TWAS hub - DIRAS3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.054	0.0230	7.7e-03	0.034	0.013	0.020	0.016	0.024	4.8e-05	0.0079	0.0015	0.0041	0.00051
2	GTEx	Nerve Tibial	0.184	0.0518	4.1e-05	0.009	NA	0.033	NA	0.053	7.0e-02	NA	0.0021	NA	0.00013
3	GTEx	Prostate	0.331	0.1100	2.8e-03	-0.009	NA	0.022	NA	0.018	6.0e-01	NA	0.0900	NA	0.12000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Forced expiratory volume in 1-second (FEV1), Best measure	6.5	20.8	30.8	5.0	5.6	2.5
Forced expiratory volume in 1-second (FEV1)	5.9	19.8	29.7	5.0	5.4	2.2
Forced vital capacity (FVC)	5.8	22.3	30.1	5.3	5.5	2.9
Forced vital capacity (FVC), Best measure	5.7	20.8	29.2	4.8	5.4	3.2
Pulse rate	4.4	7.5	11.4	-3.4	-3.3	0.4
Stomach or abdominal pain in last month	3.9	4.8	6.3	2.5	2.4	1.6
Pulse wave reflection index	3.4	4.2	7.4	2.2	2.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.5	6.7	2.6	2.6	0.2
Glaucoma (self-reported)	3.3	3.9	4.2	1.8	2.1	2.1
Lung FVC	3.1	15.7	24.2	4.9	4.4	2.0
Mood swings	3.0	5.5	9.4	2.1	1.6	3.1
Illnesses of mother	2.9	3.5	5.7	1.8	2.4	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.2	11.3	3.4	2.7	-0.0
Neuroticism (2016)	2.8	4.0	8.8	3.0	1.8	-0.2
Pulse rate, automated reading	2.8	9.1	15.1	-3.5	-3.9	0.5
Miserableness	2.8	4.9	8.4	2.9	2.4	0.7
Heel T-Score	2.6	20.3	28.6	-5.1	-5.3	-2.5
Unable to work because of sickness or disability	2.6	3.3	7.5	2.7	1.1	1.1
Medication: Gliclazide	2.5	2.8	5.0	-1.6	-2.2	0.8
Medication: Ventolin 100micrograms inhaler	2.4	3.1	4.1	-1.9	-2.0	-1.3
Fractured/broken bones in last 5 years	2.4	3.0	4.9	1.6	1.3	2.2
Number of treatments/medications taken	2.3	4.1	5.8	-1.3	-2.4	2.2
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.7	4.4	2.1	1.8	0.6
High cholesterol (Self-reported)	2.2	4.0	10.6	-1.0	-3.2	-0.5
Heart attack	1.9	2.4	3.3	1.8	0.9	1.8
Eye problems/disorders: Glaucoma	1.9	2.3	4.0	1.0	1.4	2.0
Alzheimer’s Disease (in father)	1.8	2.0	3.2	1.8	1.5	0.6
Fasting Glucose	1.8	2.1	3.9	-1.3	-2.0	0.8
Trunk fat-free mass	1.8	10.2	12.2	3.5	2.8	3.2
Trunk predicted mass	1.8	10.1	12.0	3.5	2.8	3.2
Number of full brothers	1.8	2.3	5.0	-1.1	-2.2	-0.8
Medication for cholesterol	1.8	2.8	6.2	0.8	2.5	1.3
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	5.2	-1.9	-2.3	-1.1
Commuting to job workplace: Walk	1.7	1.9	4.2	0.6	1.0	2.0
Eye problems/disorders: Cataract	1.7	1.9	4.4	-2.1	-1.0	-0.6
Basal cell carcinoma (self-reported)	1.7	2.0	4.9	0.1	-1.1	-2.2
Hair/balding pattern: Pattern 3	1.6	2.3	4.4	1.6	2.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.0	-1.7	-1.5	-0.7
Back pain experienced in last month	1.6	2.4	3.2	1.4	1.4	1.8
Heart attack/myocardial infarction (self-reported)	1.6	2.1	3.0	1.7	0.8	1.6
Hypothyroidism (self reported)	1.5	3.5	5.9	-2.4	-2.0	-0.9
