TWAS hub - NOP14-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1080	0.0460	6.0e-03	0.011	NA	0.056	NA	0.066	8.0e-02	NA	4.9e-04	NA	1.7e-04
2	GTEx	Artery Tibial	0.0973	0.0381	1.1e-03	0.074	NA	0.057	NA	0.057	1.9e-06	NA	3.0e-05	NA	3.1e-05
3	GTEx	Cells Transformed fibroblasts	0.1630	0.0470	1.0e-05	0.110	NA	0.092	NA	0.110	1.3e-08	NA	2.0e-07	NA	1.4e-08
4	GTEx	Esophagus Gastroesophageal Junction	0.1580	0.0640	8.6e-03	0.062	NA	0.024	NA	0.067	2.9e-03	NA	4.5e-02	NA	2.0e-03
5	GTEx	Nerve Tibial	0.1484	0.0523	2.4e-04	0.060	NA	0.041	NA	0.057	4.8e-05	NA	6.8e-04	NA	7.5e-05
6	GTEx	Thyroid	0.1830	0.0530	3.0e-09	0.091	NA	0.105	NA	0.108	1.9e-07	NA	2.2e-08	NA	1.3e-08
7	GTEx	Whole Blood	0.1160	0.0390	4.3e-04	0.009	NA	0.083	NA	0.061	4.9e-02	NA	4.6e-08	NA	2.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Basal cell carcinoma (self-reported)	7.4	8.8	13.7	3.6	3.0	3.7	3.4	3.1	-0.9	2.1
Health satisfaction	5.6	7.3	20.2	-4.5	-2.5	-2.8	-2.3	-2.3	2.4	-0.9
Overall health rating	5.6	12.0	44.4	-5.5	-1.8	-1.5	-2.0	-0.3	6.7	-0.6
Heart disease (mother)	5.4	6.6	11.7	-2.2	-2.6	-3.0	-3.4	-3.0	-0.8	-2.2
Tinnitus: Yes, now most or all of the time	5.1	6.0	10.6	2.0	2.8	3.3	2.6	2.9	-0.0	1.9
Medication: Aspirin	4.8	6.4	12.7	1.6	2.9	2.9	3.4	3.6	1.0	0.2
Pack years adult smoking proportion	4.6	7.1	17.3	-4.2	-1.8	-2.2	-2.7	-0.9	3.6	-1.8
Qualifications: College or University degree	4.6	14.4	43.4	5.7	1.7	2.7	2.9	0.5	-6.6	2.5
Breastfed as a baby	4.5	5.6	16.7	4.1	1.8	2.8	1.9	1.8	-1.9	1.0
Pack years of smoking	4.4	6.5	15.6	-4.0	-1.7	-2.1	-2.7	-1.1	3.2	-1.9
Commuting to job workplace: Walk	4.2	4.5	7.2	1.4	2.6	2.6	2.7	2.4	-0.9	1.3
Illnesses of siblings	3.8	5.4	9.3	-0.6	-2.3	-2.7	-2.7	-3.1	-2.8	-0.8
Supplements: Vitamin C	3.8	4.5	7.8	-2.0	-2.1	-2.8	-2.0	-2.8	-1.6	-0.9
Smoking Status	3.6	8.6	17.0	-4.1	-2.4	-3.1	-2.6	-1.6	3.6	-2.3
Severe depression (siblings)	3.6	4.0	7.2	1.8	2.1	2.4	2.7	1.9	-1.2	1.4
Noisy workplace	3.6	4.5	11.1	-3.3	-1.8	-1.8	-1.8	-0.9	3.1	-0.4
Medication: Aspirin	3.5	4.5	10.0	1.0	2.4	2.3	2.8	3.2	1.1	0.2
Chronic bronchitis/emphysema (father)	3.3	3.8	6.7	-2.3	-2.6	-1.9	-2.5	-2.0	0.9	0.0
Qualifications: O levels/GCSEs or equivalent	3.3	5.3	15.8	4.0	0.8	2.3	2.0	1.0	-3.0	0.9
Lupus	3.2	4.8	6.4	2.4	2.1	2.5	2.5	2.2	-0.5	2.4
Mineral and other dietary supplements	3.2	4.2	13.0	-3.3	-0.9	-1.3	-1.8	-0.2	3.6	-0.1
High blood pressure (siblings)	3.1	4.5	6.6	0.8	2.4	2.4	2.5	2.6	2.4	-0.5
Qualifications: None of the above	3.0	6.5	20.2	-4.1	-0.8	-1.9	-1.9	-0.7	4.5	-0.6
Medication: Cholesterol lowering	3.0	4.7	11.1	-0.2	2.3	1.8	1.9	3.0	3.3	-0.2
Hearing difficulty/problems: Yes	2.9	4.5	10.3	0.7	2.5	2.0	2.1	3.2	1.8	1.6
High blood pressure (mother)	2.9	4.1	6.6	1.7	2.2	2.5	2.6	2.6	1.0	-0.6
Number of incorrect matches in round	2.9	4.9	11.9	3.4	2.0	2.1	2.3	0.9	-2.2	1.7
Chronic bronchitis/emphysema (mother)	2.8	3.3	6.9	-2.6	-1.8	-2.1	-2.1	-1.7	1.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.9	13.5	3.6	2.4	2.1	1.7	1.3	-3.7	-0.2
Major Depression (MDD)	2.7	3.3	5.4	1.1	1.9	1.9	1.9	2.3	0.5	2.3
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	6.5	-0.5	-2.1	-1.4	-2.4	-2.5	-1.0	-0.2
Medication: Simvastatin	2.6	3.8	7.7	1.0	2.6	2.4	2.1	2.8	0.9	0.4
Alzheimer’s Disease (in father)	2.5	2.7	4.8	1.8	1.5	2.1	2.2	1.6	-0.1	1.4
