE
23	METSIM	Adipose	LRPAP1	0.14	0.12	lasso	4	0.12	4.4e-17	5.9	-6.4	2.0e-10	-0.97	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GRK4	0.09	0.12	blup	76	0.12	1.7e-06	4.6	-5.2	2.3e-07	-0.02	0.05	0.95	FALSE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LRPAP1	0.08	0.01	blup	52	0.04	2.9e-03	-4.3	-6.1	1.1e-09	-0.60	0.02	0.54	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GRK4	0.16	0.18	lasso	6	0.20	1.9e-11	5.1	-5.2	2.0e-07	-0.05	0.08	0.91	FALSE
27	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LRPAP1	0.05	0.00	blup	52	0.02	2.8e-02	-4.3	-6.8	7.5e-12	-0.43	0.04	0.15	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LRPAP1	0.10	0.06	enet	12	0.08	1.3e-09	-4.4	-6.9	3.8e-12	-0.61	0.40	0.58	FALSE
29	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LRPAP1	0.18	0.03	blup	52	0.12	1.6e-05	7.0	-6.6	3.3e-11	-0.78	0.01	0.95	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	GRK4	0.12	0.13	lasso	6	0.14	6.0e-15	4.6	-5.2	1.9e-07	-0.02	0.05	0.95	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRPAP1	0.12	0.09	blup	52	0.12	1.5e-12	7.3	-6.8	8.8e-12	-0.82	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Soft Tissue Sarcoma	LRPAP1	0.12	0.02	blup	52	0.05	6.6e-04	0.5	-7.3	1.9e-13	-0.43	0.03	0.38	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	LRPAP1	0.17	0.07	blup	52	0.11	9.1e-11	5.9	-6.5	7.2e-11	-0.78	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	MFSD10	0.07	0.02	enet	6	0.08	7.2e-08	4.5	-5.5	3.5e-08	0.00	0.02	0.98	FALSE