Fed-up feelings	1.5	2.7	6.5	2.5	0.8	1.0
Serious illness, injury or assault to yourself	1.5	1.9	5.3	0.4	0.4	2.3
Number of live births	1.5	2.1	3.2	-1.8	-1.7	-0.4
Peak expiratory flow (PEF)	1.5	3.4	4.0	2.0	1.5	2.0
Exposure to tobacco smoke outside home	1.5	1.9	3.5	-1.5	-1.9	0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.7	1.4	0.7	1.6
Medication: Bendroflumethiazide	1.5	2.2	4.2	-1.5	-2.0	-0.6
Cholesterol lowering medication	1.5	2.1	5.8	-0.8	-2.4	-0.2
Triglycerides	1.4	2.3	5.4	-0.5	-2.3	1.1
Systolic blood pressure, automated reading	1.4	4.0	5.9	-1.4	-2.4	2.1
Supplements: Zinc	1.4	1.5	3.3	0.8	1.8	0.8
Relative age voice broke	1.4	2.2	2.8	-1.7	-1.6	-1.1
Standing height	1.4	14.3	17.5	3.5	4.2	3.6
Blood clot in the leg (DVT)	1.4	1.8	3.0	-1.5	-1.7	-0.4
Heart disease (mother)	1.4	1.8	2.7	-1.6	-1.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.2	-1.5	-1.8	-0.2
Hair/balding pattern: Pattern 2	1.3	1.7	1.9	-1.1	-1.4	-1.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	3.1	-1.8	-1.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.0	1.7	1.6	0.8
Arm predicted mass (right)	1.3	6.8	8.2	2.9	2.0	2.8
Ever had bowel cancer screening	1.3	1.5	2.8	1.7	0.8	1.1
Diastolic blood pressure, automated reading	1.3	4.1	7.1	-1.6	-2.7	1.6
Maternal smoking around birth	1.2	1.8	3.2	-1.4	-1.8	-0.1
Alcohol intake versus 10 years previously	1.2	1.7	4.0	-0.8	0.8	2.0
Comparative body size at age 10	1.2	3.3	6.0	2.5	1.9	0.7
Number of children fathered	1.2	1.4	2.6	-0.1	-1.6	-1.2
Age at first live birth	1.2	2.1	4.5	0.6	2.1	1.2
Comparative height size at age 10	1.2	6.5	11.0	2.7	3.3	1.1
Osteoporosis (self-reported)	1.2	1.5	3.0	1.7	1.1	0.5
Mother’s age at death	1.2	1.5	3.1	0.8	0.8	1.8
Commuting to job workplace: Public transport	1.2	1.4	3.6	0.5	0.6	1.9
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.4	1.6	1.2	0.8
Arm fat-free mass (left)	1.2	6.3	7.4	2.7	2.1	2.7
Arm predicted mass (left)	1.2	6.3	8.1	2.6	1.9	2.8
Intelligence (Savage-Jansen 2018)	1.1	3.5	8.3	-2.9	-1.4	-0.4
Age at First Birth	1.1	1.6	3.9	-0.9	-0.2	2.0
Height	1.1	20.5	27.0	4.6	5.2	3.7
Sensitivity / hurt feelings	1.1	1.8	2.8	1.6	1.7	0.5
Diabetes (mother)	1.1	1.4	3.2	-0.5	-1.8	-0.9
Noisy workplace	1.1	1.3	1.8	1.3	1.3	0.7
Medication: Cholesterol lowering	1.1	1.8	3.3	-1.0	-1.8	1.0
Medication: Seretide 50 evohaler	1.1	1.2	3.1	-0.4	-1.8	-0.6
Wears glasses or contact lenses	1.1	1.2	1.5	-1.0	-1.1	1.2
Ever taken oral contraceptive pill	1.1	1.3	3.7	0.2	-0.2	1.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	1.9	1.1	0.8	1.4
Medication for hormone replacement therapy	1.0	1.1	1.8	-0.8	-1.4	-1.0
Pack years adult smoking proportion	1.0	1.5	2.6	1.6	0.6	1.2
Taking other prescription medications	1.0	1.5	3.1	-0.6	-1.0	1.8
