Hub : Genes

WLS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2190	0.0670	6.0e-04	0.037	NA	0.083	NA	0.082	8.1e-04	NA	8.6e-07	NA	9.9e-07
2	GTEx	Testis	0.4430	0.0760	2.9e-06	0.136	NA	0.122	NA	0.150	1.3e-06	NA	4.7e-06	NA	3.5e-07
3	GTEx	Thyroid	0.1410	0.0550	4.4e-03	0.014	NA	0.114	NA	0.043	2.9e-02	NA	4.9e-09	NA	3.1e-04
4	GTEx	Whole Blood	0.1430	0.0480	1.1e-03	0.077	NA	0.072	NA	0.076	1.4e-07	NA	3.7e-07	NA	1.8e-07
5	NTR	Blood	0.3613	0.0354	0.0e+00	0.191	0.221	0.244	0.230	0.228	3.0e-59	1.0e-69	1.3e-77	1.3e-72	6.0e-72
6	ROSMAP	Brain Pre-frontal Cortex	0.0991	0.0261	5.4e-06	0.064	0.065	0.061	0.072	0.060	1.1e-08	9.5e-09	2.4e-08	1.6e-09	3.1e-08
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0563	0.0217	1.4e-03	0.008	0.029	0.023	NA	0.013	3.9e-02	2.9e-04	1.1e-03	NA	1.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.6	2.6	4.6	1.4	-1.9	0.9	-2.1	-1.3	-1.7	1.6
Bipolar Disorder or Schizophrenia	0.7	1.8	4.5	1.7	-1.1	0.4	-2.1	-0.5	0.5	1.9
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	-1.1	0.2	-0.8	0.9	0.6	-1.2	-1.0
Depression (Nagel 2018)	0.5	0.8	1.2	-1.1	0.9	-0.6	0.9	0.9	-0.5	-1.0
Intelligence (Savage-Jansen 2018)	1.1	3.5	9.9	0.6	-1.0	1.4	-3.1	-2.4	-2.1	1.1
Neuroticism (Nagel 2018)	0.2	0.4	1.3	-1.2	-0.8	-0.2	0.1	-0.5	-0.2	-0.5
Schizophrenia (2018)	0.5	1.1	4.3	1.1	0.1	-0.1	-1.0	0.4	2.1	1.1
Schizophrenia vs Biploar Disorder	0.6	0.8	4.8	-0.2	0.9	-0.4	0.3	-0.1	2.2	-0.0
Worry (Nagel 2018)	0.2	0.5	2.1	-0.1	-1.4	0.3	-0.2	-0.6	0.8	-0.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	0.0	-0.3	0.5	-0.7	-0.3	-0.6	-0.8
Alzheimer’s Disease (in father)	0.1	0.2	0.6	-0.2	0.1	-0.7	0.2	0.4	-0.3	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	-0.6	-0.1	-0.3	0.3	0.4	-0.3	-0.7
Crohns Disease (2017)	0.1	0.1	0.6	-0.0	-0.3	-0.0	-0.2	-0.8	0.0	0.2
Irritable Bowel Disease (IBD)	0.3	0.7	1.6	-1.3	0.2	-0.5	1.2	0.2	1.3	0.0
Ulcerative Colitis (UC)	0.9	1.7	4.1	-2.0	0.6	-0.4	2.0	1.3	1.4	-0.1
Major Depression (MDD)	0.5	0.6	1.7	-0.6	1.3	-1.0	0.7	0.2	0.6	0.0
Reaction Time	0.6	1.1	3.2	-1.0	-0.0	0.9	-1.3	-1.8	0.6	0.6
Verbal and Numeric Reasoning (VNR)	1.0	2.3	7.0	0.2	-0.5	1.2	-2.6	-1.1	-2.4	0.5
Breast Cancer	0.3	0.7	2.3	0.5	-0.0	0.5	0.0	0.2	-1.5	-1.4
Ovarian Cancer	1.3	1.7	6.1	2.5	-0.2	-0.7	1.2	1.5	0.1	1.1
Prostate Cancer	1.2	1.7	4.9	-0.4	-1.1	2.2	-1.4	-0.8	-1.1	1.3
Age at First Birth	1.0	1.5	4.6	0.6	-0.6	0.6	-0.4	1.0	-1.8	-2.1
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.2	0.6	-0.5	-0.9	-0.1	-0.8	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	2.4	-0.6	0.6	-0.9	1.6	1.5	0.4	-0.2
Coronary Artery Disease (CAD)	0.4	0.5	1.5	0.7	-0.0	-0.6	0.1	0.0	1.1	1.2
Crohns Disease (2012)	0.5	0.8	1.8	1.2	-1.0	0.4	-0.5	-1.4	-0.1	0.8
Mean Putamen Volume	1.1	1.2	2.9	-1.6	0.5	-0.1	1.0	1.7	-1.3	0.0
Fasting Glucose	0.4	0.5	0.7	-0.6	0.9	-0.8	-0.8	-0.8	-0.6	-0.2
HbA1C	0.4	0.4	1.7	-0.4	-0.3	-0.1	-0.5	-0.7	-1.3	-0.4
HDL Cholesterol	0.2	0.3	0.8	0.1	-0.2	0.9	-0.2	0.7	-0.8	0.3
LDL Cholesterol	0.1	0.2	0.8	-0.2	0.0	-0.0	0.4	-0.5	-0.9	0.4
Lupus	0.3	0.5	1.2	-1.1	0.8	1.1	0.4	-0.2	0.6	0.5
Neuroticism (2016)	0.3	0.4	2.2	-0.0	-0.1	0.2	-0.6	-0.7	0.3	1.5
Primary Biliary Cirrhosis	0.5	0.7	2.4	0.1	1.5	0.4	0.1	-0.1	0.8	-1.2
Rheumatoid Arthritis	1.0	1.4	6.0	0.8	0.5	-0.3	-1.1	-2.5	1.3	0.2