Irritable Bowel Disease (IBD)	2.4	5.6	10.6	0.5	2.8	2.0	2.5	3.3	2.9	1.5
Average weekly champagne plus white wine intake	2.4	3.3	11.5	3.0	0.5	1.0	1.1	0.2	-3.4	0.7
Financial situation satisfaction	2.4	3.0	9.4	-3.1	-1.0	-2.1	-1.7	-1.0	1.6	-0.2
Supplements: Fish oil (including cod liver oil)	2.4	3.1	12.0	2.8	0.1	0.6	1.1	-0.4	-3.5	0.0
Medication: Amlodipine	2.2	3.1	7.4	-0.1	1.6	1.3	1.2	2.0	2.1	-2.7
Shortness of breath walking on level ground	2.2	2.7	11.5	-2.0	-1.4	-1.1	-0.2	-0.4	3.4	0.2
Chest pain or discomfort	2.2	3.1	15.8	-2.1	-0.5	-0.4	-0.5	0.8	4.0	0.4
Unable to work because of sickness or disability	2.2	2.8	13.5	-2.1	-0.1	-0.2	0.4	1.2	3.7	0.4
Relative age voice broke	2.1	3.2	9.9	3.2	0.9	1.8	0.8	0.8	-2.3	1.4
Medication: Atorvastatin	2.1	2.5	10.2	-1.5	-0.7	-1.2	-0.8	-0.9	1.4	-3.2
Average weekly beer plus cider intake	2.1	3.1	8.1	-2.9	-1.1	-2.3	-1.1	-2.0	0.6	-1.0
Average weekly spirits intake	2.0	2.5	6.3	1.2	1.0	1.9	1.6	1.6	0.7	2.5
Time employed in main current job	2.0	2.3	4.8	-2.2	-1.1	-1.9	-1.3	-0.3	0.7	-2.1
Father’s age at death	2.0	2.7	5.7	1.4	-1.7	-1.3	-1.2	-2.2	-2.4	0.7
Ever highly irritable/argumentative for 2 days	2.0	2.4	10.6	0.6	1.3	1.1	1.3	1.0	0.1	3.3
Pulse wave peak to peak time	2.0	2.3	5.0	-0.4	-1.8	-1.6	-2.2	-1.9	-1.3	-0.0
Ever had bowel cancer screening	2.0	2.3	3.9	2.0	1.8	1.9	0.8	1.0	-0.5	1.9
Crohns Disease (2017)	1.9	4.2	7.9	0.7	2.6	1.7	2.6	2.8	1.8	1.4
Prostate Cancer	1.9	2.7	5.1	-0.7	-1.9	-1.8	-2.0	-2.3	-0.6	-1.4
Falls in the last year	1.9	2.5	7.7	-0.3	0.8	1.4	0.7	2.0	2.8	1.7
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	11.1	0.9	-1.6	-0.8	-0.9	-2.0	-3.3	1.4
Medication: Gliclazide	1.9	2.1	5.7	-2.4	-1.5	-1.4	-1.2	-0.9	1.6	-0.3
Lung FVC	1.8	9.4	30.1	4.1	3.0	2.0	2.3	0.7	-5.5	-0.1
Eye problems/disorders: Diabetes related eye disease	1.8	1.9	3.2	0.9	1.4	1.7	1.8	1.6	1.2	0.7
Supplements: Glucosamine	1.8	2.4	9.1	2.2	0.7	0.7	1.2	-0.3	-3.0	-0.7
Alcohol usually taken with meals	1.8	2.8	8.2	2.5	0.7	1.1	1.0	0.4	-2.9	1.7
Pain all over the body in last month	1.8	1.9	7.4	-0.2	0.9	0.7	0.2	1.8	2.7	1.0
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.2	-1.6	-2.1	-1.6	-1.6	-1.9	0.6	-1.0
Mouth/teeth dental problems: Dentures	1.8	3.0	10.1	-2.1	0.0	-0.5	-0.4	0.7	3.2	-2.3
Lung cancer (father)	1.8	2.1	3.8	-1.1	-1.9	-1.5	-2.0	-1.8	-0.7	-0.5
Pulse wave Arterial Stiffness index	1.8	2.1	5.1	0.6	1.9	1.5	2.3	1.8	0.7	-0.2
Glaucoma (self-reported)	1.8	2.1	4.1	2.0	0.6	1.5	1.1	0.1	-1.9	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	8.8	-1.2	0.6	0.6	0.4	2.0	3.0	-0.1
Breast cancer (self-reported)	1.8	2.1	3.8	1.5	2.0	1.6	1.7	1.0	-1.1	1.1
Leg fat percentage (left)	1.8	6.3	28.4	-3.2	-1.1	-0.6	-1.6	1.1	5.3	0.6
Ulcerative Colitis (UC)	1.7	3.2	7.1	0.3	1.7	1.6	1.6	2.4	2.7	1.1
Angina	1.7	2.3	9.3	-1.4	0.7	0.2	0.1	1.3	3.1	-1.5
Arm fat percentage (right)	1.7	6.7	27.7	-3.5	-1.3	-1.1	-1.6	0.8	5.3	0.8
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	21.1	3.6	1.3	1.4	1.2	-0.0	-4.6	0.0
Worry too long after embarrassment	1.7	2.9	6.6	0.4	-1.6	-1.5	-1.1	-2.4	-2.6	-1.2
Chronotype (morning person)	1.6	3.6	11.1	-2.4	-0.2	-1.0	-0.5	0.6	3.3	-2.6
Diabetes (mother)	1.6	2.0	6.4	-1.9	-1.3	-1.0	-1.1	-0.3	2.5	-0.3