Medication: Simvastatin	1.0	1.5	3.4	-0.5	-1.8	0.9
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.3	-2.1	-1.4	-0.4
Birth weight of first child	1.0	1.8	3.2	-0.9	-1.2	-1.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.0	0.2	1.7	-1.3
Arm fat-free mass (right)	1.0	5.0	7.0	2.6	1.6	2.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.1	0.1	1.4	2.0
Whole body fat-free mass	1.0	5.9	6.8	2.6	2.1	2.6
Whole body water mass	1.0	5.8	6.9	2.5	2.0	2.6
Basal metabolic rate	1.0	5.3	7.2	2.3	1.9	2.7
HbA1C	0.9	0.9	1.6	-0.8	-1.3	0.8
Allergy or Eczema	0.9	2.4	3.9	-2.0	-1.8	-0.3
Respiratory disease	0.9	1.9	2.8	-1.6	-1.7	0.6
Ever had hysterectomy (womb removed)	0.9	1.0	2.9	1.7	0.2	-0.1
Medication: Metformin	0.9	1.3	2.4	-0.5	-1.0	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.0	-0.9	-1.6	-1.7
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.0	-0.5	-0.0	-1.7
Mouth/teeth dental problems: Dentures	0.9	1.5	2.4	0.2	-1.6	1.4
Tense / ‘highly strung’	0.9	1.4	1.9	1.2	1.0	1.4
Hair/balding pattern: Pattern 4	0.9	2.1	2.7	1.4	1.6	1.3
Headache pain in last month	0.9	1.5	2.2	0.4	1.5	1.5
Gout (self-reported)	0.9	1.3	1.9	1.3	0.6	1.4
Medication: Amlodipine	0.9	1.3	3.6	0.0	-0.5	1.9
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.2	1.0	0.2	1.5
Medication: Omeprazole	0.9	1.0	1.7	1.0	0.6	1.3
Medication: Blood pressure	0.9	1.6	3.1	-1.0	-1.8	-1.0
Irritability	0.9	1.5	2.0	1.4	0.9	1.3
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.9	-1.4	-0.9	0.6
Myopia	0.9	1.3	2.5	0.7	1.6	1.0
Schizophrenia (2018)	0.8	1.7	2.9	-1.5	-0.1	-1.7
Rheumatoid Arthritis	0.8	1.1	1.6	-0.5	-1.2	-1.2
Hearing difficulty/problems: Yes	0.8	1.3	1.8	0.9	1.1	1.4
Medication: Levothyroxine sodium	0.8	1.4	2.4	-1.1	-1.5	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	2.8	-1.0	-1.7	-1.3
Qualifications: None of the above	0.8	1.8	4.7	-0.8	-2.2	0.4
Family relationship satisfaction	0.8	1.0	2.6	-0.6	-0.4	-1.6
Illnesses of siblings: Diabetes	0.8	1.0	2.1	1.4	0.3	0.8
Diabetes diagnosed by doctor	0.8	1.3	2.7	-0.0	-1.1	1.6
Illnesses of father: None of the above (group 1)	0.8	1.0	3.0	0.1	0.4	-1.7
Average weekly beer plus cider intake	0.8	1.1	3.0	-0.5	-0.3	1.7
Bipolar Disorder (2018)	0.7	1.1	2.8	0.7	-0.0	1.7
Depressed Affect (Nagel 2018)	0.7	1.5	2.6	1.6	0.7	1.2
Neuroticism (Nagel 2018)	0.7	1.5	3.0	1.7	1.1	0.6
HDL Cholesterol	0.7	1.2	1.9	1.3	1.4	0.1
LDL Cholesterol	0.7	1.0	2.0	-1.0	-1.4	-0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.0	-1.0	-0.6	-1.0
Multivitamins +/- minerals	0.7	0.8	2.4	-1.6	-0.1	0.3
Number of incorrect matches in round	0.7	1.1	2.0	-0.6	-0.9	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	1.4	0.8	0.8
Had other major operations	0.7	0.9	1.2	-0.6	-1.1	-1.0