Schizophrenia (2014)	0.6	1.3	4.7	1.3	-0.9	0.3	-0.3	-0.3	2.2	1.2
Triglycerides	0.2	0.3	0.7	0.2	-0.7	-0.8	0.8	0.1	-0.0	-0.7
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.1	0.1	0.5	0.4	-1.2	-1.4	0.4	0.7
Ulcerative Colitis	0.7	1.0	2.7	-1.3	0.8	0.1	1.6	1.3	0.3	0.3
Blood Eosinophil Count	0.1	1.0	3.9	-0.4	-2.0	0.1	-0.5	0.0	-0.1	1.5
Blood Platelet Count	0.0	0.1	0.2	0.3	-0.2	0.1	-0.2	0.5	-0.1	0.2
Blood Red Count	0.2	2.4	10.0	0.4	-3.2	-1.0	2.2	-0.1	0.5	0.5
Blood White Count	0.2	1.7	6.8	-0.1	-2.6	-1.1	-0.6	-1.2	-1.0	0.9
Heel T-Score	4.4	35.2	118.8	-10.9	9.2	3.8	-0.3	-0.1	-0.4	-5.4
BMI	0.5	3.2	6.4	-1.9	1.1	-2.5	1.5	0.6	-1.9	-2.1
Height	0.3	5.6	24.8	2.2	0.4	5.0	-1.9	-0.8	-2.2	-0.3
Waist Hip Ratio (WHR)	0.1	0.6	2.2	-1.1	-1.5	-0.6	0.4	0.5	-0.5	-0.2
Systolic Blood Pressure	0.2	0.8	1.6	-0.1	-0.9	0.1	1.2	0.8	-1.0	-1.2
Smoking Status	0.6	1.3	3.8	-0.1	0.1	-0.2	2.0	1.7	1.3	-1.0
Allergy or Eczema	0.1	0.2	0.8	0.0	-0.1	0.3	-0.9	-0.2	-0.3	0.3
Cardiovascular Disease	0.6	2.1	3.3	-1.5	-0.6	-1.7	1.8	0.8	-1.7	-1.4
Hypothyroidism (self reported)	0.1	0.3	0.9	-0.9	0.5	-0.5	-0.0	-0.8	-0.4	0.1
Respiratory disease	0.3	0.8	1.8	0.6	0.8	0.1	1.1	1.3	0.7	-0.9
Type 2 Diabetes (T2D) (2018)	0.5	0.8	2.7	0.0	-0.3	1.6	-1.2	-0.7	-0.7	0.8
Lung FEV1/FVC ratio	0.4	1.9	3.1	1.6	-1.7	0.7	-1.8	-1.4	-1.3	0.7
Lung FVC	0.2	1.1	4.0	2.0	0.7	-1.3	0.9	0.6	0.5	-0.2
Neuroticism	0.7	1.7	6.6	-1.0	0.5	-1.4	1.1	0.5	-0.9	-2.6
Chronotype (morning person)	0.3	0.6	1.5	-1.2	0.6	-0.6	0.1	-0.9	0.2	1.1
Hair Pigment	0.1	1.8	5.9	1.3	0.1	-1.4	2.4	1.8	-0.0	-0.3
Tanning	0.1	0.6	2.0	-1.4	0.9	-0.4	-0.8	0.1	-0.2	0.8
Hand grip strength (left)	0.5	1.3	3.6	-0.8	1.9	0.4	-0.1	0.7	-1.6	-1.2
Number of treatments/medications taken	0.2	0.4	1.5	0.2	0.2	-1.0	1.2	0.1	-0.4	-0.5
Average weekly spirits intake	0.7	0.9	2.5	-0.8	-0.2	-1.6	1.4	0.8	0.6	-0.5
Sensitivity / hurt feelings	0.5	0.8	3.5	-0.2	-1.9	-0.3	0.4	-1.1	0.8	0.3
Frequency of depressed mood in last 2 weeks	0.8	1.2	4.3	-1.3	2.1	-0.3	0.3	0.9	0.1	-1.2
Hearing difficulty/problems: Yes	0.8	1.2	3.0	-1.1	-1.7	0.4	0.7	0.0	-1.4	1.1
Relative age of first facial hair	0.3	0.7	1.7	0.7	-0.9	0.5	-0.8	0.2	-1.3	1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-1.0	1.2	1.0	0.7	-0.1	-0.3	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.4	-0.4	-0.0	-0.4	0.5	-0.2	1.5	0.3
Ever had hysterectomy (womb removed)	0.6	0.6	1.8	-0.7	-0.2	-0.7	1.4	0.7	0.1	-1.1
Systolic blood pressure, automated reading	0.1	0.4	1.2	-0.0	-1.1	0.6	0.2	0.1	-0.5	-0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.8	0.7	0.7	-0.8	1.3	1.0	0.5	-1.3
Angina	0.7	1.0	2.0	-1.3	1.4	-1.4	0.7	-0.4	0.4	-0.5
Medication for hormone replacement therapy	0.8	0.9	2.6	0.3	-0.3	0.6	-1.5	-1.6	0.6	0.9
Vitamin and mineral supplements	0.4	0.5	1.9	-0.5	0.5	-0.7	0.5	-0.4	0.1	-1.4
Supplements: Zinc	1.7	1.9	4.6	2.1	-0.9	-0.6	-0.2	-0.3	1.7	2.1
Medication: Co-codamol	0.6	0.7	3.3	-0.3	0.4	-1.8	0.5	0.3	0.0	-1.1
Medication: Metformin	0.2	0.3	0.9	-0.9	0.1	-0.2	-0.2	-0.5	-0.8	-0.7
Diabetes (father)	1.1	1.3	3.7	-0.0	1.9	-0.3	1.6	1.3	0.2	-1.1
Diabetes (mother)	0.2	0.3	1.2	0.2	0.5	-1.1	0.6	0.1	0.4	-0.4
Severe depression (siblings)	0.6	0.7	2.1	-0.3	-1.4	0.6	-0.7	-0.5	-1.3	0.2
Pack years adult smoking proportion	0.4	0.5	1.0	1.0	-1.0	0.1	-1.0	-0.7	-0.2	0.4