Body mass index (BMI)	1.6	6.9	32.3	-3.4	-0.7	-0.7	-1.2	1.2	5.7	0.9
Medication: Paracetamol	1.6	2.7	5.0	-2.2	-1.8	-1.5	-1.5	-0.7	2.0	1.1
Gout (self-reported)	1.6	2.2	4.0	0.7	2.0	1.7	1.9	1.9	0.4	0.7
Body fat percentage	1.6	6.4	26.4	-3.4	-1.4	-0.9	-1.6	0.9	5.1	0.8
Leg fat percentage (right)	1.6	6.0	25.5	-3.2	-1.2	-1.0	-1.7	0.6	5.1	0.4
Age at last live birth	1.6	2.3	7.5	1.6	-1.1	-1.1	-0.6	-1.6	-2.7	-0.8
Arm fat percentage (left)	1.6	6.4	28.8	-3.2	-0.8	-0.5	-1.1	1.4	5.4	1.2
Handedness (chirality/laterality): Left-handed	1.6	2.0	10.1	1.3	0.2	0.3	-0.2	-1.1	-3.2	-0.8
Pain type(s) experienced in last month: Hip pain	1.6	2.0	8.0	-1.3	-0.9	-0.6	-1.3	0.6	2.8	-1.2
Irritability	1.6	2.7	4.8	-2.2	-1.8	-2.0	-1.6	-1.5	1.2	1.0
Bipolar Disorder (2011)	1.5	1.5	2.5	1.6	1.4	1.2	1.5	1.2	0.1	0.9
Forced vital capacity (FVC)	1.5	5.6	21.4	3.6	1.3	1.2	1.2	-0.2	-4.6	0.1
Mouth/teeth dental problems	1.5	2.3	6.2	2.5	1.0	1.3	1.0	0.3	-2.2	1.2
Heart attack	1.5	1.9	4.5	-0.5	1.4	0.8	0.7	2.1	2.0	-1.2
Number of full brothers	1.5	1.9	4.6	0.7	2.1	1.4	1.9	1.6	0.2	0.2
Wheeze or whistling in the chest in last year	1.5	2.6	10.1	-1.9	-0.7	-0.2	-0.7	0.6	3.2	1.8
Age at first live birth	1.5	2.6	6.3	1.0	-1.7	-1.5	-0.9	-2.1	-2.5	-0.8
Angina (self-reported)	1.5	2.0	8.2	-1.0	0.9	0.4	0.2	1.4	2.9	-1.3
Smoking status: Previous	1.5	2.2	4.5	-2.1	-1.1	-1.6	-1.2	-1.3	1.1	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.2	-1.1	-1.3	-1.6	-1.1	-1.8	-0.8	-0.7
High cholesterol (Self-reported)	1.5	2.7	7.5	-0.2	1.8	1.3	1.3	1.9	2.7	-1.2
Risk taking	1.5	2.3	4.7	1.3	1.1	1.8	1.6	1.5	0.7	2.2
Myopia	1.5	2.1	4.7	2.2	1.1	1.6	1.1	0.7	-1.9	0.9
Crohns Disease (2012)	1.4	2.3	4.3	0.7	1.8	1.4	1.8	2.1	1.6	0.6
Relative age of first facial hair	1.4	2.9	6.8	2.5	1.3	1.5	1.5	1.0	-2.6	0.5
Fed-up feelings	1.4	2.6	3.5	-1.9	-1.4	-1.9	-1.7	-1.8	-0.2	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.1	-0.1	0.9	1.5	1.3	2.0	1.9	1.6
Qualifications: A levels/AS levels or equivalent	1.4	3.0	10.6	3.3	0.2	1.7	0.6	0.2	-2.7	-0.2
Number of full sisters	1.4	1.7	6.8	-1.2	-1.1	-0.4	-1.5	-0.2	2.6	-0.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	3.2	0.6	-1.7	-1.3	-1.1	-1.8	-1.7	-0.0
Knee pain experienced in last month	1.4	2.2	6.7	-2.3	-1.3	-1.0	-0.8	-0.1	2.6	0.4
Illnesses of father: Heart disease	1.4	2.0	4.7	-0.0	1.1	1.6	1.1	1.8	2.2	1.1
Qualifications: nursing, teaching	1.4	2.2	5.5	2.3	1.0	1.4	1.5	0.9	-1.9	-0.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	7.4	1.6	0.7	-0.1	0.2	-0.5	-2.7	0.5
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.5	-0.6	1.4	0.8	0.7	2.1	1.9	-1.2
Mean Putamen Volume	1.3	1.5	3.6	1.2	1.5	1.4	0.7	1.9	-0.5	0.7
HDL Cholesterol	1.3	2.1	11.4	-0.4	-0.1	-0.8	-0.6	-1.0	-1.1	-3.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.6	0.6	0.7	1.6	1.3	1.5	1.6	1.4
Trunk fat percentage	1.3	5.1	21.2	-2.9	-1.1	-0.6	-1.3	1.1	4.6	1.2
Average weekly fortified wine intake	1.3	1.6	3.9	0.6	0.8	1.5	2.0	1.8	0.8	0.2
Taking other prescription medications	1.3	2.0	4.8	-0.1	1.4	1.4	1.2	1.7	2.2	0.5
Medication: Ramipril	1.3	1.7	4.3	0.2	1.9	1.0	1.4	2.1	1.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	9.2	-1.4	0.4	0.7	0.7	1.6	3.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	22.8	2.3	0.7	0.2	0.1	-0.9	-4.8	-0.4