Neuroticism score	0.7	1.5	2.7	1.6	0.6	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.9	-0.6	-1.1	1.4
Loud music exposure frequency	0.7	0.8	1.3	1.1	0.9	-0.4
High blood pressure (siblings)	0.7	1.0	1.7	-0.8	-1.3	-0.9
Pain experienced in last month	0.7	1.2	2.2	-1.5	-1.1	-0.2
Supplements: Calcium	0.7	0.8	1.2	1.1	0.9	0.5
Bipolar Disorder (2011)	0.6	0.6	1.3	0.2	1.1	-0.7
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.8	1.3	-0.2
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	-0.2	0.1	1.4
Allergy	0.6	1.4	2.1	1.5	1.4	-0.5
Medication: Ramipril	0.6	0.8	1.3	0.1	-1.0	1.2
Weight	0.6	2.9	6.7	1.2	0.6	2.6
Happiness	0.6	0.8	1.5	-0.9	-0.1	-1.2
Pulse wave peak to peak time	0.6	0.7	1.3	0.9	1.1	-0.2
Medication for pain relief, constipation, heartburn	0.6	0.9	1.7	0.9	0.5	-1.3
Migraine (self-reported)	0.6	0.7	2.0	-0.2	1.4	-0.3
Age at last live birth	0.6	0.9	2.3	-0.6	1.5	0.1
Medication: Aspirin	0.6	0.8	1.9	-0.6	-1.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.6	1.3	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.7	0.8	1.3	0.9
Guilty feelings	0.6	1.0	2.2	1.5	0.6	0.6
Alcohol drinker status: Previous	0.6	0.7	1.8	0.4	0.2	-1.4
Pack years of smoking	0.6	0.9	1.7	1.3	0.0	1.0
Depression (Nagel 2018)	0.5	0.7	1.4	0.9	1.2	0.1
Schizophrenia vs Biploar Disorder	0.5	0.6	1.1	0.2	1.0	-0.8
Crohns Disease (2017)	0.5	1.2	2.6	1.6	0.2	0.9
Ovarian Cancer	0.5	0.7	1.9	0.2	-0.1	-1.4
Prostate Cancer	0.5	0.8	1.6	1.3	0.4	0.7
Coronary Artery Disease (CAD)	0.5	0.6	1.1	-0.5	-1.0	-0.7
Ulcerative Colitis	0.5	0.8	1.7	0.6	0.5	1.3
BMI	0.5	2.9	4.9	-0.8	-2.2	1.8
Chronotype (morning person)	0.5	1.1	2.5	1.6	0.8	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	0.8	0.9	0.9	0.7
Medication: Co-codamol	0.5	0.6	1.1	-0.2	-0.9	1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.3	1.1	0.4	-0.3
Supplements: Glucosamine	0.5	0.7	1.6	-1.3	-0.6	0.1
Financial difficulties in last 2 years	0.5	0.7	1.5	-0.8	-1.2	-0.1
Pain all over the body in last month	0.5	0.5	1.5	0.3	0.1	1.2
Fluid intelligence score	0.5	1.1	2.9	-1.7	-0.5	0.1
Illnesses of siblings	0.5	0.8	1.7	0.7	1.3	0.4
Arm fat percentage (right)	0.5	1.8	2.3	-1.2	-1.5	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	-0.8	0.5	1.0
Birth weight	0.5	1.1	2.5	-0.9	0.1	1.6
Neck or shoulder pain in last month	0.5	0.7	1.5	1.2	0.5	0.6
Medication: Allopurinol	0.5	0.7	1.9	0.5	0.1	1.4
Mean time to correctly identify matches	0.5	0.9	2.2	-0.8	-1.5	-0.0
Arm fat percentage (left)	0.5	2.2	3.4	-1.5	-1.9	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-1.1	0.3	-0.5
Loneliness, isolation	0.5	0.7	1.1	-0.6	-1.1	-0.7
Mineral and other dietary supplements	0.5	0.6	1.8	1.4	0.1	-0.2
Breast cancer (self-reported)	0.5	0.6	0.8	0.5	0.9	0.9
Medication: Aspirin	0.5	0.7	1.7	-0.1	-1.3	0.5