Impedance of leg (right)	0.2	0.8	3.0	0.6	-0.5	-1.1	1.7	0.9	0.1	-0.5
Leg fat-free mass (left)	0.2	0.8	1.4	-0.7	1.2	0.8	-0.9	-0.9	-1.1	-0.6
Trunk fat percentage	0.3	1.1	6.2	0.2	0.2	-2.5	0.8	-0.3	0.3	-0.9
Hand grip strength (right)	0.4	1.0	3.0	0.5	1.6	-0.2	0.2	1.0	-1.7	-0.6
Townsend deprivation index at recruitment	0.5	0.7	3.9	-0.2	0.5	-0.8	0.2	-0.2	0.0	-2.0
Current tobacco smoking	0.4	0.6	2.3	1.5	-0.7	0.3	-0.0	0.9	0.4	-0.5
Average weekly fortified wine intake	0.8	1.0	2.6	-0.3	0.9	-0.9	0.8	1.6	-0.8	-1.1
Maternal smoking around birth	0.0	0.1	0.1	-0.4	-0.2	0.3	-0.4	-0.1	0.2	-0.1
Fed-up feelings	0.7	1.3	2.6	-0.8	1.4	-1.6	-0.0	-0.2	-1.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	-1.0	1.3	-0.4	1.1	0.5	-0.3	-0.9
Relative age voice broke	0.2	0.3	1.7	-0.5	0.4	0.3	-1.3	0.1	-0.1	0.3
Taking other prescription medications	0.8	1.2	4.2	-0.3	-0.0	-2.1	1.8	1.0	0.0	-0.5
Age when periods started (menarche)	0.4	0.8	3.8	1.9	-0.2	0.2	-1.1	-0.8	-0.0	0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.6	-1.9	-0.1	-0.2	1.2	0.1	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	2.6	6.0	18.2	-3.7	4.3	1.8	-0.3	-0.6	2.1	-1.4
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	6.1	0.3	-0.7	2.0	-2.5	-2.2	0.1	1.2
Qualifications: CSEs or equivalent	0.8	1.1	3.4	-1.8	-0.4	-1.6	0.4	0.2	-1.1	0.2
Serious illness, injury or assault to yourself	1.8	2.1	6.9	-0.4	-1.4	1.7	-0.6	-0.4	-2.6	1.6
High blood pressure	0.4	1.0	2.1	-1.0	0.2	-0.9	1.3	0.3	-1.1	-1.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.3	0.5	-0.5	-0.2	0.2	-0.7	-0.7
Multivitamins +/- minerals	0.7	0.9	2.1	1.0	-0.3	1.2	0.4	1.4	0.5	1.0
Stomach or abdominal pain in last month	1.2	1.4	2.6	-1.2	1.6	-1.5	-0.1	-1.4	1.0	-1.0
Supplements: Glucosamine	0.7	0.9	3.9	-2.0	0.1	-0.8	0.6	0.9	-0.8	0.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-1.1	-1.1	0.5	0.5	0.7	-0.6	-0.6
Medication: Atenolol	0.4	0.5	2.3	0.3	0.1	-0.2	1.5	0.6	0.7	-0.0
Medication: Levothyroxine sodium	1.1	1.8	6.8	-2.6	-0.6	0.3	-0.7	-1.9	-0.6	0.9
Sitting height	0.7	4.8	15.4	-0.9	3.4	3.9	-1.3	-0.3	-1.8	-1.1
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	-1.4	-0.2	-1.2	-0.6	-0.8	0.5	0.4
High blood pressure (mother)	0.6	0.8	2.0	-0.7	0.8	-1.4	-0.2	-1.2	0.9	0.3
Body mass index (BMI)	0.4	1.8	6.8	-0.8	1.5	-2.6	1.1	0.0	0.3	-1.3
Impedance of leg (left)	0.1	0.7	2.7	0.7	-0.3	-0.7	1.6	0.6	-0.1	-0.9
Leg predicted mass (left)	0.1	0.7	1.4	-0.6	1.2	0.8	-0.9	-0.8	-1.1	-0.5
Trunk fat mass	0.2	0.9	3.2	-0.2	0.8	-1.8	0.6	-0.3	-0.4	-1.4
Waist circumference	0.1	0.4	1.4	-0.1	0.2	-1.2	0.9	0.1	-0.4	-0.7
Number of incorrect matches in round	1.5	2.5	5.5	-2.3	1.8	-1.5	1.4	0.6	1.2	-1.6
Past tobacco smoking	1.3	2.5	5.9	1.4	-0.6	1.7	-2.4	-2.0	-1.2	0.8
Alcohol usually taken with meals	0.8	1.3	3.2	1.1	-1.3	1.0	-0.6	-0.4	1.1	1.8
Nervous feelings	0.5	1.0	3.7	-0.6	-1.3	0.9	0.3	-0.2	1.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	-0.8	1.3	-0.1	0.6	0.3	0.8	-0.9
Hearing difficulty/problems with background noise	0.5	0.8	3.8	-1.9	0.5	-0.1	1.1	-0.2	-0.4	0.2
Hair/balding pattern: Pattern 2	1.5	1.9	5.8	-1.5	0.1	2.4	-1.5	-0.7	1.1	1.2
Had menopause	0.7	0.9	3.0	0.8	-1.7	0.7	-0.4	-0.0	1.2	0.8
Had other major operations	0.5	0.7	2.5	-1.3	-0.3	1.6	-0.1	0.2	0.5	-0.3