Emphysema/chronic bronchitis	1.3	1.5	3.7	-1.0	-1.2	-0.7	-1.9	-1.2	-0.1	1.6
Loneliness, isolation	1.3	1.7	7.0	-0.8	0.9	1.0	0.8	1.4	2.6	0.3
Back pain experienced in last month	1.3	1.9	9.7	-1.3	-0.9	-0.4	-0.0	0.6	3.1	-0.6
Number of self-reported non-cancer illnesses	1.3	2.3	11.4	-1.9	-0.3	0.0	-0.0	0.5	3.4	-0.9
Hearing aid user	1.3	1.5	3.7	0.4	1.4	1.1	0.9	1.9	1.6	0.2
Commuting to job workplace: Cycle	1.3	1.6	5.6	2.4	0.9	1.4	0.5	0.4	-1.2	0.9
Vascular/heart problems diagnosed by doctor	1.3	3.6	13.5	1.8	-0.5	-0.2	0.1	-1.3	-3.7	2.6
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.2	-0.3	1.2	0.7	0.4	1.6	2.1	-1.5
Leg fat mass (left)	1.3	4.9	21.1	-3.0	-0.8	-0.7	-1.3	1.0	4.6	0.8
Blood White Count	1.2	9.1	41.1	-3.4	1.0	-0.0	-0.5	2.7	6.4	-1.6
Vitamin and mineral supplements	1.2	1.7	4.7	-2.2	-0.2	-0.7	-0.4	0.5	2.2	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.3	-0.6	1.2	0.8	1.0	1.6	1.8	0.4
Depression (self-reported)	1.2	1.4	3.8	-1.9	-1.1	-1.2	-0.6	-0.6	0.8	-1.5
Arm fat mass (right)	1.2	4.9	21.7	-2.9	-0.8	-0.6	-1.1	1.0	4.7	1.0
Forced vital capacity (FVC), Best measure	1.2	4.5	24.3	2.2	0.4	-0.1	-0.0	-1.2	-4.9	-0.3
Whole body fat mass	1.2	5.1	20.0	-3.1	-1.2	-1.0	-1.6	0.6	4.5	0.7
Leg fat mass (right)	1.2	4.5	19.1	-2.9	-0.7	-0.8	-1.3	0.8	4.4	0.7
Asthma (self-reported)	1.2	2.3	4.4	-1.0	1.1	1.2	1.4	2.0	2.1	1.6
Medication: Paracetamol	1.2	1.9	4.0	-2.0	-1.3	-1.2	-0.9	-0.3	1.9	1.3
Diastolic blood pressure, automated reading	1.2	3.8	8.2	-2.8	-1.6	-1.5	-1.6	-0.5	2.9	-1.8
Alcohol drinker status: Previous	1.2	1.4	4.8	-0.8	0.7	0.5	-0.3	1.4	2.2	1.1
Ovarian Cancer	1.1	1.4	2.7	0.7	0.9	1.4	0.8	1.6	1.4	1.2
Triglycerides	1.1	1.8	5.4	-0.1	0.4	1.1	0.8	1.3	2.3	1.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.0	0.7	1.7	1.2	1.2	1.6	0.2	-0.2
Cardiovascular Disease	1.1	3.7	17.3	-1.1	0.8	0.9	0.6	2.2	4.2	-1.0
Waist circumference	1.1	4.2	20.5	-2.6	-0.2	-0.5	-0.5	1.3	4.5	-0.3
Past tobacco smoking	1.1	2.1	5.8	2.4	1.0	1.5	1.2	0.7	-1.8	0.8
Medication: Seretide 50 evohaler	1.1	1.3	2.6	-1.4	-1.0	-1.2	-0.9	-1.6	-0.7	-0.9
Alcohol intake frequency.	1.1	2.6	8.5	-0.5	1.6	1.1	0.8	2.1	2.9	1.0
Arm fat mass (left)	1.1	4.5	20.3	-2.7	-0.5	-0.5	-0.9	1.2	4.5	0.9
Mother’s age at death	1.1	1.4	5.3	1.5	-0.7	-0.5	-0.4	-0.9	-2.3	0.4
BMI	1.0	6.1	26.0	-3.0	-1.4	-1.2	-1.8	0.4	5.1	0.9
Respiratory disease	1.0	2.2	8.9	-1.3	0.6	0.8	0.6	1.6	3.0	1.0
Neuroticism	1.0	2.3	4.5	-1.7	-1.5	-2.1	-1.6	-2.0	-0.2	0.1
Medication for hormone replacement therapy	1.0	1.2	3.7	1.0	0.5	0.9	-0.2	1.5	1.9	0.3
Current tobacco smoking	1.0	1.7	7.5	-1.7	-0.2	-0.6	-0.7	0.7	2.7	-0.5
Serious illness, injury or assault to yourself	1.0	1.2	6.1	-1.0	-0.1	0.1	-0.7	0.5	2.5	0.5
Number of live births	1.0	1.4	3.2	1.4	1.8	0.9	0.9	0.4	-1.4	-0.6
Asthma	1.0	2.0	3.7	-0.8	1.1	1.1	1.5	1.8	1.9	1.3
Illnesses of mother	1.0	1.3	2.3	1.5	0.6	1.0	1.0	0.2	-1.5	1.5
Birth weight	1.0	2.3	5.7	1.8	1.5	1.1	1.4	1.1	-2.4	0.5
Medication: Omeprazole	1.0	1.2	3.8	-0.7	0.9	0.4	0.2	1.3	1.9	-1.2
Wears glasses or contact lenses	1.0	1.2	2.9	1.7	0.6	0.5	0.6	0.5	-1.2	-1.6
Hand grip strength (left)	0.9	2.3	5.4	2.3	1.5	1.6	1.2	1.1	-1.6	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	5.6	-1.4	0.2	0.5	-0.0	1.0	2.4	0.1
High blood pressure	0.9	2.6	9.0	-1.4	0.3	0.1	-0.2	0.9	3.0	-2.5