Hearing aid user	0.5	0.5	1.5	0.2	0.2	-1.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	-0.9	-0.8	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	-0.5	-0.3	-1.1
Major Depression (MDD)	0.4	0.5	0.7	0.5	0.8	-0.8
Breast Cancer	0.4	1.0	2.2	1.5	0.3	0.8
Lupus	0.4	0.6	1.0	0.6	1.0	0.5
Blood Red Count	0.4	4.1	7.3	-2.1	-2.7	-0.7
Systolic Blood Pressure	0.4	1.9	4.4	-0.6	-0.9	2.1
Hand grip strength (left)	0.4	1.1	1.3	1.0	1.0	1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.2	0.3	0.2	1.1
Severe depression (siblings)	0.4	0.5	1.3	0.3	0.1	1.1
High blood pressure	0.4	1.1	3.1	-0.4	-1.8	0.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.8	-1.3	-0.8	0.4
Sitting height	0.4	2.5	4.4	1.0	1.5	2.1
Past tobacco smoking	0.4	0.8	2.1	0.1	-0.6	-1.5
Had menopause	0.4	0.5	1.0	-0.2	-0.5	-1.0
Diabetes (self-reported)	0.4	0.6	0.9	-0.4	-0.9	0.9
Hip circumference	0.4	1.6	3.5	1.1	0.2	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.7	-0.7	-0.9	0.4
Pulse wave Arterial Stiffness index	0.4	0.4	0.6	-0.5	-0.8	0.6
Length of working week for main job	0.4	0.4	0.9	0.0	-0.9	0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.8	-0.4	0.2	-1.4
Body fat percentage	0.4	1.6	2.5	-0.9	-1.6	1.2
Leg fat percentage (right)	0.4	1.3	1.9	-0.3	-1.4	1.4
Wheeze or whistling in the chest in last year	0.4	0.8	1.6	-0.8	-0.3	1.3
Shortness of breath walking on level ground	0.4	0.5	1.3	0.3	-0.0	1.2
Medication: Blood pressure	0.4	0.8	1.5	0.6	-0.7	1.2
Medication: Ibuprofen	0.4	0.5	0.9	-1.0	-0.4	0.7
Had major operations	0.4	0.5	1.4	-0.4	0.0	1.2
Leg fat-free mass (right)	0.4	1.9	2.5	1.3	1.3	1.6
Long-standing illness, disability or infirmity	0.4	0.6	1.8	0.3	-0.3	1.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	-0.3	0.0	1.2
Commuting to job workplace: Cycle	0.4	0.4	1.3	0.1	-0.1	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.2	0.2	1.8	-0.6
Irritable Bowel Disease (IBD)	0.3	0.6	1.4	1.2	0.0	0.7
Reaction Time	0.3	0.5	0.9	-0.9	-0.9	0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	-1.3	-0.8	0.1
Crohns Disease (2012)	0.3	0.5	0.9	0.9	-0.0	0.9
Smoking Status	0.3	0.8	0.8	0.9	0.9	0.9
Cardiovascular Disease	0.3	0.9	1.5	0.4	-1.1	1.2
Average weekly spirits intake	0.3	0.4	0.8	-0.1	-0.6	0.9
Angina	0.3	0.4	0.7	-0.1	-0.8	0.7
Diabetes (father)	0.3	0.3	0.9	-0.9	-0.3	-0.2
Leg fat-free mass (left)	0.3	1.4	2.7	1.0	0.8	1.6
Trunk fat percentage	0.3	1.3	2.0	-0.8	-1.4	1.1
Current tobacco smoking	0.3	0.5	1.1	0.5	0.0	1.1
Average weekly fortified wine intake	0.3	0.3	0.4	0.7	-0.6	-0.3
Age when periods started (menarche)	0.3	0.7	1.3	1.1	0.6	0.6
High blood pressure (mother)	0.3	0.4	1.1	0.4	0.2	-1.1
Impedance of leg (left)	0.3	1.5	2.4	1.4	1.6	0.4
Leg predicted mass (left)	0.3	1.7	3.0	1.1	0.9	1.7
Trunk fat mass	0.3	1.4	3.6	-0.0	-0.7	1.9