Forced vital capacity (FVC)	0.1	0.5	1.7	0.4	1.3	0.3	-0.1	0.9	-0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.9	13.0	-3.2	3.6	2.3	-1.2	-0.9	1.5	-1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	-1.2	1.1	0.3	0.3	0.9	0.2	-0.6
Qualifications: None of the above	0.2	0.3	0.7	0.8	-0.5	0.1	0.5	-0.3	0.9	0.5
Financial difficulties in last 2 years	0.3	0.4	1.9	1.4	-0.1	-0.4	0.1	-0.3	-0.7	-0.2
Mouth/teeth dental problems	0.3	0.5	1.3	1.1	-0.3	0.1	-0.8	-0.7	0.9	0.7
Heart attack	3.0	3.9	11.4	-1.3	1.5	-2.1	3.4	2.5	-0.3	-0.9
Allergy	0.2	0.4	1.2	0.2	-0.6	0.1	-0.5	-1.1	-0.1	0.9
Pain all over the body in last month	2.3	2.5	5.2	0.3	-2.0	1.6	-1.6	-2.3	0.5	1.6
Diabetes (self-reported)	0.4	0.6	1.8	0.3	0.4	0.6	-1.1	-1.3	0.2	0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.6	-0.3	0.6	-0.7	0.7	0.8	0.0	-0.6
Medication: Ramipril	1.4	1.9	3.2	-1.0	-0.5	-1.3	1.8	1.0	-1.7	-1.7
Medication: Simvastatin	0.3	0.5	1.8	-1.0	0.3	-0.7	0.1	0.2	-1.3	-0.2
Fluid intelligence score	0.4	0.7	1.8	0.8	-0.2	1.1	-1.4	-0.5	-1.2	0.2
Illnesses of siblings	3.1	4.4	9.0	2.0	-1.4	3.0	-2.3	-1.8	1.1	2.4
Neuroticism score	0.5	1.0	2.1	-1.5	-0.0	-1.2	1.0	0.4	-0.5	-1.4
Weight	0.2	1.0	3.2	-0.7	1.8	-0.8	0.4	-0.2	-0.7	-1.5
Impedance of arm (right)	0.5	2.4	11.1	1.3	-3.3	-0.4	-1.0	-0.8	0.1	1.6
Arm fat percentage (right)	0.3	1.2	7.1	-0.3	-0.0	-2.7	0.2	-0.7	0.2	-0.7
Trunk fat-free mass	0.4	2.4	6.4	-1.2	2.5	1.7	-0.5	-0.2	-1.7	-1.9
Hip circumference	0.2	0.8	1.5	-0.7	1.1	-1.2	0.7	-0.6	-0.0	-1.1
Time employed in main current job	1.1	1.3	3.5	-1.3	-0.9	-0.9	1.0	1.9	-0.8	-0.3
Alcohol intake versus 10 years previously	0.5	0.7	1.5	1.1	-0.0	0.9	-0.8	-1.2	-0.6	-0.6
Father’s age at death	0.4	0.6	1.1	-0.7	0.5	0.9	0.7	1.1	0.6	0.6
Worrier / anxious feelings	0.5	1.0	3.5	-1.9	0.4	-1.1	0.6	0.0	-0.5	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	3.2	-0.1	0.9	-0.3	1.8	1.8	1.2	0.3
Falls in the last year	0.5	0.7	2.0	0.3	-1.4	-1.4	0.9	0.5	-0.1	-0.4
Hair/balding pattern: Pattern 3	2.3	3.4	10.4	-1.2	0.8	-3.2	2.1	1.7	-1.1	-1.8
Number of live births	0.9	1.2	5.4	1.6	-0.1	0.1	0.6	0.4	2.3	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.8	0.9	0.1	0.1	-0.7	0.1	-0.8	-0.0
Pulse rate	0.3	0.6	1.5	0.8	0.4	-0.8	1.0	0.4	-1.2	0.0
Happiness	0.9	1.1	2.4	-0.8	1.6	-0.4	1.3	1.1	-0.6	-1.1
Noisy workplace	0.7	0.8	1.8	-0.7	0.8	0.8	-0.9	-1.3	-1.0	0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.3	1.1	-0.3	1.5	-0.1	1.5	-0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.6	-0.2	0.1	1.9	-0.9	-0.8	0.2	0.7
Mouth/teeth dental problems: Dentures	0.6	1.1	2.9	-0.7	0.0	-0.7	1.7	1.4	0.4	-1.2
Asthma	0.3	0.7	1.1	1.0	1.1	0.5	0.6	1.0	0.6	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.0	-0.1	0.6	-0.7	1.0	1.6	-0.8	-1.7
Medication: Cholesterol lowering	0.3	0.5	1.2	-0.5	-0.1	-1.0	1.1	0.4	-0.8	0.6
Depression (self-reported)	0.8	1.0	3.3	0.9	0.4	0.0	1.6	1.8	0.1	-0.6
Medication: Lansoprazole	1.3	1.5	4.5	-1.0	0.5	-1.6	1.6	-0.3	2.1	-0.0
Prospective memory result	0.6	0.8	3.0	-1.7	1.2	-0.9	-0.3	-0.1	0.0	-0.5
Lung cancer (father)	1.6	1.9	4.8	-0.7	1.4	-1.0	2.2	1.8	1.1	-0.7
Illnesses of mother	0.7	0.8	4.5	0.5	-0.7	2.1	-0.0	0.6	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	0.9	-0.1	0.7	-0.1	0.2	-0.7	0.9
Pulse wave Arterial Stiffness index	1.2	1.4	5.9	-0.2	-0.1	-2.4	0.6	0.6	-0.3	-1.8