Trunk fat mass	0.9	3.9	15.4	-2.7	-1.0	-0.7	-1.4	0.8	3.9	0.9
Alcohol intake versus 10 years previously	0.9	1.3	3.1	0.4	1.4	0.9	0.7	1.5	1.8	-0.2
Exposure to tobacco smoke at home	0.9	1.0	1.6	-1.3	-1.1	-1.1	-1.0	-0.7	0.8	1.0
Medication: Blood pressure	0.9	1.6	2.7	-0.1	1.6	0.7	1.1	1.5	1.6	-1.5
Medication: Allopurinol	0.9	1.1	2.1	0.3	1.4	1.4	1.2	1.4	0.7	0.2
Family relationship satisfaction	0.9	1.2	2.5	0.5	1.5	0.9	0.7	0.6	-1.2	1.6
Hypertension (Self-reported)	0.9	2.4	9.8	-1.2	0.5	0.4	-0.0	1.2	3.1	-2.0
Illnesses of siblings: Diabetes	0.9	1.0	3.7	0.4	0.4	1.2	0.7	0.9	1.9	0.8
Medication for cholesterol	0.9	1.4	4.4	1.1	0.3	-0.0	1.0	-0.9	-2.1	1.6
Osteoarthritis (self-reported)	0.9	1.2	5.6	-1.3	0.3	0.2	0.1	1.0	2.4	-0.2
Medication: Lisinopril	0.9	1.2	4.5	-0.9	-0.8	-0.5	-0.2	0.3	2.1	-1.4
Pain experienced in last month	0.9	1.6	6.2	1.6	0.4	0.7	-0.0	0.0	-2.5	1.2
Intelligence (Savage-Jansen 2018)	0.8	2.5	7.9	2.4	0.7	1.1	0.6	0.6	-2.8	1.0
Neuroticism (Nagel 2018)	0.8	1.9	4.7	-0.8	-1.4	-1.5	-1.5	-2.2	-1.1	0.7
Verbal and Numeric Reasoning (VNR)	0.8	1.9	7.6	2.1	0.5	0.8	0.3	0.2	-2.7	0.1
Fasting Glucose	0.8	0.9	2.2	-0.7	-1.2	-1.1	-0.8	-1.5	-0.8	-0.1
LDL Cholesterol	0.8	1.2	3.1	-0.1	0.4	1.3	0.5	1.8	1.8	-0.2
Ulcerative Colitis	0.8	1.2	5.8	-0.5	0.3	0.2	0.0	1.0	2.4	1.2
Multivitamins +/- minerals	0.8	1.0	3.2	1.8	-0.1	0.6	0.1	-0.6	-1.4	1.0
Stomach or abdominal pain in last month	0.8	1.0	4.4	-1.1	-0.2	-0.1	0.4	1.2	2.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	5.4	-0.8	-0.2	0.0	-0.3	0.2	2.3	0.4
Hearing difficulty/problems with background noise	0.8	1.2	2.3	0.8	1.5	0.9	0.8	1.4	-0.1	1.5
Fluid intelligence score	0.8	1.7	2.7	1.6	1.5	1.6	1.0	1.2	-1.4	0.1
Prospective memory result	0.8	0.9	1.7	-0.8	-0.3	-1.3	-0.1	-1.2	-1.2	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.0	0.2	0.7	1.3	1.4	1.3	0.8	1.0
Long-standing illness, disability or infirmity	0.8	1.2	2.6	-1.6	-0.5	-0.7	-0.7	-0.3	1.3	-1.6
Eye problems/disorders: Cataract	0.8	0.9	4.9	0.3	0.5	0.5	1.0	0.3	-0.1	-2.2
Guilty feelings	0.8	1.3	3.6	0.5	-0.8	-0.5	0.5	-1.5	-1.9	1.2
Supplements: Calcium	0.8	0.9	2.3	0.4	-0.9	-0.6	-0.3	-1.5	-1.1	-1.2
Bipolar Disorder (2018)	0.7	1.2	2.3	1.0	1.5	1.0	1.4	1.3	0.1	-0.4
Depression (Nagel 2018)	0.7	1.0	3.8	-1.0	0.1	0.5	0.1	0.9	2.0	1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	2.2	-1.5	-1.2	-1.1	-0.7	-0.5	0.9	-0.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	6.1	-0.3	-0.1	0.7	0.2	1.5	2.5	0.3
Townsend deprivation index at recruitment	0.7	1.0	5.8	-0.9	0.0	0.0	-0.6	0.2	2.4	-0.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.5	-0.1	1.0	0.9	0.7	1.1	1.1	1.2
Standing height	0.7	7.1	37.5	3.0	0.1	-0.4	0.1	-1.8	-6.1	0.0
Birth weight of first child	0.7	1.3	3.5	1.9	0.2	0.8	0.2	0.1	-1.8	1.3
Peak expiratory flow (PEF)	0.7	1.6	7.7	1.3	-0.3	-0.2	-0.8	-1.1	-2.8	-0.4
Exposure to tobacco smoke outside home	0.7	0.9	2.5	-1.6	-0.4	-0.4	0.0	0.9	1.6	-0.5
Medication: Ibuprofen	0.7	0.8	1.7	-0.6	0.8	0.7	0.9	0.8	1.3	0.9
Mean time to correctly identify matches	0.7	1.4	5.3	1.1	-0.4	-0.3	-0.2	-1.0	-2.3	-1.3
Medication: Blood pressure	0.7	1.3	4.0	-1.0	0.3	0.5	0.1	1.2	2.0	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	2.4	-1.0	-0.4	-0.8	-1.1	0.4	1.6	0.5
