Best TWAS P=8.4e-28 · Best GWAS P=3.69e-64 conditioned to 4.01e-78
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | TCTEX1D1 | 0.28 | 0.20 | enet | 31 | 0.24 | 3.6e-09 | -3.5 | -5.3 | 1.4e-07 | 0.04 | 0.10 | 0.90 | FALSE |
| 2 | GTEx | Artery Aorta | SGIP1 | 0.21 | 0.08 | lasso | 8 | 0.11 | 1.1e-06 | 6.7 | -6.5 | 6.5e-11 | 0.08 | 0.75 | 0.24 | FALSE |
| 3 | GTEx | Artery Aorta | TCTEX1D1 | 0.20 | 0.17 | lasso | 11 | 0.16 | 2.4e-09 | -7.2 | -7.0 | 3.0e-12 | 0.01 | 0.63 | 0.36 | FALSE |
| 4 | GTEx | Artery Coronary | TCTEX1D1 | 0.19 | 0.04 | lasso | 3 | 0.07 | 1.9e-03 | -7.2 | -7.0 | 2.4e-12 | 0.04 | 0.05 | 0.50 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | WLS | 0.22 | 0.04 | enet | 26 | 0.08 | 8.6e-07 | 2.0 | -10.9 | 8.4e-28 | 0.05 | 0.54 | 0.02 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | TCTEX1D1 | 0.29 | 0.24 | enet | 35 | 0.27 | 1.2e-20 | -3.6 | 5.2 | 2.0e-07 | -0.05 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Colon Sigmoid | WDR78 | 0.21 | 0.00 | lasso | 8 | 0.03 | 3.7e-02 | 6.9 | 6.8 | 1.1e-11 | 0.00 | 0.10 | 0.34 | FALSE |
| 8 | GTEx | Esophagus Mucosa | SGIP1 | 0.10 | 0.05 | lasso | 5 | 0.02 | 1.4e-02 | 2.6 | -5.3 | 1.3e-07 | 0.03 | 0.49 | 0.07 | FALSE |
| 9 | GTEx | Nerve Tibial | DIRAS3 | 0.18 | 0.01 | lasso | 6 | 0.05 | 1.3e-04 | 4.9 | -5.3 | 8.8e-08 | 0.05 | 0.52 | 0.02 | TRUE |
| 10 | GTEx | Testis | WLS | 0.44 | 0.14 | lasso | 15 | 0.15 | 3.5e-07 | 10.4 | 9.2 | 5.8e-20 | -0.13 | 0.97 | 0.00 | TRUE |
| 11 | GTEx | Testis | SGIP1 | 0.28 | 0.22 | lasso | 8 | 0.21 | 1.3e-09 | 6.1 | -6.5 | 1.2e-10 | 0.05 | 0.90 | 0.10 | FALSE |
| 12 | GTEx | Thyroid | SGIP1 | 0.19 | 0.07 | enet | 29 | 0.08 | 6.8e-07 | 6.9 | -6.0 | 1.5e-09 | 0.06 | 0.89 | 0.10 | FALSE |
| 13 | GTEx | Whole Blood | TCTEX1D1 | 0.05 | 0.01 | enet | 10 | 0.02 | 9.9e-03 | -7.1 | -5.2 | 2.2e-07 | 0.01 | 0.11 | 0.55 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | SGIP1 | 0.12 | 0.14 | enet | 23 | 0.15 | 1.2e-18 | -6.6 | -7.1 | 1.2e-12 | 0.03 | 0.87 | 0.13 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TCTEX1D1 | 0.07 | 0.08 | lasso | 4 | 0.09 | 1.6e-18 | -7.1 | -5.5 | 3.1e-08 | 0.00 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGIP1 | 0.06 | 0.02 | blup | 240 | 0.04 | 5.4e-05 | -8.2 | 5.9 | 3.0e-09 | 0.00 | 0.00 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | WLS | 0.06 | 0.01 | blup | 181 | 0.03 | 2.9e-04 | 10.4 | -5.4 | 6.9e-08 | 0.19 | 0.09 | 0.05 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TCTEX1D1 | 0.11 | 0.11 | blup | 72 | 0.07 | 6.2e-05 | -7.1 | -5.9 | 3.6e-09 | -0.01 | 0.00 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | TCTEX1D1 | 0.06 | 0.06 | lasso | 7 | 0.05 | 2.1e-06 | -7.1 | -6.3 | 3.2e-10 | 0.00 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TCTEX1D1 | 0.05 | 0.08 | lasso | 1 | 0.07 | 1.3e-05 | -7.1 | -7.1 | 9.8e-13 | 0.01 | 0.00 | 0.99 | TRUE |