Impedance of arm (left)	0.7	3.4	13.2	1.5	-3.6	0.1	-1.3	-1.2	0.2	2.3
Arm fat mass (right)	0.2	0.9	4.0	-0.3	0.7	-2.0	0.1	-0.6	-0.4	-1.0
Trunk predicted mass	0.4	2.5	6.2	-1.2	2.5	1.7	-0.6	-0.2	-1.7	-1.9
Standing height	0.3	3.2	12.2	0.2	0.9	3.5	-1.5	-0.8	-2.4	-0.6
Length of working week for main job	1.1	1.2	3.0	-1.2	-0.3	-0.8	-0.8	-1.4	-1.7	-0.3
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.1	-0.3	-0.7	0.2	-0.8	-0.7	-0.6
Breastfed as a baby	0.2	0.3	0.8	0.7	-0.1	-0.1	0.8	0.9	0.2	-0.2
Tense / ‘highly strung’	0.7	1.2	2.3	-1.3	-0.1	-0.8	1.5	0.8	1.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.5	0.3	0.4	-1.1	1.6	1.1	0.4	-1.4
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	-0.6	-0.1	0.9	0.8	0.1	-0.8	-1.1
Birth weight of first child	1.2	2.1	8.7	-1.3	1.5	0.1	1.4	0.3	3.0	0.0
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.3	0.3	-0.4	-0.7	-0.3	-0.5	-0.4
Pulse wave reflection index	2.1	2.6	7.5	-0.1	0.1	-2.7	1.7	1.7	-0.4	-2.2
Ever highly irritable/argumentative for 2 days	1.8	2.2	4.3	-0.7	2.1	0.5	1.7	1.9	-0.8	-1.6
Loud music exposure frequency	1.3	1.5	3.2	1.2	-0.5	0.4	-0.8	-1.4	1.6	1.8
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	0.4	0.1	0.9	0.6	-0.1	-0.3	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.2	0.8	-1.1	1.0	-1.1	-0.9	0.3	1.8
Blood clot in the leg (DVT)	0.4	0.5	1.9	-0.0	-1.4	-0.1	-0.6	-0.3	0.8	0.6
Medication: Paracetamol	0.3	0.5	1.1	0.7	1.0	-0.5	0.7	0.5	0.8	-0.7
Headache pain in last month	0.3	0.5	1.4	-1.1	0.1	-1.2	0.9	0.1	0.5	-0.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.9	0.3	0.9	1.0	-0.9	-0.0	2.0	-0.7
Glaucoma (self-reported)	0.5	0.6	1.7	0.4	-1.3	-0.1	0.0	-0.3	0.9	1.2
Gout (self-reported)	0.4	0.5	2.6	-0.3	-0.2	-0.8	-0.1	0.0	-1.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	4.2	-2.0	0.4	-0.6	-0.2	-1.2	-0.5	0.6
Medication: Amlodipine	0.7	1.0	3.5	-0.2	-1.3	-0.2	0.4	-0.1	-1.9	-1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.8	-0.0	-1.1	1.4	-0.1	0.6	0.9	1.1
Birth weight	0.9	2.0	5.1	1.8	-1.4	2.2	-0.5	-0.5	-1.6	1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.5	-0.8	-0.1	0.7	-1.2	-0.7	0.3	-0.0
High blood pressure (siblings)	1.4	2.0	4.8	-1.0	1.5	-2.2	1.5	1.2	-0.6	-1.5
Forced vital capacity (FVC), Best measure	0.1	0.5	1.1	0.4	1.0	1.0	0.3	1.0	-0.7	0.1
Body fat percentage	0.4	1.6	7.4	-0.2	0.6	-2.7	1.2	-0.2	0.5	-1.3
Leg fat percentage (right)	1.1	4.0	10.9	-0.7	1.4	-3.3	2.8	1.0	0.6	-2.3
Arm fat-free mass (right)	0.4	1.9	7.3	-0.6	2.7	1.4	-0.4	-0.3	-1.0	-1.6
Exposure to tobacco smoke outside home	0.2	0.3	1.5	-0.3	0.2	-0.6	0.3	-0.0	-1.2	-0.4
Comparative body size at age 10	0.4	1.0	2.6	0.4	1.6	-0.8	1.3	-0.0	0.9	-1.0
Number of full brothers	0.6	0.8	1.4	-0.9	1.2	0.5	0.3	0.9	1.0	-1.1
Worry too long after embarrassment	0.3	0.5	3.2	-1.8	0.3	-0.3	0.0	-0.5	0.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.2	0.2	1.5	-0.6	2.1	1.4	0.7	-0.9
Wheeze or whistling in the chest in last year	0.5	0.9	2.1	1.0	-0.9	-1.4	1.1	0.5	0.8	-0.2
Number of children fathered	2.6	2.9	8.5	-2.9	2.4	-0.7	1.4	1.0	0.2	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	7.6	-1.2	-1.3	1.4	-2.8	-1.7	-2.5	0.4
Age at first live birth	1.7	3.1	6.9	0.1	1.8	-0.4	1.0	2.0	-2.5	-2.6
