Best TWAS P=1.24e-39 · Best GWAS P=4.25e-41 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM167A | 0.11 | 0.09 | enet | 17 | 0.10 | 5.4e-12 | -4.8 | 5.4 | 6.1e-08 | 0.03 | 0.96 | 0.04 | FALSE |
| 2 | GTEx | Artery Coronary | DHFR | 0.33 | 0.10 | enet | 45 | 0.13 | 3.9e-05 | 3.1 | 5.4 | 7.0e-08 | 0.21 | 0.49 | 0.05 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | RP11-343L5.2 | 0.06 | 0.05 | lasso | 3 | 0.04 | 9.6e-04 | -5.3 | -5.4 | 8.2e-08 | 0.00 | 0.20 | 0.55 | FALSE |
| 4 | GTEx | Colon Transverse | RPS23 | 0.30 | 0.08 | enet | 16 | 0.20 | 1.1e-09 | -2.2 | -5.2 | 2.3e-07 | 0.04 | 0.79 | 0.02 | TRUE |
| 5 | GTEx | Liver | RASGRF2 | 0.30 | 0.05 | lasso | 7 | 0.09 | 2.0e-03 | 3.4 | 5.7 | 1.2e-08 | 0.49 | 0.09 | 0.33 | FALSE |
| 6 | GTEx | Testis | XRCC4 | 0.43 | 0.52 | enet | 13 | 0.53 | 1.8e-27 | -6.6 | 6.7 | 1.6e-11 | 0.02 | 0.01 | 0.99 | TRUE |
| 7 | GTEx | Thyroid | RASGRF2 | 0.26 | 0.03 | enet | 21 | 0.11 | 9.7e-09 | 13.3 | 7.3 | 2.0e-13 | 0.62 | 0.01 | 0.99 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | CTC-459I6.1 | 0.08 | 0.01 | enet | 29 | 0.01 | 9.6e-03 | 9.1 | -7.2 | 6.4e-13 | -0.55 | 0.03 | 0.82 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RASGRF2 | 0.03 | 0.03 | lasso | 3 | 0.02 | 8.6e-06 | 13.4 | 13.2 | 1.2e-39 | 1.00 | 0.00 | 1.00 | TRUE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | XRCC4 | 0.01 | 0.01 | blup | 95 | 0.01 | 1.1e-02 | -6.7 | 6.3 | 2.6e-10 | 0.03 | 0.02 | 0.85 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | RASGRF2 | 0.12 | 0.07 | blup | 232 | 0.07 | 4.3e-07 | 13.4 | 9.1 | 8.1e-20 | 0.71 | 0.00 | 1.00 | FALSE |