Depressed Affect (Nagel 2018)	0.6	1.2	2.3	-1.4	-1.0	-1.1	-1.3	-1.5	0.3	0.3
Blood Platelet Count	0.6	6.5	33.4	-2.5	-0.2	-0.5	-0.9	1.1	5.8	-2.0
Waist Hip Ratio (WHR)	0.6	2.6	11.9	-1.2	0.7	0.2	0.8	1.4	3.5	-1.4
Systolic blood pressure, automated reading	0.6	1.7	6.6	-1.3	0.3	0.2	-0.3	0.4	2.6	-1.9
Supplements: Zinc	0.6	0.7	1.5	-0.5	-0.4	-0.7	-0.8	-0.9	-0.8	-1.2
Medication: Co-codamol	0.6	0.7	2.1	-0.4	0.9	0.4	0.4	1.1	1.5	0.6
Diabetes (father)	0.6	0.7	1.2	0.5	1.0	1.0	1.1	0.4	0.7	1.1
Age when periods started (menarche)	0.6	1.5	4.9	2.2	0.4	1.0	1.2	-0.1	-1.7	0.7
Qualifications: CSEs or equivalent	0.6	0.7	1.4	-0.7	0.9	0.4	1.0	1.1	1.2	-0.4
Sitting height	0.6	4.2	21.6	1.1	0.0	-0.9	-0.3	-2.1	-4.7	-0.8
Nervous feelings	0.6	1.1	2.2	-0.5	-1.5	-1.3	-1.3	-1.2	-0.3	-0.4
Had menopause	0.6	0.7	2.0	1.4	-0.3	0.3	0.6	-0.2	-1.4	0.6
Financial difficulties in last 2 years	0.6	0.8	3.2	-1.8	0.5	0.1	0.1	0.3	1.3	0.4
Diabetes (self-reported)	0.6	1.0	3.0	-0.3	0.4	0.7	0.7	1.5	1.7	0.7
Hair/balding pattern: Pattern 3	0.6	0.9	1.5	1.2	1.1	1.2	1.2	0.8	-0.3	0.1
Pulse rate	0.6	1.0	5.4	-1.1	0.1	-0.4	-0.4	0.4	0.4	-2.3
Happiness	0.6	0.7	1.1	-0.7	-0.4	-1.0	-0.8	-1.0	-1.0	0.6
Medication: Lansoprazole	0.6	0.7	4.1	0.2	-0.2	0.0	-0.5	0.4	0.8	2.0
Blood clot in the leg (DVT)	0.6	0.7	2.5	-0.8	-0.0	-0.5	-0.8	0.8	1.6	0.6
Comparative body size at age 10	0.6	1.8	4.8	0.8	0.6	1.3	0.7	1.5	1.5	2.2
Medication for pain relief, constipation, heartburn	0.6	1.1	2.1	1.1	-0.9	-0.2	-0.9	-1.4	-1.4	-0.5
Pulse rate, automated reading	0.6	1.8	7.8	-1.6	-0.5	-0.1	-0.8	1.2	2.8	-0.3
Average weekly red wine intake	0.6	0.9	2.3	-0.1	-1.0	-0.8	-0.8	-1.3	-1.5	-0.7
Smoking status: Current	0.6	1.0	4.5	-1.1	-0.2	-0.6	-0.6	0.5	2.1	-0.4
Alcohol drinker status: Never	0.6	0.7	1.4	-0.1	1.2	0.1	0.7	1.2	1.1	-0.5
Worry (Nagel 2018)	0.5	1.1	2.1	-0.8	-0.9	-1.2	-1.2	-1.5	-0.8	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	1.1	0.5	0.8	0.8	1.2	-0.1	0.9
Age at First Birth	0.5	0.7	1.9	0.8	-0.6	-0.8	-0.6	-0.9	-1.4	-0.5
Heel T-Score	0.5	4.3	8.6	2.9	2.7	2.2	2.2	1.9	-0.8	0.6
Systolic Blood Pressure	0.5	2.6	8.4	-1.5	-0.0	-0.1	-0.2	-0.2	2.8	-2.9
Ever had hysterectomy (womb removed)	0.5	0.5	0.9	0.3	0.9	0.9	0.7	0.9	0.2	0.8
Hand grip strength (right)	0.5	1.4	2.4	1.6	1.5	1.0	1.3	0.8	-1.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.6	0.8	0.7	0.6	1.1	1.1	0.0
Medication: Atenolol	0.5	0.6	1.0	-1.0	-0.5	-0.5	-0.7	-0.4	1.0	-0.9
Neuroticism score	0.5	1.0	2.3	-1.5	-0.9	-1.3	-0.8	-0.6	1.1	0.2
Hip circumference	0.5	2.1	4.6	-2.0	-1.5	-1.4	-1.5	-0.3	2.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.2	-1.5	0.1	-0.1	0.4	-0.1	1.5	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.3	-0.1	0.9	0.9	1.0	1.5	0.9	-0.4
Headache pain in last month	0.5	0.9	2.5	-1.5	-0.7	-0.7	-0.4	0.3	1.6	0.1
Neck or shoulder pain in last month	0.5	0.7	2.0	-1.0	0.3	-0.1	0.1	0.3	1.4	-1.2
Had major operations	0.5	0.6	1.4	-0.1	-1.2	-0.8	-1.0	-0.8	-0.8	-0.1
Mood swings	0.5	0.8	3.1	-1.3	0.4	-0.1	-0.0	0.2	1.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.6	-0.7	-0.4	-0.0	-0.7	0.4	1.6	-0.3
Ever taken oral contraceptive pill	0.5	0.5	1.2	-0.1	-0.8	-1.0	-0.1	-0.3	-0.7	-1.1
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	0.7	0.2	0.9	0.2	0.6	-0.4	1.4
Medication: Bendroflumethiazide	0.5	0.7	1.8	-1.2	-0.8	-0.4	-1.1	-0.0	1.3	0.2