Pulse wave peak to peak time	1.3	1.5	6.9	0.3	-0.1	2.6	-0.8	-0.6	-0.2	1.6
Health satisfaction	1.0	1.3	3.5	-0.9	-0.1	-1.5	1.9	0.7	-1.2	-0.4
Shortness of breath walking on level ground	0.4	0.5	1.6	-0.0	0.3	-1.3	-0.4	-0.4	-0.4	-1.0
Qualifications: College or University degree	0.3	0.9	3.0	0.4	-1.0	1.7	-1.2	-0.0	-0.9	-0.0
Eye problems/disorders: None of the above	1.1	1.2	2.4	-0.3	-0.7	1.1	-1.3	-0.6	-1.5	1.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	5.2	-0.5	-0.5	-1.2	2.3	0.8	-0.0	-0.8
Emphysema/chronic bronchitis	1.4	1.6	6.6	0.1	0.5	-0.1	2.6	1.6	-0.4	-1.2
Medication for pain relief, constipation, heartburn	1.6	2.8	6.5	0.1	-1.6	1.4	-2.5	-2.0	0.3	2.0
Neck or shoulder pain in last month	0.2	0.3	0.9	0.0	0.1	-0.7	-0.4	-1.0	0.4	0.5
Medication: Blood pressure	0.4	0.7	2.5	-0.4	-0.7	-0.9	0.6	-0.3	-1.6	0.4
Angina (self-reported)	0.7	0.9	2.0	-1.3	1.4	-1.3	0.8	-0.3	0.2	-0.4
Migraine (self-reported)	1.0	1.3	3.7	0.3	-0.8	-0.2	-1.5	-1.9	1.2	0.9
Medication: Ibuprofen	0.8	0.9	2.9	0.2	0.4	0.1	1.1	1.7	-0.4	-1.4
Medication: Allopurinol	1.1	1.4	4.7	-2.2	0.1	-0.4	0.2	-0.1	-2.1	-0.8
Medication: Omeprazole	0.8	1.0	2.5	1.0	-0.7	0.3	1.6	1.5	-0.7	0.1
Medication: Seretide 50 evohaler	0.3	0.3	1.1	-0.2	-0.0	-1.1	-0.2	0.2	0.6	-0.9
Mean time to correctly identify matches	0.5	0.9	3.3	-1.8	0.3	0.4	-0.6	-1.2	0.3	-0.8
Heart disease (mother)	0.6	0.8	3.1	-0.2	0.5	-1.8	0.2	-0.7	1.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.6	1.0	0.4	-0.5	0.9	1.1	1.3	0.8
Whole body fat mass	0.2	0.9	3.4	-0.3	0.8	-1.8	0.7	-0.4	-0.3	-1.3
Leg fat mass (right)	0.4	1.5	4.1	-0.5	1.2	-2.0	1.3	-0.0	-0.3	-1.8
Arm predicted mass (right)	0.3	1.6	5.9	-0.1	2.4	1.4	-0.2	-0.2	-1.2	-1.4
Pulse rate, automated reading	0.4	1.3	3.0	0.9	-0.5	-0.1	-1.7	-1.6	-1.6	-0.5
Alcohol intake frequency.	0.4	0.9	1.7	0.0	0.0	1.1	0.5	-1.2	1.3	1.2
Comparative height size at age 10	0.3	1.6	4.2	0.5	0.5	1.5	-2.1	-1.9	-0.5	0.5
Number of full sisters	0.3	0.4	1.4	-0.2	0.4	0.2	0.8	0.3	-0.6	-1.2
Suffer from ‘nerves’	0.6	0.9	4.5	-0.5	0.4	0.4	0.6	1.1	2.1	-0.3
Overall health rating	0.3	0.6	1.7	0.6	-1.3	-0.8	0.6	-0.4	0.5	1.0
Chest pain or discomfort	0.8	1.1	4.4	-1.3	-0.1	-2.1	1.0	-0.2	-0.4	-0.8
Had major operations	1.5	1.7	6.3	-1.9	0.1	-0.0	-0.4	-0.3	-2.5	-1.3
Age at last live birth	0.9	1.3	2.9	0.3	0.9	1.3	0.5	1.7	-1.5	-0.9
Family relationship satisfaction	0.5	0.6	2.0	-1.4	0.1	0.5	0.7	0.4	0.8	-0.8
Leg pain on walking	0.6	0.8	1.7	-1.0	0.9	-1.0	1.3	0.0	0.9	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.1	5.2	-1.3	-0.1	-2.3	-0.0	-0.7	0.2	0.7
Commuting to job workplace: Car/motor vehicle	1.5	1.7	4.3	-2.1	1.5	-1.0	1.6	0.9	0.8	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	-0.4	-0.8	-0.2	-0.0	-1.2	1.1	0.7
Medication: Aspirin	0.9	1.2	2.2	-1.1	1.4	-0.5	1.5	1.3	-0.2	-1.0
Supplements: Vitamin C	0.6	0.7	3.3	-0.9	1.8	-0.2	-0.5	0.5	0.1	-0.7
Knee pain experienced in last month	0.1	0.2	0.5	0.4	0.3	-0.3	0.4	-0.4	0.7	0.6
Hypertension (Self-reported)	0.3	0.8	1.4	-1.1	0.3	-0.6	1.0	-0.0	-1.1	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.8	-0.4	1.0	-1.7	2.2	0.8	0.7	-0.5
Illnesses of father: Heart disease	0.7	1.0	2.3	-1.2	1.2	-1.2	0.4	-0.0	1.5	-0.3
Illnesses of siblings: Diabetes	0.6	0.7	1.3	0.1	-0.9	-0.0	1.1	0.9	-0.9	-1.0