Waist circumference	0.3	1.2	2.5	1.1	0.1	1.6
Alcohol usually taken with meals	0.3	0.4	1.0	-0.3	0.4	-1.0
Nervous feelings	0.3	0.6	1.0	0.9	1.0	-0.4
Mouth/teeth dental problems	0.3	0.5	0.9	0.0	1.0	-0.7
Father’s age at death	0.3	0.4	0.6	0.8	-0.3	-0.8
Depression (self-reported)	0.3	0.4	0.7	0.5	0.4	0.8
Medication: Lansoprazole	0.3	0.3	0.8	0.9	-0.1	-0.3
Impedance of arm (left)	0.3	1.5	3.2	-1.8	-0.2	-1.1
Arm fat mass (right)	0.3	1.1	2.9	-0.2	-0.7	1.7
Breastfed as a baby	0.3	0.4	0.7	0.1	-0.7	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.5	-0.6	-0.7	0.5
Worry too long after embarrassment	0.3	0.5	0.7	0.7	0.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.7	0.9	0.6	0.0
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.9	-0.4	-0.3
Emphysema/chronic bronchitis	0.3	0.3	0.8	0.9	-0.0	0.4
Angina (self-reported)	0.3	0.5	1.1	0.1	-1.0	0.6
Whole body fat mass	0.3	1.3	3.6	-0.0	-0.6	1.9
Leg fat mass (right)	0.3	1.2	2.9	0.2	-0.8	1.7
Suffer from ‘nerves’	0.3	0.5	1.3	1.1	0.4	-0.5
Overall health rating	0.3	0.6	1.0	1.0	-0.1	0.9
Leg pain on walking	0.3	0.4	1.1	1.0	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	1.1	0.1	0.0
Hypertension (Self-reported)	0.3	0.9	2.3	-0.4	-1.5	0.2
Illnesses of father: Heart disease	0.3	0.4	1.1	1.0	0.1	0.3
Smoking status: Previous	0.3	0.5	0.9	0.0	0.7	1.0
Leg predicted mass (right)	0.3	1.7	2.2	1.2	1.2	1.5
Average weekly champagne plus white wine intake	0.3	0.5	1.1	0.5	0.1	-1.1
Financial situation satisfaction	0.3	0.4	1.0	1.0	0.0	-0.5
Ever smoked	0.3	0.5	1.1	0.0	0.7	1.0
Leg fat percentage (left)	0.3	1.0	1.8	0.2	-1.0	1.3
Risk taking	0.3	0.5	0.7	0.3	0.7	0.9
Heart disease (siblings)	0.3	0.4	0.5	-0.5	-0.6	0.7
Leg fat mass (left)	0.3	1.2	2.9	0.4	-0.7	1.7
Mean Putamen Volume	0.2	0.2	0.2	0.2	0.5	0.5
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.9	-0.1	-0.2
Schizophrenia (2014)	0.2	0.5	0.7	-0.8	0.6	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	0.2	-0.7	0.8
Lung FEV1/FVC ratio	0.2	0.9	2.0	0.8	1.4	0.1
Neuroticism	0.2	0.5	0.9	0.9	0.1	0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	0.4	-0.8	0.2
Vitamin and mineral supplements	0.2	0.3	0.8	0.9	0.2	-0.4
Impedance of leg (right)	0.2	0.8	1.4	0.9	1.2	0.5
Townsend deprivation index at recruitment	0.2	0.3	0.8	-0.2	0.1	0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.3	0.5	0.5
Medication: Atenolol	0.2	0.3	0.7	0.0	-0.8	0.4
Body mass index (BMI)	0.2	1.0	1.5	-0.1	-1.2	1.2
Hearing difficulty/problems with background noise	0.2	0.4	1.0	0.3	1.0	-0.1
Impedance of arm (right)	0.2	1.0	2.2	-1.5	0.2	-0.8
Worrier / anxious feelings	0.2	0.4	0.9	1.0	-0.2	-0.4
Exposure to tobacco smoke at home	0.2	0.3	0.5	0.7	-0.4	0.2
Health satisfaction	0.2	0.2	0.5	0.4	0.7	0.3
Chest pain or discomfort	0.2	0.2	0.4	0.7	0.4	0.3