Illnesses of father: High blood pressure	0.5	0.7	3.9	0.0	-0.3	-0.3	0.1	-0.8	-0.2	-2.0
Age started oral contraceptive pill	0.5	0.6	2.6	-0.2	-0.5	-0.7	-0.0	-0.8	-0.1	-1.6
Cholesterol lowering medication	0.5	0.8	3.3	-0.8	-0.8	-0.4	-0.7	-0.4	0.3	-1.8
Heart disease (siblings)	0.5	0.6	1.8	-1.0	0.4	0.3	0.6	0.6	1.4	-0.8
Rheumatoid Arthritis	0.4	0.5	2.6	-0.0	0.4	-0.1	-0.3	-0.2	-0.9	-1.6
Blood Eosinophil Count	0.4	3.2	5.0	-2.2	-2.0	-1.9	-2.2	-1.6	1.5	-0.4
Blood Red Count	0.4	4.1	6.9	-2.3	-1.9	-2.6	-1.8	-2.4	-0.0	-2.0
Number of treatments/medications taken	0.4	0.7	2.0	-0.6	0.4	0.3	0.5	1.3	1.4	-0.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	-0.1	0.5	0.8	0.8	0.6	0.7	1.4
Hair/balding pattern: Pattern 2	0.4	0.5	2.7	-0.3	-0.5	0.3	-0.4	-0.3	1.6	0.0
Weight	0.4	1.9	6.8	-1.9	-0.7	-0.8	-1.0	0.3	2.6	0.9
Impedance of arm (right)	0.4	1.6	7.1	1.0	-1.2	-0.5	-0.4	-1.3	-2.7	0.0
Length of working week for main job	0.4	0.4	1.5	-1.2	0.2	-0.5	-1.0	0.1	0.3	-0.4
Tense / ‘highly strung’	0.4	0.7	2.5	-1.6	-0.4	-0.8	-0.2	-0.5	1.1	-0.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	-1.2	-0.6	-0.2	-0.2	0.2	1.2	-0.3
Eye problems/disorders: None of the above	0.4	0.4	1.0	-0.7	-0.4	-0.9	-1.0	-0.3	-0.6	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	-1.3	-0.0	-0.6	-0.4	-0.3	1.1	-0.3
Diabetes diagnosed by doctor	0.4	0.7	3.1	-0.8	-0.2	0.2	0.1	1.0	1.8	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.4	1.1	-0.0	-0.2	-0.8	-0.7	-0.2	-0.9	-1.0
Bipolar Disorder or Schizophrenia	0.3	0.8	1.3	0.6	1.0	1.0	0.9	1.1	1.0	0.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.4	-0.0	-0.4	-0.8	-0.7	-0.0	-1.2	-0.4
Reaction Time	0.3	0.6	2.2	1.0	-0.6	-0.2	0.0	-0.7	-1.5	-0.4
Body Mass Index (BMI) (2010)	0.3	0.5	0.9	0.2	-0.4	-0.5	-0.9	-0.8	-0.7	-0.8
Coronary Artery Disease (CAD)	0.3	0.3	1.5	0.4	-0.0	0.4	0.3	0.4	-0.2	-1.2
Schizophrenia (2014)	0.3	0.7	3.9	-0.8	0.0	0.1	0.2	0.5	2.0	0.5
Height	0.3	5.4	21.1	1.2	-0.6	-1.7	-1.0	-2.5	-4.6	-2.2
Allergy or Eczema	0.3	0.8	2.4	0.1	1.3	0.9	0.2	1.6	0.0	0.8
Lung FEV1/FVC ratio	0.3	1.3	5.2	0.7	-0.9	-0.5	-0.3	-1.5	-2.3	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	1.0	0.2	0.3	-0.4	0.0	0.0	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.0	-0.3	-0.7	-0.4	-1.1	-0.6	0.0	1.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.0	-0.0	1.1	0.9	0.2	1.4	-0.0	0.7
Medication: Levothyroxine sodium	0.3	0.4	2.1	0.0	0.3	0.5	-0.2	0.7	1.5	0.2
Had other major operations	0.3	0.4	2.3	-0.1	-0.1	-0.2	-0.2	-0.3	0.4	-1.5
Allergy	0.3	0.7	1.4	1.1	-0.1	-0.0	0.5	-0.8	-1.0	-1.2
Hair/balding pattern: Pattern 4	0.3	0.8	3.7	0.1	-0.5	-0.7	-0.9	-0.5	-0.6	1.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	-0.6	-0.7	-0.4	-0.6	-0.8	0.7	0.8
Number of children fathered	0.3	0.4	1.1	0.3	1.0	0.5	0.4	0.5	0.1	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	0.3	0.8	0.9	0.2	0.8	0.3	0.2
Comparative height size at age 10	0.3	1.6	3.8	1.7	0.9	0.6	0.4	-0.2	-2.0	-1.7
Suffer from ‘nerves’	0.3	0.5	0.9	0.5	0.9	0.8	0.8	0.9	-0.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	0.2	-0.3	-0.3	-0.3	-0.8	-1.2	1.1
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.8	-0.9	-0.0	-0.1	-0.2	-1.0	0.0
Fractured/broken bones in last 5 years	0.3	0.4	2.0	0.5	-0.0	0.5	0.3	0.3	0.5	1.4