Smoking status: Previous	1.9	2.8	5.6	-1.8	1.4	-1.6	2.4	1.6	1.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	6.8	0.4	-0.6	0.3	0.1	0.6	-2.6	0.0
Whole body fat-free mass	0.3	1.8	4.6	-1.0	2.1	1.5	-0.6	-0.5	-1.4	-1.4
Leg fat-free mass (right)	0.2	1.1	1.9	-0.8	1.2	1.4	-1.1	-1.0	-1.0	-0.6
Arm fat percentage (left)	0.2	0.9	5.3	-0.1	-0.4	-2.3	-0.0	-1.0	0.3	-0.2
Average weekly red wine intake	1.7	2.4	5.8	2.1	-2.4	0.4	-1.6	-0.2	-0.1	2.0
Handedness (chirality/laterality): Left-handed	1.3	1.5	6.1	0.4	1.2	0.6	1.1	2.5	-0.5	-1.1
Mood swings	1.0	1.8	8.3	-1.1	-0.4	-0.2	1.2	0.7	-2.9	-1.0
Loneliness, isolation	0.6	0.9	2.2	-1.5	0.9	-1.2	0.3	-0.5	1.0	-0.6
Long-standing illness, disability or infirmity	0.3	0.5	1.6	0.5	0.4	1.3	-0.0	-1.0	0.4	0.6
Ever had bowel cancer screening	0.2	0.2	0.6	-0.4	0.6	-0.2	0.1	0.0	-0.8	-0.7
Diabetes diagnosed by doctor	0.9	1.4	3.0	0.7	-0.8	0.8	-1.7	-1.6	-0.8	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	4.8	2.2	0.0	-0.3	0.2	-0.5	1.4	-0.3
Friendships satisfaction	1.0	1.2	6.2	-2.5	0.1	0.7	-0.4	-0.7	-1.0	-0.0
Qualifications: nursing, teaching	0.9	1.4	3.7	-1.9	0.8	0.8	0.4	0.4	-1.6	-1.4
Commuting to job workplace: Walk	1.1	1.2	3.0	1.7	-1.4	-0.3	-1.0	-1.3	-0.6	0.5
Eye problems/disorders: Cataract	1.1	1.3	3.2	-0.6	0.8	0.1	-1.5	-1.8	1.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.7	2.6	12.3	0.4	0.8	-0.6	0.7	1.4	-3.5	-1.6
Medication for cholesterol	0.8	1.2	2.3	1.5	-1.3	0.8	1.0	1.5	-0.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.2	-1.5	0.7	0.0	1.1	0.7	1.8	0.9
Back pain experienced in last month	0.5	0.7	2.2	0.6	1.5	-0.6	0.5	0.4	0.7	-0.9
Mineral and other dietary supplements	0.8	1.1	4.7	-0.1	1.5	-0.7	-0.1	-0.6	0.1	-2.2
Breast cancer (self-reported)	0.2	0.2	0.4	-0.0	-0.7	0.6	0.4	0.4	-0.4	0.3
Asthma (self-reported)	0.4	0.8	1.6	0.8	1.3	0.5	0.7	1.2	0.6	-0.7
Osteoporosis (self-reported)	4.9	6.0	24.0	2.5	-4.9	-1.7	-0.1	-0.1	1.7	2.4
Osteoarthritis (self-reported)	0.5	0.6	1.5	-0.7	0.8	0.6	-0.1	0.0	-1.2	-1.2
Medication: Aspirin	1.1	1.5	3.3	-1.6	1.8	-0.5	1.3	1.0	-0.3	-1.3
Medication: Gliclazide	0.4	0.4	0.9	-0.8	0.1	-1.0	0.6	-0.3	-0.5	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	1.7	1.3	-1.3	1.0	-0.1	0.3	-0.4	0.4
Smoking status: Current	0.3	0.5	1.5	1.2	-0.9	0.1	0.2	0.7	0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.0	1.0	0.8	0.1	0.6	1.0	1.0	0.5
Whole body water mass	0.3	1.6	4.0	-0.8	2.0	1.5	-0.8	-0.6	-1.4	-1.3
Leg predicted mass (right)	0.2	1.1	1.9	-0.8	1.3	1.4	-1.1	-1.0	-1.0	-0.6
Arm fat mass (left)	0.2	0.7	3.2	-0.1	0.6	-1.8	-0.2	-1.0	0.1	-0.6
Number of self-reported non-cancer illnesses	0.3	0.6	1.9	-0.7	0.5	-0.8	-0.4	-1.4	0.6	-0.4
Average weekly champagne plus white wine intake	1.8	2.5	9.5	-3.1	-2.1	-0.1	-1.2	-0.6	-0.6	1.2
Miserableness	1.5	2.5	5.4	-1.5	2.3	-0.3	1.8	1.4	-1.1	-2.0
Guilty feelings	0.7	1.0	3.5	-1.9	0.8	-0.1	-0.1	-0.8	-0.7	-1.3
Wears glasses or contact lenses	0.8	0.9	3.3	-0.3	-0.7	-0.1	0.6	1.1	-1.8	-1.0
Ever taken oral contraceptive pill	0.3	0.4	1.1	0.6	-0.8	0.5	-0.2	0.4	-1.1	-0.1
Hearing aid user	2.1	2.4	9.2	0.6	0.8	1.4	2.1	3.0	0.2	-0.4
Mother’s age at death	0.5	0.7	3.7	1.9	-0.6	-0.0	0.5	-0.2	-0.3	0.6
Financial situation satisfaction	0.8	0.9	2.8	0.9	-0.2	-0.5	-1.5	-1.7	-0.5	0.6