Supplements: Vitamin C	0.2	0.2	0.4	-0.3	-0.6	0.3
Knee pain experienced in last month	0.2	0.3	0.7	0.0	-0.8	0.5
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.4	-0.5	-0.7
Smoking status: Current	0.2	0.3	0.7	0.4	0.0	0.9
Arm fat mass (left)	0.2	0.9	2.0	-0.4	-0.8	1.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	-0.1	-0.7	0.8
Medication: Paracetamol	0.2	0.3	0.6	-0.6	-0.8	0.2
Medication: Lisinopril	0.2	0.3	0.5	0.7	0.0	0.5
Medication: Atorvastatin	0.2	0.3	0.6	-0.4	-0.8	-0.4
Illnesses of father: High blood pressure	0.2	0.3	0.8	0.9	0.1	-0.1
Age started oral contraceptive pill	0.2	0.3	0.7	0.3	-0.8	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.7	-0.1	-0.3
Worry (Nagel 2018)	0.1	0.1	0.3	0.6	0.0	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.5	0.3	0.2
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.4	-0.2	0.6
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.0	-0.4	0.1
Blood Eosinophil Count	0.1	0.6	0.9	-0.9	-0.9	0.5
Blood Platelet Count	0.1	0.8	1.1	1.1	1.0	0.5
Blood White Count	0.1	0.5	1.2	0.5	0.3	1.1
Waist Hip Ratio (WHR)	0.1	0.2	0.6	0.3	-0.0	-0.8
Relative age of first facial hair	0.1	0.2	0.5	-0.1	-0.7	-0.1
Hand grip strength (right)	0.1	0.4	0.4	0.6	0.6	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.5	-0.1	-0.2
Time employed in main current job	0.1	0.1	0.1	-0.4	0.2	0.0
Falls in the last year	0.1	0.1	0.2	0.3	-0.5	0.3
Asthma	0.1	0.2	0.3	-0.3	-0.6	0.3
Prospective memory result	0.1	0.1	0.4	-0.2	-0.0	-0.6
Lung cancer (father)	0.1	0.1	0.2	0.4	-0.0	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.1	0.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	0.3	0.3	-0.2
Medication: Paracetamol	0.1	0.2	0.4	-0.5	-0.2	0.6
Number of full sisters	0.1	0.1	0.2	-0.4	0.3	-0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	0.1	-0.3	-0.7
Average weekly red wine intake	0.1	0.2	0.2	0.3	0.5	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.2	0.4	0.4
Friendships satisfaction	0.1	0.1	0.2	-0.0	-0.3	-0.5
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.5	-0.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	0.0	0.3	-0.6
Asthma (self-reported)	0.1	0.1	0.2	-0.3	-0.5	0.3
Alcohol drinker status: Never	0.1	0.1	0.3	0.3	-0.5	0.1
Number of operations (self-reported)	0.1	0.2	0.5	0.7	-0.3	-0.2
Ever depressed for a whole week	0.1	0.1	0.2	0.5	0.4	-0.0
Impedance of whole body	0.1	0.3	0.4	-0.6	0.5	-0.5
Hair Pigment	0.0	1.1	1.5	1.2	-0.4	1.2
Tanning	0.0	0.4	0.8	0.9	-0.5	0.5
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.1	-0.1	0.2
Qualifications: College or University degree	0.0	0.1	0.3	-0.5	-0.1	-0.1
Alcohol intake frequency.	0.0	0.0	0.0	0.1	-0.2	-0.2

Hub : Genes

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Trait associations