Breast Cancer	0.2	0.4	2.4	0.5	-0.2	0.1	0.1	0.6	0.1	1.6
HbA1C	0.2	0.2	0.4	0.7	0.4	0.2	0.6	0.0	-0.2	0.6
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.7	0.0	0.5	-0.7	0.3	0.5	0.5
Hypothyroidism (self reported)	0.2	0.4	1.1	-0.9	-0.3	-0.3	-0.6	-0.2	1.1	0.1
Tanning	0.2	1.9	6.2	-2.5	-0.5	-1.2	-1.8	-0.4	1.4	-0.5
Medication: Metformin	0.2	0.3	0.9	-0.3	-0.4	-0.0	0.1	0.2	0.9	-0.9
Impedance of leg (right)	0.2	1.0	4.3	1.2	-0.4	0.0	0.1	-0.9	-2.1	-0.5
Maternal smoking around birth	0.2	0.2	0.8	-0.7	0.1	-0.2	0.1	0.2	0.6	0.9
Impedance of leg (left)	0.2	0.8	3.1	1.3	-0.2	0.6	0.4	0.0	-1.8	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.5	0.4	0.2	0.5	-0.7	0.1	-0.2	1.2
Worrier / anxious feelings	0.2	0.4	1.4	0.6	-0.0	0.0	0.7	0.4	-1.2	0.8
Impedance of arm (left)	0.2	1.1	5.6	1.2	-0.5	0.2	0.3	-0.5	-2.4	0.2
Leg pain on walking	0.2	0.3	1.0	-0.5	0.3	0.2	0.0	0.7	1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.1	-0.1	0.5	-0.1	-0.0	0.2	0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.1	0.1	-0.0	-0.1	-0.0	-0.2	-1.5	1.0
Friendships satisfaction	0.2	0.2	0.8	-0.6	-0.0	-0.2	-0.9	-0.2	0.2	0.2
Miserableness	0.2	0.3	0.5	-0.3	0.6	0.2	0.7	0.7	0.7	0.3
Ever smoked	0.2	0.4	0.7	-0.2	0.4	0.4	0.5	0.8	0.8	0.7
Number of operations (self-reported)	0.2	0.3	0.5	-0.1	-0.7	-0.6	-0.7	-0.6	-0.2	-0.5
Impedance of whole body	0.2	1.2	5.6	1.4	-0.5	0.4	0.2	-0.3	-2.4	0.1
Schizophrenia (2018)	0.1	0.3	1.4	-0.0	0.1	0.4	0.1	0.4	1.2	0.4
Neuroticism (2016)	0.1	0.2	1.2	-0.0	-0.0	-0.1	-0.3	-0.1	-1.1	0.4
Sensitivity / hurt feelings	0.1	0.1	0.4	-0.2	0.2	0.1	0.4	0.5	0.7	-0.0
Trunk fat-free mass	0.1	0.4	1.8	0.6	0.4	-0.4	-0.0	-0.5	-1.3	0.1
Trunk predicted mass	0.1	0.4	1.9	0.6	0.5	-0.3	0.1	-0.4	-1.4	0.2
Pulse wave reflection index	0.1	0.1	0.3	-0.2	-0.3	-0.1	-0.4	0.4	0.5	-0.1
Loud music exposure frequency	0.1	0.2	0.7	0.2	0.1	0.2	-0.4	0.2	0.4	0.8
Arm fat-free mass (right)	0.1	0.3	1.2	0.3	0.6	0.4	0.2	0.6	0.2	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.1	0.3	-0.3	-0.4	-0.2	-0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.2	0.3	0.1	0.2	-0.1	0.3	0.4
Migraine (self-reported)	0.1	0.2	0.3	-0.4	-0.1	-0.3	-0.4	0.6	0.5	-0.2
Leg fat-free mass (right)	0.1	0.3	1.3	-0.1	0.3	0.1	0.1	0.6	0.4	1.1
Leg predicted mass (right)	0.1	0.3	1.2	-0.1	0.4	0.2	0.1	0.7	0.5	1.1
Ever depressed for a whole week	0.1	0.2	0.5	0.1	0.4	0.2	0.7	0.2	0.4	0.3
Hair Pigment	0.0	0.4	1.2	-0.8	-0.3	-0.1	0.7	-0.2	1.1	-0.5
Leg fat-free mass (left)	0.0	0.2	0.7	-0.5	0.1	-0.2	-0.1	0.3	0.7	0.8
Leg predicted mass (left)	0.0	0.2	0.6	-0.5	0.1	-0.3	-0.2	0.2	0.8	0.8
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.3	0.1	0.5	0.2	0.1	0.4	0.3	0.1
Arm predicted mass (right)	0.0	0.2	0.5	-0.2	0.4	0.1	-0.0	0.5	0.7	0.7
Whole body fat-free mass	0.0	0.1	0.2	0.1	0.3	-0.2	-0.1	-0.1	-0.3	0.5
Osteoporosis (self-reported)	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.3	0.1	0.1	0.2
Whole body water mass	0.0	0.1	0.3	0.0	0.2	-0.2	-0.1	-0.1	-0.2	0.6
Basal metabolic rate	0.0	0.1	0.5	-0.4	0.1	-0.3	-0.3	0.1	0.4	0.7
Arm fat-free mass (left)	0.0	0.2	0.7	-0.4	0.2	-0.2	-0.3	0.1	0.8	0.4
Arm predicted mass (left)	0.0	0.2	0.5	-0.4	0.1	-0.2	-0.4	0.2	0.7	0.6

Hub : Genes

NOP14-AS1

Models

Trait associations