Tinnitus: Yes, now most or all of the time	5.5	6.5	17.1	-2.4	1.2	-2.7	4.1	3.4	0.6	-1.4
Commuting to job workplace: Public transport	0.6	0.8	3.6	0.9	-0.5	-0.2	-0.1	0.1	-1.9	-0.8
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	0.3	-0.7	-0.4	0.1	-0.1	0.2	0.1
Medication: Blood pressure	0.8	1.5	2.9	-1.4	1.7	-1.3	0.7	-0.5	-0.2	-1.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	-0.1	1.2	-0.0	0.7	0.4	0.9	-1.1
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.2	0.0	-1.3	1.5	-0.9	0.0	-0.8	1.3
High cholesterol (Self-reported)	0.4	0.8	2.0	-1.4	-0.1	-1.4	-0.4	-1.1	-0.0	0.3
Medication: Bendroflumethiazide	0.3	0.4	2.1	-1.5	0.1	0.1	0.3	-0.8	-0.0	-0.3
Medication: Paracetamol	0.3	0.4	1.8	0.4	0.7	0.7	0.3	-0.3	1.3	-0.0
Medication: Lisinopril	0.7	1.0	2.3	-0.4	1.5	-0.1	0.4	-1.5	0.4	-1.3
Medication: Atorvastatin	2.1	2.7	5.5	2.2	-1.4	0.1	-1.6	-2.0	-0.1	2.4
Illnesses of father: High blood pressure	0.5	0.7	1.5	0.1	1.1	-0.5	0.6	0.2	-1.2	-1.1
Alcohol drinker status: Never	0.5	0.6	1.5	-0.7	1.2	0.4	0.8	0.8	0.3	-0.6
Ever smoked	0.6	1.1	3.9	0.3	0.4	-0.8	1.5	2.0	1.0	0.0
Basal metabolic rate	0.3	1.5	4.2	-0.9	2.0	1.0	-0.5	-0.5	-1.3	-1.4
Leg fat percentage (left)	1.0	3.7	9.3	-0.7	1.5	-3.0	2.6	0.8	0.5	-2.5
Arm fat-free mass (left)	0.4	2.0	8.4	-0.8	2.9	0.8	0.2	0.1	-0.7	-1.9
Number of operations (self-reported)	0.9	1.3	5.2	-2.3	-0.8	0.2	0.5	0.1	-1.3	-1.1
Average weekly beer plus cider intake	1.3	1.9	4.0	-1.0	0.9	-1.8	1.7	0.8	-2.0	-0.9
Irritability	0.6	1.1	2.7	-1.2	1.0	-0.7	-0.4	-0.2	-1.6	-1.3
Risk taking	0.5	0.7	1.7	-1.1	1.3	0.2	0.1	0.9	-0.5	-1.1
Ever had prostate specific antigen (PSA) test	1.8	2.1	9.1	0.6	1.4	-0.1	-0.3	0.7	-3.0	-1.6
Fractured/broken bones in last 5 years	1.3	1.6	6.2	2.5	-1.6	-0.5	1.4	0.1	0.4	-0.1
Age started oral contraceptive pill	0.8	1.0	3.1	1.0	-1.0	1.8	-0.8	-0.9	0.7	0.3
Diastolic blood pressure, automated reading	0.2	0.7	2.2	-0.0	0.0	-0.4	0.6	0.4	-1.5	-1.4
Ever depressed for a whole week	0.8	1.0	2.9	0.7	1.7	-0.5	0.4	0.0	1.4	-1.1
Unable to work because of sickness or disability	0.6	0.8	1.8	1.2	-0.0	-0.8	-0.3	-1.2	1.3	0.5
Commuting to job workplace: Cycle	0.3	0.3	1.1	-0.8	1.1	0.2	-0.1	0.3	0.6	-0.0
Myopia	0.5	0.7	2.2	0.1	0.0	-0.8	-1.3	0.4	-1.5	0.3
Vascular/heart problems diagnosed by doctor	0.5	1.2	4.0	0.4	-0.1	0.6	-2.0	-0.8	1.4	1.2
Cholesterol lowering medication	0.2	0.3	1.0	0.2	-0.3	-0.7	-0.7	-0.4	-1.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	5.1	0.7	-0.7	0.1	2.3	2.0	-0.9	-0.2
Pain experienced in last month	0.9	1.5	3.9	2.0	-1.4	0.7	0.7	1.6	-1.1	0.1
Supplements: Calcium	2.5	2.7	6.9	2.3	-2.3	0.9	-0.6	-0.6	0.7	2.6
Basal cell carcinoma (self-reported)	0.9	1.1	3.5	-0.7	0.7	-1.9	0.2	-1.3	1.0	0.5
Heart attack/myocardial infarction (self-reported)	3.2	4.1	12.5	-1.2	1.7	-2.1	3.5	2.6	0.1	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.1	-0.2	-1.5	-0.1	-0.6	-0.4	0.6	0.4
Heart disease (siblings)	2.6	3.2	8.6	-1.6	1.2	-2.9	1.6	1.0	-1.0	-2.3
Alcohol drinker status: Previous	1.2	1.4	3.5	-0.4	-0.6	1.1	-0.6	-1.4	1.4	1.9
Pack years of smoking	0.2	0.3	0.9	0.8	-0.9	-0.1	-0.5	-0.5	-0.3	0.4
Impedance of whole body	0.3	1.4	5.6	1.7	-2.4	-0.1	0.0	-0.3	0.1	1.1
Leg fat mass (left)	0.4	1.5	3.3	-0.6	1.3	-1.8	1.2	-0.2	-0.3	-1.8
Arm predicted mass (left)	0.4	2.0	8.1	-0.6	2.8	0.9	0.0	-0.0	-0.8	-2.0